Siena Mantooth

Works (10)

Updated: March 6th, 2026 15:29

2025 article

884 Localized IL-12 immunotherapy via co-formulation in an injectable hydrogel

Helein, G. T., Mantooth, S. M., Nguyen, T. T., & Zaharoff, D. A. (2025, November 1). Regular and Young Investigator Award Abstracts.

By: G. Helein n, S. Mantooth n, T. Nguyen n & D. Zaharoff n

topics (OpenAlex): Immunotherapy and Immune Responses; Monoclonal and Polyclonal Antibodies Research; CAR-T cell therapy research
Source: NC State University Libraries
Added: November 13, 2025

2025 article

An injectable hydrogel enhances intratumoral retention and antitumor efficacy of cytokine immunotherapy in murine triple negative breast tumor models

Mantooth, S. M., Green, J. M., Green, W. D., Nguyen, K. G., Mantooth, K. A., Meritet, D. M., … Zaharoff, D. A. (2025, April 25). Journal of Controlled Release.

By: S. Mantooth*, J. Green, W. Green, K. Nguyen*, K. Mantooth, D. Meritet n, J. Milner, D. Zaharoff*

author keywords: Hydrogel; Intratumoral; Immunotherapy; Breast cancer; Cytokine; Chitosan
topics (OpenAlex): Immunotherapy and Immune Responses; Cancer Cells and Metastasis; Immune cells in cancer
Source: Web Of Science
Added: May 27, 2025

2025 article

Chitosan–Glycerol Injectable Hydrogel for Intratumoral Delivery of Macromolecules

Kobrin, R. L., Mantooth, S. M., Mulry, A. L., Zaharoff, D. J., Zaharoff, D. J., Zaharoff, D. A., & Zaharoff, D. A. (2025, August 2). Gels.

By: R. Kobrin n, S. Mantooth n, A. Mulry n, D. Zaharoff n, D. Zaharoff n, D. Zaharoff n, D. Zaharoff n

topics (OpenAlex): Nanoparticle-Based Drug Delivery; 3D Printing in Biomedical Research; Hydrogels: synthesis, properties, applications; Orthopaedic implants and arthroplasty; Electrospun Nanofibers in Biomedical Applications; Total Knee Arthroplasty Outcomes
Source: NC State University Libraries
Added: March 4, 2026

2024 article

Characterization of an Injectable Chitosan Hydrogel for the Tunable, Localized Delivery of Immunotherapeutics

Mantooth, S. M., Hancock, A. M., Thompson, P. M., George, V. P. J., Meritet, D. M., Vrabel, M. R., … Zaharoff, D. A. (2024, January 19). ACS Biomaterials Science & Engineering, Vol. 10, pp. 905–920.

By: S. Mantooth n, A. Hancock n , P. Thompson n , V. George n, D. Meritet n, M. Vrabel  n, J. Hu n , D. Zaharoff n

author keywords: hydrogel; chitosan; immunotherapy; intratumoral
MeSH headings : Humans; Chitosan; Hydrogels / chemistry; Injections; Neoplasms
topics (OpenAlex): Nanoparticle-Based Drug Delivery; 3D Printing in Biomedical Research; Hydrogels: synthesis, properties, applications
TL;DR: The goal of the present work was to construct a novel, injectable hydrogel that could be tuned for localized immunotherapy delivery and displayed several clinically important features, including injectability, biocompatibility, and imageability. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 4, 2024

2024 article

Intratumoral delivery of immunotherapy to treat breast cancer: current development in clinical and preclinical studies

Mantooth, S. M., Abdou, Y., Saez-Ibañez, A. R., Upadhaya, S., & Zaharoff, D. A. (2024, May 13). Frontiers in Immunology.

By: S. Mantooth n, Y. Abdou *, A. Saez-Ibañez*, S. Upadhaya* & D. Zaharoff n

author keywords: breast cancer; cancer immunotherapy; intratumoral; localized delivery; neoadjuvant; hydrogel; delivery systems
MeSH headings : Humans; Female; Breast Neoplasms / therapy; Breast Neoplasms / immunology; Immunotherapy / methods; Animals
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; RNA Interference and Gene Delivery
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 11, 2024

2023 article

Focal Cryo-Immunotherapy with Intratumoral IL-12 Prevents Recurrence of Large Murine Tumors

Vrabel, M. R., Schulman, J. A., Gillam, F. B., Mantooth, S. M., Nguyen, K. G., & Zaharoff, D. A. (2023, April 8). Cancers.

By: M. Vrabel  n, J. Schulman  n, F. Gillam n, S. Mantooth n, K. Nguyen n & D. Zaharoff n

author keywords: focal ablation; cryoablation; IL-12; intratumoral; immunotherapy; abscopal response; checkpoint therapy
topics (OpenAlex): Immunotherapy and Immune Responses; Cancer Immunotherapy and Biomarkers; Cancer Cells and Metastasis
TL;DR: Cryo-immunotherapy with localized CS/IL-12 reduces recurrences and enhances the elimination of large primary tumors, and induces significant but limited systemic antitumor immunity. (via Semantic Scholar)
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Source: Web Of Science
Added: May 15, 2023

2022 article

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

Nguyen, K. G., Mantooth, S. M., Vrabel, M. R., & Zaharoff, D. A. (2022, May 3). Frontiers in Immunology.

By: K. Nguyen n, S. Mantooth n, M. Vrabel  n & D. Zaharoff n

author keywords: Intranasal vaccination; COVID-19; mucosal immunity; SARS-CoV-2; Receptor binding domain (RBD); chitosan; CpG
MeSH headings : Animals; Antibody Formation; COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Immunoglobulin G; Mice; SARS-CoV-2; Vaccines, Subunit
topics (OpenAlex): SARS-CoV-2 and COVID-19 Research; Immunotherapy and Immune Responses; Respiratory viral infections research
TL;DR: Data indicate that the designed vaccine platform is versatile, adaptable and capable of overcoming key constraints of current COVID-19 vaccines. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 31, 2022

2021 article

259 Injectable chitosan hydrogel for localized delivery of immune checkpoint inhibitors

Mantooth, S., Zaharoff, D., & Mantooth, S. (2021, November 1). Regular and Young Investigator Award Abstracts.

By: S. Mantooth n, D. Zaharoff n & S. Mantooth  n

topics (OpenAlex): Nanoplatforms for cancer theranostics; Cancer Research and Treatments; Nanoparticle-Based Drug Delivery
TL;DR: A novel injectable chitosan hydrogel was found to provide sustained release of a large model protein over a 1–2 week period with favorable in vitro kinetics and can be engineered to provide faster or slower release as needed. (via Semantic Scholar)
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Source: Web Of Science
Added: April 18, 2022

2021 article

620 Onco-immunological mechanisms of focal ablation and localized IL-12 immunotherapy

Vrabel, M., Zaharoff, D., & Mantooth, S. (2021, November 1). Regular and Young Investigator Award Abstracts.

By: M. Vrabel  n, D. Zaharoff n & S. Mantooth n

topics (OpenAlex): Cancer Cells and Metastasis; Cancer Research and Treatments; Nanoplatforms for cancer theranostics
TL;DR: In the spontaneously metastatic LLC model, delivering CS/IL-12 two days before treatment, either resection or cryoablation, reduced the number of metastatic lung nodules and furthermore prevented the recurrence of the primary tumor after resection. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 18, 2022

2021 article

Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders

Nguyen, K. G., Wagner, E. S., Vrabel, M. R., Mantooth, S. M., Meritet, D. M., & Zaharoff, D. A. (2021, October 25). Bladder Cancer.

By: K. Nguyen n, E. Wagner n, M. Vrabel  n, S. Mantooth n, D. Meritet n & D. Zaharoff n

author keywords: Bladder cancer; Interleukin-12; immunotherapy; chitosan; intravesical
topics (OpenAlex): Urinary Tract Infections Management; Immune Cell Function and Interaction; Bladder and Urothelial Cancer Treatments
TL;DR: The lack of cystitis and acute inflammation justifies continued investigation of intravesical CS/IL-12 immunotherapy in larger animals and patients with bladder cancer. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 10, 2022

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