@article{kim_chiera_linder_trempus_smart_horowitz_2010, title={Overexpression of Transcription Factor Sp2 Inhibits Epidermal Differentiation and Increases Susceptibility to Wound- and Carcinogen-Induced Tumorigenesis}, volume={70}, ISSN={["1538-7445"]}, DOI={10.1158/0008-5472.can-10-1213}, abstractNote={Abstract
               Sp proteins are evolutionarily conserved transcription factors required for the expression of a wide variety of genes that are critical for development and cell cycle progression. Deregulated expression of certain Sp proteins is associated with the formation of a variety of human tumors; however, direct evidence that any given Sp protein is oncogenic has been lacking. Here, we report that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas. Transgenic mice specifically overexpressing murine Sp2 in epidermal basal keratinocytes were highly susceptible to wound- and carcinogen-induced papillomagenesis. Transgenic animals that were homozygous rather than hemizygous for the Sp2 transgene exhibited a striking arrest in the epidermal differentiation program, perishing within 2 weeks of birth. Our results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect. Cancer Res; 70(21); 8507–16. ©2010 AACR.}, number={21}, journal={CANCER RESEARCH}, author={Kim, Tae-Hyung and Chiera, Shannon L. and Linder, Keith E. and Trempus, Carol S. and Smart, Robert C. and Horowitz, Jonathan M.}, year={2010}, month={Nov}, pages={8507–8516} }