Samuel Hedlund

College of Agriculture and Life Sciences

Works (1)

Updated: June 19th, 2023 21:41

2021 journal article

Pioneer Axons Utilize a Dcc Signaling-Mediated Invasion Brake to Precisely Complete Their Pathfinding Odyssey

JOURNAL OF NEUROSCIENCE, 41(31), 6617–6636.

By: N. Kikel-Coury*, L. Green *, E. Nichols *, A. Zellmer*, S. Pai n, S. Hedlund n, K. Marsden n , C. Smith *

author keywords: DREZ; invasion; neuron; pathfinding; zebrafish
MeSH headings : Animals; Axon Guidance / physiology; DCC Receptor / metabolism; Ganglia, Spinal / embryology; Signal Transduction / physiology; Zebrafish; Zebrafish Proteins / metabolism
TL;DR: Time-lapse super-resolution imaging in zebrafish DRG pioneer neurons is used to investigate how embryonic axons control their cytoskeleton to navigate to and invade at the correct anatomic position and reveals a molecularly-controlled brake on invadopodia stabilization until the sensory neuron growth cone is present at the dorsal root entry zone, which is ultimately essential for growth cone entry into the spinal cord and behavioral response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 23, 2021

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