Sheri Lynn Plant Kernodle

Works (6)

Updated: January 24th, 2025 05:01

2024 journal article

BBL enzymes exhibit enantiospecific preferences in the biosynthesis of pyridine alkaloids in Nicotiana tabacum L.

PHYTOCHEMISTRY, 232.

By: Z. Allen n, S. Kernodle n, R. Shi n, H. Liu *, M. Timko *, T. Steede n, R. Dewey n, R. Lewis n 

author keywords: Alkaloid biosynthesis; Enantiomers; Nicotiana; Nicotine; Plant natural products; Secondary metabolism; Scalemic; Tobacco
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 21, 2025

2023 journal article

Modified physiology of burley tobacco plants genetically engineered to express Yb<sub>1</sub>, a functional EGY enzyme

PLANTA, 258(4).

By: R. Shi n, S. Kernodle n, T. Steede n & R. Lewis n 

author keywords: Burley tobacco; Gene editing; Nicotiana tabacum; Nitrogen use efficiency; RNA-sequencing
TL;DR: Results indicate that complex changes in the transcriptome of tobacco can be manifested by altered expression of Yb 1, and metabolic pathways affecting carbon and nitrogen metabolism that might be altered as the result of genetic variability at the Yb1 and Yb2 loci. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023

2022 journal article

Analyses of diverse low alkaloid tobacco germplasm identify naturally occurring nucleotide variability contributing to reduced leaf nicotine accumulation

MOLECULAR BREEDING, 42(1).

By: N. Burner  n, A. McCauley n, S. Pramod *, J. Frederick *, T. Steede n, S. Kernodle n, R. Lewis n 

author keywords: Nicotiana tabacum; Tobacco; Nicotine alkaloids; Transcription factors; QTL mapping
TL;DR: P phenotyped a series of 81 selected diverse tobacco introductions to identify a sub-group with authentic low alkaloid phenotypes and found a newly discovered 5 bp deletion in the gene MYC2a on linkage group 5 was found to likely partially underlie the ultra-low alkaloids phenotype of TI 313. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

2022 article

Combined reduced expression of two gene families lowers nicotine content to ultra-low levels in cultivated tobacco

Kernodle, S. P., Webb, S., Steede, T. M., & Lewis, R. S. (2022, July 2). PLANT CELL REPORTS, Vol. 7.

By: S. Kernodle n, S. Webb n, T. Steede n & R. Lewis n 

author keywords: Tobacco; Nicotiana tabacum; Nicotine; Alkaloids; RNA interference; MPO; Methyl Putrescine Oxidase
MeSH headings : Gene Expression Regulation, Plant; Plant Leaves / genetics; Plant Leaves / metabolism; RNA Interference; Tobacco / genetics; Tobacco / metabolism; Tobacco Products
TL;DR: Tobacco genotypes expressing an RNAi construct designed to reduce expression of the Methyl Putrescine Oxidase (MPO) gene family associated with nicotine biosynthesis are produced and evaluated under field conditions. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2022 journal article

Editing of A622 genes results in ultra-low nicotine whole tobacco plants at the expense of dramatically reduced growth and development

MOLECULAR BREEDING, 42(4).

By: N. Burner  n, S. Kernodle n, T. Steede n & R. Lewis n 

author keywords: Tobacco; Nicotiana tabacum; Nicotine; Alkaloids; Gene editing; A622
TL;DR: A622 knockout lines exhibited lower nicotine levels than previously created genotypes with deleterious mutations in BBL genes also associated with one of the latter steps in tobacco alkaloid biosynthesis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022

2020 journal article

Identification and editing of a hybrid lethality gene expands the range of interspecific hybridization potential in Nicotiana

THEORETICAL AND APPLIED GENETICS, 133(10), 2915–2925.

By: J. Ma n, W. Hancock n, J. Nifong n, S. Kernodle n & R. Lewis n 

MeSH headings : CRISPR-Cas Systems; Crosses, Genetic; DNA Transposable Elements; Gene Editing; Genes, Lethal; Genes, Plant; Hybridization, Genetic; Tobacco / genetics
TL;DR: Gene editing was used to verify that Nt6549g30 is the gene at the N. tabacum Hybrid Lethality 1 (NtHL1) locus controlling the hybrid lethality reaction in crosses with N. africana and demonstrate the possibility of expanding the gene pool for a crop species through gene editing. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 20, 2020

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