Susan M. Lankford

Works (7)

Updated: July 9th, 2023 21:20

2010 journal article

Mesenchymal Stem Cells Require MARCKS Protein for Directed ChemotaxisIn Vitro

American Journal of Respiratory Cell and Molecular Biology, 43(3), 253–258.

By: J. Miller n, S. Lankford n, K. Adler n & A. Brody n

author keywords: mesenchymal; MARCKS; chemotaxis; chemokines; phosphorylation
MeSH headings : Animals; Blotting, Western; Bone Marrow Cells / cytology; Cell Differentiation; Cell Movement; Cells, Cultured; Chemokine CCL2 / pharmacology; Chemokine CXCL12 / pharmacology; Chemotaxis / drug effects; Complement C5a / pharmacology; Dose-Response Relationship, Drug; Fetal Blood; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / physiology; Lung / cytology; Lung / metabolism; Macrophages / cytology; Macrophages / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / physiology; Mesenchymal Stem Cells / cytology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments / pharmacology; Phosphorylation
TL;DR: It is illustrated, for the first time, that myristoylated alanine-rich C kinase substrate (MARCKS) protein plays an integral role in BM-MSC-directed chemotaxis in vitro. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2009 journal article

Mesenchymal stem cells produce Wnt isoforms and TGF-beta(1) that mediate proliferation and procollagen expression by lung fibroblasts

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 297(5), L1002–L1011.

By: K. Salazar  n, S. Lankford n & A. Brody n

author keywords: peptide growth factors; pulmonary fibrosis
MeSH headings : Animals; Antibodies / pharmacology; Bone Marrow Cells / cytology; Cell Proliferation / drug effects; Coculture Techniques; Collagen Type I / genetics; Collagen Type I / metabolism; Culture Media, Conditioned / pharmacology; Fetal Blood / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation / drug effects; Humans; Intracellular Signaling Peptides and Proteins; Lung / cytology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Mice; Platelet-Derived Growth Factor / metabolism; Polymerase Chain Reaction; Protein Isoforms / metabolism; Proteins / pharmacology; Solubility / drug effects; Transforming Growth Factor beta1 / antagonists & inhibitors; Transforming Growth Factor beta1 / metabolism; Wnt Proteins / metabolism; beta Catenin / metabolism
TL;DR: It is demonstrated that MSC from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate LF proliferation and matrix production, two hallmarks of fibroproliferative lung disease. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 122(1-2), 159–166.

By: S. Lankford n, C. Petty n, A. La Voy  n, S. Reckling n, W. Tompkins n & G. Dean n

author keywords: Foxp3; feline; Treg; regulatory T cells; toll-like receptors
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cats; Cloning, Molecular; Forkhead Transcription Factors / chemistry; Forkhead Transcription Factors / genetics; Humans; Molecular Sequence Data; RNA, Messenger / analysis; T-Lymphocytes, Regulatory / metabolism; Toll-Like Receptors / physiology
TL;DR: The feline FOXP3 is 1293 nucleotides in length and codes for a protein that shares high homology to other species and provides useful tools to further investigate Foxp3 and Tregs in cats. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

In vivo depletion of CD4(+)CD25(+) regulatory T cells in cats

JOURNAL OF IMMUNOLOGICAL METHODS, 329(1-2), 81–91.

By: S. Smithberg n, J. Fogle n, A. Mexas n, S. Reckling n, S. Lankford n, M. Tompkins n, G. Dean n

author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors
TL;DR: It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 journal article

Modeling the airway epithelium in allergic asthma: Interleukin-13-induced effects in differentiated murine tracheal epithelial cells

In Vitro Cellular & Developmental Biology. Animal, 41(7), 217–224.

By: S. Lankford, M. Macchione, A. Crews, S. McKane, N. Akley & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Cloning of canine cytochrome P450 2E1 CDNA: identification and characterization of two variant alleles

Drug Metabolism and Disposition, 28(8), 981–986.

By: S. Lankford, S. Bai & J. Goldstein

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 30(5), 583–590.

By: S. Lankford*, D. Plummer*, P. Hellyer, D. Christ & S. Bai*

author keywords: angiotensin; losartan; EXP3174; pharmacokinetics; pharmacodynamics; pig
MeSH headings : Angiotensin II / administration & dosage; Animals; Anti-Arrhythmia Agents / pharmacokinetics; Anti-Arrhythmia Agents / pharmacology; Antihypertensive Agents / pharmacokinetics; Antihypertensive Agents / pharmacology; Area Under Curve; Blood Pressure / drug effects; Disease Models, Animal; Half-Life; Hypertension / chemically induced; Hypertension / drug therapy; Imidazoles / pharmacokinetics; Imidazoles / pharmacology; Infusions, Intravenous; Losartan / pharmacokinetics; Losartan / pharmacology; Receptors, Angiotensin / drug effects; Swine; Tetrazoles / pharmacokinetics; Tetrazoles / pharmacology
TL;DR: The pharmacokinetics of losartan and EXP3174, an active metabolite ofLosartan, were evaluated in the anesthetized pig after both a single intravenous dose and during constant intravenous infusion to determine the degree of inhibition of angiotensin II-induced increase in the diastolic pressure. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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