Sudikshya Paudel

College of Agriculture and Life Sciences

Works (6)

Updated: April 5th, 2024 14:37

2023 article

Adrenomedullin Stimulates Proliferation, Migration and Adhesion of Porcine Trophectoderm Cells Via CALCRL-AKT-TSC2-MTORC1 Cell Signaling Pathway

Liu, B., Paudel, S., Flowers, W. L., Piedrahita, J. A., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.

By: B. Liu n , S. Paudel n, W. Flowers n , J. Piedrahita n  & X. Wang n 

author keywords: adrenomedullin; peri-implantation; pig conceptus
TL;DR: Results suggest that porcine ADM in histotroph act on its receptor component CALCRL to activate AKT-TSC2-MTOR, particularly MTORC1 signaling cascade, leading to elongation, migration and attachment of conceptuses. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2023 article

Adrenomedullin: A Novel Peptide Hormone for Uterine Receptivity and Conceptus Elongation in Pigs?

Paudel, S., Liu, B., Cummings, M. J., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.

By: S. Paudel n, B. Liu n , M. Cummings  n & X. Wang n 

author keywords: conceptuses; implantation; pregnancy
TL;DR: A significant role for ADM is indicated in uterine receptivity for implantation and conceptus growth and development in pigs, and a framework for future studies of ADM signaling to affect proliferation and migration of Tr cells, spacing of blastocysts, implantations and placentation in pigs is provided. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2023 journal article

Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway

Amino Acids, 55(6), 743–756.

By: B. Liu n , S. Paudel n, W. Flowers n , J. Piedrahita n  & X. Wang n 

author keywords: Adrenomedullin; Trophectoderm cells; MTOR; Pigs; Implantation
MeSH headings : Pregnancy; Female; Swine; Animals; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Adrenomedullin / pharmacology; Signal Transduction; TOR Serine-Threonine Kinases / genetics; TOR Serine-Threonine Kinases / metabolism; Cell Proliferation; Sirolimus / pharmacology
TL;DR: Results suggest that porcine ADM in histotroph acts on its receptor component CALCRL to activate AKT-TSC2-MTOR, particularly MTORC1 signaling cascade, leading to elongation, migration and attachment of conceptuses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 24, 2023

2022 journal article

Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice

MOLECULAR HUMAN REPRODUCTION, 28(7).

By: M. Cummings  n, H. Yu *, S. Paudel n, G. Hu *, X. Li *, M. Hemberger *, X. Wang n 

author keywords: SIRT1; implantation; stromal cell decidualization; pregnancy; Sirtuin 1; progesterone receptor signaling
MeSH headings : Aging; Animals; Blastocyst; Decidua / metabolism; Embryo Implantation / physiology; Female; Hedgehog Proteins / metabolism; Mice; Pregnancy; Sirtuin 1 / genetics; Sirtuin 1 / metabolism; Stromal Cells / metabolism; Uterus / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2021 article

Amino Acids in Cell Signaling: Regulation and Function

AMINO ACIDS IN NUTRITION AND HEALTH: AMINO ACIDS IN GENE EXPRESSION, METABOLIC REGULATION, AND EXERCISING PERFORMANCE, Vol. 1332, pp. 17–33.

By: S. Paudel n, G. Wu * & X. Wang n 

author keywords: Functional amino acids; Transceptor; Sensor; mTORC1; AMPK; MAPK
MeSH headings : Amino Acids; Animals; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1 / genetics; Signal Transduction
TL;DR: This work will discuss functional amino acids in cell signaling pathways in mammals with a particular emphasis on mTORC1, AMPK, and MAPK pathways for protein synthesis, nutrient sensing, and anti-inflammatory responses, as well as cell survival, growth, and development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

2021 journal article

Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses

BIOLOGY OF REPRODUCTION, 105(4), 876–891.

By: S. Paudel n, B. Liu n , M. Cummings  n, K. Quinn *, F. Bazer *, K. Caron *, X. Wang n 

author keywords: adrenomedullin; conceptus; uterine fluid; uterus; pigs
MeSH headings : Adrenomedullin / genetics; Adrenomedullin / metabolism; Animals; Embryo, Mammalian / metabolism; Female; Receptors, Adrenomedullin / genetics; Receptors, Adrenomedullin / immunology; Spatio-Temporal Analysis; Sus scrofa / embryology; Sus scrofa / genetics; Uterus / metabolism
TL;DR: It is suggested that adrenomedullin plays a significant role in uterine receptivity and conceptus growth and development, via the stimulation of cell proliferation and activation of MTORC1 signaling pathway in the porcine conceptus trophectoderm. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021

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