Shawn M. Gomez

Works (8)

Updated: May 2nd, 2025 21:18

2024 article

Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic Approaches

Xu, Y., Peng, X. L., East, M. P., McCabe, I. C., Stroman, G. C., Jenner, M. R., … Yeh, J. J. (2024, December 5). Cancer Discovery.

By: Y. Xu*, X. Peng *, M. East *, I. McCabe*, G. Stroman*, M. Jenner *, P. Chan *, A. Morrison* ...

MeSH headings : Humans; Pancreatic Neoplasms / drug therapy; Pancreatic Neoplasms / genetics; Pancreatic Neoplasms / pathology; Pancreatic Neoplasms / metabolism; Protein Kinase Inhibitors / therapeutic use; Protein Kinase Inhibitors / pharmacology; Carcinoma, Pancreatic Ductal / drug therapy; Carcinoma, Pancreatic Ductal / genetics
topics (OpenAlex): Pancreatic and Hepatic Oncology Research; Phagocytosis and Immune Regulation; Cancer Genomics and Diagnostics
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Source: Web Of Science
Added: February 17, 2025

2022 article

Direct Detection of Glutathione Biosynthesis, Conjugation, Depletion and Recovery in Intact Hepatoma Cells

Jeffries, R. E., Gomez, S. M., Macdonald, J. M., & Gamcsik, M. P. (2022, April 25). International Journal of Molecular Sciences.

By: R. Jeffries n, S. Gomez n, J. Macdonald n & M. Gamcsik n

author keywords: glutathione; antioxidant; nuclear magnetic resonance spectroscopy; noninvasive; alkylating agent; metabolism
MeSH headings : Animals; Bioreactors; Bridged Bicyclo Compounds; Carcinoma, Hepatocellular; Glutathione / metabolism; Humans; Liver Neoplasms; Rats
topics (OpenAlex): Sulfur Compounds in Biology; Amino Acid Enzymes and Metabolism; Cancer, Hypoxia, and Metabolism; Glutathione Transferases and Polymorphisms
TL;DR: Standard NMR techniques can directly monitor intracellular processes such as glutathione depletion with a time resolution of approximately < 2 min, and are demonstrated to be effective in alginate-encapsulated JM-1 hepatomas. (via Semantic Scholar)
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Source: Web Of Science
Added: June 6, 2022

2022 article

EMBER: multi-label prediction of kinase-substrate phosphorylation events through deep learning

Kirchoff, K. E., & Gomez, S. M. (2022, February 9). Bioinformatics.

By: K. Kirchoff * & S. Gomez n

MeSH headings : Phosphorylation; Deep Learning; Phylogeny; Phosphotransferases; Proteins
topics (OpenAlex): Machine Learning in Bioinformatics; Computational Drug Discovery Methods; Protein Structure and Dynamics
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Source: Web Of Science
Added: March 21, 2022

2021 article

Stem/Proliferative and Differentiated Cells within Primary Murine Colonic Epithelium Display Distinct Intracellular Free Ca2+ Signal Codes

Mestril, S., Kim, R., Hinman, S. S., Gomez, S. M., & Allbritton, N. L. (2021, September 12). Advanced Healthcare Materials.

By: S. Mestril n, R. Kim *, S. Hinman *, S. Gomez n & N. Allbritton*

author keywords: Ca2+; colon; hydrogels; intestine; primary cells; stiffness
MeSH headings : Animals; Cell Differentiation; Colon; Epithelium; Intestinal Mucosa; Mice; Signal Transduction
topics (OpenAlex): Cancer Cells and Metastasis; Genetic factors in colorectal cancer; Digestive system and related health
TL;DR: The ability to monitor Ca2+ oscillations with the spatial and temporal resolution offered by this platform, combined with its amenability to high‐content screens, provides a powerful tool for investigating real‐time communication within a wide range of primary tissues in addition to the colonic epithelium. (via Semantic Scholar)
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Source: Web Of Science
Added: September 20, 2021

2020 article

The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases

Berginski, M. E., Moret, N., Liu, C., Goldfarb, D., Sorger, P. K., & Gomez, S. M. (2020, September 26). Nucleic Acids Research.

By: M. Berginski *, N. Moret *, C. Liu *, D. Goldfarb *, P. Sorger * & S. Gomez n

MeSH headings : Gene Expression Regulation, Enzymologic; Internet; Knowledge Bases; Phosphotransferases / metabolism
topics (OpenAlex): Computational Drug Discovery Methods; Cell Image Analysis Techniques; Bioinformatics and Genomic Networks
TL;DR: A data resource, the Dark Kinase Knowledgebase (DKK), that is specifically focused on providing data and reagents for understudied kinases to the broader research community, and seeks to continually support and enhance knowledge on potentially high-impact druggable targets. (via Semantic Scholar)
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Source: Web Of Science
Added: February 8, 2021

2018 article

Spatiotemporal organization of exocytosis emerges during neuronal shape change

Urbina, F. L., Gomez, S. M., & Gupton, S. L. (2018, January 19). The Journal of Cell Biology.

By: F. Urbina*, S. Gomez n & S. Gupton *

MeSH headings : Animals; Axon Guidance / drug effects; Axon Guidance / physiology; Carrier Proteins / genetics; Cell Line, Tumor; Cell Shape; Clathrin / genetics; Clathrin / metabolism; Exocytosis / drug effects; Exocytosis / physiology; HEK293 Cells; Humans; Image Processing, Computer-Assisted; Mice; Mice, Knockout; Nerve Tissue Proteins / genetics; Netrin-1 / pharmacology; Neurites / drug effects; Neurites / physiology; Neurogenesis; Neurons / cytology; Neurons / drug effects; Neurons / physiology; Primary Cell Culture; Software; Ubiquitin-Protein Ligases; Vesicle-Associated Membrane Protein 2 / metabolism
topics (OpenAlex): Cellular transport and secretion; Lipid Membrane Structure and Behavior; Erythrocyte Function and Pathophysiology
TL;DR: Spatial statistics uncovered distinct spatiotemporal regulation of exocytosis in the soma and neurites of developing neurons that was modulated by developmental stage, exposure to the guidance cue netrin-1, and the brain-enriched ubiquitin ligase tripartite motif 9. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2018 article

Unexplored therapeutic opportunities in the human genome

Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., … Zahoránszky-Köhalmi, G. (2018, February 23). Nature Reviews Drug Discovery.

By: T. Oprea *, C. Bologa *, S. Brunak *, A. Campbell*, G. Gan *, A. Gaulton *, S. Gomez n, R. Guha * ...

topics (OpenAlex): Computational Drug Discovery Methods; Receptor Mechanisms and Signaling; Protein Degradation and Inhibitors; CRISPR and Genetic Engineering; RNA and protein synthesis mechanisms
TL;DR: How the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins is discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 article

Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood

Dickinson, A. J., Meyer, M., Pawlak, E. A., Gomez, S., Jaspers, I., & Allbritton, N. L. (2015, January 1). Integrative Biology.

By: A. Dickinson *, M. Meyer*, E. Pawlak*, S. Gomez n, I. Jaspers * & N. Allbritton n

MeSH headings : Cells, Cultured; Enzyme Activation; Humans; Killer Cells, Natural / enzymology; Phosphotransferases (Alcohol Group Acceptor) / blood; Phosphotransferases (Alcohol Group Acceptor) / chemistry
topics (OpenAlex): Sphingolipid Metabolism and Signaling; Immune Cell Function and Interaction; Immune cells in cancer; Calcium signaling and nucleotide metabolism
TL;DR: In contrast to the SK activity, S1PP activity was homogeneous across the peripheral blood NK cells, suggesting a bias in the SK pathway towards proliferation and migration, activities supported by S1P. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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