Siena Mantooth

Works (7)

Updated: June 12th, 2024 05:01

2024 journal article

Characterization of an Injectable Chitosan Hydrogel for the Tunable, Localized Delivery of Immunotherapeutics

ACS BIOMATERIALS SCIENCE & ENGINEERING, 10(2), 905–920.

By: S. Mantooth n, A. Hancock n , P. Thompson n , P. Varghese  n, D. Meritet n, M. Vrabel  n, J. Hu n , D. Zaharoff n

author keywords: hydrogel; chitosan; immunotherapy; intratumoral
TL;DR: The goal of the present work was to construct a novel, injectable hydrogel that could be tuned for localized immunotherapy delivery and displayed several clinically important features, including injectability, biocompatibility, and imageability. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 4, 2024

2024 review

Intratumoral delivery of immunotherapy to treat breast cancer: current development in clinical and preclinical studies

[Review of ]. FRONTIERS IN IMMUNOLOGY, 15.

By: S. Mantooth n, Y. Abdou *, A. Saez-Ibanez*, S. Upadhaya* & D. Zaharoff n

author keywords: breast cancer; cancer immunotherapy; intratumoral; localized delivery; neoadjuvant; hydrogel; delivery systems
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Source: Web Of Science
Added: June 11, 2024

2023 journal article

Focal Cryo-Immunotherapy with Intratumoral IL-12 Prevents Recurrence of Large Murine Tumors

CANCERS, 15(8).

By: M. Vrabel  n, J. Schulman  n, F. Gillam n, S. Mantooth n, K. Nguyen n & D. Zaharoff n

author keywords: focal ablation; cryoablation; IL-12; intratumoral; immunotherapy; abscopal response; checkpoint therapy
TL;DR: Cryo-immunotherapy with localized CS/IL-12 reduces recurrences and enhances the elimination of large primary tumors, and induces significant but limited systemic antitumor immunity. (via Semantic Scholar)
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Source: Web Of Science
Added: May 15, 2023

2022 journal article

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

FRONTIERS IN IMMUNOLOGY, 13.

By: K. Nguyen n, S. Mantooth n, M. Vrabel  n & D. Zaharoff n

author keywords: Intranasal vaccination; COVID-19; mucosal immunity; SARS-CoV-2; Receptor binding domain (RBD); chitosan; CpG
MeSH headings : Animals; Antibody Formation; COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Immunoglobulin G; Mice; SARS-CoV-2; Vaccines, Subunit
TL;DR: Data indicate that the designed vaccine platform is versatile, adaptable and capable of overcoming key constraints of current COVID-19 vaccines. (via Semantic Scholar)
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Source: Web Of Science
Added: May 31, 2022

2021 article

INJECTABLE CHITOSAN HYDROGEL FOR LOCALIZED DELIVERY OF IMMUNE CHECKPOINT INHIBITORS

Mantooth, S., Zaharoff, D., & Mantooth, S. (2021, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 9, pp. A281–A281.

By: S. Mantooth n, D. Zaharoff n & S. Mantooth  n

TL;DR: A novel injectable chitosan hydrogel was found to provide sustained release of a large model protein over a 1–2 week period with favorable in vitro kinetics and can be engineered to provide faster or slower release as needed. (via Semantic Scholar)
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Source: Web Of Science
Added: April 18, 2022

2021 article

ONCO-IMMUNOLOGICAL MECHANISMS OF FOCAL ABLATION AND LOCALIZED IL-12 IMMUNOTHERAPY

Vrabel, M., Zaharoff, D., & Mantooth, S. (2021, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 9, pp. A650–A650.

By: M. Vrabel  n, D. Zaharoff n & S. Mantooth n

TL;DR: In the spontaneously metastatic LLC model, delivering CS/IL-12 two days before treatment, either resection or cryoablation, reduced the number of metastatic lung nodules and furthermore prevented the recurrence of the primary tumor after resection. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 18, 2022

2021 journal article

Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders

BLADDER CANCER, 7(4), 427–437.

By: K. Nguyen n, E. Wagner n, M. Vrabel  n, S. Mantooth n, D. Meritet n & D. Zaharoff n

author keywords: Bladder cancer; Interleukin-12; immunotherapy; chitosan; intravesical
TL;DR: The lack of cystitis and acute inflammation justifies continued investigation of intravesical CS/IL-12 immunotherapy in larger animals and patients with bladder cancer. (via Semantic Scholar)
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Source: Web Of Science
Added: January 10, 2022

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