Works (73)

Updated: April 4th, 2024 16:25

2024 journal article

Biomarkers of Metabolic Adaptation to High Dietary Fats in a Mouse Model of Obesity Resistance

METABOLITES, 14(1).

By: F. Milhem n, L. Hamilton n, E. Skates n, M. Wilson n, S. Johanningsmeier n & S. Komarnytsky n

author keywords: body composition; metabolic inflexibility; metabolic rate; dietary fats; skeletal muscle remodeling; glucose tolerance; microbiome
TL;DR: It is shown that NR mice developed healthier fat/lean body mass ratios compared with the obesity-prone (super-responder, SR) phenotypes by upregulating gene expression networks that promote the accumulation of type 2a, fast-twitch, oxidative muscle tissues. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: January 26, 2024

2024 article

Comparative evaluation of the antioxidant and anti-inflammatory potential of fennel essential oil obtained by conventional and supercritical fluid extraction

Tanveer, M., Shehzad, A., Komarnytsky, S., Butt, M. S., Shahid, M., & Aadil, R. M. (2024, February 15). BIOMASS CONVERSION AND BIOREFINERY, Vol. 2.

author keywords: Soxhlet extraction; Supercritical fluid extraction; Antioxidant Assays; Pakistani fennel; Egyptian fennel
Sources: Web Of Science, ORCID
Added: March 4, 2024

2024 journal article

Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract

FASEB JOURNAL, 38(3).

By: N. Surzenko*, J. Bastidas*, R. Reid*, J. Curaba*, W. Zhang*, H. Bostan*, M. Wilson*, A. Dominique* ...

author keywords: autoantibodies; autophagy; glandular therapy; nutrition; oral tolerance; phagocytosis; RNA-Seq
TL;DR: The potency of a nutritional supplement containing nuclear fraction of bovine thymus in enhancing the functional recovery from TBI is demonstrated, for the first time, in enhancing the functional recovery from TBI. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 19, 2024

2024 journal article

Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism

NUTRIENTS, 16(1).

By: F. Milhem n, E. Skates*, M. Wilson* & S. Komarnytsky n

author keywords: dietary fats; energy substrate; body composition; metabolic rate; individual variability; personalized nutrition
TL;DR: NR mice showed an increased ability to metabolize excessive dietary fats in skeletal muscle at the expense of reduced exercise capacity that persisted for the duration of the study, underscore the need for further comprehensive investigations into the mechanisms of obesity resistance. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 22, 2024

2024 journal article

Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States

Biomolecules.

By: L. Grodsky n, M. Wilson n, T. Rathinasabapathy n & S. Komarnytsky n

TL;DR: Reduction of diet-induced inflammation confers partial protection against insulin resistance, but not obesity, and the possibility of achieving overweight phenotypes that are accompanied by minimal insulin resistance if inflammation is controlled is suggested. (via Semantic Scholar)
Source: ORCID
Added: April 1, 2024

2023 journal article

Alleviation of Pain, PAIN Interference, and Oxidative Stress by a Novel Combination of Hemp Oil, Calamari Oil, and Broccoli: A Randomized, Double-Blind, Placebo-Controlled Trial

NUTRIENTS, 15(12).

By: C. Carlisle*, K. Polley*, C. Panda*, K. Barron*, M. Hamrock*, A. Dominique*, B. Metzger*, S. Le Brun-Blashka*, S. Komarnytsky n

author keywords: whole food; botanical; dietary supplement; bioactive components; antioxidants; hemp oil; pain management; nutrition
MeSH headings : Adult; Humans; Middle Aged; Aged; Fatty Acids, Omega-3; Leukocytes, Mononuclear; Brassica; Chronic Pain / drug therapy; Reactive Oxygen Species / pharmacology; Dietary Supplements; Oxidative Stress; Double-Blind Method
TL;DR: Results indicated that supplementation with a novel combination of hemp oil, calamari oil, and broccoli has the potential to manage chronic pain when combined with standard chiropractic care, as suggested by its effects on pain intensity and oxidative stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 10, 2023

2023 article

Berries in Microbiome-Mediated Gastrointestinal, Metabolic, and Immune Health

Komarnytsky, S., Wagner, C., Gutierrez, J., & Shaw, O. M. (2023, February 4). CURRENT NUTRITION REPORTS, Vol. 2.

By: S. Komarnytsky n, C. Wagner n, J. Gutierrez n & O. Shaw*

author keywords: Gut microbiota; Immune modulation; Chronic inflammation; Metabolic syndrome; Dietary fiber; Phenolic metabolites; Clinical study
MeSH headings : Humans; Fruit / metabolism; Microbiota; Polyphenols / metabolism; Gastrointestinal Tract; Gastrointestinal Microbiome
TL;DR: Mechanisms may explain many of the differences in microbiota and host gastrointestinal responses associated with increased consumption of berries, and highlight potential opportunities to intentionally shift gut microbiome profiles or to modulate risk factors associated with better nutrition and health outcomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science
Added: February 5, 2023

2023 review

Current Status and Nutritional Value of Green Leaf Protein

[Review of ]. NUTRIENTS, 15(6).

By: C. Balfany n, J. Gutierrez*, M. Moncada n & S. Komarnytsky n

author keywords: green biomass; plant leaves; alternative proteins; amino acid; functionality; complete protein; nutritional value; leaf protein concentrate
MeSH headings : Plant Leaves / chemistry; Crops, Agricultural; Nutritive Value; Plant Proteins / metabolism; Minerals / analysis
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: ORCID, Web Of Science
Added: March 9, 2023

2023 review

Essential Minerals and Metabolic Adaptation of Immune Cells

[Review of ]. NUTRIENTS, 15(1).

By: M. Alghamdi n, J. Gutierrez n & S. Komarnytsky n

author keywords: micronutrient; malnutrition; macrophage polarization; intestinal immunity; mucosal integrity; dietary intervention
MeSH headings : Humans; Cytokines; Minerals; Inflammation; Chemokines; Complement System Proteins; Trace Elements
TL;DR: This review discusses recent advances in the understanding of the contribution of select minerals in optimizing the responses of innate and adaptive immune outcomes as related to metabolic adaptation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: December 29, 2022

2023 journal article

Guided Metabolic Detoxification Program Supports Phase II Detoxification Enzymes and Antioxidant Balance in Healthy Participants

NUTRIENTS, 15(9).

By: C. Panda*, S. Komarnytsky n, M. Fleming*, C. Marsh*, K. Barron*, S. Le Brun-Blashka*, B. Metzger*

author keywords: whole food; botanical; detoxification program; liver; antioxidants; free radicals; hepatic markers; GST; SOD; GSH; GSSG ratio
TL;DR: Consuming a whole food nutritional intervention as a part of the guided detoxification program supported phase II detoxification, in part, by promoting enhanced free radical scavenging and maintaining redox homeostasis under the body’s natural glutathione recycling capacity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: May 30, 2023

2023 review

Progression to Obesity: Variations in Patterns of Metabolic Fluxes, Fat Accumulation, and Gastrointestinal Responses

[Review of ]. METABOLITES, 13(9).

By: F. Milhem n & S. Komarnytsky n

author keywords: dietary obesity; weight gain; high-fat diet; lipid oxidation; metabolic inflexibility; metabolic rate; obesity-prone; obesity-resistant
TL;DR: Pattern of fat accumulation with a focus on visceral and ectopic adipose tissue, microbiome composition, and the immune status of the gastrointestinal tract have emerged as the most promising targets that allow personalization of obesity and warrant further investigations into the critical issue of a wider and long-term weight control. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 27, 2023

2023 journal article

Total Utilization-Upcycling of Mushroom Protein By-Product: Characterization and Assessment as an Alternative Batter Ingredient for Fried Shrimp

FOODS, 12(4).

By: D. Garcia n, S. You n, R. Aleman*, J. King*, S. Komarnytsky n, R. Hoskin n, M. Moncada n

author keywords: repurposing; waste; food ingredients; sustainability; value-added
Sources: ORCID, Web Of Science
Added: February 11, 2023

2022 review

All Polyphenols Are Not Created Equal: Exploring the Diversity of Phenolic Metabolites

[Review of ]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(7), 2077–2091.

By: C. Vong n, T. Rathinasabapathy n, M. Moncada n & S. Komarnytsky n

Contributors: C. Vong n, T. Rathinasabapathy n, M. Moncada n & S. Komarnytsky n

author keywords: (poly)phenols; phenolic acids; microbiome; microbial catabolism; methylation
MeSH headings : Antioxidants; Flavonoids / metabolism; Humans; Phenols / chemistry; Polyphenols / metabolism; Tannins
TL;DR: There is a critical need for precise identification of the individual phenolic metabolite signatures originating from different polyphenol groups to enable future translation of these findings into break-through nutritional interventions and dietary guidelines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science
Added: February 12, 2022

2022 journal article

Effect of Wild Blueberry Metabolites on Biomarkers of Gastrointestinal and Immune Health In Vitro

Immuno, 2(2), 293–306.

By: T. Rathinasabapathy n, J. Lomax n, K. Srikanth*, D. Esposito n, C. Kay n & S. Komarnytsky n

TL;DR: Wild blueberries are a rich source of dietary fiber and (poly)phenols with gastrointestinal and immune health-promoting properties, however, their mechanisms of action on the intestinal epithelial cells and transient tissue macrophages remain to be elucidated. (via Semantic Scholar)
Source: ORCID
Added: March 30, 2022

2022 review

Gains and Losses of Agricultural Food Production: Implications for the Twenty-First Century

[Review of ]. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, 13, 239–261.

By: S. Komarnytsky n, S. Retchin*, C. Vong n & M. Lila n

author keywords: agricultural food systems; genetic improvement; biofortification; phytochemicals; alternative proteins; sustainable agriculture
MeSH headings : Agriculture; Animals; Biodiversity; Climate Change; Crops, Agricultural; Food Supply
TL;DR: This review introduces the concept of agricultural food systems losses and focuses on improved sources of agricultural diversity, proteins with enhanced resilience, and novel monitoring, processing, and distribution technologies that are poised to improve food security, reduce food loss and waste, and improve health profiles in the near future. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: May 23, 2022

2022 article

Mushrooms as Functional and Nutritious Food Ingredients for Multiple Applications

You, S. W., Hoskin, R. T., Komarnytsky, S., & Moncada, M. (2022, June 8). ACS FOOD SCIENCE & TECHNOLOGY, Vol. 6.

By: S. You n, R. Hoskin n, S. Komarnytsky n & M. Moncada n

author keywords: food formulation; novel ingredients; nutrition; functionality
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: June 9, 2022

2022 review

Plant-Based Support of Respiratory Health during Viral Outbreaks

[Review of ]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(7), 2064–2076.

By: T. Rathinasabapathy n, L. Sakthivel* & S. Komarnytsky n

Contributors: T. Rathinasabapathy n, L. Sakthivel* & S. Komarnytsky n

author keywords: licorice; coneflower; ginger; mullein; horehound; elderberry; nettle; antiviral; anti-inflammatory; expectorant; COVID-19
MeSH headings : Disease Outbreaks; Humans; Phytotherapy; Plant Extracts / pharmacology; Respiratory System; Virus Diseases / drug therapy
TL;DR: Investigating metabolites and their botanical sources holds potential to uncover new mediators of the respiratory health outcomes as well as molecular targets for future break-through therapeutic interventions targeting respiratory viral outbreaks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: February 12, 2022

2021 review

Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils

[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(11).

By: S. Komarnytsky n, T. Rathinasabapathy n, C. Wagner n, B. Metzger*, C. Carlisle*, C. Panda*, S. Le Brun-Blashka*, J. Troup*, S. Varadharaj*

Contributors: S. Komarnytsky n, T. Rathinasabapathy n, C. Wagner n, B. Metzger*, C. Carlisle*, C. Panda*, S. Le Brun-Blashka*, J. Troup*, S. Varadharaj*

author keywords: ECS tone; phytocannabinoids; inflammation resolution; oxidative stress; systemic redox balance
MeSH headings : Adenosine / metabolism; Animals; Cannabinoids / metabolism; Cannabis / metabolism; Diet; Endocannabinoids / metabolism; Fatty Acids, Unsaturated / metabolism; Homeostasis / physiology; Humans; Inflammation / metabolism; Lipid Metabolism / physiology; Oxidative Stress / physiology; Plant Extracts / metabolism; Signal Transduction / physiology; TRPV Cation Channels / metabolism
TL;DR: Clinical evidence reviewed in this study links PUFAs and cannabinoids to changes in ECS tone, immune function, metabolic and oxidative stress adaptation, and overall maintenance of a well-balanced systemic function of the body. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science
Added: May 24, 2021

2021 journal article

Immune Responses Are Differentially Regulated by Root, Stem, Leaf, and Flower Extracts of Female and Male CBD Hemp (Cannabis sativa L.) Plants

Immuno.

By: L. Esposito*, E. Overbaugh n, J. Xiong*, T. Rathinasabapathy*, S. Komarnytsky*, D. Silva*, D. Esposito*

TL;DR: While all tissues of hemp showed moderate anti-inflammatory properties, female flowers demonstrated the highest activity and CBD showed the strongestAnti-inflammatory activity in this study, the dynamics of distribution and accumulation of 10 main cannabinoids in hemp were quantified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: October 26, 2021

2021 journal article

Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.)

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14).

By: N. Chiang*, S. Ray*, J. Lomax n, S. Goertzen n, S. Komarnytsky n, C. Ho*, J. Munafo*

author keywords: culinary sage; cognition and memory function; brain-derived neurotrophic factor (BDNF); sage extract; benzyl 6-O-beta-D-apiofuranosyl-beta-D-glucoside (B6AG)
MeSH headings : Animals; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; Cell Line, Tumor; Chromatography, High Pressure Liquid; Gene Expression Regulation, Neoplastic / drug effects; Gene Expression Regulation, Neoplastic / genetics; Glioma / genetics; Glioma / metabolism; Mass Spectrometry; Plant Leaves / chemistry; Rats; Salvia officinalis / chemistry; Signal Transduction / drug effects; Signal Transduction / genetics
TL;DR: This study provided a foundation for future investigations, including quantitative inquiries on the distribution of B6AG within the different plant organs, explorations in optimizing post-harvest practices, and aid in the development of sage varieties with elevated levels of B 6AG. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: July 10, 2021

2021 journal article

Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3).

By: M. Wilson n, V. Konda*, K. Heidt n, T. Rathinasabapathy n, A. Desai* & S. Komarnytsky n

Contributors: M. Wilson n, V. Konda*, K. Heidt n, T. Rathinasabapathy n, A. Desai* & S. Komarnytsky n

author keywords: postmenopausal; estrogens; hot flashes; HRT; ERr 731
MeSH headings : Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / metabolism; Hot Flashes; Menopause / drug effects; Molecular Structure; Ovariectomy; Phytoestrogens / chemistry; Phytoestrogens / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Roots / chemistry; Postmenopause; Rats; Rheum / chemistry; Vasomotor System / drug effects
TL;DR: Data validate the OVX/Tskin rat model as a suitable screening platform to evaluate botanical and pharmaceutical treatments of menopause, while providing further evidence for the efficacy of ERr 731 towards alleviating vasomotor menopausal symptoms and improving wellbeing during the menopausal transition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: ORCID, Web Of Science
Added: January 21, 2021

2020 review

Celtic Provenance in Traditional Herbal Medicine of Medieval Wales and Classical Antiquity

[Review of ]. FRONTIERS IN PHARMACOLOGY, 11.

By: C. Wagner n, J. De Gezelle n & S. Komarnytsky n

author keywords: medicinal plants; ethnopharmacology; ethnobotany; herbal texts; bioactive compounds
TL;DR: This review provides initial evidence for traces of Celtic framework in the Welsh herbal tradition and warrants further investigations of bioactivity and clinical applications of the described plant leads. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: April 27, 2020

2020 journal article

Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model

Food Chemistry, 331, 127279.

By: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Food matrix; By-product; Stability; Antioxidant; Anti-inflammatory
MeSH headings : Animals; Anthocyanins / analysis; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antioxidants / analysis; Blueberry Plants / chemistry; Digestion; Food-Processing Industry; Fruit / chemistry; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacokinetics; Plant Proteins, Dietary / chemistry; Polyphenols / pharmacokinetics; Proanthocyanidins / analysis; RAW 264.7 Cells; Vitis / chemistry
TL;DR: Protein-polyphenol particle digests retained 1.5 to 2-fold higher antioxidant capacity and suppressed the expression of pro-inflammatory cytokines, iNOS, IL6, and IL1β, compared to unmodified extract digests, which only suppressed IL6. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: June 19, 2020

2020 journal article

Exploring the Anti-Acne Potential of Impepho [Helichrysum odoratissimum (L.) Sweet] to Combat Cutibacterium acnes Virulence

FRONTIERS IN PHARMACOLOGY, 10.

By: M. De Canha*, S. Komarnytsky n, L. Langhansova* & N. Lall*

author keywords: Helichrysum odoratissimum (L; ) Sweet; Cutibacterium acnes; anti-acne; antibiofilm; pathogenesis
TL;DR: This study provides scientific validation for the traditional use of H. odoratissimum as an ointment for pimples, not only due to its ability to control C. acnes proliferation but also because of its inhibitory activity on various targets associated with bacterial virulence leading to acne progression. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 10, 2020

2020 journal article

Spicing up gastrointestinal health with dietary essential oils

Phytochemistry Reviews, 19(2), 243–263.

Contributors: M. Tanveer n, C. Wagner n, M. Haq*, N. Ribeiro n, T. Rathinasabapathy n, M. Butt*, A. Shehzad*, S. Komarnytsky n

author keywords: Essential oils; Indigestion; Gastroesophageal reflux; Dyspepsia; Gastritis
TL;DR: 8 botanical interventions including fennel, rosemary, ginger, peppermint, and dill were identified that prevented gastric ulcer formation, reduced production of gastric acids, or promoted upper gastrointestinal healing in preclinical or early phase human studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: March 5, 2020

2020 review

The Enigma of Bioactivity and Toxicity of Botanical Oils for Skin Care

[Review of ]. FRONTIERS IN PHARMACOLOGY, 11.

By: E. Moore n, C. Wagner n & S. Komarnytsky n

author keywords: natural oils; skin barrier function; skin aging; wound healing; atopic dermatitis; for skin care
TL;DR: This review contrasted the functionality of skin oils versus the differential biological and toxicological effects of major plant oils, and to correlate them to their compositional changes to promote awareness of health practitioners and botanical product manufacturers for the safety and efficacy of oil-based interventions based on their fatty acid profiles. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 13, 2020

2019 journal article

Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling

FRONTIERS IN PHARMACOLOGY, 10(SEP).

By: D. Esposito n, J. Overall n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, J. Overall n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: skin regeneration; wound healing; Alaskan berries; integrins; proanthocyanidins; epicatechins
TL;DR: Targeting cellular bioenergetics and integrin-mediated cell–ECM signaling with bioactives from Alaskan wild berries shows considerable therapeutic promise to treat chronic skin wounds and inflammatory skin disorders, as well as more generally to support regenerative healing responses and restore function in a variety of tissue and organ settings after injury or aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: October 14, 2019

2019 journal article

Phenylpropanoid Glycerol Glucosides Attenuate Glucose Production in Hepatocytes

ACS OMEGA, 4(6), 10670–10676.

By: A. Murray*, K. Palatini n, S. Komarnytsky n, T. Gianfagna* & J. Munafo*

TL;DR: Direct structure–activity analysis of phenylpropanoid glycerol glucosides indicated that the hydroxylation pattern of the hydroxy cinnamic acid moiety and acetylation were responsible for the differences in activity. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 22, 2019

2018 journal article

Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage

FOOD AND CHEMICAL TOXICOLOGY, 111, 445–453.

By: E. Skates n, J. Overall n, K. DeZego n, M. Wilson n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: Bioactive food components; Polyphenols; Obesity; Diabetes; Bioenergetics; Functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Diet; Diet, High-Fat / adverse effects; Energy Metabolism; Fruit / chemistry; Lipid Metabolism; Male; Metabolic Diseases; Methylation; Mice; Mice, Inbred C57BL; Rubus / chemistry
TL;DR: It is shown that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Botanical Provenance of Traditional Medicines From Carpathian Mountains at the Ukrainian-Polish Border

FRONTIERS IN PHARMACOLOGY, 9.

By: W. Kozlowska*, C. Wagner n, E. Moore n, A. Matkowski* & S. Komarnytsky n

author keywords: ethnobotany; traditional knowledge; herbal texts; bioactive compounds; functional foods; folk remedies
TL;DR: The use of herbal medicines in the Beskid mountain ranges located south of Krakow and Lviv, two influential medieval centers of apothecary tradition in the region are described, with strong preferences for local use of St John's-wort, wormwood, garlic, and gentian. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Anthocyanins in metabolic health and disease

Nutrigenomics and Proteomics in Health and Disease: towards a Systems-Level Understanding of Gene-Diet Interactions, 2nd Edition, 92–124.

By: J. Overall, M. Lila & S. Komarnytsky

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript

JOURNAL OF ETHNOPHARMACOLOGY, 203, 171–181.

By: C. Wagner n, J. De Gezelle n, M. Robertson, K. Robertson, M. Wilson n & S. Komarnytsky n

author keywords: Traditional use; ethnobotany; medicinal plants; microbial infections; antibiotics
MeSH headings : Anti-Bacterial Agents / history; Anti-Bacterial Agents / isolation & purification; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / history; Ethnobotany / history; Ethnopharmacology / history; History, Medieval; Humans; Medicine, Traditional / history; Phytotherapy / history; Phytotherapy / methods; Plant Preparations / history; Plant Preparations / pharmacology; Plants, Medicinal / chemistry; Scotland
TL;DR: Using historical medical sources such as those associated with traditional Celtic medicine to guide rigorous, evidence-based scientific investigation, provides additional leads for new and alternative bioactive molecules for combating bacterial diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Health modifying regions in the oat (Avena sativa) genome responsible for beneficial effects on immune and gastrointestinal health

FASEB Journal, 31.

By: W. Bussler, K. Dezego, M. Bowen, A. Buige, D. Esposito, M. Lila, S. Komarnytsky

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Metabolic Effects of Berries with Structurally Diverse Anthocyanins

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2).

By: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

Contributors: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
TL;DR: Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans

JOURNAL OF FUNCTIONAL FOODS, 37, 1–7.

By: B. Graf*, S. Kamat*, K. Cheong*, S. Komarnytsky n, M. Driscoll* & R. Di*

author keywords: Aging; C elegans; Physical performance; Phytoecdysteroid; Respiration; Quinoa
TL;DR: Data suggest that quinoa supplementation slows C. elegans aging and improves metabolic health, and 20HE is the primary bioactive constituent responsible for favorable effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

Chinese Journal of Natural Medicines, 15(11), 816–824.

By: J. Xiong n, M. Grace n, D. Esposito n, S. Komarnytsky n, F. Wang* & M. Lila n

Contributors: J. Xiong n, M. Grace n, D. Esposito n, S. Komarnytsky n, F. Wang* & M. Lila n

author keywords: Acacia mearnsii; Proanthocyanidins; Anti-inflammatory; alpha-Amylase; alpha-Glucosidase
MeSH headings : Acacia / chemistry; Animals; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Carbohydrate Metabolism / drug effects; Glycoside Hydrolase Inhibitors / pharmacology; Inflammation / metabolism; Interleukin-1beta / metabolism; Lipopolysaccharides; Macrophages / drug effects; Mice; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Bark / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / isolation & purification; Polyphenols / pharmacology; Proanthocyanidins / pharmacology; RAW 264.7 Cells; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR: Polyphenols isolated from Acacia mearnsii bark crude extract and fractions obtained by high-speed counter-current chromatography and evaluated their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities showed significant activities against reactive oxygen species, nitric oxide production, and expression of pro-inflammatory genes interleukin-1β. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory

MOLECULAR NUTRITION & FOOD RESEARCH, 61(9).

By: K. Jackson n, T. Rathinasabapathy n, D. Esposito n & S. Komarnytsky n

Contributors: K. Jackson n, T. Rathinasabapathy n, D. Esposito n & S. Komarnytsky n

author keywords: Blood glucose; Cell bioenergetics; Diabetes; Dietary supplementation; Metabolic syndrome
MeSH headings : Animals; Cell Line, Tumor; Chicory / chemistry; Gluconeogenesis / drug effects; Hypoglycemic Agents / pharmacology; MAP Kinase Signaling System; Pharmacogenetics; Phosphatidylinositol 3-Kinases / physiology; Plant Roots / chemistry; Quinic Acid / analogs & derivatives; Quinic Acid / pharmacology; Rats; Structure-Activity Relationship
TL;DR: It is concluded that the caffeic acid moiety was important for suppression of hepatic gluconeogenesis and hyperglycemia, ultimately strengthening the link between dietary interventions based on caffeic Acid-containing plant foods and healthy glucose metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity

Journal of Chemistry, 2017, 1–10.

By: T. Rathinasabapathy*, K. Palatini Jackson, Y. Thor n, A. Buru*, D. Esposito n, X. Li n, M. Pichika*, A. Hamzah*, S. Komarnytsky n

Contributors: T. Rathinasabapathy*, K. Palatini Jackson, Y. Thor n, A. Buru*, D. Esposito n, X. Li n, M. Pichika*, A. Hamzah*, S. Komarnytsky n

TL;DR: The tetrahydrothiazolopyridine moiety served as an active pharmacophore for inhibiting 11β-HSD1 and offered a novel therapeutic strategy to ameliorate metabolic alterations found in obesity and diabetes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts

Food Chemistry, 210, 85–95.

By: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

Contributors: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

author keywords: Anacardic acids; Triterpene acids; Carotenoids; Tocopherols; Polyphenols; Anti-inflammatory
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / isolation & purification; Antioxidants / pharmacology; Cell Line; Dose-Response Relationship, Drug; Macrophages / drug effects; Macrophages / metabolism; Mice; Pistacia; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Reactive Oxygen Species / antagonists & inhibitors; Reactive Oxygen Species / metabolism
TL;DR: The P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages and significantly inhibited the release of nitric oxide and reactive oxygen species in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents

Food & Function, 7(10), 4285–4298.

By: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

Contributors: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

MeSH headings : Animals; Antioxidants; Cell Survival / drug effects; Cooking; Macrophages / drug effects; Macrophages / metabolism; Mice; Phytochemicals; Pistacia / chemistry; RAW 264.7 Cells; Reactive Oxygen Species; Respiratory Burst; Seeds / chemistry
TL;DR: The SNP had the strongest effect in decreasing non-mitochondrial oxidative burst associated with inflammatory response in macrophages, and was the most potent to inhibit the expression of COX2. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2015 journal article

1,25-Dihydroxyvitamin D-3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration

EUROPEAN JOURNAL OF NUTRITION, 54(6), 1001–1012.

By: C. Ricciardi*, J. Bae*, D. Esposito n, S. Komarnytsky n, P. Hu*, J. Chen*, L. Zhao*

author keywords: Vitamin D receptor; Brown adipocyte; UCP1; Mitochondrial respiration
MeSH headings : 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics; Adipocytes, Brown / physiology; Adipocytes, Brown / ultrastructure; Animals; Calcitriol / pharmacology; Calcitriol / physiology; Cell Differentiation / physiology; Energy Metabolism; Gene Expression; Ion Channels / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria / metabolism; Mitochondrial Proteins / genetics; Obesity / metabolism; Oxygen Consumption / physiology; PPAR gamma / metabolism; RNA, Messenger / analysis; Receptors, Calcitriol / deficiency; Receptors, Calcitriol / genetics; Receptors, Calcitriol / physiology; Signal Transduction; Uncoupling Protein 1; Vitamin D3 24-Hydroxylase / genetics
TL;DR: The results demonstrate the suppressive effects of 1,25(OH)2D3/VDR signaling on brown adipocyte differentiation and mitochondrial respiration and the role of the vitamin D system in regulating BAT development and function in obesity warrant further investigation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes

JOURNAL OF FUNCTIONAL FOODS, 15, 396–407.

By: J. Kellogg n, D. Esposito n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: J. Kellogg n, D. Esposito n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Seaweed; Phlorotannin; Monoglycosyldiacylglycerol; Inflammation; Insulin resistance; Fucus distichus
TL;DR: Overall, the Alaskan seaweed F. distichus inhibited proinflammatory responses and improved lipid metabolism, suggesting the potential for seaweed phytochemicals to attenuate inflammatory diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(27), 6172–6180.

By: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

Contributors: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

author keywords: gastrointestinal tract; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animals; Anthocyanins / administration & dosage; Anthocyanins / chemistry; Fruit / chemistry; Gastrointestinal Microbiome / drug effects; Glucose / metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Obesity / physiopathology; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Ribes / chemistry; Weight Gain / drug effects
TL;DR: The data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of Anthocyanins against obesity and associated insulin resistance. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 article

Flavonoid Supplementation and Cardiovascular Disease

Bussler, W., Hildebrand, J., Mixon, C., Wagoner, T., Komarnytsky, S., & Harris, G. (2015, May). Dietary Supplements in Health Promotion, pp. 281–318.

By: W. Bussler, J. Hildebrand, C. Mixon, T. Wagoner, S. Komarnytsky & G. Harris

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: November 11, 2019

2015 journal article

Hepatoprotective Activity of Easter Lily (Lilium longiflorum Thunb.) Bulb Extracts

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(44), 9722–9728.

By: W. Tang*, J. Munafo*, K. Palatini n, D. Esposito n, M. Huang*, S. Komarnytsky n, C. Ho*, T. Gianfagna*

author keywords: Lilium longiflorum Thunb; Easter lily; steroidal glycoside; hepatoprotective activity; hypoglycemic activity
MeSH headings : Animals; Cholesterol; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / metabolism; Female; Flowers / chemistry; Humans; Lilium / chemistry; Liver / drug effects; Liver / metabolism; Mice; Mice, Inbred C57BL; Molecular Structure; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Protective Agents / administration & dosage; Protective Agents / chemistry
TL;DR: The data suggest that steroidal glycosides 1-5 might play a role in the hepatoprotective activity of the BuOH extracts, while the results of the TC measurements and OGTT study indicate that other constituents present in the CB extract are responsible for its hypocholesterolemic and hypoglycemic activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 306(10), C918–C930.

By: J. Bae*, C. Ricciardi*, D. Esposito n, S. Komarnytsky n, P. Hu*, B. Curry*, P. Brown*, Z. Gao* ...

author keywords: brown adipose tissue; brown adipocytes; UCP-1; pattern recognition receptor; inflammation
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Adipocytes / pathology; Adipose Tissue, Brown / drug effects; Adipose Tissue, Brown / metabolism; Adipose Tissue, Brown / pathology; Animals; Cell Line; Cytokines / genetics; Cytokines / metabolism; Diet, High-Fat; Electron Transport / drug effects; Gene Expression Regulation; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Ion Channels / genetics; Ion Channels / metabolism; Isoproterenol / pharmacology; Male; Mice; Mitochondria / drug effects; Mitochondria / metabolism; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; Nod1 Signaling Adaptor Protein / genetics; Nod1 Signaling Adaptor Protein / metabolism; Nod2 Signaling Adaptor Protein / genetics; Nod2 Signaling Adaptor Protein / metabolism; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Promoter Regions, Genetic; RNA, Messenger / genetics; RNA, Messenger / metabolism; Signal Transduction; Toll-Like Receptor 2 / genetics; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / genetics; Toll-Like Receptor 4 / metabolism; Uncoupling Protein 1
TL;DR: The role of selected PRR activation in inducing inflammation and downregulation of UCP-1 expression and mitochondrial respiration in brown adipocytes is demonstrated and novel targets in BAT are uncovered for obesity treatment and prevention. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 66(8), 1304–1314.

By: V. Le*, D. Esposito n, M. Grace n, D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim* ...

Contributors: V. Le*, D. Esposito n, M. Grace n, D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim* ...

MeSH headings : 3T3 Cells; Animals; Apoptosis / drug effects; Cell Line, Tumor; Cyclin B1 / metabolism; Cytochromes c / metabolism; Diet; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrolyzable Tannins / pharmacology; Juglans / chemistry; MCF-7 Cells; Mice; Mice, Nude; Mitochondria / drug effects; Nuts / chemistry; Plant Extracts / pharmacology
TL;DR: The results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract as well as antimitogenic effects of walnuts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7022–7028.

By: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Vaccinium angustifolium; lowbush blueberry; polyphenols; proanthocyanidins; chlorogenic acid
MeSH headings : Acute Disease; Animals; Anthocyanins / pharmacology; Base Sequence; Biomarkers / metabolism; Blueberry Plants / chemistry; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; DNA Primers; In Vitro Techniques; Inflammation / metabolism; Macrophages / drug effects; Macrophages / metabolism; Mice; Polymerase Chain Reaction
TL;DR: Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Acceleration of cutaneous wound healing by brassinosteroids

WOUND REPAIR AND REGENERATION, 21(5), 688–696.

By: D. Esposito*, T. Rathinasabapathy*, B. Schmidt*, M. Shakarjian*, S. Komarnytsky n & I. Raskin*

Contributors: D. Esposito*, T. Rathinasabapathy*, B. Schmidt*, M. Shakarjian*, S. Komarnytsky n & I. Raskin*

MeSH headings : Administration, Topical; Animals; Blotting, Western; Brassinosteroids / pharmacology; Cell Proliferation; Cells, Cultured; Intercellular Adhesion Molecule-1 / drug effects; Intercellular Adhesion Molecule-1 / metabolism; Male; Mice; Mice, Inbred C57BL; Signal Transduction / drug effects; Skin / injuries; Skin / pathology; Transforming Growth Factor beta / drug effects; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / drug effects; Tumor Necrosis Factor-alpha / metabolism; Wound Healing / drug effects
TL;DR: Topical application of brassinosteroids accelerates wound healing by positively modulating inflammatory and reepithelialization phases of the wound repair process, in part by enhancing Akt signaling in the skin at the edges of the wounds and enhancing migration of fibroblasts in the wounded area. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Effects of Pregnane Glycosides on Food Intake Depend on Stimulation of the Melanocortin Pathway and BDNF in an Animal Model

Journal of Agricultural and Food Chemistry, 61(8), 1841–1849.

By: S. Komarnytsky n, D. Esposito n, T. Rathinasabapathy*, A. Poulev* & I. Raskin*

Contributors: S. Komarnytsky n, D. Esposito n, T. Rathinasabapathy*, A. Poulev* & I. Raskin*

author keywords: appetite; satiety; body weight; milkweed; Asclepias
MeSH headings : Animals; Appetite / drug effects; Asclepias / chemistry; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; Cell Line, Tumor; Eating / drug effects; Female; Glycosides / administration & dosage; Humans; Male; Melanocortins / metabolism; Models, Animal; Plant Extracts / administration & dosage; Pregnanes / administration & dosage; Rats; Rats, Wistar
TL;DR: The results support the multimodal effects of pregnane glycosides on feeding regulation, which depends on the activity of the melanocortin signaling pathway and BDNF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2013 journal article

Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells

JOURNAL OF CELLULAR PHYSIOLOGY, 228(5), 1120–1126.

By: S. Komarnytsky n, D. Esposito n, A. Poulev* & I. Raskin*

MeSH headings : 3-Hydroxysteroid Dehydrogenases / antagonists & inhibitors; 3-Hydroxysteroid Dehydrogenases / biosynthesis; Adrenal Cortex Hormones / metabolism; Androstenedione / analogs & derivatives; Animals; Cell Line, Tumor; Cholesterol Side-Chain Cleavage Enzyme / antagonists & inhibitors; Cholesterol Side-Chain Cleavage Enzyme / biosynthesis; Corticosterone / biosynthesis; Corticosterone / metabolism; Cortisone / metabolism; Glycosides / administration & dosage; Humans; Pregnanes / administration & dosage; Progesterone / analogs & derivatives; Progesterone / biosynthesis; Steroid 11-beta-Hydroxylase / antagonists & inhibitors; Steroid 11-beta-Hydroxylase / biosynthesis; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / biosynthesis; Structure-Activity Relationship
TL;DR: Data suggest that pregnane glycosides specifically suppress steroidogenesis through strong inhibition of 11β‐hydroxylase and steroid 17‐alpha‐monooxygenase, and weak inhibition of cytochrome P450 side chain cleavage enzyme and 21β‐ dehydrogenase/isomerase, but not 3 β‐hydroxysteroid dehydrogenases/isomersase. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro

JOURNAL OF ETHNOPHARMACOLOGY, 148(2), 433–440.

By: D. Esposito n, J. Munafo*, T. Lucibello*, M. Baldeon*, S. Komarnytsky n & T. Gianfagna*

author keywords: Lilium longiflorum Thunb.; Steroidal glycoside; Furostanol saponin; Transforming growth factor beta; Nitric oxide; Wound healing
MeSH headings : 3T3 Cells; Animals; Carbohydrate Sequence; Cell Movement / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Dermis / cytology; Dermis / drug effects; Dermis / metabolism; Ethnopharmacology / methods; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Glycosides / chemistry; Glycosides / pharmacology; Human Umbilical Vein Endothelial Cells; Humans; Lilium / chemistry; Mice; Molecular Sequence Data; Nitric Oxide / metabolism; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Roots / chemistry; Skin / cytology; Skin / drug effects; Skin / metabolism; Steroids / chemistry; Steroids / pharmacology; Transforming Growth Factor beta / metabolism; Wound Healing / drug effects
TL;DR: This is the first evidence that steroidal glycosides from Lilium longiflorum may potentially play a role in the wound healing process and may provide a scientific basis for the historical use of lily bulbs for this purpose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Hypoglycemic effects of brassinosteroid in diet-induced obese mice

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 303(5), E652–E658.

By: D. Esposito*, P. Kizelsztein*, S. Komarnytsky n & I. Raskin*

author keywords: homobrassinolide; glucose; insulin resistance; diabetes; phosphoenolpyruvate carboxykinase
MeSH headings : AMP-Activated Protein Kinases / metabolism; Animals; Brassinosteroids / administration & dosage; Brassinosteroids / therapeutic use; Cell Line; Cyclic AMP / antagonists & inhibitors; Cyclic AMP / metabolism; Diet, High-Fat / adverse effects; Dietary Supplements; Gene Expression Regulation; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Hyperglycemia / prevention & control; Hypoglycemic Agents / therapeutic use; Insulin Resistance; Liver / enzymology; Liver / metabolism; Male; Mice; Mice, Inbred C57BL; Obesity / blood; Obesity / diet therapy; Obesity / etiology; Phosphoenolpyruvate Carboxykinase (ATP) / genetics; Phosphoenolpyruvate Carboxykinase (ATP) / metabolism; Phosphorylation; Protein Processing, Post-Translational; RNA, Messenger / metabolism; Random Allocation
TL;DR: The results indicate the antidiabetic effects of brassinosteroids and begin to elucidate their putative cellular targets both in vitro and in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Modulation of muscle mass and myogenic stem cells with natural products

Planta Medica, 78(11).

By: D. Esposito n, I. Raskin* & S. Komarnytsky n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 5, 2020

2012 conference paper

Modulation of muscle mass and myogenic stem cells with natural products

Planta Medica, 78(11), 1096–1096.

By: D. Esposito, I. Raskin & S. Komarnytsky

Source: NC State University Libraries
Added: August 6, 2018

2012 article

Plant-Derived Antibodies for Academic, Industrial, and Therapeutic Applications

Komarnytsky, S., & Borisjuk, N. (2012, April). Antibody-Mediated Drug Delivery Systems, pp. 365–381.

By: S. Komarnytsky n & N. Borisjuk*

TL;DR: This work reports the discovery of restriction enzymes that digest DNA at well-defined locations and the combination of restriction digestion and ligation of the DNA fragments that created the first recombinant DNA in 1972. (via Semantic Scholar)
Source: ORCID
Added: November 11, 2019

2011 journal article

Akt-Dependent Anabolic Activity of Natural and Synthetic Brassinosteroids in Rat Skeletal Muscle Cells

Journal of Medicinal Chemistry, 54(12), 4057–4066.

By: D. Esposito*, T. Rathinasabapathy*, A. Poulev*, S. Komarnytsky* & I. Raskin*

Contributors: D. Esposito*, T. Rathinasabapathy*, A. Poulev*, S. Komarnytsky* & I. Raskin*

MeSH headings : Anabolic Agents / chemical synthesis; Anabolic Agents / chemistry; Anabolic Agents / pharmacology; Animals; Cell Line; Cell Survival / drug effects; Cholestanones / chemical synthesis; Cholestanones / chemistry; Cholestanones / pharmacology; Mice; Muscle, Skeletal / cytology; Muscle, Skeletal / drug effects; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Rats; Stereoisomerism; Structure-Activity Relationship
TL;DR: Presence of the 6-keto group in the B ring and stereochemistry of 22α,23α-vicinal hydroxyl groups in the side chain were critical for the anabolic activity, possibly due to higher cytotoxicity of the 22β,23β-hydroxylated brassinosteroids. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2011 journal article

Anabolic effect of plant brassinosteroid

FASEB JOURNAL, 25(10), 3708–3719.

By: D. Esposito*, S. Komarnytsky*, S. Shapses* & I. Raskin*

author keywords: homobrassinolide; protein synthesis; muscle mass
MeSH headings : Anabolic Agents / administration & dosage; Anabolic Agents / pharmacology; Animals; Body Composition / drug effects; Cells; Cholestanones / administration & dosage; Cholestanones / pharmacology; Dietary Proteins; Lethal Dose 50; Male; Molecular Structure; Muscle Fibers, Skeletal / drug effects; Muscle, Skeletal / cytology; Muscle, Skeletal / drug effects; Orchiectomy; Rats; Rats, Wistar
TL;DR: It is suggested that oral application of HB triggers selective anabolic response with minimal or no androgenic side‐effects and begin to elucidate the putative cellular targets for plant brassinosteroids in mammals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism

International Journal of Obesity, 35(2), 236–243.

By: S. Komarnytsky*, A. Cook* & I. Raskin*

author keywords: satiety; body weight; cholecystokinin; protease inhibitors; potato
MeSH headings : Animals; Cells, Cultured; Cholecystokinin / metabolism; Duodenum / metabolism; Energy Intake / drug effects; Energy Intake / physiology; Gastric Emptying / drug effects; Male; Phytotherapy; Plant Preparations / administration & dosage; Plant Preparations / pharmacology; Protease Inhibitors / administration & dosage; Protease Inhibitors / pharmacology; Proteins / metabolism; Rats; Rats, Wistar; Satiation / drug effects; Satiation / physiology; Solanum tuberosum / enzymology; Trypsin Inhibitors / administration & dosage; Trypsin Inhibitors / pharmacology
TL;DR: Evidence is provided that PPIC is effective in reducing food intake and body weight gain in healthy rats when administered orally by increasing circulating CCK levels through a trypsin-dependent mechanism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: November 11, 2019

2009 journal article

20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model

American Journal of Physiology - Endocrinology and Metabolism, 296(3).

By: P. Kizelsztein, D. Govorko, S. Komarnytsky*, A. Evans, Z. Wang, W. Cefalu, I. Raskin

author keywords: gluconeogenic enzymes; adiponectin; obesity and diabetes
MeSH headings : AMP-Activated Protein Kinases / metabolism; Adiponectin / blood; Animals; Blood Glucose / drug effects; Blood Glucose / metabolism; Body Weight / drug effects; Carcinoma, Hepatocellular; Cells, Cultured; Dietary Fats / pharmacology; Ecdysterone / chemistry; Ecdysterone / metabolism; Ecdysterone / pharmacology; Glucose Intolerance / drug therapy; Glucose Intolerance / metabolism; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Insulin / blood; Insulin Resistance; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Obesity / drug therapy; Obesity / metabolism; Phosphatidylinositol 3-Kinases / metabolism; Rats; STAT1 Transcription Factor / drug effects
TL;DR: The anti-obesity and anti-diabetic effects of 20HE are demonstrated and its putative cellular targets both in vitro and in vivo are elucidated. (via Semantic Scholar)
Source: ORCID
Added: November 11, 2019

2009 journal article

Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex

Journal of Neuroimmunology, 217(1-2), 28–37.

By: P. Kizelsztein*, S. Komarnytsky* & I. Raskin*

author keywords: EAE; Hsp70; Inflammation; NF-kappa B; Oral; Triptolide
MeSH headings : Administration, Oral; Analysis of Variance; Animals; Cell Line, Transformed; Cytokines / metabolism; Cytoplasm / drug effects; Cytoplasm / metabolism; Disease Models, Animal; Diterpenes / administration & dosage; Diterpenes / pharmacology; Encephalomyelitis, Autoimmune, Experimental / chemically induced; Encephalomyelitis, Autoimmune, Experimental / metabolism; Encephalomyelitis, Autoimmune, Experimental / pathology; Encephalomyelitis, Autoimmune, Experimental / prevention & control; Epoxy Compounds / administration & dosage; Epoxy Compounds / pharmacology; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / metabolism; I-kappa B Proteins / metabolism; Immunoprecipitation; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / pharmacology; Lymph Nodes / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Myelin Proteolipid Protein; NF-KappaB Inhibitor alpha; NF-kappa B / metabolism; Peptide Fragments; Phenanthrenes / administration & dosage; Phenanthrenes / pharmacology; Phosphorylation / drug effects; Phytotherapy / methods; RNA, Messenger / metabolism; Signal Transduction / drug effects; Time Factors; Tripterygium / chemistry; Up-Regulation / drug effects
TL;DR: Triptolide delayed disease onset, reduced clinical symptoms, decreased the relapse rate, and suppressed inflammation and demyelination in CNS tissue of EAE mice when compared to vehicle-treated animals, indicating that daily oral administration of triptolide exhibits not only a preventive but also a therapeutic effect on EAE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 11, 2019

2007 journal article

Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line

American Journal of Physiology - Endocrinology and Metabolism, 293(6).

By: D. Govorko, S. Logendra, Y. Wang, D. Esposito, S. Komarnytsky*, D. Ribnicky, A. Poulev, Z. Wang, W. Cefalu, I. Raskin

author keywords: phosphoenolpyruvate carboxykinase; polyphenols; diabetes
MeSH headings : Animals; Artemisia / chemistry; Cell Line, Tumor; Chalcones / analysis; Chalcones / isolation & purification; Chalcones / pharmacology; Chromones / analysis; Chromones / isolation & purification; Chromones / pharmacology; Cyclic AMP / analogs & derivatives; Cyclic AMP / pharmacology; Dexamethasone / pharmacology; Enzyme Inhibitors / pharmacology; Flavonoids / analysis; Flavonoids / isolation & purification; Flavonoids / pharmacology; Gene Expression / drug effects; Gluconeogenesis / drug effects; Glucose / metabolism; Hypoglycemic Agents / analysis; Hypoglycemic Agents / isolation & purification; Hypoglycemic Agents / pharmacology; Insulin / pharmacology; Morpholines / pharmacology; Phenols / analysis; Phenols / isolation & purification; Phenols / pharmacology; Phosphoenolpyruvate Carboxykinase (GTP) / genetics; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation / drug effects; Plant Extracts / pharmacology; Plant Shoots / chemistry; Polyphenols; Proto-Oncogene Proteins c-akt / metabolism; Pyrazoles / pharmacology; Pyrimidines / pharmacology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Thionucleotides / pharmacology
TL;DR: Results indicate that the isolated compounds may be responsible for much of the glucose-lowering activity of the Artemisia dracunculus extract, which was reported to decrease PEPCK mRNA expression in STZ-induced diabetic rats. (via Semantic Scholar)
Source: ORCID
Added: November 11, 2019

2007 journal article

Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography

Journal of Chromatography A, 1151(1-2), 45–50.

By: C. Okunji*, S. Komarnytsky*, G. Fear*, A. Poulev*, D. Ribnicky*, P. Awachie, Y. Ito*, I. Raskin*

author keywords: Garcinia kola; tyrosinase; biflavanones; high-speed counter-current chromatography (HSCCC)
MeSH headings : Countercurrent Distribution / methods; Flavonoids / chemistry; Flavonoids / isolation & purification; Garcinia kola / chemistry; Molecular Structure; Peptides / chemistry; Peptides / isolation & purification; Reproducibility of Results; Seeds / chemistry
TL;DR: In continuation of the search for bioactive natural products that can be used for the treatment of dermatological disorders associated with melanin hyperpigmentation, 50 extracts/fractions from 21 families of medicinal plants from West and Central Africa were evaluated for inhibitory activity against tyrosinase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: November 11, 2019

2007 journal article

Protease inhibitors and their peptidomimetic derivatives as potential drugs

Pharmacology and Therapeutics, 113(2), 354–368.

By: G. Fear*, S. Komarnytsky* & I. Raskin*

author keywords: protease; protease inhibitors; therapeutic application; clinical trials; approved drugs
MeSH headings : Animals; Communicable Diseases / enzymology; Diabetes Mellitus / enzymology; Fungi / enzymology; Humans; Inflammation / enzymology; Neoplasms / enzymology; Peptides / pharmacology; Plant Extracts / pharmacology; Protease Inhibitors / pharmacology; Viruses / enzymology
TL;DR: Modulation of protease activity with synthetic peptidomimetic inhibitors has proven to be clinically useful for treating human immunodeficiency virus and hypertension and shows potential for medicinal application in cancer, obesity, cardiovascular, inflammatory, neurodegenerative diseases, and various infectious and parasitic diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 11, 2019

2006 journal article

Cosecretion of protease inhibitor stabilizes antibodies produced by plant roots

Plant Physiology, 141(4), 1185–1193.

By: S. Komarnytsky*, N. Borisjuk*, N. Yakoby*, A. Garvey* & I. Raskin*

MeSH headings : Antibodies, Monoclonal / biosynthesis; Antibodies, Monoclonal / genetics; Antibodies, Monoclonal / metabolism; Calreticulin / metabolism; Culture Media; Humans; Hydroponics; Immunoglobulin G / biosynthesis; Plant Roots / metabolism; Plants, Genetically Modified / metabolism; Protein Engineering / methods; Recombinant Proteins / biosynthesis; Serine Proteinase Inhibitors / genetics; Serine Proteinase Inhibitors / metabolism; Tobacco / genetics; Trypsin Inhibitor, Bowman-Birk Soybean / genetics
TL;DR: Results suggest that constitutive cosecretion of a protease inhibitor combined with the use of the plant signal peptide and the antibiotic marker-free transformation system offers a novel strategy to achieve high yields of complex therapeutic proteins secreted from plant roots. (via Semantic Scholar)
Source: ORCID
Added: November 11, 2019

2004 journal article

A quick and efficient system for antibiotic-free expression of heterologous genes in tobacco roots

Plant Cell Reports, 22(10), 765–773.

By: S. Komarnytsky*, A. Gaume*, A. Garvey*, N. Borisjuk* & I. Raskin*

author keywords: plant genetic engineering; selectable marker; rol genes; hairy roots; recombinant protein production
MeSH headings : Agrobacterium tumefaciens / genetics; Culture Media; Gene Expression; Genetic Markers; Genetic Vectors; Glucuronidase / metabolism; Plant Roots / genetics; Plant Roots / metabolism; Plants, Genetically Modified; Recombinant Proteins / isolation & purification; Recombinant Proteins / metabolism; Tobacco / genetics; Transformation, Genetic
TL;DR: This work has developed a rapid transformation tool using hairy root formation as a selection marker for transgenic plants and found higher levels of transgene expression in the roots correlated positively with the rates of root elongation on hormone-free medium and thus could be used for positive selection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 11, 2019

2003 article

Functional Analysis of Promoter Elements in Plants

Genetic Engineering, pp. 113–141.

By: S. Komarnytsky* & N. Borisjuk*

MeSH headings : Cell Nucleus / metabolism; Plants / genetics; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Transcription Factors / metabolism; Transcription, Genetic
TL;DR: A minimal gene regulatory network typically consists of an input signal receptor and a transduction pathway linking the extracellular environment with intracellular targets, a core complex of transacting regulatory proteins and relevant cis-acting DNA sequences, and a subsequent molecular output from the target genes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: November 11, 2019

2003 journal article

Functional analysis of promoter elements in plants.

Genetic Engineering, 25, 113–141. http://www.scopus.com/inward/record.url?eid=2-s2.0-3543141756&partnerID=MN8TOARS

By: S. Komarnytsky & N. Borisjuk

Source: ORCID
Added: November 11, 2019

2003 journal article

Rhizosecretion of recombinant proteins from plant hairy roots

Plant Cell Reports, 21(12), 1188–1193.

By: A. Gaume*, S. Komarnytsky*, N. Borisjuk* & I. Raskin*

author keywords: hairy roots; recombinant proteins; rhizosecretion; transgenic plants
MeSH headings : Alkaline Phosphatase / genetics; Cloning, Molecular / methods; Gene Expression Regulation; Humans; Plant Roots / metabolism; Plants, Genetically Modified; Recombinant Proteins / metabolism; Rhizobium / genetics; Seeds; Tobacco / genetics
TL;DR: The ability of Agrobacterium rhizogenes to induce the formation of large amounts of root tissue on transgenic tobacco plants engineered to secrete a model recombinant protein, human secreted alkaline phosphatase (SEAP), was exploited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 11, 2019

2002 journal article

Plants and human health in the twenty-first century

Trends in Biotechnology, 20(12), 522–531.

By: I. Raskin*, D. Ribnicky*, S. Komarnytsky*, N. Ilic, A. Poulev, N. Borisjuk*, A. Brinker*, D. Moreno* ...

MeSH headings : Dietary Supplements / classification; Drugs, Chinese Herbal / therapeutic use; Food, Fortified / classification; Food, Genetically Modified; Forecasting; Humans; Phytotherapy / methods; Phytotherapy / trends; Plant Extracts / classification; Plant Extracts / therapeutic use; Plants, Genetically Modified / metabolism; Plants, Medicinal; Recombinant Proteins / biosynthesis; Recombinant Proteins / therapeutic use; Technology, Pharmaceutical / methods; Technology, Pharmaceutical / trends
TL;DR: The history, future, scientific background and regulatory issues related to botanical therapeutics, including plant-derived pharmaceuticals, multicomponent botanical drugs, dietary supplements, functional foods and plant-produced recombinant proteins are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: November 11, 2019

2001 journal article

Phylogenetic tree of the australian species of Nicotiana based on the random amplified polymorphic DNA

Biopolymers and Cell, 17(4), 278–282.

By: S. Komarnytsky* & I. Komarnytsky*

Source: ORCID
Added: November 11, 2019

2000 journal article

Production of recombinant proteins in tobacco guttation fluid

Plant Physiology, 124(3), 927–933. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033729827&partnerID=MN8TOARS

By: S. Komarnytsky, N. Borisjuk, L. Borisjuk, M. Alam & I. Raskin

Source: ORCID
Added: November 11, 2019

2000 journal article

Tobacco ribosomal DNA spacer element stimulates amplification and expression of heterologous genes

Nature Biotechnology, 18(12), 1303–1306.

By: N. Borisjuk*, L. Borisjuk, S. Komarnytsky*, S. Timeva*, V. Hemleben*, Y. Gleba*, I. Raskin*

author keywords: gene amplification; enhanced transcription; protein expression; transgenic plants; recombinant proteins
MeSH headings : Acetolactate Synthase / genetics; Acetolactate Synthase / metabolism; Base Sequence; DNA, Ribosomal Spacer / genetics; Drug Resistance; Gene Amplification; Gene Expression; Herbicides / pharmacology; Molecular Sequence Data; Plants, Genetically Modified; Plants, Toxic; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Tobacco / genetics; Transcription, Genetic; Transgenes
TL;DR: It is shown that the cis-acting genetic element aps (amplification-promoting sequence), isolated from the nontranscribed spacer region of tobacco ribosomal DNA (rDNA), increases the level of expression of recombinant proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 11, 2019

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