Samuel Lai

Tiruthani, K., Cruz-Teran, C., Chan, J. F. W., Ma, A., Mcsweeney, M., Wolf, W., … Lai, S. K. (2024, February 7). Engineering a "muco-trapping" ACE2-immunoglobulin hybrid with picomolar affinity as an inhaled, pan-variant immunotherapy for COVID-19. BIOENGINEERING & TRANSLATIONAL MEDICINE. https://doi.org/10.1002/btm2.10650

Pearson, J., Wessler, T., Chen, A., Boucher, R. C., Freeman, R., Lai, S. K., … Forest, G. (2023). Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection. JOURNAL OF THEORETICAL BIOLOGY, 565. https://doi.org/10.1016/j.jtbi.2023.111470

Talkington, A. M., McSweeney, M. D., Wessler, T., Rath, M. K., Li, Z., Zhang, T., … Lai, S. K. (2022). A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes. JOURNAL OF CONTROLLED RELEASE, 343, 518–527. https://doi.org/10.1016/j.jconrel.2022.01.022

McSweeney, M., Stewart, I., Richardson, Z., Kang, H., Park, Y., Kim, C., … Lai, S. (2022, August 30). Stable nebulization and muco-trapping properties of regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19. BIOENGINEERING & TRANSLATIONAL MEDICINE. https://doi.org/10.1002/btm2.10391

Huckaby, J. T., Landoni, E., Jacobs, T. M., Savoldo, B., Dotti, G., & Lai, S. K. (2021). Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(9). https://doi.org/10.1136/jitc-2021-002737

Cruz-Teran, C., Tiruthani, K., McSweeney, M., Ma, A., Pickles, R., & Lai, S. K. (2021). [Review of Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy]. ADVANCED DRUG DELIVERY REVIEWS, 169, 100–117. https://doi.org/10.1016/j.addr.2020.12.004

Shrestha, B., Schaefer, A., Zhu, Y., Saada, J., Jacobs, T. M., Chavez, E. C., … Lai, S. K. (2021). Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception. SCIENCE TRANSLATIONAL MEDICINE, 13(606). https://doi.org/10.1126/scitranslmed.abd5219

Talkington, A. M., Wessler, T., Lai, S. K., Cao, Y., & Forest, M. G. (2021). Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery. BULLETIN OF MATHEMATICAL BIOLOGY, 83(12). https://doi.org/10.1007/s11538-021-00950-z

Talkington, A. M., McSweeney, M. D., Zhang, T., Li, Z., Nyborg, A. C., LaMoreaux, B., … Lai, S. K. (2021). High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies. JOURNAL OF CONTROLLED RELEASE, 338, 804–812. https://doi.org/10.1016/j.jconrel.2021.08.051

Lai, S. K., McSweeney, M. D., & Pickles, R. J. (2021). Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19. JOURNAL OF CONTROLLED RELEASE, 329, 87–95. https://doi.org/10.1016/j.jconrel.2020.11.057

McSweeney, M. D., Shen, L., DeWalle, A. C., Joiner, J. B., Ciociola, E. C., Raghuwanshi, D., … Lai, S. K. (2021). Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice. JOURNAL OF CONTROLLED RELEASE, 329, 774–781. https://doi.org/10.1016/j.jconrel.2020.10.011

Schaefer, A., & Lai, S. K. (2021, June 26). The biophysical principles underpinning muco-trapping functions of antibodies. HUMAN VACCINES & IMMUNOTHERAPEUTICS. https://doi.org/10.1080/21645515.2021.1939605

Schiller, J. L., Fogle, M. M., Bussey, O., Kissner, W. J., Hill, D. B., & Lai, S. K. (2020). Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds. ACTA BIOMATERIALIA, 107, 91–101. https://doi.org/10.1016/j.actbio.2020.03.002

Voorhees, P. J., Cruz-Teran, C., Edelstein, J., & Lai, S. K. (2020). [Review of Challenges & opportunities for phage-based in situ microbiome engineering in the gut]. JOURNAL OF CONTROLLED RELEASE, 326, 106–119. https://doi.org/10.1016/j.jconrel.2020.06.016

Shrestha, B., Schaefer, A., Chavez, E. C., Kopp, A. J., Jacobs, T. M., Moench, T. R., & Lai, S. K. (2020). Engineering tetravalent IgGs with enhanced agglutination potencies for trapping vigorously motile sperm in mucin matrix. ACTA BIOMATERIALIA, 117, 226–234. https://doi.org/10.1016/j.actbio.2020.09.020

Schroeder, H. A., Newby, J., Schaefer, A., Subramani, B., Tubbs, A., Gregory Forest, M., … Lai, S. K. (2020). LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus. MUCOSAL IMMUNOLOGY, 13(5), 814–823. https://doi.org/10.1038/s41385-020-0267-9

Huckaby, J. T., Jacobs, T. M., Li, Z., Perna, R. J., Wang, A., Nicely, N. I., & Lai, S. K. (2020). Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers. COMMUNICATIONS CHEMISTRY, 3(1). https://doi.org/10.1038/s42004-020-00369-y

Hoang, T., Toler, E., DeLong, K., Mafunda, N. A., Bloom, S. M., Zierden, H. C., … Ensign, L. M. (2020). The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis. PLOS PATHOGENS, 16(1). https://doi.org/10.1371/journal.ppat.1008236

Schiller, J. L., & Lai, S. K. (2020). [Review of Tuning Barrier Properties of Biological Hydrogels]. ACS APPLIED BIO MATERIALS, 3(5), 2875–2890. https://doi.org/10.1021/acsabm.0c00187

Huckaby, J. T., Parker, C. L., Jacobs, T. M., Schaefer, A., Wadsworth, D., Nguyen, A., … Lai, S. K. (2019). Engineering Polymer-Binding Bispecific Antibodies for Enhanced Pretargeted Delivery of Nanoparticles to Mucus-Covered Epithelium. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(17), 5604–5608. https://doi.org/10.1002/anie.201814665

Patel, K. B., Mao, S., Forest, M. G., Lai, S. K., & Newby, J. M. (2019). Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes. PHYSICAL REVIEW E, 100(2). https://doi.org/10.1103/PhysRevE.100.022408

Xu, F., Newby, J. M., Schiller, J. L., Schroeder, H. A., Wessler, T., Chen, A., … Lai, S. K. (2019). Modeling Barrier Properties of Intestinal Mucus Reinforced with IgG and Secretory IgA against Motile Bacteria. ACS INFECTIOUS DISEASES, 5(9), 1570–1580. https://doi.org/10.1021/acsinfecdis.9b00109

McSweeney, M. D., Price, L. S. L., Wessler, T., Ciociola, E. C., Herity, L. B., Piscitelli, J. A., … Lai, S. K. (2019). Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG. JOURNAL OF CONTROLLED RELEASE, 311, 138–146. https://doi.org/10.1016/j.jconrel.2019.08.017

Schiller, J. L., Marvin, A., McCallen, J. D., & Lai, S. K. (2019). Robust antigen-specific tuning of the nanoscale barrier properties of biogels using matrix-associating IgG and IgM antibodies. ACTA BIOMATERIALIA, 89, 95–103. https://doi.org/10.1016/j.actbio.2019.03.023

Chen, A., McKinley, S. A., Wang, S., Shi, F., Mucha, P. J., Forest, M. G., & Lai, S. K. (2014). Transient Antibody-Mucin Interactions Produce a Dynamic Molecular Shield against Viral Invasion. BIOPHYSICAL JOURNAL, 106(9), 2028–2036. https://doi.org/10.1016/j.bpj.2014.02.038