Works (7)
Updated: July 9th, 2023 21:20
2010 journal article
Mesenchymal Stem Cells Require MARCKS Protein for Directed ChemotaxisIn Vitro
American Journal of Respiratory Cell and Molecular Biology, 43(3), 253–258.
author keywords: mesenchymal; MARCKS; chemotaxis; chemokines; phosphorylation
MeSH headings : Animals; Blotting, Western; Bone Marrow Cells / cytology; Cell Differentiation; Cell Movement; Cells, Cultured; Chemokine CCL2 / pharmacology; Chemokine CXCL12 / pharmacology; Chemotaxis / drug effects; Complement C5a / pharmacology; Dose-Response Relationship, Drug; Fetal Blood; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / physiology; Lung / cytology; Lung / metabolism; Macrophages / cytology; Macrophages / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / physiology; Mesenchymal Stem Cells / cytology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments / pharmacology; Phosphorylation
TL;DR:
It is illustrated, for the first time, that myristoylated alanine-rich C kinase substrate (MARCKS) protein plays an integral role in BM-MSC-directed chemotaxis in vitro.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2009 journal article
Mesenchymal stem cells produce Wnt isoforms and TGF-beta(1) that mediate proliferation and procollagen expression by lung fibroblasts
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 297(5), L1002–L1011.
author keywords: peptide growth factors; pulmonary fibrosis
MeSH headings : Animals; Antibodies / pharmacology; Bone Marrow Cells / cytology; Cell Proliferation / drug effects; Coculture Techniques; Collagen Type I / genetics; Collagen Type I / metabolism; Culture Media, Conditioned / pharmacology; Fetal Blood / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation / drug effects; Humans; Intracellular Signaling Peptides and Proteins; Lung / cytology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Mice; Platelet-Derived Growth Factor / metabolism; Polymerase Chain Reaction; Protein Isoforms / metabolism; Proteins / pharmacology; Solubility / drug effects; Transforming Growth Factor beta1 / antagonists & inhibitors; Transforming Growth Factor beta1 / metabolism; Wnt Proteins / metabolism; beta Catenin / metabolism
TL;DR:
It is demonstrated that MSC from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate LF proliferation and matrix production, two hallmarks of fibroproliferative lung disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 122(1-2), 159–166.
author keywords: Foxp3; feline; Treg; regulatory T cells; toll-like receptors
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cats; Cloning, Molecular; Forkhead Transcription Factors / chemistry; Forkhead Transcription Factors / genetics; Humans; Molecular Sequence Data; RNA, Messenger / analysis; T-Lymphocytes, Regulatory / metabolism; Toll-Like Receptors / physiology
TL;DR:
The feline FOXP3 is 1293 nucleotides in length and codes for a protein that shares high homology to other species and provides useful tools to further investigate Foxp3 and Tregs in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
In vivo depletion of CD4(+)CD25(+) regulatory T cells in cats
JOURNAL OF IMMUNOLOGICAL METHODS, 329(1-2), 81–91.
author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors
TL;DR:
It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Modeling the airway epithelium in allergic asthma: Interleukin-13-induced effects in differentiated murine tracheal epithelial cells
In Vitro Cellular & Developmental Biology. Animal, 41(7), 217–224.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Cloning of canine cytochrome P450 2E1 CDNA: identification and characterization of two variant alleles
Drug Metabolism and Disposition, 28(8), 981–986.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 30(5), 583–590.
author keywords: angiotensin; losartan; EXP3174; pharmacokinetics; pharmacodynamics; pig
MeSH headings : Angiotensin II / administration & dosage; Animals; Anti-Arrhythmia Agents / pharmacokinetics; Anti-Arrhythmia Agents / pharmacology; Antihypertensive Agents / pharmacokinetics; Antihypertensive Agents / pharmacology; Area Under Curve; Blood Pressure / drug effects; Disease Models, Animal; Half-Life; Hypertension / chemically induced; Hypertension / drug therapy; Imidazoles / pharmacokinetics; Imidazoles / pharmacology; Infusions, Intravenous; Losartan / pharmacokinetics; Losartan / pharmacology; Receptors, Angiotensin / drug effects; Swine; Tetrazoles / pharmacokinetics; Tetrazoles / pharmacology
TL;DR:
The pharmacokinetics of losartan and EXP3174, an active metabolite ofLosartan, were evaluated in the anesthetized pig after both a single intravenous dose and during constant intravenous infusion to determine the degree of inhibition of angiotensin II-induced increase in the diastolic pressure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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