Works (127)
Updated: April 3rd, 2024 20:56
2023 journal article
A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling
A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling. CELL ADHESION & MIGRATION, 17(1), 1–16.
author keywords: Beta2-integrin; ICAM-1; MARCKS; neutrophils; outside-in; >
MeSH headings : Alanine; CD18 Antigens / metabolism; Neutrophils; Peptides / pharmacology; Signal Transduction; Myristoylated Alanine-Rich C Kinase Substrate / antagonists & inhibitors
TL;DR:
MANS treatment significantly attenuated ICAM-1/Mn2+-stimulated static adhesion, cell spreading andβ2-integrin clustering, suggesting a role for MARCKS function in outside-in β2-Integrin activation.
(via Semantic Scholar)
open access via www.tandfonline.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2023
2022 journal article
Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis
FRONTIERS IN VETERINARY SCIENCE, 9.
Contributors: R. Bayless n , R. Bayless, R. Bayless, R. Bayless, R. Bayless, R. Bayless, R. Bayless
Ed(s): R. Bayless n
author keywords: neutrophil (PMN); Withaferin A (PubChem CID; 265237); equine; inflammation; phytochemical; veterinary medicine; novel therapeutic
TL;DR:
The data demonstrate that WFA may reduce neutrophil-mediated inflammation through multiple mechanisms, including suppression of inflammatory responses and promotion of apoptosis, and additional research is needed to elucidate the molecular mechanisms for these effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022
2018 journal article
Pharmacokinetics and ex vivo anti‐inflammatory effects of oral misoprostol in horses
Equine Veterinary Journal, 51(3), 415–421.
author keywords: horse; leucocyte; E prostanoid receptor agonist; pharmacokinetics; inflammation; tumour necrosis factor-
MeSH headings : Abortifacient Agents, Nonsteroidal / administration & dosage; Abortifacient Agents, Nonsteroidal / pharmacokinetics; Administration, Oral; Animals; Area Under Curve; Cells, Cultured; Horse Diseases / drug therapy; Horse Diseases / metabolism; Horses / blood; Horses / metabolism; Inflammation / drug therapy; Inflammation / metabolism; Inflammation / veterinary; Leukocytes / drug effects; Leukocytes / metabolism; Misoprostol / administration & dosage; Misoprostol / pharmacokinetics
TL;DR:
Misoprostol is rapidly absorbed following oral administration in horses, and a single 5 μg/kg dose had no significant inhibitory effect on ex vivo LPS‐stimulated TNFα mRNA production in leucocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 6, 2019
2017 journal article
Endothelial alterations in a canine model of immune thrombocytopenia
Platelets, 30(1), 88–97.
author keywords: Dog; endothelium; ITP
MeSH headings : Animals; Biomarkers; Biopsy; Blood Coagulation; Blood Platelets / metabolism; Blood Platelets / ultrastructure; Disease Models, Animal; Dogs; Endothelium / metabolism; Endothelium / ultrastructure; Flow Cytometry; Lysophospholipids / blood; Male; Platelet Activation; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / drug therapy; Purpura, Thrombocytopenic, Idiopathic / etiology; Purpura, Thrombocytopenic, Idiopathic / metabolism; Sphingosine / analogs & derivatives; Sphingosine / blood; von Willebrand Factor / metabolism
TL;DR:
The results indicate that endothelial damage occurs in the canine ITP model and variability in the degree of endothelialDamage may account for differences in the bleeding phenotype among patients with ITP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: March 18, 2019
2017 journal article
Inhibition of microsomal prostaglandin E-synthase-1 (mPGES-1) selectively suppresses PGE 2 in an in vitro equine inflammation model
Veterinary Immunology and Immunopathology, 192, 33–40.
author keywords: Prostaglandin E-2; Prostaglandin E-synthase; Leukocyte; Anti-inflammatory; NSAID; Horse
MeSH headings : Animals; Blotting, Western / veterinary; Dinoprostone / antagonists & inhibitors; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay / veterinary; Horses; Inflammation / metabolism; Inflammation / physiopathology; Inflammation / veterinary; Leukocytes / metabolism; Microsomes / enzymology; Prostaglandin-E Synthases / antagonists & inhibitors; Prostaglandin-E Synthases / metabolism; Prostaglandin-E Synthases / physiology; Real-Time Polymerase Chain Reaction / veterinary
TL;DR:
It is demonstrated that mPGES-1 is a potentially safer and effective therapeutic target for treatment of equine inflammatory disease when compared to traditional non-steroidal anti-inflammatory drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Misoprostol Inhibits Equine Neutrophil Adhesion, Migration, and Respiratory Burst in an In Vitro Model of Inflammation
Frontiers in Veterinary Science, 4.
author keywords: horse; leukocyte; chemotaxis; reactive oxygen species; inflammation; anti-inflammatory; NSAID
TL;DR:
Data indicate that misoprostol-targeting of E-prostanoid (EP) receptors potently inhibits equine neutrophil effector functions in vitro, and suggest misop frostol may hold promise as a novel anti-inflammatory therapeutic in the horse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2017 journal article
Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes
Frontiers in Veterinary Science, 4.
author keywords: horse; leukocyte; chemokine; inflammation; anti-inflammatory; non-steroidal anti-inflammatory drug
TL;DR:
Results indicate that misoprostol exerts anti-inflammatory effects on equine leukocytes when applied before or after a pro-inflammatory stimulus, and these effects were cytokine-specific and sometimes differed at the mRNA and protein levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2015 chapter
Diagnostic procedures in the examination of the equine alimentary system
In B. P. Smith (Ed.), Large Animal Internal Medicine (5th ed., pp. 638–653). St Louis, MO: Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: March 5, 2021
2015 chapter
Disorders of the esophagus
In B. P. Smith (Ed.), Large Animal Internal Medicine (5th ed., pp. 663–668). St Louis, MO: Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: March 14, 2021
2015 chapter
Non-steroidal anti-inflammatory drug toxicity
In B. P. Smith (Ed.), Large Animal Internal Medicine (5th ed., pp. 732–734). St Louis, MO: Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: March 14, 2021
2014 journal article
A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?
British Journal of Haematology, 167(1), 110–120.
author keywords: immune thrombocytopenia; canine; interleukin-8; animal model
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / immunology; Blood Platelets / immunology; Blood Platelets / metabolism; Cytokines / blood; Cytokines / metabolism; Disease Models, Animal; Dogs; Hemorrhage / immunology; Phenotype; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / diagnosis; Purpura, Thrombocytopenic, Idiopathic / immunology
TL;DR:
Evaluation of cytokine profiles led to the identification of platelets as a potential source of serum interleukin‐8 (IL8) in dogs, suggesting that platelet IL8 may be a previously unrecognized modulator of platelet‐neutrophil crosstalk in humans with ITP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation
Inflammation, 38(3), 1126–1141.
author keywords: neutrophil; chemotaxis; adhesion; migration; innate immunity; PKC signaling
MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Cell Adhesion / immunology; Cell Movement; Cells, Cultured; Enzyme Inhibitors / pharmacology; Humans; Inflammation / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; N-Formylmethionine Leucyl-Phenylalanine / metabolism; Neutrophil Activation / immunology; Neutrophil Infiltration / immunology; Neutrophils / immunology; Phosphorylation; Protein Isoforms / antagonists & inhibitors; Protein Isoforms / metabolism; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / metabolism
TL;DR:
It is concluded that δ-PKC-mediated MARCKS phosphorylation is essential for human neutrophil migration and adhesion in vitro, and this results implicate €1,000,000 phosphorylated actin binding protein and protein kinase C (PKC) as a key step in the inflammatory response of neutrophils.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Myristoylated Alanine Rich C Kinase Substrate (MARCKS) is essential to β2-integrin dependent responses of equine neutrophils
Veterinary Immunology and Immunopathology, 160(3-4), 167–176.
author keywords: Neutrophil; Migration; Adhesion; Respiratory burst; Beta2-integrin; Inflammation
MeSH headings : Amino Acid Sequence; Animals; Antigen-Antibody Complex / physiology; CD18 Antigens / immunology; CD18 Antigens / physiology; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Movement / drug effects; Cell Movement / physiology; Conserved Sequence; Horses / immunology; Horses / physiology; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / physiology; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophil Infiltration / drug effects; Neutrophil Infiltration / immunology; Neutrophil Infiltration / physiology; Peptide Fragments / genetics; Peptide Fragments / pharmacology; Respiratory Burst / drug effects; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
It is demonstrated that inhibition of MARCKS function significantly attenuates β2-integrin-dependent neutrophil functions including migration, adhesion, and immune complex-mediated respiratory burst, and strongly implicate MARC KS as a potential regulator of β 2-integrins in neutrophils.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein
PLOS ONE, 8(6).
Ed(s): P. Aspenstrom
MeSH headings : 3T3 Cells; Animals; Becaplermin; Chemotaxis / drug effects; Chemotaxis / physiology; Collagen / metabolism; Fibroblasts / cytology; Fibronectins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Proto-Oncogene Proteins c-sis / pharmacology
TL;DR:
Genetic structure-function analysis revealed that MANS peptide-mediated attenuation of NIH-3T3 cell migration does not require the presence of the myristic acid moiety on the amino-terminus, and suggests that MARCKS-mediated regulation of fibroblast migration involves the MARC KS amino- terminus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils
American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.
author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Bartonellaspp. Infection in Healthy and Sick Horses and Foals from the Southeastern United States
Journal of Veterinary Internal Medicine, 26(6), 1408–1412.
author keywords: Bartonella vinsonii; coinfection; foals; lameness
MeSH headings : Animals; Antibodies, Bacterial; Bacteremia / blood; Bacteremia / veterinary; Bartonella / isolation & purification; Bartonella Infections / epidemiology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Female; Fluorescent Antibody Technique, Indirect / veterinary; Horse Diseases / epidemiology; Horse Diseases / microbiology; Horses; Male; Polymerase Chain Reaction / veterinary; Serologic Tests; Southeastern United States
TL;DR:
Horses in the southeastern United States are naturally infected with B. berkhofii genotypes I and III, and a bacteria most similar to Candidatus Bartonella volans, and further investigation into the pathogenic potential of Bart onella spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019
2012 journal article
Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein
Journal of Leukocyte Biology, 92(3), 633–639.
author keywords: cytoplasmic translocation; J774A.1 cells; monocyte chemotactic protein 1; chemotaxis
MeSH headings : Actin Cytoskeleton / immunology; Actin Cytoskeleton / metabolism; Animals; Blotting, Western; Chemotaxis, Leukocyte / physiology; Intracellular Signaling Peptides and Proteins / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Macrophages / immunology; Macrophages / metabolism; Membrane Proteins / immunology; Membrane Proteins / metabolism; Mice; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport / physiology
TL;DR:
Results suggest that MARCKS is involved in directed migration of macrophages via a process involving its phosphorylation, cytoplasmic translocation, and interaction with actin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
EVALUATION OF CYCLOOXYGENASE PROTEIN EXPRESSION IN TRAUMATIZED VERSUS NORMAL TISSUES FROM EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA)
Journal of Zoo and Wildlife Medicine, 43(2), 289–295.
author keywords: Chelonian; eastern box turtle; Terrapene carolina; cyclooxygenase-1; cyclooxygenase-2; nonsteroidal anti-inflammatory drug
MeSH headings : Animals; Cyclooxygenase 1 / genetics; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Gene Expression Regulation, Enzymologic / physiology; Muscle, Skeletal / enzymology; Turtles; Wounds and Injuries / metabolism; Wounds and Injuries / veterinary
TL;DR:
Traditional nonsteroidal anti-inflammatory drugs that block both COX isoforms might be more efficacious than COX-2–selective drugs, and NSAIDs should be evaluated for potential liver and kidney toxicity in turtles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 22, 2019
2011 journal article
Identification of Bartonella henselae in a horse from Germany
Veterinary Microbiology, 150(3-4), 414–415.
MeSH headings : Animals; Bartonella Infections / veterinary; Bartonella henselae / isolation & purification; Female; Germany; Horse Diseases / microbiology; Horses
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Two Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Paralogs are Required for Normal Development in Zebrafish
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294(9), 1511–1524.
author keywords: MARCKS; zebrafish; development
MeSH headings : Amino Acid Sequence; Animals; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Morpholinos / pharmacology; Multigene Family; Myristoylated Alanine-Rich C Kinase Substrate; Phenotype; Phylogeny; Sequence Homology, Amino Acid; Zebrafish / genetics; Zebrafish / growth & development
TL;DR:
It is demonstrated that Marcksa and Marcksb are required for normal zebrafish development and suggested that zebra fish are a suitable model to further study MARCKS function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 chapter
Antibiotic associated diarrhea
In N. E. Robinson (Ed.), Current Therapy in Equine Medicine (6th ed., pp. 433–435). St. Louis, MO: Saunders.
Ed(s): N. Robinson
Source: NC State University Libraries
Added: March 16, 2021
2009 chapter
Disorders of the esophagus
In B. P. Smith (Ed.), Large Animal Internal Medicine (4th ed., pp. 688–695). St Louis, MO: Mosby-Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: March 16, 2021
2009 journal article
Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis
Journal of Orthopaedic Research, 27(9), 1204–1208.
author keywords: canine; osteoarthritis; cyclooxygenase; lipoxygenase; eicosanoids
MeSH headings : Animals; Arachidonate 5-Lipoxygenase / metabolism; Arthroplasty, Replacement, Hip; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Dinoprostone / metabolism; Disease Models, Animal; Dogs; Femur Head / metabolism; Femur Head / pathology; Hip Joint / enzymology; Hip Joint / pathology; Leukotriene B4 / metabolism; Osteoarthritis, Hip / metabolism; Osteoarthritis, Hip / pathology; Osteoarthritis, Hip / surgery; Synovial Membrane / enzymology; Synovial Membrane / pathology
TL;DR:
Both COX‐2 and 5‐LOX are appropriate targets for the management of pain associated with naturally occurring OA, evaluated in a naturally occurring canine model of secondary OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 chapter
Inflammatory diseases of the gastrointestinal tract causing diarrhea
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (3rd ed., pp. 857–876). Philadelphia, Pa: WB Saunders.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: March 14, 2021
2009 chapter
Medical disorders of the large intestine
In B. P. Smith (Ed.), Large Animal Internal Medicine (4th ed., pp. 742–750). St Louis, MO: Mosby-Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: March 16, 2021
2009 journal article
Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein Regulation of Human Neutrophil Migration
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 42(5), 586–594.
author keywords: inflammation; adhesion; beta 2 integrin; actin
MeSH headings : Actins / metabolism; CD18 Antigens / metabolism; Cell Adhesion / drug effects; Cell Membrane / drug effects; Cell Membrane / metabolism; Cell Polarity / drug effects; Chemotactic Factors / pharmacology; Chemotaxis, Leukocyte / drug effects; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Neutrophils / cytology; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / pharmacology; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
Treating isolated human neutrophils with MANS significantly inhibited both their migration and beta2 integrin-dependent adhesion in response to N-formyl-methionyl-leucyl-phenylalanine (fMLF), IL-8, or leukotriene (LT)B(4).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 chapter
Non-steroidal anti-inflammatory drug toxicity
In B. P. Smith (Ed.), Large Animal Internal Medicine (4th ed., pp. 754–757). St Louis, MO: Mosby-Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: March 16, 2021
2009 chapter
Pathophysiology of gastrointestinal inflammation
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (3rd ed., pp. 785–790). Philadelphia, PA: WB Saunders.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: March 14, 2021
2009 chapter
Right dorsal ulcerative colitis
In N. E. Robinson & K. A. Sprayberry (Eds.), Current Therapy in Equine Medicine (6th ed., pp. 430–432). St. Louis, MO: Saunders.
Ed(s): N. Robinson & K. Sprayberry
Source: NC State University Libraries
Added: March 16, 2021
2009 journal article
Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulus
Equine Veterinary Journal, 42(1), 47–52.
Contributors: M. Sheats n, V. Cook n, n , A. Blikslager n & A. Pease n
author keywords: horse; colic; large colon volvulus; ultrasound; multiple organ dysfunction syndrome; oedema
MeSH headings : Animals; Colic / diagnostic imaging; Colic / surgery; Colic / veterinary; Colonic Diseases / diagnostic imaging; Colonic Diseases / surgery; Colonic Diseases / veterinary; Female; Horse Diseases / diagnostic imaging; Horse Diseases / surgery; Horses; Intestinal Volvulus / diagnostic imaging; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Male; Treatment Outcome; Ultrasonography
TL;DR:
A shorter time to colon wall involution was associated with decreased post operative morbidity in horses presented for surgical correction of large colon volvulus without resection and may aid in identifying those cases at risk of MODS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Detection ofBartonella henselaein the Blood of 2 Adult Horses
Journal of Veterinary Internal Medicine, 22(2), 495–498.
author keywords: arthropathy; bartonellosis; purpura hemorrhagica; vasculitis
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteremia / drug therapy; Bacteremia / microbiology; Bacteremia / veterinary; Bartonella Infections / blood; Bartonella Infections / drug therapy; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; Culture Media; DNA, Bacterial / blood; Female; Horse Diseases / blood; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Joint Diseases / drug therapy; Joint Diseases / microbiology; Joint Diseases / veterinary; Male; Polymerase Chain Reaction / veterinary; Vasculitis / drug therapy; Vasculitis / microbiology; Vasculitis / veterinary
TL;DR:
The presence of Bartonella sp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 chapter
Diagnostic procedures in the examination of the equine alimentary system
In B. P. Smith (Ed.), Large Animal Internal Medicine (4th edition., pp. 667–676). St Louis, MO: Mosby-Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: March 14, 2021
2008 journal article
Disseminated large granular lymphoma in a horse
EQUINE VETERINARY EDUCATION, 20(9), 459–463.
author keywords: horse; lymphoma; weight loss; diarrhoea; T lymphocytes
TL;DR:
In this gelding, ante mortem diagnosis of CD3+ intestinal large granular lymphoma was made via cytology of abdominal fluid and immunohistochemistry of a rectal muscle biopsy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 129(3-4), 192–199.
author keywords: Endotoxemia; LPS; p38 MAPK; Equine; Leukocytes; Inflammation
MeSH headings : Animals; Cells, Cultured; Chemokines / genetics; Chemokines / metabolism; Cytokines / genetics; Cytokines / metabolism; Gene Expression Regulation / physiology; Horses / blood; Horses / immunology; Horses / metabolism; Leukocytes / drug effects; Leukocytes / metabolism; Lipopolysaccharides / pharmacology; RNA, Messenger / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
TNFalpha,IL-1beta, IL-6 and IL-8 are induced upon LPS stimulation of equine leukocytes and that this induction of gene expression is dependent on the p38 MAPK pathway, however, there are differences in the efficacy of the p 38 inhibitors tested here that may be explained by differences in specificity or potency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
The effect of lidocaine on in vitro adhesion and migration of equine neutrophils
Veterinary Immunology and Immunopathology, 129(1-2), 137–142.
Contributors: V. Cook n, L. Neuder n, A. Blikslager n & n
author keywords: Neutrophils; Equine; Immune functions; Local anesthetics
MeSH headings : Anesthetics, Local / pharmacology; Animals; Cell Adhesion / drug effects; Cell Adhesion / immunology; Cell Movement / drug effects; Cell Movement / immunology; Horses / blood; Horses / immunology; Interleukin-8 / immunology; Leukotriene B4 / immunology; Lidocaine / pharmacology; Neutrophil Activation / drug effects; Neutrophil Activation / immunology; Neutrophils / drug effects; Neutrophils / immunology; Platelet Activating Factor / immunology
TL;DR:
In conclusion, lidocaine did not inhibit neutrophil migration or adhesion in vitro at therapeutic concentrations, and increased migration and adhesion at higher concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Tonic protein kinase A activity maintains inactive beta 2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase
JOURNAL OF LEUKOCYTE BIOLOGY, 83(4), 964–971.
author keywords: PMN; PKA; ROCK; avidity; adhesion; cytoskeleton
MeSH headings : Adult; CD18 Antigens / blood; CD18 Antigens / drug effects; Carbazoles / pharmacology; Cell Adhesion; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / blood; Homeostasis; Humans; Indoles / pharmacology; Myosin-Light-Chain Kinase / blood; Neutrophils / enzymology; Neutrophils / physiology; Oligopeptides / pharmacology; Phosphorylation; Pyrroles / pharmacology; rho-Associated Kinases / blood
TL;DR:
It is demonstrated that tonic PKA activity prevents activation of β2 integrins and adhesion by inhibiting MLC phosphorylation via a MLCK‐dependent but ROCK‐independent pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 129(3-4), 181–191.
author keywords: Other animals; Inflammation; Laminitis
MeSH headings : Animals; CD18 Antigens / metabolism; Cell Adhesion; Cells, Cultured; Chemotaxis, Leukocyte / physiology; Dose-Response Relationship, Drug; Enzyme Inhibitors / pharmacology; Gene Expression Regulation / physiology; Horses / physiology; Imidazoles / pharmacology; Inflammation / metabolism; Leukotriene B4 / metabolism; Neutrophils / metabolism; Pyridines / pharmacology; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
Findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 article
A peptide against the N-terminus of MARCKS protein attenuates leukocyte migration.
404nOtfound, Vol. 175, p. A915.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Cyclooxygenase (COX) Inhibitors and the Intestine
Journal of Veterinary Internal Medicine, 21(3), 367–377.
TL;DR:
The major noncyclooxygenase targets of the COX inhibitors of particular relevance to inflammation and the gastrointestinal tract are phosphatidylinositol 3'-kinase Akt signaling, uncoupling of oxidative phosphorylation, PPARgamma, nuclear factor KB, mitogen activated protein kinases, and heat shock proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2007 journal article
Nonsecretory multiple myeloma in a horse
EQUINE VETERINARY EDUCATION, 19(11), 564–568.
author keywords: horse; myeloma; nuclear scintigraphy; lameness; neoplasia
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant
JOURNAL OF LEUKOCYTE BIOLOGY, 82(5), 1311–1321.
author keywords: PK4; chemotaxis; fMLF
MeSH headings : Actins / metabolism; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / antagonists & inhibitors; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / physiology; Cell Adhesion; Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism; Cells, Cultured; Chemotaxis; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / physiology; Cyclic GMP / analogs & derivatives; Cyclic GMP / pharmacology; Cyclic GMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic GMP-Dependent Protein Kinases / physiology; Enzyme Inhibitors / pharmacology; Humans; Interleukin-8 / pharmacology; Leukotriene B4 / pharmacology; Microfilament Proteins / genetics; Microfilament Proteins / metabolism; N-Formylmethionine Leucyl-Phenylalanine / analogs & derivatives; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Neutrophils / drug effects; Neutrophils / metabolism; Phosphoproteins / genetics; Phosphoproteins / metabolism; Phosphorylation / drug effects; Platelet Activating Factor / pharmacology; Protein Kinase C / antagonists & inhibitors; Protein Kinase C / physiology; Serine / chemistry; Serine / genetics; Serine / metabolism; Signal Transduction; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
The data show that chemoattractant stimulation of human neutrophils induces a rapid and transient PKA‐dependent VASP Ser 157 phosphorylation, andhesion does not appear to be an important regulator of the state of Vasodilator‐stimulated phosphoprotein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Restoration of Barrier Function in Injured Intestinal Mucosa
Physiological Reviews, 87(2), 545–564.
Contributors: A. Blikslager n , A. Moeser*, J. Gookin* , * & J. Odle*
MeSH headings : Animals; Epithelial Cells / physiology; Humans; Inflammation / pathology; Intestinal Diseases / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Mucous Membrane / cytology; Mucous Membrane / physiology
TL;DR:
Ex vivo studies of mammalian small intestine have revealed the importance of closure of the interepithelial tight junctions and the paracellular space, which underscores the critical role of tight junction closure in measures of barrier function such as transepithelial electrical resistance.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2007 journal article
Spontaneous rupture of the guttural pouch as a complication of treatment for guttural pouch empyema
EQUINE VETERINARY EDUCATION, 19(7), 351–355.
Contributors: C. Fogle n , M. Gerard n, A. Johansson n, B. Breuhaus n , A. Blikslager n & n
author keywords: horse; guttural pouch; empyema; rupture; complication
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 118(3-4), 294–303.
author keywords: other animals; endotoxin shock; lipopolysaccharide; inflammation
MeSH headings : Animals; Cells, Cultured; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Enzyme Activation; Epoprostenol / metabolism; Gene Expression Regulation, Enzymologic; Horses / blood; Horses / genetics; Imidazoles / pharmacology; Leukocytes / metabolism; Prostaglandins / genetics; Prostaglandins / metabolism; Pyridines / pharmacology; RNA, Messenger / metabolism; Time Factors; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
It is concluded that p 38 MAPK is essential for LPS-induced COX-2 expression suggesting that p38 MAPK are a potential target for anti-inflammatory therapy during equine endotoxemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Thoracic discospondylitis with associated epaxial muscle atrophy in a Quarter Horse gelding
EQUINE VETERINARY EDUCATION, 19(2), 67–71.
author keywords: horse; discospondylitis; epaxial muscle; right dorsal colitis
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Cholangiohepatitis, suppurative cholangitis, and cholelithiasis
Compendium on Continuing Education for the Practicing Veterinarian Equine Edition, 1, 222–225.
Source: NC State University Libraries
Added: March 23, 2021
2006 journal article
Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets
INFECTION AND IMMUNITY, 74(10), 5497–5505.
MeSH headings : Animals; Antibodies / pharmacology; CD18 Antigens / drug effects; Cryptosporidiosis / immunology; Cryptosporidiosis / pathology; Cryptosporidium parvum; Diarrhea / immunology; Diarrhea / microbiology; Disease Models, Animal; Ileum / immunology; Ileum / microbiology; Ileum / pathology; Immunoglobulin G / pharmacology; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Lipid Peroxidation; Neutrophils / enzymology; Neutrophils / immunology; Peroxidase / analysis; Peroxidase / metabolism; Peroxynitrous Acid / metabolism; Prostaglandins / metabolism; Superoxides / metabolism; Swine
TL;DR:
These studies are the first to demonstrate that neutrophilic inflammation arising in response to infection by a noninvasive epithelial pathogen results in physiologic rather than pathological effects in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Predisposing factors for small colon impaction in horses and outcome of medical and surgical treatment: 44 cases (1999–2004)
Journal of the American Veterinary Medical Association, 229(10), 1612–1616.
Contributors: L. Frederico n, * & A. Blikslager*
MeSH headings : Abdomen / pathology; Animals; Cathartics / therapeutic use; Diarrhea / complications; Diarrhea / veterinary; Fecal Impaction / drug therapy; Fecal Impaction / surgery; Fecal Impaction / veterinary; Female; Horse Diseases / drug therapy; Horse Diseases / surgery; Horses; Male; Prognosis; Retrospective Studies; Risk Factors; Treatment Outcome
TL;DR:
It is suggested that diarrhea may be a risk factor for development of small Colon impaction and that horses with small colon impaction that have abdominal distension at the time of initial examination are more likely to require surgical than medical treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Red maple (Acer rubrum) leaf toxicosis in horses: A retrospective study of 32 cases
JOURNAL OF VETERINARY INTERNAL MEDICINE, 20(5), 1197–1201.
Contributors: A. Alward n, C. Corriher, M. Barton*, D. Sellon*, A. Blikslager n & n
author keywords: equidae; Heinz body; hemolysis; methemoglobin
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
Red maple (Acer rubrum) leaf toxicosis in horses: a retrospective study of 32 cases.
Journal of Veterinary Internal Medicine, 20(5), 1197–1201,
TL;DR:
This study suggests that information obtained on initial examination cannot be used to accurately predict survival in horses with red maple toxicosis, but horses that receive corticosteroids are unlikely to survive.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 9, 2019
2006 article
Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 1457–1462.
author keywords: blood culture; colostrum; horse; passive immunity; sepsis score; survival
TL;DR:
Although both serum IgG and lactoferrin concentrations increase in healthy foals after ingestion of colostrum, only serum Igg is significantly correlated with the sepsis score and outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Use of an insect cell culture growth medium to isolate bacteria from horses with effusive, fibrinous pericarditis: A preliminary study
Veterinary Microbiology, 121(1-2), 177–181.
author keywords: insect cell culture medium; mare reproductive loss syndrome; 16S rDNA; DNA sequencing
MeSH headings : Animals; Bacteria / genetics; Bacteria / isolation & purification; Bacterial Infections / microbiology; Bacterial Infections / pathology; Bacterial Infections / veterinary; Culture Media; Culture Techniques / veterinary; Disease Outbreaks / veterinary; Horse Diseases / microbiology; Horse Diseases / pathology; Horses; Insecta / cytology; Insecta / microbiology; Kentucky / epidemiology; Pericardial Effusion / microbiology; Pericardial Effusion / pathology; Pericarditis / microbiology; Pericarditis / pathology; Pericarditis / veterinary; Pilot Projects; Retrospective Studies
TL;DR:
Bacterial isolation from equine pericardial fluid samples was attempted using an insect cell culture growth medium (ICCGM), but a similar or novel caterpillar-associated bacteria was not identified; however, use of an ICCGM might enhance isolation of bacteria from equines pericARDial fluid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2005 journal article
Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis
JOURNAL OF LEUKOCYTE BIOLOGY, 78(1), 248–258.
author keywords: integrin; adhesion; migration; actin cytoskeleton; phosphatidylinositol-3 kinase
MeSH headings : Actin Cytoskeleton / drug effects; Actin Cytoskeleton / metabolism; CD18 Antigens / metabolism; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Polarity / drug effects; Cell Polarity / physiology; Cells, Cultured; Chemotaxis, Leukocyte / drug effects; Chemotaxis, Leukocyte / physiology; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / metabolism; Cytoskeleton / drug effects; Cytoskeleton / enzymology; Dose-Response Relationship, Drug; Enzyme Activation / drug effects; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Humans; Neutrophils / drug effects; Neutrophils / enzymology; Peptides / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors
TL;DR:
The data suggest that asymmetrical PKA activity is necessary and sufficient for actin cytoskeletal polarization and migration during neutrophil chemotaxis, and suggest PI‐3K is an effector of PKA during Chemotaxis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2005 journal article
Protective role of neutrophils in mice experimentally infected with Rhodococcus equi
INFECTION AND IMMUNITY, 73(10), 7040–7042.
MeSH headings : Actinomycetales Infections / immunology; Actinomycetales Infections / microbiology; Animals; Antibodies, Monoclonal / pharmacology; Female; Liver / microbiology; Lung / microbiology; Mice; Mice, Inbred BALB C; Neutrophils / drug effects; Neutrophils / immunology; Rhodococcus equi / isolation & purification; Spleen / microbiology
TL;DR:
Neutrophils are important in controlling early infections with the intracellular bacterium Rhodococcus equi, and antineutrophil monoclonal antibody-induced neutrophil deficiency during the first week after experimental infection of mice with R. equi resulted in more severe disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Large granular lymphoma in a mule
VETERINARY RECORD, 155(15), 462–463.
MeSH headings : Animals; Equidae; Fatal Outcome; Female; Immunohistochemistry / veterinary; Intestinal Neoplasms / diagnosis; Intestinal Neoplasms / pathology; Intestinal Neoplasms / veterinary; Lymphoma, Non-Hodgkin / diagnosis; Lymphoma, Non-Hodgkin / pathology; Lymphoma, Non-Hodgkin / veterinary
TL;DR:
The heterogeneity of granular lymphocytes with respect to the size and number of the granules, cytochemical and histochemical reactions, and biological behaviour of the neoplasms is described by Kariya and others (1997), but there are no previous reports of this type of neoplasm in a mule in the literature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 286(6), G906–G913.
Contributors: D. Shifflett n, * , A. Moeser* & A. Blikslager*
author keywords: intestine; prostaglandin; transepithelial electrical resistance; cyclooxygenase 2
MeSH headings : Animals; Cyclooxygenase 2; Electric Impedance; Enzyme Activation; Enzyme Inhibitors / pharmacology; Female; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Prostaglandin-Endoperoxide Synthases / metabolism; Recovery of Function; Swine; p38 Mitogen-Activated Protein Kinases
TL;DR:
COX-2 expression appears to be positively and negatively regulated by the p38 MAPK and the JNK pathways, respectively, and ERK1/2 appear to be involved in COX- 2-independent reparative events that remain to be defined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2004 journal article
Moxifloxacin pharmacokinetics in horses and disposition into phagocytes after oral dosing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(1), 57–60.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / pharmacokinetics; Female; Fluoroquinolones; Horses / metabolism; Moxifloxacin; Phagocytes / metabolism; Quinolines / administration & dosage; Quinolines / blood; Quinolines / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1β- and COX-2-dependent mechanism
American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(1), G50–G57.
Contributors: D. Shifflett n, F. Bottone Jr., K. Young*, A. Moeser*, * & A. Blikslager*
author keywords: intestine; prostaglandin; transepithelial electrical resistance; tight junction
MeSH headings : Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Electric Impedance; Female; Ileum / blood supply; Ileum / physiopathology; Interleukin-1 / administration & dosage; Interleukin-1 / metabolism; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; Male; Neutrophils; Prostaglandin-Endoperoxide Synthases / metabolism; Swine
TL;DR:
PMNs augment recovery of TER in ischemia-injured ileal mucosa via IL-1beta-dependent upregulation of COX-2, and this action was inhibited by pretreatment with the nonselective cyclooxygenase (COX) inhibitor indomethacin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2003 journal article
A Retrospective Analysis of Hepatic Injury in Horses with Proximal Enteritis (1984-2002)
Journal of Veterinary Internal Medicine, 17(6), 896–901.
MeSH headings : Acid-Base Equilibrium / physiology; Alanine Transaminase / blood; Animals; Aspartate Aminotransferases / blood; Blood Cell Count / veterinary; Enteritis / complications; Enteritis / enzymology; Enteritis / veterinary; Heart Rate / physiology; Horse Diseases / enzymology; Horse Diseases / etiology; Horses; Intestinal Obstruction / veterinary; Liver Diseases / enzymology; Liver Diseases / etiology; Liver Diseases / veterinary; Logistic Models; Retrospective Studies; gamma-Glutamyltransferase / blood
TL;DR:
The conclusion is that horses with PE are more likely to have hepatic injury than horses with SISO.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 28, 2019
2003 journal article
A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002)
JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(6), 896–901.
author keywords: colic; duodenitis-proximal jejunitis; equine; gastric reflux; hepatopathy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Equine primary immunodeficiencies
Compendium on Continuing Education for the Practicing Veterinarian, 25(7), 548–556.
Source: NC State University Libraries
Added: August 6, 2018
2003 chapter
Examination for disorders of the gastrointestinal tract
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (2nd ed., pp. 769–780). Philadelphia, Pa: WB Saunders.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: March 23, 2021
2003 journal article
Hypomagnesemia in Hospitalized Horses
Journal of Veterinary Internal Medicine, 17(6), 860–867.
MeSH headings : Animals; Blood Chemical Analysis / veterinary; Case-Control Studies; Female; Horse Diseases / blood; Horses; Hospitalization; Magnesium / blood; Magnesium Deficiency / blood; Magnesium Deficiency / veterinary; Male; Regression Analysis
TL;DR:
Horses evaluated at the North Carolina State University, College of Veterinary Medicine (NCSU-CVM) veterinary teaching hospital between January 1999 and May 2001 were evaluated for signalment, serum chemistry panel analyses, number of hospitalization days, discharge status, and diagnosis of hypomagnesemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019
2003 journal article
Hypomagnesemia in hospitalized horses
JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(6), 860–867.
author keywords: electrolyte; equine; fluid balance; magnesium
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 chapter
Inflammatory diseases of the gastrointestinal tract causing diarrhea
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (2nd ed., pp. 884–913). Philadelphia, Pa: WB Saunders.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: March 23, 2021
2003 chapter
Oral diseases
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (2nd ed., pp. 846–855). Philadelphia, PA: WB Saunders.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: March 23, 2021
2003 journal article
PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(1), G46–G56.
author keywords: phosphatidylinositol 3-kinase; tight junction; occludin; zonula occludens-1
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Anti-Ulcer Agents / pharmacology; Electric Impedance; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Humans; Ileum / metabolism; Intestinal Mucosa / enzymology; Intestinal Mucosa / ultrastructure; Ischemia / metabolism; Male; Membrane Proteins / metabolism; Microscopy, Electron; Occludin; Osmotic Pressure; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / metabolism; Platelet Aggregation Inhibitors / pharmacology; Recovery of Function / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Swine; Tight Junctions / enzymology; Urea / pharmacology; Zonula Occludens-1 Protein
TL;DR:
These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2003 chapter
Pathophysiology of gastrointestinal inflammation
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (2nd ed., pp. 780–789). Philadelphia, Pa: WB Saunders.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: March 23, 2021
2003 chapter
Right Dorsal Colitis
In Current Therapy in Equine Medicine (pp. 141–143).
Sources: Crossref, NC State University Libraries
Added: November 17, 2019
2003 journal article
Suppurative cholangiohepatitis and enteritis in adult horses
JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(4), 583–587.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Suppurative cholangiohepatitis and enteritis in adult horses.
Journal of Veterinary Internal Medicine, 17(4), 583–587,
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: September 9, 2019
2003 journal article
Therapeutics for gastrointestinal diseases
Veterinary Clinics of North America. Equine Practice, 19(3), XI-.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2003 journal article
Treatment of acute and chronic gastrointestinal inflammation.
Veterinary Clinics of North America. Equine Practice, 19(3), 697-.
MeSH headings : Acute Disease; Animals; Anti-Inflammatory Agents / therapeutic use; Chronic Disease; Gastroenteritis / drug therapy; Gastroenteritis / veterinary; Horse Diseases / drug therapy; Horses; Inflammation Mediators / metabolism
TL;DR:
Newer strategies targeting specific cells and molecules that regulate a subset of the events occurring during inflammation are rapidly becoming available and should allow clinicians to reduce the detrimental effects of inflammation without inhibiting the beneficial aspects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Ultrasonographic findings in horses with right dorsal colitis: five cases (2000-2001)
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 222(9), 1248–1251.
MeSH headings : Abdominal Pain / etiology; Abdominal Pain / veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Case-Control Studies; Colitis / chemically induced; Colitis / diagnostic imaging; Colitis / veterinary; Colon / diagnostic imaging; Colon / pathology; Female; Horse Diseases / chemically induced; Horse Diseases / diagnostic imaging; Horse Diseases / pathology; Horses; Male; Phenylbutazone / adverse effects; Retrospective Studies; Ultrasonography
TL;DR:
Results suggest that ultrasonographic measurement of mural thickness and evaluation of the appearance of the right dorsal colon may be useful in the diagnosis of right dorsal colitis in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Equine rounds-Case presentation: Idiopathic eosinophilic enteritis in a 10-week-old colt
Compendium on Continuing Education for the Practicing Veterinarian, 24(4), 342–344.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Nasal adenocarcinoma with diffuse metastases involving the orbit, cerebrum, and multiple cranial nerves in a horse
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 221(10), 1460–1463.
MeSH headings : Adenocarcinoma / diagnosis; Adenocarcinoma / secondary; Adenocarcinoma / veterinary; Animals; Brain Neoplasms / diagnosis; Brain Neoplasms / secondary; Brain Neoplasms / veterinary; Cerebrospinal Fluid / chemistry; Cranial Nerve Neoplasms / diagnosis; Cranial Nerve Neoplasms / secondary; Cranial Nerve Neoplasms / veterinary; Diagnosis, Differential; Fatal Outcome; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Male; Nose Neoplasms / diagnosis; Nose Neoplasms / pathology; Nose Neoplasms / veterinary; Orbital Neoplasms / diagnosis; Orbital Neoplasms / secondary; Orbital Neoplasms / veterinary; Prognosis; Tomography, X-Ray Computed / veterinary
TL;DR:
A 9-year-old Trakehner gelding examined because of right exophthalmus found a lack of menace response in the right eye, reduced direct and consensual right pupillary light reflexes, ventrolateral strabismus of the rightEye, mild right-sided facial asymmetry, a head tilt to the left, and increased extensor tone in theright limbs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum
SURGERY, 132(3), 461–470.
MeSH headings : Animals; Antibodies, Monoclonal / immunology; CD11 Antigens / physiology; CD18 Antigens / physiology; Electric Impedance; Ileum / blood supply; Ileum / metabolism; Ileum / pathology; Ischemia / metabolism; Ischemia / pathology; Neutrophils / physiology; Permeability; Polyethylene Glycols / pharmacology; Superoxide Dismutase / pharmacology; Swine
TL;DR:
Pretreatment with anti-CD11/CD18 monoclonal antibody and superoxide dismutase-polyethylene glycol significantly reduced neutrophil infiltration and normalized transepithelial electrical resistance and mannitol fluxes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Percutaneous retrieval of a jugular catheter fragment from the pulmonary artery of a foal
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 220(2), 212–214.
MeSH headings : Animals; Catheterization / adverse effects; Catheterization / veterinary; Catheters, Indwelling; Diarrhea / therapy; Diarrhea / veterinary; Foreign-Body Migration / surgery; Horse Diseases / etiology; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Jugular Veins; Male; Pulmonary Artery
TL;DR:
This is the first report of successful retrieval of a catheter fragment from the pulmonary artery in a horse, and the owner inadvertently cut the catheter at the level of the hub during attempted removal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 25(2), 99–104.
MeSH headings : Actinomycetales Infections / drug therapy; Actinomycetales Infections / veterinary; Administration, Oral; Animals; Animals, Newborn; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Area Under Curve; Azithromycin / administration & dosage; Azithromycin / blood; Azithromycin / pharmacokinetics; Azithromycin / therapeutic use; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid / veterinary; Female; Horse Diseases / drug therapy; Horses / metabolism; Infusions, Intravenous / veterinary; Macrophages, Alveolar / metabolism; Male; Phagocytes / metabolism; Rhodococcus equi
TL;DR:
The properties of azithromycin suggest that it may be an alternative to erythromycin for treatment of Rhodococcus equi pneumonia in foals and its disposition in plasma, polymorphonuclear leukocytes (PMN), and alveolar cells was examined to investigate this possibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Protein kinase A regulates beta 2 integrin avidity in neutrophils
Journal of Leukocyte Biology, 71(6), 1042–1048.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Protein kinase A regulates beta2 integrin avidity in neutrophils.
Journal of Leukocyte Biology, 71(6), 1042–1048, http://europepmc.org/abstract/med/12050191
Source: ORCID
Added: September 9, 2019
2002 review
Role of the enteric nervous system in the pathophysiology of secretory diarrhea
[Review of ]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 16(3), 222–228.
author keywords: alimentary; enterocolitis; inflammation; neuroimmune
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Role of the enteric nervous system in the pathophysiology of secretory diarrhea.
Journal of Veterinary Internal Medicine, 16(3), 222–228,
TL;DR:
New approaches targeting the enteric nervous system show promise for the treatment of secretory diarrhea, and Neural reflex pathways increase epithelial fluid secretion in response to several enteric pathogens of veterinary importance.
(via Semantic Scholar)
Source: ORCID
Added: September 9, 2019
2002 journal article
The effects of cAMP modulation upon the adhesion and respiratory burst activity of immune complex-stimulated equine neutrophils
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 88(1-2), 65–77.
author keywords: neutrophil; cAMP; adhesion; integrin; immune complex
MeSH headings : Adrenergic beta-Agonists / pharmacology; Animals; Antigen-Antibody Complex / immunology; Cell Adhesion / immunology; Clenbuterol / pharmacology; Cyclic AMP / antagonists & inhibitors; Cyclic AMP / immunology; Cyclic AMP-Dependent Protein Kinases / immunology; Horses / blood; Horses / immunology; Isoproterenol / pharmacology; Neutrophils / cytology; Neutrophils / immunology; Pentoxifylline / pharmacology; Phosphodiesterase Inhibitors / pharmacology; Respiratory Burst / immunology; Rolipram / pharmacology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 article
The effects of cyclo-oxygenase inhibitors on bile-injured and normal equine colon
Campbell, N. B., Jones, S. L., & Blikslager, A. T. (2002, July). EQUINE VETERINARY JOURNAL, Vol. 34, pp. 493–498.
author keywords: horse; colon; mucosa; cyclo-oxygenase; flunixin; etodolac
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / administration & dosage; Clonixin / adverse effects; Clonixin / analogs & derivatives; Colitis / chemically induced; Colitis / veterinary; Colon / drug effects; Colon / pathology; Colon / physiopathology; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / administration & dosage; Cyclooxygenase Inhibitors / adverse effects; Deoxycholic Acid / adverse effects; Etodolac / administration & dosage; Etodolac / adverse effects; Horse Diseases / chemically induced; Horses; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Isoenzymes / metabolism; Permeability; Prostaglandin Antagonists / administration & dosage; Prostaglandin Antagonists / adverse effects; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / biosynthesis
TL;DR:
Although recovery from bile-induced colonic injury maybe independent of COX-elaborated prostanoids, treatment of control tissues with nonselective COX inhibitors may lead to marked increases in permeability, and selective inhibition ofCOX-2 may reduce the incidence of adverse effects in horses requiring NSAID therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
The effects of cyclo-oxygenase inhibitors on bile-injured and normal equine colon.
Equine Veterinary Journal, 34(5), 493–498, http://europepmc.org/abstract/med/12358053
Source: ORCID
Added: September 9, 2019
2001 journal article
Acute and chronic mineral oil pneumonitis in two horses
Equine Veterinary Education, 13(5), 230–234.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2001 journal article
Case presentation - Dysphagia caused by squamous cell carcinoma in two horses
Compendium on Continuing Education for the Practicing Veterinarian, 23(11), 1020–1024.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Neodymium:yttrium-aluminum-garnet laser ablation of a urethral web to relieve urinary outflow obstruction in a horse
Journal of the American Veterinary Medical Association, 218(12), 1970–1972.
MeSH headings : Animals; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Hysteroscopy / veterinary; Laser Therapy / veterinary; Male; Urethra / microbiology; Urethra / pathology; Urethral Obstruction / surgery; Urethral Obstruction / veterinary; Urinary Catheterization / veterinary
TL;DR:
The proximal location of the urethral lesion in this horse would have made use of traditional surgical methods problematic, whereas transendoscopic laser photoablation was easy and effective.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Signaling mechanism for equine neutrophil activation by immune complexes
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 82(1-2), 87–100.
author keywords: neutrophil; adhesion; integrin; phosphatidylinositol 3-kinase; immune complex; Fe receptor; equine
MeSH headings : Animals; Antigen-Antibody Complex / physiology; CD18 Antigens / physiology; Cell Adhesion; Horses / immunology; Neutrophil Activation; Neutrophils / physiology; Phosphatidylinositol 3-Kinases / physiology; Respiratory Burst
TL;DR:
It is shown here that adhesion of equine PMN to immobilized IC requires beta 2 integrins, and like in human PMN, IC-induced activation of beta 2 Integrin-dependent functions in equinePMN is dependent on PI3K activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
The future of antiinflammatory therapy
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 17(2), 245-+.
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cell Adhesion Molecules; Cyclooxygenase Inhibitors / therapeutic use; Horse Diseases / drug therapy; Horses; Inflammation / drug therapy; Inflammation / veterinary; Inflammation Mediators
TL;DR:
These areas of antiinflammatory research are rapidly yielding drugs with diverse future applications in equine medicine, and new pharmacologic agents that specifically target prostanoid mediators of inflammation by specifically inhibiting the activity of cyclooxygenase 2 are potent antiinflammatory agents with fewer gastrointestinal side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
The future of antiinflammatory therapy.
Equine Practice, 17(2), 245–262, http://europepmc.org/abstract/med/15658174
Source: ORCID
Added: September 9, 2019
2000 journal article
Rhabdomyolysis in two foals with polysaccharide storage myopathy
Compendium on Continuing Education for the Practicing Veterinarian, 22(5), 503.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Role of neutrophils in intestinal mucosal injury
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 217(4), 498–500.
MeSH headings : Animals; Intestinal Mucosa / blood supply; Intestinal Mucosa / pathology; Ischemia / etiology; Ischemia / pathology; Neutrophils / physiology
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
Unusual presentation of nutritional secondary hyperparathyroidism in a Paint colt
Equine Veterinary Education, 2(6), 388–394.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2000 journal article
Vaccine-associated anaphylactic-like reaction in a horse
Compendium on Continuing Education for the Practicing Veterinarian, 22(1), 81–84.
Source: NC State University Libraries
Added: August 6, 2018
1999 article
A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation
Betsuyaku, T., Liu, F., Senior, R. M., Haug, J. S., Brown, E. J., Jones, S. L., … Link, D. C. (1999, March). JOURNAL OF CLINICAL INVESTIGATION, Vol. 103, pp. 825–832.
MeSH headings : Actins / metabolism; Animals; Antigens, CD / analysis; Calcium / metabolism; Cell Adhesion / genetics; Cell Degranulation; Chemokine CXCL2; Chemokines / pharmacology; Chemotactic Factors / pharmacology; Chemotaxis, Leukocyte; Collagenases / metabolism; Interleukin-8 / pharmacology; Matrix Metalloproteinase 9; Mice; Mice, Mutant Strains; Monokines / pharmacology; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Neutrophil Activation; Neutrophils / drug effects; Receptors, Granulocyte Colony-Stimulating Factor / genetics; Receptors, Granulocyte Colony-Stimulating Factor / metabolism; Receptors, Interleukin / analysis; Receptors, Interleukin-8A; Skin / immunology; Superoxides / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
Data demonstrate that selective defects in PMN activation are present in G- CSFR-deficient mice and indicate that G-CSF plays an important role in regulating PMN chemokine responsiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1999 chapter
Phagocytosis
In Fundamental Immunology (pp. 997–1020). New York: Raven Press.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
A role for the actin-bundling protein L-plastin in the regulation of leukocyte integrin function
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(16), 9331–9336.
MeSH headings : Amino Acid Sequence; Cell Adhesion; Humans; Integrins / metabolism; Membrane Glycoproteins; Microfilament Proteins; Molecular Sequence Data; Neutrophils / metabolism; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / chemistry; Phosphoproteins / metabolism; Phosphorylation; Protein Kinase C / metabolism; Serine / metabolism; Signal Transduction
TL;DR:
A novel role for L-plastin is established in the regulation of leukocyte adhesion and it is suggested that many signaling events implicated in integrin regulation act via induction of L- plastin phosphorylation.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1998 chapter
Disorders of the large intestine
In S. R. W. Bailey (Ed.), Equine internal medicine (pp. 636–694). Philadelphia, PA: W.B. Saunders.
Ed(s): S. W. Bailey
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Electrolyte disturbances in foals with severe rhabdomyolysis
JOURNAL OF VETERINARY INTERNAL MEDICINE, 12(3), 173–177.
author keywords: horses; hyperkalemia; muscle; myopathy; selenium
MeSH headings : Animals; Animals, Newborn; Blood Urea Nitrogen; Creatinine / blood; Female; Hemoglobins / analysis; Horse Diseases; Horses; Male; Muscle, Skeletal / pathology; Myoglobin / analysis; Rhabdomyolysis / complications; Rhabdomyolysis / physiopathology; Rhabdomyolysis / veterinary; Water-Electrolyte Imbalance / etiology; Water-Electrolyte Imbalance / physiopathology; Water-Electrolyte Imbalance / veterinary
TL;DR:
Marked electrolyte abnormalities characterized by profound hyperkalemia, hyponatremia, hypocalcemia, and hyperphosphatemia were noted in 4 neonatal foals with acute rhabdomyolysis and pigmenturia and selenium deficiency with or without vitamin E deficiency, possibly combined with increased oxidant stress due to sepsis or hypoxia and reperfusion injury after parturition.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1998 journal article
Electrolyte disturbances in foals with severe rhabdomyolysis.
Journal of Veterinary Internal Medicine, 12(3), 173–177, http://europepmc.org/abstract/med/9595379
Source: ORCID
Added: September 9, 2019
1998 chapter
Examination for disorders of the large intestine
In W. Bayly & S. Reed (Eds.), Equine Internal Medicine (pp. 655–660). Philadelphia, Pa: WB Saunders.
Ed(s): W. Bayly & S. Reed
Source: NC State University Libraries
Added: April 2, 2021
1998 chapter
Inflammatory diseases of the large intestine causing diarrhea
In W. Bayly & S. Reed (Eds.), Equine Internal Medicine (pp. 663–682). Philadelphia, Pa: WB Saunders.
Ed(s): W. Bayly & S. Reed
Source: NC State University Libraries
Added: April 2, 2021
1998 chapter
Obstructive conditions of the large intestine
In W. Bayly & S. Reed (Eds.), Equine Internal Medicine (pp. 682–694). Philadelphia, Pa: WB Saunders.
Ed(s): W. Bayly & S. Reed
Source: NC State University Libraries
Added: April 2, 2021
1998 chapter
Pathophysiology of colonic inflammation and diarrhea
(W. Bayly & S. Reed, Eds.). Philadelphia, Pa: WB Saunders.
Ed(s): W. Bayly & S. Reed
Source: NC State University Libraries
Added: April 2, 2021
1998 chapter
Pathophysiology of intestinal injury
In W. Bayly & S. Reed (Eds.), Equine Internal Medicine (pp. 636–639). Philadelphia, Pa: WB Saunders.
Ed(s): W. Bayly & S. Reed
Source: NC State University Libraries
Added: April 2, 2021
1998 journal article
Pharmacokinetics of gentamicin in healthy adult horses during intravenous fluid administration
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 21(3), 247–249.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cross-Over Studies; Electrolytes / blood; Fluid Therapy; Gentamicins / administration & dosage; Gentamicins / pharmacokinetics; Horses / blood; Injections, Intravenous / veterinary; Isotonic Solutions / administration & dosage; Ringer's Solution
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1998 chapter
Physiology of the large intestine
In W. Bayly & S. Reed (Eds.), Equine internal medicine (pp. 651–655). Philadelphia, Pa: WB Saunders.
Ed(s): W. Bayly & S. Reed
Source: NC State University Libraries
Added: April 2, 2021
1998 journal article
Two signaling mechanisms for activation of alpha(M)beta(2) avidity in polymorphonuclear neutrophils
JOURNAL OF BIOLOGICAL CHEMISTRY, 273(17), 10556–10566.
MeSH headings : Cell Adhesion / drug effects; Enzyme Activation; GTP-Binding Proteins / metabolism; Humans; Macrophage-1 Antigen / immunology; Macrophage-1 Antigen / metabolism; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Protein Binding; Protein Serine-Threonine Kinases / metabolism; Receptors, Fc / metabolism; Signal Transduction; Tetradecanoylphorbol Acetate / pharmacology; Up-Regulation; p21-Activated Kinases
TL;DR:
This work has examined activation of the PMN integrin αMβ2, assessing both adhesion and generation of the epitope recognized by the activation-specific antibody CBRM1/5, and found that PI 3-kinase has a role in activation of αM β2 by immune complexes, but it is found that there is no role for it in αMαβ2 activation by ligands for trimeric G protein-coupled receptors.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1996 journal article
FcγRII-mediated Adhesion and Phagocytosis Induce L-Plastin Phosphorylation in Human Neutrophils
Journal of Biological Chemistry, 271(24), 14623–14630.
MeSH headings : Actinin; Antibodies, Monoclonal; Antigens, CD / immunology; CD18 Antigens / immunology; Calcium / blood; Cell Adhesion; Cell Membrane / physiology; Cells, Cultured; Egtazic Acid / pharmacology; Humans; Immunoglobulin Fab Fragments / pharmacology; Kinetics; Leukocyte-Adhesion Deficiency Syndrome / blood; Leukocyte-Adhesion Deficiency Syndrome / immunology; Membrane Glycoproteins; Microfilament Proteins; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Neutrophils / drug effects; Neutrophils / immunology; Neutrophils / physiology; Phagocytosis; Phosphoproteins / blood; Phosphorylation; Receptors, IgG / physiology; Tetradecanoylphorbol Acetate / pharmacology; Vinculin
TL;DR:
It is concluded that efficient FcγRII-mediated phosphorylation of L-plastin requires cell adhesion but does not require IgG-induced rearrangements of the actin cytoskeleton, and plastin was normally phosphorylated in response to adhesion to immune complexes even when the act in cytos skeleton was disrupted with cytochalasin D.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 20, 2019
1996 chapter
Functional cooperation between Fc receptors and complement receptors in phagocytes
In J. G. J. van de Winkel & P. J. A. Capel (Eds.), Human IgG Fc Receptors (pp. 149–163). Georgetown, Texas: RG Landes Co.
Ed(s): J. van de Winkel & P. Capel
Source: NC State University Libraries
Added: April 6, 2021
1995 journal article
Hydrops uteri in a caprine doe pregnant with goat-sheep hybrid fetuses.
Journal of the American Veterinary Medical Association, 206(12), 1920–1922, http://europepmc.org/abstract/med/7790309
Source: ORCID
Added: September 9, 2019
1995 journal article
Hydrops uteri in a goat pregnant with goat-sheep hybrid fetuses
Journal of the American Veterinary Medical Association, 206(12), 1920–1922.
Source: NC State University Libraries
Added: September 9, 2019
1994 journal article
Bromophenacyl bromide binding to the actin-bundling protein l-plastin inhibits inositol trisphosphate-independent increase in Ca2+ in human neutrophils.
Proceedings of the National Academy of Sciences, 91(9), 3534–3538.
author keywords: CYTOSKELETON; SIGNAL TRANSDUCTION; INOSITOL PHOSPHATES; INFLAMMATION; MONOCLONAL ANTIBODY
MeSH headings : Acetophenones / chemistry; Actins / physiology; Amino Acid Sequence; Calcium / metabolism; Cytochalasins / pharmacology; Cytoskeleton / physiology; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate / physiology; Membrane Glycoproteins; Microfilament Proteins; Molecular Sequence Data; Neutrophils / physiology; Phosphoproteins / metabolism; Receptors, Fc / physiology; Signal Transduction
TL;DR:
The finding that bromophenacyl bromide (BPB) inhibited IgG-stimulated increases in [Ca2+]i with an IC50 of 0.2 microM suggests that the actin cytoskeleton is essential for signal transduction from plasma membrane Fc receptors and that l-plastin has a critical role in activation of this pathway.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019
1994 journal article
Renal dysplasia and benign ureteropelvic polyps associated with hydronephrosis in a foal
Journal of the American Veterinary Medical Association, 204(8), 1230–1234.
Source: NC State University Libraries
Added: September 9, 2019
1994 journal article
Renal dysplasia and benign ureteropelvic polyps associated with hydronephrosis in a foal.
Journal of the American Veterinary Medical Association, 204(8), 1230–1234, http://europepmc.org/abstract/med/8014095
Source: ORCID
Added: September 9, 2019
1993 journal article
Clostridium septicum septicemia in a neonatal foal with hemorrhagic enteritis
The Cornell Veterinarian, 83(2), 143–151. http://europepmc.org/abstract/med/8467700
Sources: ORCID, NC State University Libraries
Added: September 9, 2019
1991 journal article
Subepiglottic cyst causing upper airway obstruction in a neonatal calf
Journal of the American Veterinary Medical Association, 199(6), 747–749.
Source: NC State University Libraries
Added: September 9, 2019
1991 journal article
What is your diagnosis: Mandibular ameloblastoma in a horse
Journal of the American Veterinary Medical Association, 199, 630–631.
Source: NC State University Libraries
Added: April 6, 2021
1990 journal article
What is your diagnosis: Retropharyngeal caseous lymphadenitis in a goat
Journal of the American Veterinary Medical Association, 197, 395–396.
Source: NC State University Libraries
Added: April 6, 2021
chapter
Disorders of the esophagus
Blikslager, A. T., & Jones, S. L. In Large animal internal medicine (3rd Ed.) (pp. 607–617). St. Louis: Mosby.
Source: NC State University Libraries
Added: August 6, 2018
chapter
Esophageal diseases
Jones, S. L., & Blikslager, A. T. In W. M. B. S. M. Reed & D. C. Sellon (Eds.), Equine internal medicine (pp. 855–863). Philadelphia: W. B. Saunders.
Ed(s): W. S. M. Reed & D. Sellon
Source: NC State University Libraries
Added: August 6, 2018
chapter
Ischemic disorders of the intestinal tract
Blikslager, A. T., & Jones, S. L. In W. M. B. S. M. Reed & D. C. Sellon (Eds.), Equine internal medicine (pp. 913–922). Philadelphia: W. B. Saunders.
Ed(s): W. S. M. Reed & D. Sellon
Source: NC State University Libraries
Added: August 6, 2018
chapter
Obstructive disorders of the intestinal tract
Blikslager, A. T., & Jones, S. L. In W. M. B. S. M. Reed & D. C. Sellon (Eds.), Equine internal medicine (pp. 922–936). Philadelphia: W. B. Saunders.
Ed(s): W. S. M. Reed & D. Sellon
Source: NC State University Libraries
Added: August 6, 2018
chapter
Pathophysiology of the gastronintestinal tract
Blikslager, A. T., Jones, S. L., Grondhal, M. L., Merritt, A. M., & Malbert, C. H. In R. H. Dunlop & C. H. Malbert (Eds.), Veterinary pathophysiology (pp. 111–142). Ames, IA: Blackwell Pub.
Ed(s): . R. H. Dunlop & C. Malbert
Source: NC State University Libraries
Added: August 6, 2018
Employment
Updated: January 18th, 2021 11:36
1998 - present
North Carolina State University Raleigh, North Carolina, US
Herbert Benjamin Distinguished Professor
Clinical Sciences
1989 - 1992
University of California Davis Davis, CA, US
Equine Medicine Resident
Veterinary Medicine
1988 - 1989
Texas A&M University College Station, Texas, US
Large Animal Medicine and Surgery Intern
Veterinary Medicine
Education
Updated: January 18th, 2021 11:34
1992 - 1997
Washington University in St. Louis St Louis, Missouri, US
PhD
Immunology
1985 - 1988
The University of Tennessee Knoxville Knoxville, TN, US
DVM
Veterinary Medicine
1983 - 1985
The Pennsylvania State University State College, PA, US
MS
Physiology
1979 - 1983
Bucknell University Lewisburg, PA, US
BS
Chemistry
Funding History
Funding history based on the linked ORCID record. Updated: January 18th, 2021 11:44
grant
June 1, 2009 - August 31, 2024
Interdisciplinary Biomedical Research Training Program
NIH Office of the Director
grant
August 1, 2008 - July 31, 2023
Comparative Medicine and Translational Research Training Program
NIH Office of the Director
grant
September 30, 1994 - August 31, 1998
CYTOSKELETON AND SIGNAL TRANSDUCTION IN PHAGOCYTES
National Institute of Allergy and Infectious Diseases
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