Works (25)

Updated: August 3rd, 2023 21:15

2020 journal article

Local and regional temporal trends (2013-2019) of canine Ehrlichia spp. seroprevalence in the USA

PARASITES & VECTORS, 13(1).

By: J. Gettings*, S. Self*, C. McMahan*, D. Brown*, S. Nordone n & M. Yabsley*

author keywords: Ehrlichia canis; Ehrlichia chaffeensis; Ehrlichia ewingii; Temporal trends; USA; Vector-borne
MeSH headings : Animals; Antibodies, Bacterial / blood; Appalachian Region; Bayes Theorem; Dog Diseases / epidemiology; Dog Diseases / immunology; Dog Diseases / microbiology; Dogs; Ehrlichia / classification; Ehrlichia / immunology; Ehrlichia canis / immunology; Ehrlichia chaffeensis / immunology; Ehrlichiosis / epidemiology; Ehrlichiosis / immunology; Ehrlichiosis / veterinary; Humans; Seroepidemiologic Studies; United States / epidemiology
TL;DR: The findings from this study indicate that dogs across a wide area of the USA are at risk of exposure to tick exposure and these results should provide veterinarians and pet owners with the information they need to make informed decisions about prevention of tick exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Regional and Local Temporal Trends of Borrelia burgdorferi and Anaplasma spp. Seroprevalence in Domestic Dogs: Contiguous United States 2013-2019

FRONTIERS IN VETERINARY SCIENCE, 7.

By: J. Gettings*, S. Self*, C. McMahan*, D. Brown*, S. Nordone n & M. Yabsley*

author keywords: Anaplasma spp; Borrelia burgdorferi; public health; vector-borne; veterinary epidemiology; ticks and tick-borne pathogens
TL;DR: Dogs are valuable sentinels for some vector-borne pathogens, and these trends may help public health providers better understand the risk of exposure for humans. (via Semantic Scholar)
Source: Web Of Science
Added: November 30, 2020

2019 review

Canine vector-borne disease: mapping and the accuracy of forecasting using big data from the veterinary community

[Review of ]. ANIMAL HEALTH RESEARCH REVIEWS, 20(1), 47–60.

By: S. Self*, Y. Liu, S. Nordone n, M. Yabsley*, H. Walden*, R. Lund*, D. Bowman*, C. Carpenter, C. McMahan*, J. Gettings*

author keywords: Anaplasma; canine vector-borne disease; Ehrlichia; epidemiology; forecast; heartworm; Lyme; One Health
MeSH headings : Aging; Animals; Big Data; Dog Diseases / epidemiology; Dog Diseases / parasitology; Dog Diseases / prevention & control; Dogs; Humans; Immunocompromised Host; Pets; Risk Factors; Vector Borne Diseases / epidemiology; Vector Borne Diseases / veterinary; Zoonoses
TL;DR: A review summarizes the fidelity of VBD forecasts and illustrates the practical use of CAPC pathogen prevalence maps and forecast data in the practice of veterinary medicine and client education. (via Semantic Scholar)
Source: Web Of Science
Added: February 3, 2020

2019 journal article

Quantifying the relationship between human Lyme disease and Borrelia burgdorferi exposure in domestic dogs

GEOSPATIAL HEALTH, 14(1), 111–120.

By: Y. Liu, S. Nordone n, M. Yabsley*, R. Lund*, C. McMahan* & J. Gettings*

author keywords: Lyme disease; Canine sentinel; Borrelia burgdorferi; USA
MeSH headings : Animals; Bayes Theorem; Borrelia burgdorferi; Dog Diseases / epidemiology; Dogs; Humans; Incidence; Lyme Disease / epidemiology; Pets / microbiology; Seroepidemiologic Studies; United States / epidemiology
TL;DR: Bayesian statistical methods were used to fit a spatio-temporal spline regression model to estimate the relationship between human LD incidence and canine seroprevalence, and a strong non-linear monotonically increasing association was found. (via Semantic Scholar)
Source: Web Of Science
Added: June 4, 2019

2017 journal article

A Bayesian spatio-temporal model for forecasting Anaplasma species seroprevalence in domestic dogs within the contiguous United States

PLOS ONE, 12(7).

By: Y. Liu, S. Watson*, J. Gettings*, R. Lund*, S. Nordone n, M. Yabsley*, C. McMahan*

MeSH headings : Anaplasma / immunology; Anaplasmosis / blood; Anaplasmosis / immunology; Animals; Antibodies, Bacterial / blood; Bayes Theorem; Climate; Dog Diseases / blood; Dog Diseases / immunology; Dogs; Forecasting / methods; Population Density; Prevalence; Seroepidemiologic Studies; United States
TL;DR: The forecast presented herein can a priori alert veterinarians to areas expected to see Anaplasma spp. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

A Bayesian spatio-temporal model for forecasting the prevalence of antibodies to Borrelia burgdorferi, causative agent of Lyme disease, in domestic dogs within the contiguous United States

PLOS ONE, 12(5).

By: S. Watson*, Y. Liu, R. Lund*, J. Gettings*, S. Nordone n, C. McMahan*, M. Yabsley*

MeSH headings : Animals; Animals, Domestic; Antibodies, Bacterial / blood; Bayes Theorem; Dog Diseases / blood; Dog Diseases / immunology; Dogs; Forecasting; Lyme Disease / blood; Lyme Disease / immunology; Lyme Disease / veterinary; Models, Theoretical; Seroepidemiologic Studies; United States
TL;DR: The forecast presented from this model can be used to alert veterinarians in areas likely to see above average B. burgdorferi antibody prevalence in dogs in the upcoming year and may ultimately prove useful in predicting areas where human Lyme disease risk may emerge. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Disruption of Trim9 function abrogates macrophage motility in vivo

Journal of Leukocyte Biology, 102(6), 1371–1380.

By: D. Tokarz n, A. Heffelfinger n, D. Jima n, J. Gerlach n, R. Shah n, I. Rodriguez-Nunez n, A. Kortum n, A. Fletcher n ...

author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Endothelial alterations in a canine model of immune thrombocytopenia

Platelets, 30(1), 88–97.

By: D. LeVine n, R. Cianciolo*, K. Linder n, P. Bizikova n, A. Birkenheuer n, M. Brooks*, A. Salous*, S. Nordone n ...

author keywords: Dog; endothelium; ITP
MeSH headings : Animals; Biomarkers; Biopsy; Blood Coagulation; Blood Platelets / metabolism; Blood Platelets / ultrastructure; Disease Models, Animal; Dogs; Endothelium / metabolism; Endothelium / ultrastructure; Flow Cytometry; Lysophospholipids / blood; Male; Platelet Activation; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / drug therapy; Purpura, Thrombocytopenic, Idiopathic / etiology; Purpura, Thrombocytopenic, Idiopathic / metabolism; Sphingosine / analogs & derivatives; Sphingosine / blood; von Willebrand Factor / metabolism
TL;DR: The results indicate that endothelial damage occurs in the canine ITP model and variability in the degree of endothelialDamage may account for differences in the bleeding phenotype among patients with ITP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: March 18, 2019

2016 journal article

Forecasting United States heartworm Dirofilaria immitis prevalence in dogs

PARASITES & VECTORS, 9.

By: D. Bowman*, Y. Liu, C. McMahan*, S. Nordone n, M. Yabsley* & R. Lund*

author keywords: Autoregression; CAR Model; Head-banging; Heartworm; Kriging; Prevalence; Spatio-temporal correlation
MeSH headings : Animals; Climate; Culicidae / growth & development; Dirofilaria immitis / isolation & purification; Dirofilariasis / epidemiology; Dirofilariasis / parasitology; Dog Diseases / epidemiology; Dog Diseases / parasitology; Dogs; Forecasting; Models, Statistical; Prevalence; Spatio-Temporal Analysis; United States / epidemiology
TL;DR: The forecast presented herein can a priori alert veterinarians to areas expected to see higher than normal heartworm activity and may prove useful for forecasting other diseases. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?

British Journal of Haematology, 167(1), 110–120.

By: D. LeVine n, A. Birkenheuer n, M. Brooks*, S. Nordone n, D. Bellinger*, S. Jones n, T. Fischer*, S. Oglesbee* ...

author keywords: immune thrombocytopenia; canine; interleukin-8; animal model
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / immunology; Blood Platelets / immunology; Blood Platelets / metabolism; Cytokines / blood; Cytokines / metabolism; Disease Models, Animal; Dogs; Hemorrhage / immunology; Phenotype; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / diagnosis; Purpura, Thrombocytopenic, Idiopathic / immunology
TL;DR: Evaluation of cytokine profiles led to the identification of platelets as a potential source of serum interleukin‐8 (IL8) in dogs, suggesting that platelet IL8 may be a previously unrecognized modulator of platelet‐neutrophil crosstalk in humans with ITP. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

N-Terminal Pro-C-Natriuretic Peptide and Cytokine Kinetics in Dogs with Endotoxemia

JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(5), 1447–1453.

By: A. Floras*, M. Holowaychuk*, D. Bienzle*, A. Bersenas*, S. Sharif*, T. Harvey*, S. Nordone n, G. Wood*

author keywords: Biomarker; ELISA; Immunology; Inflammation; Multiplex; Sepsis
MeSH headings : Animals; Chemokine CCL2 / blood; Chemokine CXCL10 / blood; Chemokines / blood; Cross-Over Studies; Cytokines / blood; Dog Diseases / blood; Dog Diseases / metabolism; Dogs / blood; Endotoxemia / blood; Endotoxemia / metabolism; Endotoxemia / veterinary; Female; Interleukin-10 / blood; Interleukin-6 / blood; Interleukin-8 / blood; Natriuretic Peptide, C-Type / blood; Sepsis / blood; Sepsis / metabolism; Sepsis / veterinary; Tumor Necrosis Factor-alpha / blood
TL;DR: Serum NT‐proCNP concentration does not change significantly in response to LPS administration in healthy dogs and certain serum cytokine and chemokine concentrations are significantly increased within 1–4 hours after L PS administration and warrant further investigation as tools for the detection and management of sepsis in dogs. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils

American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.

By: J. Li, M. D’Annibale-Tolhurst, K. Adler*, S. Fang*, Q. Yin*, A. Birkenheuer*, M. Levy n, S. Jones* ...

author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2013 journal article

Infection with feline immunodeficiency Virus alters intestinal epithelial transport and mucosal immune responses to probiotics

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 153(1-2), 146–152.

By: L. Stoeker*, E. Overman, S. Nordone, A. Moeser*, R. Simoes* & G. Dean

author keywords: HIV; FIV; Lactobacillus; Mucosal immune system
MeSH headings : Animals; Biological Transport; Cats; Electric Impedance; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / metabolism; Immunity, Mucosal / drug effects; Intestinal Mucosa / metabolism; Probiotics / pharmacology
TL;DR: A novel role for FIV in upregulating transcellular transport across the gastrointestinal epithelial barrier is suggested and the potential therapeutic use of probiotic bacteria to restore intestinal homeostasis is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery

CLINICAL AND VACCINE IMMUNOLOGY, 19(9), 1374–1381.

By: A. Kajikawa*, L. Zhang*, J. Long n, S. Nordone n, L. Stoeker n, A. LaVoy*, S. Bumgardner n, T. Klaenhammer n, G. Dean*

MeSH headings : AIDS Vaccines / administration & dosage; AIDS Vaccines / genetics; AIDS Vaccines / immunology; Administration, Oral; Animals; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Cell Surface Display Techniques / methods; Cells, Cultured; Dendritic Cells / immunology; Female; Flagellin / genetics; Flagellin / immunology; HIV-1 / genetics; HIV-1 / immunology; Humans; Intestinal Mucosa / immunology; Lactobacillus acidophilus / genetics; Leukocytes, Mononuclear / immunology; Mice; Mice, Inbred BALB C; Salmonella typhimurium / genetics; Salmonella typhimurium / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology; gag Gene Products, Human Immunodeficiency Virus / genetics; gag Gene Products, Human Immunodeficiency Virus / immunology
TL;DR: Results suggested that the Gag-displaying L. acidophilus elicited specific immune responses and the coexistence of FliC conferred an adjuvant effect on local IgA production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Hypocalcemia and Hypovitaminosis D in Dogs with Induced Endotoxemia

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 244–251.

By: M. Holowaychuk*, A. Birkenheuer n, J. Li n, H. Marr n, A. Boll n & S. Nordone n

author keywords: Animal model; Calcium; Magnesium; Parathyroid hormone; Sepsis; Vitamin D
MeSH headings : Animals; Blood Gas Analysis / veterinary; Blood Pressure; Body Temperature; Calcium / blood; Calcium / urine; Cross-Over Studies; Dog Diseases / blood; Dog Diseases / metabolism; Dogs; Endotoxemia / blood; Endotoxemia / complications; Endotoxemia / metabolism; Endotoxemia / veterinary; Hypocalcemia / blood; Hypocalcemia / complications; Hypocalcemia / metabolism; Hypocalcemia / veterinary; Magnesium / blood; Magnesium / urine; Male; Parathyroid Hormone / blood; Vitamin D / analogs & derivatives; Vitamin D / blood
TL;DR: Hypocalcemia occurs during endotoxemia in dogs and is associated with hypovitaminosis D, and hypomagnesemia, hypoparathyroidism, alkalosis, and increased calciuresis are not associated with HypocalCEmia in endotoxemic dogs. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector

CLINICAL AND VACCINE IMMUNOLOGY, 18(11), 1834–1844.

MeSH headings : Adjuvants, Immunologic / genetics; Administration, Oral; Animals; B-Lymphocytes / immunology; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Blood / immunology; Colon / immunology; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers / administration & dosage; Female; Flagellin / genetics; Genetic Vectors; Humans; Intestinal Mucosa / immunology; Lactobacillus / genetics; Lactobacillus / immunology; Mice; Mice, Inbred BALB C; Plasmids; Toll-Like Receptor 5 / immunology
TL;DR: In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon and a significant decrease in the percentage of FoxP3+ colonic lymphocytes, and in vivo data clarify the interaction of L. Gasseri with the host immune system and support further investigation of the in vivo immunogenicity of the vector. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Assessment of urine solute and matrix effects on the performance of an enzyme-linked immunosorbent assay for measurement of interleukin-6 in dog urine

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 23(2), 316–320.

By: M. Wood n, S. Nordone n, S. Vaden n & E. Breitschwerdt n

author keywords: Cytokine; enzyme-linked immunosorbent assay; interleukin-6; matrix; urine
TL;DR: The role of urine pH, USG, and matrix are examined while optimizing a canine-specific chemiluminescent ELISA for the measurement of IL-6 in the urine of dogs to underscores the importance of critically optimizing testing modalities for biomarkers, particularly if they are immunologic in origin. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(18), 6587–6596.

MeSH headings : Acids / metabolism; Antigens, Bacterial / genetics; Antigens, Bacterial / metabolism; Cells, Cultured; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers; Drug Stability; Flagellin / genetics; Flagellin / metabolism; Genetic Vectors; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Peptide Hydrolases / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Salmonella Vaccines / genetics; Salmonella Vaccines / immunology; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology
TL;DR: Two recombinant L. acidophilus derivatives displaying Salmonella flagellin were constructed using different anchor motifs, and the surface-associated antigen was highly sensitive to simulated gastric and small intestinal juices. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils

Developmental & Comparative Immunology, 35(8), 872–880.

By: J. Li, A. Birkenheuer*, H. Marr*, M. Levy*, J. Yoder* & S. Nordone

author keywords: TREM-1; TLR; Neutrophils; Sepsis; Canine
MeSH headings : Amino Acid Sequence; Animals; Cells, Cultured; Cloning, Molecular; Conserved Sequence; Cytokines / immunology; Cytokines / metabolism; Dogs / genetics; Dogs / immunology; Humans; Lipopolysaccharides / immunology; Lipopolysaccharides / pharmacology; Membrane Glycoproteins / genetics; Membrane Glycoproteins / immunology; Membrane Glycoproteins / metabolism; Molecular Sequence Data; Neutrophils / immunology; Neutrophils / metabolism; Phylogeny; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Sequence Alignment; Teichoic Acids / immunology; Teichoic Acids / pharmacology; Toll-Like Receptors / agonists; Up-Regulation / drug effects
TL;DR: Functionally, canine TREM-1 synergistically enhances LPS-induced production of IL-8, TNF-α and a canine orthologue of CXCL1 and these data suggest that T REM-1 expression in dogs is an amplifier of pro-inflammatory responses to microbial products. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2011 journal article

Host immune responses that promote initial HIV spread

JOURNAL OF THEORETICAL BIOLOGY, 289, 17–35.

By: K. Wendelsdorf*, G. Dean n, S. Hu n, S. Nordone n & H. Banks n

author keywords: HIV; Innate inflammatory response pathway; Regulatory response pathway; Mathematical model
MeSH headings : CD4-Positive T-Lymphocytes / immunology; Dendritic Cells / immunology; HIV / physiology; HIV Infections / immunology; HIV Infections / transmission; HIV Infections / virology; Humans; Inflammation / immunology; Inflammation / virology; Lymphocyte Activation / immunology; Models, Immunological; T-Lymphocytes, Regulatory / immunology; Virus Replication / immunology
TL;DR: A model of the host inflammatory response to virus as well as inherent nTreg-mediated regulation of Th1 recruitment and activation is created to identify mechanisms of the natural inflammatory response that are best targeted to inhibit viral spread without compromising initial antiviral activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Lymphocytes and not IFN-gamma mediate expression of iNOS by intestinal epithelium in murine cryptosporidiosis

PARASITOLOGY RESEARCH, 106(6), 1507–1511.

By: S. Nordone n & J. Gookin n

MeSH headings : Animals; Cryptosporidiosis / immunology; Cryptosporidium parvum / immunology; Female; Interferon-gamma / deficiency; Interferon-gamma / immunology; Intestinal Mucosa / immunology; Intestinal Mucosa / parasitology; Lymphocytes / immunology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, SCID; Nitric Oxide Synthase Type II / biosynthesis
TL;DR: It is hypothesized that unrecognized differences in epithelial expression of inducible nitric oxide synthase (iNOS), resulting from engineered immunodeficiency, could explain the contradictory findings of prior studies regarding the importance of nitrous oxide in murine models of Cryptosporidium parvum infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Altered bone marrow dendritic cell cytokine production to toll-like receptor and CD40 ligation during chronic feline immunodeficiency virus infection

IMMUNOLOGY, 126(3), 405–412.

By: T. Lehman*, . Kevin P. O'Halloran*, S. Fallon*, L. Habermann*, J. Campbell*, S. Nordone n, G. Dean n, E. Hoover*, P. Avery*

author keywords: cell surface molecules; cytokines; dendritic cells; immunodeficiency diseases; other animals
MeSH headings : Animals; Bone Marrow Cells / immunology; CD40 Ligand / immunology; Cats; Chronic Disease; Cytokines / biosynthesis; Dendritic Cells / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Gene Expression; Immunodeficiency Virus, Feline; Interleukin-10 / biosynthesis; Interleukin-12 / biosynthesis; RNA, Messenger / genetics; Toll-Like Receptors / biosynthesis; Toll-Like Receptors / genetics; Toll-Like Receptors / immunology
TL;DR: Chronic FIV infection alters the ratio of immunoregulatory cytokines produced by BM‐DCs in response to certain pathogen‐derived signals, which is probably relevant to the increased risk of opportunistic infections seen in lentiviral infection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 article

Toll-like receptor activation profiles of wild-type, recombinant, and mutant Lactobacillus: implications for vaccine design

RETROVIROLOGY, Vol. 6.

By: L. Stoeker n, S. Nordone n, A. LaVoy n, R. Tallon n, T. Klaenhammer n & G. Dean n

TL;DR: This work is investigating the use of Lactobacillus spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation

AIDS RESEARCH AND HUMAN RETROVIRUSES, 23(11), 1387–1395.

By: S. Nordone n, G. Ignacio n, L. Su*, G. Sempowski*, D. Golenbock*, L. Li*, G. Dean n

MeSH headings : Cell Line; HIV Infections / immunology; HIV Infections / virology; HIV-1 / physiology; Humans; Interleukin-1 / biosynthesis; Interleukin-6 / biosynthesis; Lipopolysaccharides / immunology; NF-kappa B / metabolism; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 9 / metabolism; Virus Replication
TL;DR: It is suggested that although several TLR can upregulate NF-kappaB in HIV-1-infected cells, upregulation of NF-KappaB alone is insufficient to activate the viral LTR, and the possibility that TLR4 signaling pathways may be altered during chronic HIV- 1 infection is raised. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Toll-like receptor expression in feline lymphoid tissues

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 106(3-4), 229–237.

By: G. Ignacio n, S. Nordone n, K. Howard n & G. Dean n

author keywords: toll-like receptors; feline; feline immunodeficiency virus; innate immunity
MeSH headings : Animals; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cats / genetics; Cats / immunology; Cell Line; Cloning, Molecular; DNA Primers / genetics; Gene Expression; Immunodeficiency Virus, Feline / pathogenicity; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Subsets / immunology; Lymphoid Tissue / immunology; Membrane Glycoproteins / genetics; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cell Surface / genetics; Tissue Distribution; Toll-Like Receptors
TL;DR: Results demonstrate that tissue distribution of TLRs is associated with the immunological role of a particular tissue, that lymphocytes may also express these 'innate immune' receptors, and that FIV infection can alter TLR expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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