Shawn M. Gomez

Works (7)

Updated: April 5th, 2024 08:39

2022 journal article

Direct Detection of Glutathione Biosynthesis, Conjugation, Depletion and Recovery in Intact Hepatoma Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(9).

By: R. Jeffries n, S. Gomez n, J. Macdonald n & M. Gamcsik n

author keywords: glutathione; antioxidant; nuclear magnetic resonance spectroscopy; noninvasive; alkylating agent; metabolism
MeSH headings : Animals; Bioreactors; Bridged Bicyclo Compounds; Carcinoma, Hepatocellular; Glutathione / metabolism; Humans; Liver Neoplasms; Rats
TL;DR: Standard NMR techniques can directly monitor intracellular processes such as glutathione depletion with a time resolution of approximately < 2 min, and are demonstrated to be effective in alginate-encapsulated JM-1 hepatomas. (via Semantic Scholar)
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Added: June 6, 2022

2022 article

EMBER: multi-label prediction of kinase-substrate phosphorylation events through deep learning

Kirchoff, K. E., & Gomez, S. M. (2022, February 14). BIOINFORMATICS.

By: K. Kirchoff * & S. Gomez n

MeSH headings : Phosphorylation; Deep Learning; Phylogeny; Phosphotransferases; Proteins
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Added: March 21, 2022

2021 article

Stem/Proliferative and Differentiated Cells within Primary Murine Colonic Epithelium Display Distinct Intracellular Free Ca2+ Signal Codes

Mestril, S., Kim, R., Hinman, S. S., Gomez, S. M., & Allbritton, N. L. (2021, September 12). ADVANCED HEALTHCARE MATERIALS.

By: S. Mestril n, R. Kim *, S. Hinman *, S. Gomez n & N. Allbritton*

author keywords: Ca2+; colon; hydrogels; intestine; primary cells; stiffness
MeSH headings : Animals; Cell Differentiation; Colon; Epithelium; Intestinal Mucosa; Mice; Signal Transduction
TL;DR: The ability to monitor Ca2+ oscillations with the spatial and temporal resolution offered by this platform, combined with its amenability to high‐content screens, provides a powerful tool for investigating real‐time communication within a wide range of primary tissues in addition to the colonic epithelium. (via Semantic Scholar)
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Added: September 20, 2021

2020 journal article

The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases

NUCLEIC ACIDS RESEARCH, 49(D1), D529–D535.

By: M. Berginski *, N. Moret *, C. Liu *, D. Goldfarb *, P. Sorger * & S. Gomez n

MeSH headings : Gene Expression Regulation, Enzymologic; Internet; Knowledge Bases; Phosphotransferases / metabolism
TL;DR: A data resource, the Dark Kinase Knowledgebase (DKK), that is specifically focused on providing data and reagents for understudied kinases to the broader research community, and seeks to continually support and enhance knowledge on potentially high-impact druggable targets. (via Semantic Scholar)
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Added: February 8, 2021

2018 journal article

Spatiotemporal organization of exocytosis emerges during neuronal shape change

JOURNAL OF CELL BIOLOGY, 217(3), 1113–1128.

By: F. Urbina*, S. Gomez n & S. Gupton *

MeSH headings : Animals; Axon Guidance / drug effects; Axon Guidance / physiology; Carrier Proteins / genetics; Cell Line, Tumor; Cell Shape; Clathrin / genetics; Clathrin / metabolism; Exocytosis / drug effects; Exocytosis / physiology; HEK293 Cells; Humans; Image Processing, Computer-Assisted; Mice; Mice, Knockout; Nerve Tissue Proteins / genetics; Netrin-1 / pharmacology; Neurites / drug effects; Neurites / physiology; Neurogenesis; Neurons / cytology; Neurons / drug effects; Neurons / physiology; Primary Cell Culture; Software; Ubiquitin-Protein Ligases; Vesicle-Associated Membrane Protein 2 / metabolism
TL;DR: Spatial statistics uncovered distinct spatiotemporal regulation of exocytosis in the soma and neurites of developing neurons that was modulated by developmental stage, exposure to the guidance cue netrin-1, and the brain-enriched ubiquitin ligase tripartite motif 9. (via Semantic Scholar)
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Added: August 6, 2018

2018 journal article

Unexplored therapeutic opportunities in the human genome

NATURE REVIEWS DRUG DISCOVERY, 17(5), 317–332.

By: T. Oprea *, C. Bologa *, S. Brunak *, A. Campbell*, G. Gan *, A. Gaulton *, S. Gomez n, R. Guha * ...

TL;DR: How the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins is discussed. (via Semantic Scholar)
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Added: August 6, 2018

2015 journal article

Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood

INTEGRATIVE BIOLOGY, 7(4), 392–401.

By: A. Dickinson *, M. Meyer*, E. Pawlak*, S. Gomez n, I. Jaspers * & N. Allbritton n

MeSH headings : Cells, Cultured; Enzyme Activation; Humans; Killer Cells, Natural / enzymology; Phosphotransferases (Alcohol Group Acceptor) / blood; Phosphotransferases (Alcohol Group Acceptor) / chemistry
TL;DR: In contrast to the SK activity, S1PP activity was homogeneous across the peripheral blood NK cells, suggesting a bias in the SK pathway towards proliferation and migration, activities supported by S1P. (via Semantic Scholar)
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Added: August 6, 2018

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