Slavko Komarnytsky

Milhem, F., Hamilton, L. M., Skates, E., Wilson, M., Johanningsmeier, S. D., & Komarnytsky, S. (2024). Biomarkers of Metabolic Adaptation to High Dietary Fats in a Mouse Model of Obesity Resistance. METABOLITES, 14(1). https://doi.org/10.3390/metabo14010069

Tanveer, M., Shehzad, A., Komarnytsky, S., Butt, M. S., Shahid, M., & Aadil, R. M. (2024, February 15). Comparative evaluation of the antioxidant and anti-inflammatory potential of fennel essential oil obtained by conventional and supercritical fluid extraction. BIOMASS CONVERSION AND BIOREFINERY, Vol. 2. https://doi.org/10.1007/s13399-024-05405-8

Surzenko, N., Bastidas, J., Reid, R. W., Curaba, J., Zhang, W., Bostan, H., … El-Khodor, B. F. (2024). Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract. FASEB JOURNAL, 38(3). https://doi.org/10.1096/fj.202301859R

Milhem, F., Skates, E., Wilson, M., & Komarnytsky, S. (2024). Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism. NUTRIENTS, 16(1). https://doi.org/10.3390/nu16010171

Grodsky, L., Wilson, M., Rathinasabapathy, T., & Komarnytsky, S. (2024). Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States. Biomolecules. https://doi.org/10.3390/biom14040395

Carlisle, C., Polley, K., Panda, C., Barron, K., Hamrock, M., Dominique, A., … Komarnytsky, S. (2023). Alleviation of Pain, PAIN Interference, and Oxidative Stress by a Novel Combination of Hemp Oil, Calamari Oil, and Broccoli: A Randomized, Double-Blind, Placebo-Controlled Trial. NUTRIENTS, 15(12). https://doi.org/10.3390/nu15122654

Komarnytsky, S., Wagner, C., Gutierrez, J., & Shaw, O. M. (2023, February 4). Berries in Microbiome-Mediated Gastrointestinal, Metabolic, and Immune Health. CURRENT NUTRITION REPORTS, Vol. 2. https://doi.org/10.1007/s13668-023-00449-0

Balfany, C., Gutierrez, J., Moncada, M., & Komarnytsky, S. (2023). [Review of Current Status and Nutritional Value of Green Leaf Protein]. NUTRIENTS, 15(6). https://doi.org/10.3390/nu15061327

Alghamdi, M., Gutierrez, J., & Komarnytsky, S. (2023). [Review of Essential Minerals and Metabolic Adaptation of Immune Cells]. NUTRIENTS, 15(1). https://doi.org/10.3390/nu15010123

Panda, C., Komarnytsky, S., Fleming, M. N., Marsh, C., Barron, K., Le Brun-Blashka, S., & Metzger, B. (2023). Guided Metabolic Detoxification Program Supports Phase II Detoxification Enzymes and Antioxidant Balance in Healthy Participants. NUTRIENTS, 15(9). https://doi.org/10.3390/nu15092209

Milhem, F., & Komarnytsky, S. (2023). [Review of Progression to Obesity: Variations in Patterns of Metabolic Fluxes, Fat Accumulation, and Gastrointestinal Responses]. METABOLITES, 13(9). https://doi.org/10.3390/metabo13091016

Garcia, D., You, S. W., Aleman, R. S., King, J. M., Komarnytsky, S., Hoskin, R. T., & Moncada, M. (2023). Total Utilization-Upcycling of Mushroom Protein By-Product: Characterization and Assessment as an Alternative Batter Ingredient for Fried Shrimp. FOODS, 12(4). https://doi.org/10.3390/foods12040763

Vong, C. I., Rathinasabapathy, T., Moncada, M., & Komarnytsky, S. (2022). [Review of All Polyphenols Are Not Created Equal: Exploring the Diversity of Phenolic Metabolites]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(7), 2077–2091. https://doi.org/10.1021/acs.jafc.1c07179

Rathinasabapathy, T., Lomax, J., Srikanth, K., Esposito, D., Kay, C. D., & Komarnytsky, S. (2022). Effect of Wild Blueberry Metabolites on Biomarkers of Gastrointestinal and Immune Health In Vitro. Immuno, 2(2), 293–306. https://doi.org/10.3390/immuno2020019

Komarnytsky, S., Retchin, S., Vong, C. I., & Lila, M. A. (2022). [Review of Gains and Losses of Agricultural Food Production: Implications for the Twenty-First Century]. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, 13, 239–261. https://doi.org/10.1146/annurev-food-082421-114831

You, S. W., Hoskin, R. T., Komarnytsky, S., & Moncada, M. (2022, June 8). Mushrooms as Functional and Nutritious Food Ingredients for Multiple Applications. ACS FOOD SCIENCE & TECHNOLOGY, Vol. 6. https://doi.org/10.1021/acsfoodscitech.2c00107

Rathinasabapathy, T., Sakthivel, L. P., & Komarnytsky, S. (2022). [Review of Plant-Based Support of Respiratory Health during Viral Outbreaks]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(7), 2064–2076. https://doi.org/10.1021/acs.jafc.1c06227

Komarnytsky, S., Rathinasabapathy, T., Wagner, C., Metzger, B., Carlisle, C., Panda, C., … Varadharaj, S. (2021). [Review of Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(11). https://doi.org/10.3390/ijms22115479

Esposito, L. G. A., Overbaugh, E., Xiong, J., Rathinasabapathy, T., Komarnytsky, S., Silva, D. J. H., & Esposito, D. A. (2021). Immune Responses Are Differentially Regulated by Root, Stem, Leaf, and Flower Extracts of Female and Male CBD Hemp (Cannabis sativa L.) Plants. Immuno. https://doi.org/10.3390/immuno1040025

Chiang, N., Ray, S., Lomax, J., Goertzen, S., Komarnytsky, S., Ho, C.-T., & Munafo, J. P., Jr. (2021). Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.). INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14). https://doi.org/10.3390/ijms22147382

Wilson, M., Konda, V., Heidt, K., Rathinasabapathy, T., Desai, A., & Komarnytsky, S. (2021). Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3). https://doi.org/10.3390/ijms22031032

Wagner, C., De Gezelle, J., & Komarnytsky, S. (2020). [Review of Celtic Provenance in Traditional Herbal Medicine of Medieval Wales and Classical Antiquity]. FRONTIERS IN PHARMACOLOGY, 11. https://doi.org/10.3389/fphar.2020.00105

Xiong, J., Chan, Y. H., Rathinasabapathy, T., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2020). Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model. Food Chemistry, 331, 127279. https://doi.org/10.1016/j.foodchem.2020.127279

De Canha, M. N., Komarnytsky, S., Langhansova, L., & Lall, N. (2020). Exploring the Anti-Acne Potential of Impepho [Helichrysum odoratissimum (L.) Sweet] to Combat Cutibacterium acnes Virulence. FRONTIERS IN PHARMACOLOGY, 10. https://doi.org/10.3389/fphar.2019.01559

Tanveer, M., Wagner, C., Haq, M. I., Ribeiro, N. C., Rathinasabapathy, T., Butt, M. S., … Komarnytsky, S. (2020). Spicing up gastrointestinal health with dietary essential oils. Phytochemistry Reviews, 19(2), 243–263. https://doi.org/10.1007/s11101-020-09664-x

Moore, E. M., Wagner, C., & Komarnytsky, S. (2020). [Review of The Enigma of Bioactivity and Toxicity of Botanical Oils for Skin Care]. FRONTIERS IN PHARMACOLOGY, 11. https://doi.org/10.3389/fphar.2020.00785

Esposito, D., Overall, J., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2019). Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling. FRONTIERS IN PHARMACOLOGY, 10(SEP). https://doi.org/10.3389/fphar.2019.01058

Murray, A. F., Palatini, K., Komarnytsky, S., Gianfagna, T. J., & Munafo, J. P., Jr. (2019). Phenylpropanoid Glycerol Glucosides Attenuate Glucose Production in Hepatocytes. ACS OMEGA, 4(6), 10670–10676. https://doi.org/10.1021/acsomega.9b00751

Skates, E., Overall, J., DeZego, K., Wilson, M., Esposito, D., Lila, M. A., & Komarnytsky, S. (2018). Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage. FOOD AND CHEMICAL TOXICOLOGY, 111, 445–453. https://doi.org/10.1016/j.fct.2017.11.032

Kozlowska, W., Wagner, C., Moore, E. M., Matkowski, A., & Komarnytsky, S. (2018). Botanical Provenance of Traditional Medicines From Carpathian Mountains at the Ukrainian-Polish Border. FRONTIERS IN PHARMACOLOGY, 9. https://doi.org/10.3389/fphar.2018.00295

Overall, J., Lila, M. A., & Komarnytsky, S. (2017). Anthocyanins in metabolic health and disease. Nutrigenomics and Proteomics in Health and Disease: towards a Systems-Level Understanding of Gene-Diet Interactions, 2nd Edition, 92–124.

Wagner, C. S., De Gezelle, J., Robertson, M., Robertson, K., Wilson, M., & Komarnytsky, S. (2017). Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript. JOURNAL OF ETHNOPHARMACOLOGY, 203, 171–181. https://doi.org/10.1016/j.jep.2017.03.039

Bussler, W. W., Dezego, K., Bowen, M., Buige, A., Esposito, D., Lila, M. A., & Komarnytsky, S. (2017). Health modifying regions in the oat (Avena sativa) genome responsible for beneficial effects on immune and gastrointestinal health. FASEB Journal, 31.

Overall, J., Bonney, S. A., Wilson, M., Beermann, A., Grace, M. H., Esposito, D., … Komarnytsky, S. (2017). Metabolic Effects of Berries with Structurally Diverse Anthocyanins. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2). https://doi.org/10.3390/ijms18020422

Graf, B. L., Kamat, S., Cheong, K. Y., Komarnytsky, S., Driscoll, M., & Di, R. (2017). Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans. JOURNAL OF FUNCTIONAL FOODS, 37, 1–7. https://doi.org/10.1016/j.jff.2017.07.016

Xiong, J., Grace, M. H., Esposito, D., Komarnytsky, S., Wang, F., & Lila, M. A. (2017). Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities. Chinese Journal of Natural Medicines, 15(11), 816–824. https://doi.org/10.1016/s1875-5364(18)30015-3

Jackson, K. M. P., Rathinasabapathy, T., Esposito, D., & Komarnytsky, S. (2017). Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory. MOLECULAR NUTRITION & FOOD RESEARCH, 61(9). https://doi.org/10.1002/mnfr.201601118

Rathinasabapathy, T., Palatini Jackson, K. M., Thor, Y., Buru, A. S., Esposito, D., Li, X., … Komarnytsky, S. (2017). Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity. Journal of Chemistry, 2017, 1–10. https://doi.org/10.1155/2017/3182129

Grace, M. H., Esposito, D., Timmers, M. A., Xiong, J., Yousef, G., Komarnytsky, S., & Lila, M. A. (2016). Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts. Food Chemistry, 210, 85–95. https://doi.org/10.1016/j.foodchem.2016.04.088

Grace, M. H., Esposito, D., Timmers, M. A., Xiong, J., Yousef, G., Komarnytsky, S., & Lila, M. A. (2016). In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents. Food & Function, 7(10), 4285–4298. https://doi.org/10.1039/c6fo00867d

Ricciardi, C. J., Bae, J., Esposito, D., Komarnytsky, S., Hu, P., Chen, J., & Zhao, L. (2015). 1,25-Dihydroxyvitamin D-3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration. EUROPEAN JOURNAL OF NUTRITION, 54(6), 1001–1012. https://doi.org/10.1007/s00394-014-0778-9

Kellogg, J., Esposito, D., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2015). Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes. JOURNAL OF FUNCTIONAL FOODS, 15, 396–407. https://doi.org/10.1016/j.jff.2015.03.049

Esposito, D., Damsud, T., Wilson, M., Grace, M. H., Strauch, R., Li, X., … Komarnytsky, S. (2015). Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(27), 6172–6180. https://doi.org/10.1021/acs.jafc.5b00963

Bussler, W., Hildebrand, J., Mixon, C., Wagoner, T., Komarnytsky, S., & Harris, G. (2015, May). Flavonoid Supplementation and Cardiovascular Disease. Dietary Supplements in Health Promotion, pp. 281–318. https://doi.org/10.1201/b18490-14

Tang, W., Munafo, J. P., Jr., Palatini, K., Esposito, D., Huang, M.-T., Komarnytsky, S., … Gianfagna, T. J. (2015). Hepatoprotective Activity of Easter Lily (Lilium longiflorum Thunb.) Bulb Extracts. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(44), 9722–9728. https://doi.org/10.1021/acs.jafc.5b04078

Bae, J., Ricciardi, C. J., Esposito, D., Komarnytsky, S., Hu, P., Curry, B. J., … Zhao, L. (2014). Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 306(10), C918–C930. https://doi.org/10.1152/ajpcell.00249.2013

Le, V., Esposito, D., Grace, M. H., Ha, D., Pham, A., Bortolazzo, A., … White, J. B. (2014). Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 66(8), 1304–1314. https://doi.org/10.1080/01635581.2014.956246

Esposito, D., Chen, A., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2014). Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7022–7028. https://doi.org/10.1021/jf4051599

Esposito, D., Rathinasabapathy, T., Schmidt, B., Shakarjian, M. P., Komarnytsky, S., & Raskin, I. (2013). Acceleration of cutaneous wound healing by brassinosteroids. WOUND REPAIR AND REGENERATION, 21(5), 688–696. https://doi.org/10.1111/wrr.12075

Komarnytsky, S., Esposito, D., Rathinasabapathy, T., Poulev, A., & Raskin, I. (2013). Effects of Pregnane Glycosides on Food Intake Depend on Stimulation of the Melanocortin Pathway and BDNF in an Animal Model. Journal of Agricultural and Food Chemistry, 61(8), 1841–1849. https://doi.org/10.1021/jf3033649

Komarnytsky, S., Esposito, D., Poulev, A., & Raskin, I. (2013). Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells. JOURNAL OF CELLULAR PHYSIOLOGY, 228(5), 1120–1126. https://doi.org/10.1002/jcp.24262

Esposito, D., Munafo, J. P., Jr., Lucibello, T., Baldeon, M., Komarnytsky, S., & Gianfagna, T. J. (2013). Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. JOURNAL OF ETHNOPHARMACOLOGY, 148(2), 433–440. https://doi.org/10.1016/j.jep.2013.04.032

Esposito, D., Kizelsztein, P., Komarnytsky, S., & Raskin, I. (2012). Hypoglycemic effects of brassinosteroid in diet-induced obese mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 303(5), E652–E658. https://doi.org/10.1152/ajpendo.00024.2012

Esposito, D., Raskin, I., & Komarnytsky, S. (2012). Modulation of muscle mass and myogenic stem cells with natural products. Planta Medica, 78(11). https://doi.org/10.1055/s-0032-1320461

Esposito, D., Raskin, I., & Komarnytsky, S. (2012). Modulation of muscle mass and myogenic stem cells with natural products. Planta Medica, 78(11), 1096–1096.

Komarnytsky, S., & Borisjuk, N. (2012, April). Plant-Derived Antibodies for Academic, Industrial, and Therapeutic Applications. Antibody-Mediated Drug Delivery Systems, pp. 365–381. https://doi.org/10.1002/9781118229019.ch17

Esposito, D., Rathinasabapathy, T., Poulev, A., Komarnytsky, S., & Raskin, I. (2011). Akt-Dependent Anabolic Activity of Natural and Synthetic Brassinosteroids in Rat Skeletal Muscle Cells. Journal of Medicinal Chemistry, 54(12), 4057–4066. https://doi.org/10.1021/jm200028h

Esposito, D., Komarnytsky, S., Shapses, S., & Raskin, I. (2011). Anabolic effect of plant brassinosteroid. FASEB JOURNAL, 25(10), 3708–3719. https://doi.org/10.1096/fj.11-181271

Komarnytsky, S., Cook, A., & Raskin, I. (2011). Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism. International Journal of Obesity, 35(2), 236–243. https://doi.org/10.1038/ijo.2010.192

Kizelsztein, P., Govorko, D., Komarnytsky, S., Evans, A., Wang, Z., Cefalu, W. T., & Raskin, I. (2009). 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. American Journal of Physiology - Endocrinology and Metabolism, 296(3). https://doi.org/10.1152/ajpendo.90772.2008

Kizelsztein, P., Komarnytsky, S., & Raskin, I. (2009). Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex. Journal of Neuroimmunology, 217(1-2), 28–37. https://doi.org/10.1016/j.jneuroim.2009.08.017

Govorko, D., Logendra, S., Wang, Y., Esposito, D., Komarnytsky, S., Ribnicky, D., … Raskin, I. (2007). Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. American Journal of Physiology - Endocrinology and Metabolism, 293(6). https://doi.org/10.1152/ajpendo.00420.2007

Okunji, C., Komarnytsky, S., Fear, G., Poulev, A., Ribnicky, D. M., Awachie, P. I., … Raskin, I. (2007). Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography. Journal of Chromatography A, 1151(1-2), 45–50. https://doi.org/10.1016/j.chroma.2007.02.085

Fear, G., Komarnytsky, S., & Raskin, I. (2007). Protease inhibitors and their peptidomimetic derivatives as potential drugs. Pharmacology and Therapeutics, 113(2), 354–368. https://doi.org/10.1016/j.pharmthera.2006.09.001

Komarnytsky, S., Borisjuk, N., Yakoby, N., Garvey, A., & Raskin, I. (2006). Cosecretion of protease inhibitor stabilizes antibodies produced by plant roots. Plant Physiology, 141(4), 1185–1193. https://doi.org/10.1104/pp.105.074419

Komarnytsky, S., Gaume, A., Garvey, A., Borisjuk, N., & Raskin, I. (2004). A quick and efficient system for antibiotic-free expression of heterologous genes in tobacco roots. Plant Cell Reports, 22(10), 765–773. https://doi.org/10.1007/s00299-004-0761-7

Komarnytsky, S., & Borisjuk, N. (2003). Functional Analysis of Promoter Elements in Plants. Genetic Engineering, pp. 113–141. https://doi.org/10.1007/978-1-4615-0073-5_6

Komarnytsky, S., & Borisjuk, N. (2003). Functional analysis of promoter elements in plants. Genetic Engineering, 25, 113–141. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-3543141756&partnerID=MN8TOARS

Gaume, A., Komarnytsky, S., Borisjuk, N., & Raskin, I. (2003). Rhizosecretion of recombinant proteins from plant hairy roots. Plant Cell Reports, 21(12), 1188–1193. https://doi.org/10.1007/s00299-003-0660-3

Raskin, I., Ribnicky, D. M., Komarnytsky, S., Ilic, N., Poulev, A., Borisjuk, N., … Fridlender, B. (2002). Plants and human health in the twenty-first century. Trends in Biotechnology, 20(12), 522–531. https://doi.org/10.1016/S0167-7799(02)02080-2

Komarnytsky, S. I., & Komarnytsky, I. K. (2001). Phylogenetic tree of the australian species of Nicotiana based on the random amplified polymorphic DNA. Biopolymers and Cell, 17(4), 278–282. https://doi.org/10.7124/bc.0005b8

Komarnytsky, S., Borisjuk, N. V., Borisjuk, L. G., Alam, M. Z., & Raskin, I. (2000). Production of recombinant proteins in tobacco guttation fluid. Plant Physiology, 124(3), 927–933. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-0033729827&partnerID=MN8TOARS

Borisjuk, N., Borisjuk, L., Komarnytsky, S., Timeva, S., Hemleben, V., Gleba, Y., & Raskin, I. (2000). Tobacco ribosomal DNA spacer element stimulates amplification and expression of heterologous genes. Nature Biotechnology, 18(12), 1303–1306. https://doi.org/10.1038/82430