@article{ozawa_pierce_alexander_keller_tarbert_guzman_sadar_sheldon_meritet_2024, title={Cardiovascular disease in central bearded dragons (Pogona vitticeps): 54 cases (2007-2022)}, volume={85}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.23.10.0241}, abstractNote={Abstract OBJECTIVE To describe the clinical features, histopathologic lesions, and outcome of cardiovascular disease in central bearded dragons. ANIMALS 54 bearded dragons. METHODS Retrospective evaluation of captive bearded dragons with antemortem imaging or postmortem diagnosis of cardiovascular disease from 2007 to 2022 from 6 hospitals. RESULTS The total prevalence of cardiovascular disease was 3.3% (54/1,655). Physical examination findings were available in 46 cases with change in mentation being the most common finding (n = 28/46 [60.9%]), followed by dehydration (17/46 [37%]), palpable coelomic mass (13/46 [28.3%]), dyspnea (10/46 [21.7%]), and sunken eyes (10/46 [21.7%)]. Doppler auscultation revealed an arrhythmia in 5/34 (14.7%) animals. Diagnostic imaging was only performed on 21 animals, and 10 (47.6%) had cardiovascular abnormalities described. In total, 84 cardiovascular diagnoses were found in 54 animals. The most common diagnosis was myocarditis (n = 14) followed by aneurysms (11), pericardial effusion (9), atherosclerosis (7), epicarditis (7), and myocardial degeneration/necrosis (7). Overall, 62 causes of death were identified in 52 cases, with cardiovascular disease being the most common (n = 18/52 [34.5%]). Only 3/54 animals were diagnosed with congestive heart failure. Animals with aneurysms were more likely to die to due cardiovascular disease compared to other types of cardiovascular diagnoses (OR, 43.75; 95% CI, 4.88 to 392.65; P < .001). CLINICAL RELEVANCE Diagnosis of cardiovascular disease in bearded dragons is challenging given the inconsistent clinical presentation; however, it should remain a differential in animals with nonspecific signs of illness. Antemortem diagnostics are recommended in suspected cases, including diagnostic imaging. Of the cardiovascular diseases described, aneurysms most often contributed to clinical demise.}, number={5}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Ozawa, Sarah M. and Pierce, Kursten V and Alexander, Amy B. and Keller, Krista A. and Tarbert, Danielle K. and Guzman, David Sanchez-Migallon and Sadar, Miranda J. and Sheldon, Julie D. and Meritet, Danielle M.}, year={2024}, month={May} } @article{dannemiller_ozawa_petritz_musulin_2024, title={Major crossmatch compatibility of rabbit blood with rabbit, canine, and feline blood}, volume={2}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.13362}, DOI={10.1111/vec.13362}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Dannemiller, Nicholas G. and Ozawa, Sarah M. and Petritz, Olivia A. and Musulin, Sarah E.}, year={2024}, month={Feb} } @article{hastain_mumm_ozawa_petritz_gaudette_troan_stowe_2024, title={Osteosarcoma of the wing in a sulfur-crested cockatoo}, volume={1}, ISSN={["1939-165X"]}, url={https://doi.org/10.1111/vcp.13322}, DOI={10.1111/vcp.13322}, abstractNote={Abstract}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Hastain, Sydney A. and Mumm, Lauren and Ozawa, Sarah and Petritz, Olivia and Gaudette, Chris and Troan, Brigid V. and Stowe, Devorah M.}, year={2024}, month={Jan} } @article{cabot_papich_harrison_thomson_defrancesco_ozawa_2023, title={Population pharmacokinetics of single dose oral pimobendan in the ferret (Mustela putorius furo)}, volume={48}, ISSN={["1931-6283"]}, url={https://doi.org/10.1053/j.jepm.2023.09.002}, DOI={10.1053/j.jepm.2023.09.002}, abstractNote={Therapeutic options and dosing recommendations for congestive heart failure in the domestic ferret are currently extrapolated from domestic dogs and cats. The goal of this study was to determine the pharmacokinetics of oral pimobendan in the domestic ferret. Twelve domestic ferrets were administered a single dose (average 0.4 mg/kg) of pimobendan in a commercially available, chewable, meat-flavored tablet formulation. High-performance liquid chromatography and fluorescence detection were used to measure pimobendan and the metabolite O-desmethylpimobendan (ODMP) in plasma samples collected at 0, 0.25, 0.5, 1, 2, 4, 6, 9, and 12 hours after administration using a sparse sampling protocol. Pharmacokinetic parameters for pimobendan and ODMP were as follows: peak plasma concentration, 14.29 ng/mL and 16.88 ng/mL; time to peak plasma concentration, 1.69 hours and 1.97 hours; area under the curve, 129.87 ng*h/mL and 190.97 ng*h/mL; and elimination half-life, 4.97 hours and 6.32 hours, respectively. No adverse events were noted. A single dose of oral pimobendan in ferrets reached concentrations higher than that reported for dogs by the manufacturer and similar to peak plasma concentrations correlated with a therapeutic effect in healthy dogs in a separate study. Individual variability was high and plasma concentrations in at least half of the ferrets remained at or below the lower limit of quantification throughout the duration of the study. Additional studies are needed to characterize the pharmacodynamics, oral bioavailability, and duration of action to facilitate dosing recommendations for pimobendan in the domestic ferret.}, journal={JOURNAL OF EXOTIC PET MEDICINE}, author={Cabot, Megan L. and Papich, Mark G. and Harrison, Tara M. and Thomson, Andrea E. and Defrancesco, Teresa and Ozawa, Sarah M.}, year={2023}, month={Jan}, pages={1–5} } @article{hale_kapp_robertson_lewbart_ozawa_2023, title={The clinical features and treatment of fishhook injuries in freshwater turtles: 126 cases from 1997-2022}, volume={261}, ISSN={["1943-569X"]}, DOI={10.2460/javma.23.03.0146}, abstractNote={Abstract}, number={12}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Hale, Lily M. and Kapp, Sabrina L. and Robertson, James B. and Lewbart, Gregory A. and Ozawa, Sarah M.}, year={2023}, month={Dec}, pages={1829–1837} } @article{ozawa_cenani_sanchez-migallon guzman_2023, title={Treatment of Pain in Rabbits}, volume={26}, DOI={10.1016/j.cvex.2022.09.001}, abstractNote={Rabbits occupy facets of veterinary medicine spanning from companion mammals, wildlife medicine, zoologic species, and research models. Therefore, analgesia is required for a variety of conditions in rabbits and is a critical component of patient care. Considerations when selecting an analgesic protocol in rabbits include timing of administration, route of administration, degree or anticipated pain, ability to access or use controlled drugs, systemic health, and any potential side effects. This review focuses on pharmacologic and locoregional management of pain in rabbits and emphasizes the need for further studies on pain management in this species.}, number={1}, journal={Veterinary Clinics of North America: Exotic Animal Practice}, author={Ozawa, S. and Cenani, A. and Sanchez-Migallon Guzman, D.}, year={2023}, month={Jan}, pages={201–227} } @article{keeney_cohen_lewbart_ozawa_2023, title={ULTRASONOGRAPHIC EVALUATION OF COELOMIC FLUID IN HEALTHY CORN SNAKES (PANTHEROPHIS GUTTATUS)}, volume={54}, ISSN={["1937-2825"]}, DOI={10.1638/2022-0102}, abstractNote={Abstract: Free coelomic fluid can be a physiologic or pathologic finding in snakes. In this study, ultrasonography was used to assess the presence, volume, and type of coelomic fluid in 18 (16 females, 2 males) clinically healthy corn snakes (Pantherophis guttatus) using a semiquantitative scoring system. Each snake was divided into five equal regions (R1–R5) by length (from rostrum to vent) and fluid volume was scored on a scale of 0 to 4. Coelomic fluid was sampled when possible and cytologic analysis was performed. The majority of snakes (16/18) were found to have some degree of free coelomic fluid. The coelomic fluid samples that were collected (n= 6) were classified as transudates, acellular or primarily lymphocytic. Fluid was most likely to be found in R3 compared with all other regions and least likely to be found in R1 compared with R2, R3, and R4. A higher score of volume was found in R3 compared with R1 and R5. This study describes the distribution and abundance of coelomic fluid in snakes, as well as a method for point of care ultrasound (POCUS) in this species.}, number={1}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Keeney, Caitlin M. Hepps and Cohen, Eli B. and Lewbart, Gregory A. and Ozawa, Sarah M.}, year={2023}, month={Mar}, pages={65–72} } @article{ozawa_graham_sanchez-migallon guzman_tucker_petritz_sullivan_robertson_hawkins_2022, title={Clinicopathological findings in and prognostic factors for domestic rabbits with liver lobe torsion: 82 cases (2010–2020)}, volume={260}, DOI={10.2460/javma.22.03.0154}, abstractNote={Abstract}, number={11}, journal={Journal of the American Veterinary Medical Association}, author={Ozawa, S. and Graham, J. and Sanchez-Migallon Guzman, D. and Tucker, S.M. and Petritz, O.A. and Sullivan, P. and Robertson, J.B. and Hawkins, M.G.}, year={2022}, month={Jun} } @article{lehman_cohen_ozawa_hepps keeney_sommer_2022, title={Imaging Diagnosis: Thoracic radiographic features of toxoplasmosis in a 14-month-old Red Kangaroo (Macropus rufus)}, volume={63}, ISSN={["1740-8261"]}, url={https://doi.org/10.1111/vru.13155}, DOI={10.1111/vru.13155}, abstractNote={Abstract}, number={6}, journal={Veterinary Radiology and Ultrasound}, author={Lehman, K. and Cohen, E. and Ozawa, S. and Hepps Keeney, C. and Sommer, S.}, year={2022}, month={Nov}, pages={E26–E30} } @article{cherukuri_scott -cruz_lewbart_petrovich_ozawa_2022, title={Intravenous regional antibiotic perfusion as an adjunctive therapy to treat osteomyelitis in a common snapping turtle (Chelydra serpentina)}, volume={10}, ISSN={["2052-6121"]}, DOI={10.1002/vrc2.487}, abstractNote={Abstract}, number={4}, journal={VetRecord CaseReports}, author={Cherukuri, A. and Scott -Cruz, S. and Lewbart, G. and Petrovich, N. and Ozawa, S.}, year={2022}, month={Dec}, pages={e487} } @article{handberg_gaudette_knutson_nelson_ozawa_2022, title={MRI findings associated with clinical presentation and histopathology in a Mexican redknee tarantula (Brachypelma hamorii)}, volume={10}, ISSN={["2052-6121"]}, url={https://doi.org/10.1002/vrc2.517}, DOI={10.1002/vrc2.517}, abstractNote={Abstract}, journal={VETERINARY RECORD CASE REPORTS}, author={Handberg, Elizabeth and Gaudette, Chris and Knutson, Kyra and Nelson, Nathan and Ozawa, Sarah}, year={2022}, month={Oct} } @article{ozawa_guzman_hawkins_diao_masri_gunther-harrington_knych_2022, title={Pharmacokinetics of pimobendan following oral administration to New Zealand White rabbits (Oryctolagus cuniculus)}, volume={83}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.21.03.0032}, abstractNote={Abstract}, number={4}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Ozawa, Sarah M. and Guzman, David Sanchez-Migallon and Hawkins, Michelle G. and Diao, Stephanie M. and Masri, Acacia E. and Gunther-Harrington, Catherine T. and Knych, Heather K.}, year={2022}, pages={356–363} } @article{ozawa_thomson_petritz_2022, title={Safety and efficacy of oral mirtazapine in New Zealand White rabbits (Oryctolagus cuniculus)}, volume={40}, ISSN={["1931-6283"]}, url={https://doi.org/10.1053/j.jepm.2021.10.003}, DOI={10.1053/j.jepm.2021.10.003}, abstractNote={One of the most common presenting complaints in rabbits is decreased food intake and/or fecal output. This can occur as a clinical consequence of pain, anesthesia and systemic or gastrointestinal disease. In conjunction with diagnosing and treating the underlying condition, veterinary care should aim to normalize food intake and fecal output. Mirtazapine is a tetracyclic antidepressant that has appetite stimulating effects in other species. However, studies in rabbits are currently lacking. Nine six-month old, intact (4 male, 5 female) New Zealand White rabbits (Oryctolagus cuniculus) were used in a randomized, blinded, controlled, complete cross-over experiment. Each rabbit received a low-dose of mirtazapine (1 mg/kg), high-dose (3 mg/kg) and control treatment orally once a day for a total of 2 sequential days with a 5- day washout period between treatment groups. Fecal output, food intake and body weight were measured before, during and after treatment. Fecal output was 25% higher (95% CI: 6.3%–46.9%, P= 0.01) on treatment days following high-dose mirtazapine treatment. Body weight was 1.5% higher (95% CI: 0. 5% to 2.6%, P= 0.006) for all groups on the 2 days following treatment compared to baseline. Body weight was reduced by 2.1% (95% CI: -3.6% to -0.6%, P= 0.011) the week following high-dose mirtazapine treatment. Mirtazapine did not have a statistically significant effect on food intake. Oral administration of mirtazapine at 3 mg/kg once a day resulted in increased fecal output but not a concurrent increase in food intake. Overall, mirtazapine is well tolerated and may be a useful treatment to increase fecal output in rabbits. However, due to a mild reduction in weight following treatment, clinical monitoring is warranted.}, journal={JOURNAL OF EXOTIC PET MEDICINE}, publisher={Elsevier BV}, author={Ozawa, Sarah and Thomson, Andrea and Petritz, Olivia}, year={2022}, month={Jan}, pages={16–20} } @article{ozawa_sanchez-migallon guzman_keel_gunther-harrington_2021, title={Clinical and pathological findings in rabbits with cardiovascular disease: 59 cases (2001–2018)}, volume={259}, DOI={10.2460/javma.259.7.764}, abstractNote={Abstract}, number={7}, journal={Journal of American Veterinary Medical Association}, author={Ozawa, S. and Sanchez-Migallon Guzman, D. and Keel, K. and Gunther-Harrington, C.}, year={2021}, pages={764–776} } @article{ozawa_guzman_palm_robertson_norvall_choi_roy_paul-murphy_culp_2021, title={NEOURETEROCYSTOSTOMY AND URETHRAL STENT PLACEMENT IN A BLACK-HANDED SPIDER MONKEY (ATELES GEOFFROYI)}, volume={52}, ISSN={["1937-2825"]}, DOI={10.1638/2020-0131}, abstractNote={Abstract: A 27-y-old female black-handed spider monkey (Ateles geoffroyi) was evaluated 13 d after an ovariohysterectomy because of abdominal distension, anorexia, and absent urination. The animal was diagnosed with a uroabdomen and urethral obstruction from computed tomographic findings and fluid creatinine levels. During exploratory laparotomy, a defect in the right ureter was confirmed as the source of the uroabdomen. Utilizing intraoperative fluoroscopy, a urethral obstruction with an irregular luminal filling defect was evident. A self-expanding nitinol urethral stent was placed, and a ureteral transposition was performed. Two months after the procedure, the animal developed dysuria, a urinary tract infection, recurrent bladder distension and a partial urethral obstruction. Treatment with prazosin 1 mg/kg PO q12h improved urination. Reobstruction of the urethra occurred 17 mo postsurgery, and the animal was euthanatized. On postmortem examination, the animal had ingrowth into the stent with proliferative granulation tissue, detrusor muscle degeneration, pelvic adhesions, cystitis, pyelonephritis, and hydronephrosis.}, number={2}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Ozawa, Sarah and Guzman, David Sanchez-Migallon and Palm, Carrie A. and Robertson, Jessica and Norvall, Amy and Choi, Eunju and Roy, Melissa and Paul-Murphy, Joanne and Culp, William T. N.}, year={2021}, month={Jun}, pages={843–848} } @article{munevar_moore_gleeson_ozawa_murphy_paul-murphy_leonard_2019, title={Acremonium and trichosporon fungal keratoconjunctivitis in a Leopard Gecko (Eublepharis macularius)}, volume={22}, DOI={10.1111/vop.12700}, abstractNote={Abstract}, number={6}, journal={Veterinary Ophthalmology}, author={Munevar, C. and Moore, B. and Gleeson, M. and Ozawa, S. and Murphy, C. and Paul-Murphy, J. and Leonard, B.}, year={2019}, month={Nov}, pages={928–932} } @article{stern_sanchez-migalon guzman_gleeson_ozawa_lipenieks_mclarty_johnston_hicks niederhuth_2019, title={Cervical spinal nerve and brachial plexus schwannoma in a rabbit (Oryctolagus cuniculus)}, volume={31}, DOI={10.1053/j.jepm.2019.06.005}, abstractNote={Abstract A 4-year-old castrated male lop-eared rabbit (Oryctolagus cuniculus) presented for right thoracic limb weakness of 1 week duration. Radiographs of the limb and adjacent spine were unremarkable. Despite treatment with meloxicam, limb weakness slowly progressed. Four months after initial presentation, neurologic examination revealed monoplegia without loss of pain perception in the right thoracic limb. Computed tomography scans showed multifocal regions of lobular, homogeneously contrast-enhancing tissue within the right ventral vertebral canal. This tissue extended into the right intervertebral foramina at C3-4 and C4-5 and at C5-6 and C6-7. A guarded-to-poor prognosis was given to the owners, who elected palliative care. Treatment with prednisolone and antibiotics resulted in short-term improvement. The rabbit became increasingly weak and passed away 4 weeks following the CT scan. Necropsy identified spinal cord compression due to a mass within the right vertebral canal that exited at C4-5 and continued into the right brachial plexus. The identified mass was morphologically and immunohistochemically consistent with a schwannoma. This case report documents the first clinical description of schwannoma of the spinal roots and brachial plexus in a rabbit.}, journal={Journal of Exotic Pet Medicine}, author={Stern, H. and Sanchez-Migalon Guzman, D. and Gleeson, M. and Ozawa, S. and Lipenieks, L. and McLarty, E. and Johnston, E. and Hicks Niederhuth, Jill}, year={2019}, month={Oct}, pages={75–78} } @article{ozawa_mans_miller_snyder_fazio_2019, title={Cleft Palate in a Chinchilla (Chinchilla lanigera)}, volume={28}, DOI={10.1053/j.jepm.2017.08.011}, abstractNote={Abstract A 5-month-old female chinchilla (Chinchilla lanigera) was evaluated for failure to thrive, difficulty drinking, and respiratory signs. Physical examination demonstrated a thin body condition score, purulent nasal and ocular discharge, and an abnormal facial appearance. Endoscope-guided oral examination and computed tomography (CT) scan demonstrated a cleft soft palate, absent nasal turbinates, and bilateral otitis media. The animal was euthanized and necropsy confirmed the diagnosis of palatoschisis (cleft palate) of the soft palate. Other relevant postmortem findings included otitis media, interna, and externa, bony bullae proliferative changes, absent nasal turbinates and rhinosinusitis. Congenital abnormalities are rarely reported in chinchillas. While cleft palates have been reported in many other domestic animals, there are no published reports of this condition in chinchillas to the best of the authors’ knowledge.}, journal={Journal of Exotic Pet Medicine}, author={Ozawa, S. and Mans, C. and Miller, J. and Snyder, C. and Fazio, C.}, year={2019}, month={Jan}, pages={93–97} } @article{ozawa_hawkins_drazenovich_kass_knych_2019, title={Pharmacokinetics of maropitant citrate in New Zealand White rabbits (Oryctolagus cuniculus)}, volume={80}, DOI={10.2460/ajvr.80.10.963}, abstractNote={Abstract}, number={10}, journal={American Journal of Veterinary Research}, author={Ozawa, S. and Hawkins, M. and Drazenovich, T. and Kass, P. and Knych, H.}, year={2019}, pages={963–968} } @article{ozawa_mans_beaufere_2017, title={Comparison of rectal and tympanic thermometry in chinchillas (Chinchilla lanigera)}, volume={251}, DOI={10.2460/javma.251.5.552}, abstractNote={Abstract}, number={5}, journal={Journal of American Veterinary Medical Association}, author={Ozawa, S. and Mans, C. and Beaufere, H.}, year={2017}, month={Sep}, pages={552–558} } @article{ozawa_mans_szabo_di girolamo_2017, title={Epidemiology of bacterial conjunctivitis in chinchillas (Chinchilla lanigera): 49 cases (2005 to 2015)}, volume={58}, DOI={10.1111/jsap.12644}, abstractNote={ObjectivesTo evaluate the anamnesis, clinical signs, diagnostic test results, treatment and outcome of chinchillas diagnosed with bacterial conjunctivitis.}, number={4}, journal={Journal of Small Animal Practice}, author={Ozawa, S. and Mans, C. and Szabo, Z. and Di Girolamo, N.}, year={2017}, month={Apr}, pages={238–245} } @article{ozawa_mans_2016, title={Stifle Disarticulation as a Pelvic Limb Amputation Technique in a Cockatiel ( Nymphicus hollandicus) and a Northern Cardinal ( Cardinalis cardinalis)}, volume={31}, DOI={10.1647/2015-138}, abstractNote={Abstract This clinical report describes the use of stifle disarticulation in 2 avian patients as an alternative to transfemoral limb amputation. A northern cardinal (Cardinalis cardinalis) was presented for soft tissue swelling and a traumatic fracture of the third digit of the left limb, with secondary bacterial infection and necrosis. A 25-year-old cockatiel (Nymphicus hollandicus) was diagnosed with distal extremity necrosis after a nonunion of a closed tibiotarsal fracture. In both cases amputation was recommended due to the poor prognosis for healing and because both birds were poor surgical candidates for traditional methods of amputation due to patient size or age. Therefore, stifle disarticulation surgery for amputation of the pelvic limb was performed successfully in both cases and recovery was unremarkable. The outcomes of these 2 cases suggest that stifle disarticulation may be used as an alternative to transfemoral amputation in birds where prolonged surgery, anesthesia, or patient size precludes traditional amputation techniques.}, number={1}, journal={Journal of Avian Medicine and Surgery}, author={Ozawa, S. and Mans, C.}, year={2016}, pages={33–38} }