Sandra Pei-Hui Tou

Works (52)

Updated: April 2nd, 2025 11:40

2024 conference paper

Canine dilated cardiomyopathy

Western Veterinary Conference. Presented at the Western Veterinary Conference, Las Vegas, NV.

By: S. Tou 

Event: Western Veterinary Conference at Las Vegas, NV

Source: NC State University Libraries
Added: April 2, 2025

2024 chapter

Congenital and inherited anomalies of the cardiovascular system

In S. E. Aiello & M. A. Moses (Eds.), The Merck Veterinary Manual (12th ed.). Whitehouse Station, NJ: Merck & Co.

By: S. Tou 

Ed(s): S. Aiello & M. Moses

Source: NC State University Libraries
Added: April 2, 2025

2024 conference paper

Congestive heart failure diagnosis and treatment

Western Veterinary Conference. Presented at the Western Veterinary Conference, Las Vegas, NV.

By: S. Tou 

Event: Western Veterinary Conference at Las Vegas, NV

Source: NC State University Libraries
Added: April 2, 2025

2024 conference paper

Evaluation of Trazadone on Heart Rate, Heart Rate Variability and QT-intervals in Dogs

ACVIM. Presented at the ACVIM, Minneapolis, MN.

By: V. Silvia, T. DeFrancesco, S. Tou  & B. Keene

Event: ACVIM at Minneapolis, MN

Source: NC State University Libraries
Added: April 2, 2025

2024 conference paper

Guidance on the use of panel-recommended therapies in cats with hypertrophic cardiomyopathy

Western Veterinary Conference. Presented at the Western Veterinary Conference, Las Vegas, NV.

By: S. Tou 

Event: Western Veterinary Conference at Las Vegas, NV

Source: NC State University Libraries
Added: April 2, 2025

2024 conference paper

Guidance on the use of panel-recommended therapies in dogs with chronic mitral valve disease

Western Veterinary Conference. Presented at the Western Veterinary Conference, Las Vegas, NV.

By: S. Tou 

Event: Western Veterinary Conference at Las Vegas, NV

Source: NC State University Libraries
Added: April 2, 2025

2024 conference paper

Managing heart failure: a case based review

Western Veterinary Conference. Presented at the Western Veterinary Conference, Las Vegas, NV.

By: S. Tou 

Event: Western Veterinary Conference at Las Vegas, NV

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Approach to the canine murmur

Getaway Conference. Presented at the Getaway Conference, Asheville, NC.

By: S. Tou 

Event: Getaway Conference at Asheville, NC

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Approach to the feline murmur

Getaway Conference. Presented at the Getaway Conference, Asheville, NC.

By: S. Tou 

Event: Getaway Conference at Asheville, NC

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Degenerative mitral valve disease

CanWest Conference. Presented at the CanWest Conference, Banff, Alberta, Canada.

By: S. Tou 

Event: CanWest Conference at Banff, Alberta, Canada

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Degenerative mitral valve disease

Minnesota VMA. Presented at the Minnesota VMA, Minneapolis, MN.

By: S. Tou 

Event: Minnesota VMA at Minneapolis, MN

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Diagnosis of heart failure

CanWest Conference. Presented at the CanWest Conference, Banff, Alberta, Canada.

By: S. Tou 

Event: CanWest Conference at Banff, Alberta, Canada

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Dilated cardiomyopathy

CanWest Conference. Presented at the CanWest Conference, Banff, Alberta, Canada.

By: S. Tou 

Event: CanWest Conference at Banff, Alberta, Canada

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Evaluation of occult gastrointestinal bleeding in canine left-sided congestive heart failure: a pilot study

ACVIM. Presented at the ACVIM, Philadelphia, PA.

By: K. Verdoorn, M. Tolbert, S. Tou  & A. Lynch

Event: ACVIM at Philadelphia, PA

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Heart murmurs in cats

CanWest Conference. Presented at the CanWest Conference, Banff, Alberta, Canada.

By: S. Tou 

Event: CanWest Conference at Banff, Alberta, Canada

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Recognizing and treating life-threatening arrhythmias

Minnesota VMA. Presented at the Minnesota VMA, Minneapolis, MN.

By: S. Tou 

Event: Minnesota VMA at Minneapolis, MN

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Recognizing and treating life-threatening arrhythmias

CanWest Conference. Presented at the CanWest Conference, Banff, Alberta, Canada.

By: S. Tou 

Event: CanWest Conference at Banff, Alberta, Canada

Source: NC State University Libraries
Added: April 2, 2025

2023 article

Retrospective evaluation of the etiology and clinical characteristics of peripheral edema in dogs

Whelchel, B. D., Palerme, J.-S., Tou, S. P., & Ward, J. L. (2023, July 15). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 7.

By: B. Whelchel *, J. Palerme*, S. Tou n & J. Ward *

author keywords: congestive heart failure; effusion; hypoalbuminemia; pitting; thrombosis; vasculitis
topics (OpenAlex): Cardiovascular Conditions and Treatments; Veterinary Oncology Research; Platelet Disorders and Treatments
TL;DR: Distribution of edema, concurrent cavitary effusions, and clinicopathological data can help predict the underlying etiology of peripheral edema in dogs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 31, 2023

2023 conference paper

Supporting cardiac disease throughout the lifetime

ACVIM Forum. Presented at the ACVIM Forum, Philadelphia, PA.

By: S. Tou 

Event: ACVIM Forum at Philadelphia, PA

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Treating congestive heart failure

Minnesota VMA. Presented at the Minnesota VMA, Minneapolis, MN.

By: S. Tou 

Event: Minnesota VMA at Minneapolis, MN

Source: NC State University Libraries
Added: April 2, 2025

2023 conference paper

Treatment of heart failure

CanWest Conference. Presented at the CanWest Conference, Banff, Alberta, Canada.

By: S. Tou 

Event: CanWest Conference at Banff, Alberta, Canada

Source: NC State University Libraries
Added: April 2, 2025

2022 journal article

Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure*

JOURNAL OF VETERINARY CARDIOLOGY, 40, 99–109.

By: A. Walker*, T. DeFrancesco n , J. Bonagura n , B. Keene n, K. Meurs n , S. Tou n , K. Kurtz*, B. Aona* ...

author keywords: Canine; Survival; Grain-free; Echocardiography; Nutritional
MeSH headings : Animals; Dogs; Cardiomyopathy, Dilated / diagnosis; Cardiomyopathy, Dilated / veterinary; Diet / veterinary; Dog Diseases / diagnosis; Echocardiography / veterinary; Edible Grain; Heart Failure / complications; Heart Failure / therapy; Heart Failure / veterinary; Retrospective Studies
topics (OpenAlex): Cardiovascular Conditions and Treatments; Cardiovascular Function and Risk Factors; Congenital Heart Disease Studies
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Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2022 conference paper

Chronic mitral valve disease

DC Academy Veterinary Medicine. Presented at the DC Academy Veterinary Medicine.

By: S. Tou 

Source: NC State University Libraries
Added: April 2, 2025

2022 conference paper

Congestive heart failure

DC Academy of Veterinary Medicine. Presented at the DC Academy of Veterinary Medicine.

By: S. Tou 

Event: DC Academy of Veterinary Medicine

Source: NC State University Libraries
Added: April 2, 2025

2022 conference paper

Dilated cardiomyopathy

DC Academy of Veterinary Medicine. Presented at the DC Academy of Veterinary Medicine.

By: S. Tou 

Event: DC Academy of Veterinary Medicine

Source: NC State University Libraries
Added: April 2, 2025

2022 conference paper

Hypertrophic cardiomyopathy

DC Academy of Veterinary Medicine. Presented at the DC Academy of Veterinary Medicine.

By: S. Tou 

Event: DC Academy of Veterinary Medicine

Source: NC State University Libraries
Added: April 2, 2025

2022 conference paper

Interventional cardiology

NCVC. Presented at the NCVC, Raleigh, NC.

By: S. Tou 

Event: NCVC at Raleigh, NC

Source: NC State University Libraries
Added: April 2, 2025

2021 journal article

A deleterious mutation in the ALMS1 gene in a naturally occurring model of hypertrophic cardiomyopathy in the Sphynx cat

ORPHANET JOURNAL OF RARE DISEASES, 16(1).

By: K. Meurs n , B. Williams n, D. DeProspero n, S. Friedenberg*, D. Malarkey*, J. Ezzell *, B. Keene n, D. Adin n, T. DeFrancesco n , S. Tou n 

author keywords: Hypertrophic cardiomyopathy; ALMS1; Feline; Mitogenic; Sphynx
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cats / genetics; Cell Cycle Proteins / genetics; Exons; Mice; Mutation / genetics
topics (OpenAlex): Cardiomyopathy and Myosin Studies; Congenital heart defects research; Congenital Heart Disease Studies
TL;DR: This study demonstrates a novel form of cardiomyopathy associated with ALMS1 in the cat, and suggests that variants in genes involved with cardiac development and cell regulation, like the AL MS1 gene, may deserve further consideration for association with familial hypertrophic cardiopathy. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021

2021 journal article

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy

ANIMAL GENETICS, 52(4), 542–544.

By: . K. O'Donnell, D. Adin n, C. Atkins n, T. DeFrancesco n , B. Keene n, S. Tou n , K. Meurs n 

author keywords: cardiomyopathy; feline; genetic; HCM; mutation
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cat Diseases / genetics; Cat Diseases / metabolism; Cats; Female; Genetic Variation; Male; Myosin Heavy Chains / genetics; Myosin Heavy Chains / metabolism
topics (OpenAlex): Cardiovascular Conditions and Treatments; Cardiomyopathy and Myosin Studies; Congenital Heart Disease Studies
TL;DR: The lack of these MYBPC3 and MYH7 variants in this feline HCM population indicates that the clinical utility of genetic testing for these variants may be isolated to the two cat breeds in which these variants have been identified. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2021 personal communication

Letter to the editor regarding "Efficacy of adding ramipril (VAsotop) to the combination of furosemide (Lasix) and pimobendan (VEtmedin) in dogs with mitral valve degeneration: The VALVE trial"

Atkins, C., Keene, B., DeFrancesco, T. C., Tou, S., Chetboul, V., Cote, E., … Stepien, R. L. (2021, March).

By: C. Atkins n, B. Keene n, T. DeFrancesco n , S. Tou n , V. Chetboul *, E. Cote *, S. Ettinger, P. Fox * ...

MeSH headings : Animals; Dogs; Furosemide / therapeutic use; Mitral Valve; Pyridazines / therapeutic use; Ramipril / therapeutic use
topics (OpenAlex): Cardiovascular Conditions and Treatments; Mechanical Circulatory Support Devices; Cardiac Arrhythmias and Treatments
TL;DR: The VALVE trial did not assess the efficacy of RAAS suppression using biomarkers, and the question of whether ramipril adequately or optimally suppressed RAAS, while failing to improve survival in the face of these diuretic dosages, remains unanswered. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021

2021 journal article

Myxomatous mitral valve disease in Miniature Schnauzers and Yorkshire Terriers: 134 cases (2007-2016)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 259(12), 1428–1432.

By: D. DeProspero n, . Kerry A. O'Donnell n, T. DeFrancesco n , B. Keene n, S. Tou n , D. Adin n, C. Atkins n, K. Meurs n 

MeSH headings : Animals; Dog Diseases / epidemiology; Dogs; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / veterinary; Prospective Studies
topics (OpenAlex): Cardiovascular Conditions and Treatments; Veterinary Oncology Research; Microbial infections and disease research
TL;DR: Features of the disease among Miniature Schnauzers and Yorkshire Terriers were similar, but there were also a few discernable differences between these 2 breeds and from historical findings for dogs with MMVD of other breeds. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 conference paper

Population pharmacokinetics of oral pimobendan and its metabolite in dogs with myxomatous mitral valve degeneration

ACVIM Virtual Forum. Presented at the ACVIM Virtual Forum.

By: A. McManamey, T. DeFrancesco, K. Meurs, B. Keene, S. Tou , J. Bonagura, M. Papich

Event: ACVIM Virtual Forum

Source: NC State University Libraries
Added: April 2, 2025

2021 article

Use of whole genome analysis to identify shared genomic variants across breeds in canine mitral valve disease

Williams, B., Friedenberg, S. G., Keene, B. W., Tou, S. P., DeFrancesco, T. C., & Meurs, K. M. (2021, June 27). HUMAN GENETICS, Vol. 6.

By: B. Williams n, S. Friedenberg*, B. Keene n, S. Tou n, T. DeFrancesco n  & K. Meurs n 

MeSH headings : Animals; Breeding; Dog Diseases / genetics; Dogs; Genetic Variation; Genome-Wide Association Study; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Mutation; Whole Genome Sequencing
topics (OpenAlex): Cardiovascular Conditions and Treatments; Congenital heart defects research; Cardiac Valve Diseases and Treatments
TL;DR: The findings indicate that development of MMVD in the dog may be related to a combination of genetic and environmental factors that impact specific molecular pathways rather than a single shared genetic variant across or within breeds. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2020 journal article

Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 600–606.

By: D. Adin*, C. Atkins n, O. Domenig, T. DeFrancesco n , B. Keene n, S. Tou n , J. Stern* , K. Meurs n 

author keywords: ACE-inhibitor; enalapril; genotype; pharmacogenetic; pharmacogenomic
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Genetic Predisposition to Disease; Genotype; Humans; Mitral Valve Prolapse / enzymology; Mitral Valve Prolapse / genetics; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Polymorphism, Genetic; Renin-Angiotensin System / physiology; Retrospective Studies
topics (OpenAlex): Renin-Angiotensin System Studies; Hormonal Regulation and Hypertension; Cardiovascular Conditions and Treatments
TL;DR: The results support the use of aldosterone receptor antagonists with ACE‐inhibitors when RAAS inhibition is indicated for dogs, especially those positive for the ACE gene polymorphism, which did not alter baseline RAAS activity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 16, 2020

2020 journal article

Retrospective evaluation of the safety and tolerability of pimobendan in cats with obstructive vs nonobstructive cardiomyopathy

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(6), 2211–2222.

By: J. Ward *, E. Kussin*, M. Tropf *, S. Tou n , T. DeFrancesco n  & B. Keene n

author keywords: cardiac; cardiomyopathy; feline; hypertrophic; positive inotrope
MeSH headings : Animals; Cardiomyopathies / drug therapy; Cardiomyopathies / veterinary; Cardiotonic Agents / adverse effects; Cat Diseases / drug therapy; Cats; Heart Failure / drug therapy; Heart Failure / veterinary; Pyridazines / adverse effects; Retrospective Studies
topics (OpenAlex): Cardiovascular Conditions and Treatments; Cardiac Arrhythmias and Treatments; Mechanical Circulatory Support Devices
TL;DR: Pimobendan is well tolerated in cats with cardiomyopathy and CHF, regardless of the presence of OTO, and was discontinued due to adverse effects in 4/260 cats. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 26, 2020

2019 journal article

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Human Genetics, 138(5), 515–524.

By: K. Meurs n , S. Friedenberg*, J. Kolb *, C. Saripalli*, P. Tonino *, K. Woodruff n, N. Olby n , B. Keene n ...

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Connectin / genetics; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / veterinary; Disease Models, Animal; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation, Missense / genetics; Protein Kinases / genetics; Whole Genome Sequencing
topics (OpenAlex): Cardiomyopathy and Myosin Studies; Cardiovascular Conditions and Treatments; Congenital heart defects research
TL;DR: The dog provides a large animal model of familial dilated cardiomyopathy and is an excellent model to improve the understanding of the genotypic phenotypic relationships, penetrance, expression and the pathophysiology of variants in the titin gene. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 17, 2019

2019 journal article

Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type

JOURNAL OF VETERINARY CARDIOLOGY, 21, 1–9.

By: D. Adin n, T. DeFrancesco n , B. Keene n, S. Tou n , K. Meurs n , C. Atkins n, B. Aona n, K. Kurtz n ...

author keywords: Nutritional; Heart failure; Dog; Taurine
MeSH headings : Animals; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / veterinary; Diet / adverse effects; Diet / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Edible Grain / adverse effects; Female; Male; Phenotype
topics (OpenAlex): Cardiovascular Conditions and Treatments; Congenital Heart Disease Studies; Neuroscience of respiration and sleep
TL;DR: Dietary-associated DCM occurs with some GF diets and can improve with nutritional management, including diet change, and the role of taurine supplementation, even without deficiency, is uncertain. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Myxomatous mitral valve disease in the miniature poodle: A retrospective study

VETERINARY JOURNAL, 244, 94–97.

By: K. Meurs n , D. Adin n, . K. O'Donnell, B. Keene n, C. Atkins n, T. DeFrancesco n , S. Tou n 

author keywords: Canine; Genetic; Miniature poodle; Mitral valve; Myxomatous valve
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / genetics; Dogs; Female; Male; Mitral Valve Prolapse / diagnostic imaging; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / genetics; Mitral Valve Prolapse / veterinary; North Carolina / epidemiology; Pedigree; Records; Retrospective Studies; Severity of Illness Index
topics (OpenAlex): Cardiovascular Conditions and Treatments; Congenital heart defects research; Coronary Artery Anomalies
TL;DR: In the miniature poodles reported here, MMVD appears to be a fairly late onset disease and often is a mild phenotype. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2018 journal article

Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration

VETERINARY JOURNAL, 232, 16–19.

By: K. Meurs n , S. Friedenberg *, B. Williams n, B. Keene n, C. Atkins n, D. Adin n, B. Aona n, T. DeFrancesco n  ...

author keywords: Canine; Cavalier King Charles spaniel; Dachshund; Genetic; Mitral valve; Myxomatous valve
MeSH headings : Animals; DNA / blood; Dog Diseases / genetics; Dogs; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / genetics; Mutation; Species Specificity; Whole Genome Sequencing / veterinary
topics (OpenAlex): Congenital heart defects research; Cardiovascular Conditions and Treatments; Veterinary Oncology Research
TL;DR: Although mitral valve disease in the CKCS and Dachshund is a familial disease, it was hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated withthe development of canine MMVD and this work identified genetic cause in the genes responsible for the human disease. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Accuracy of point-of-care lung ultrasonography for the diagnosis of cardiogenic pulmonary edema in dogs and cats with acute dyspnea

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 250(6), 666–675.

By: J. Ward*, G. Lisciandro, B. Keene*, S. Tou*  & T. DeFrancesco* 

MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Dog Diseases / diagnosis; Dogs; Dyspnea / diagnosis; Dyspnea / veterinary; Observer Variation; Point-of-Care Systems; Prospective Studies; Pulmonary Edema / diagnosis; Pulmonary Edema / veterinary; Ultrasonography / instrumentation; Ultrasonography / veterinary
topics (OpenAlex): Ultrasound in Clinical Applications; Phonocardiography and Auscultation Techniques; Pleural and Pulmonary Diseases
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 18(4).

By: K. Meurs n , J. Stern n , C. Atkins n, D. Adin n, B. Aona n, J. Condit n, T. DeFrancesco n , Y. Reina-Doreste n ...

author keywords: Polymorphism; canine; angiotensin-converting enzyme; enalapril
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Breeding; Dogs; Genotype; Heart Diseases / drug therapy; Heart Diseases / enzymology; Heart Diseases / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic
topics (OpenAlex): Cardiovascular Conditions and Treatments; Renin-Angiotensin System Studies; Pharmacological Effects and Assays
TL;DR: It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor, and an ACE polymorphism is associated with lower levels of ACE activity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Patent ductus arteriosus in cats (Felis catus): 50 cases (2000-2015)

JOURNAL OF VETERINARY CARDIOLOGY, 19(1), 35–43.

By: A. Bascunan *, K. Mankin *, A. Saunders *, J. Bright*, V. Scharf n, A. Singh *, . L. O'Sullivan, B. Brisson * ...

author keywords: Congenital; Feline; Pulmonary hypertension; Surgery; Shunt
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cat Diseases / physiopathology; Cat Diseases / therapy; Cats; Ductus Arteriosus, Patent / diagnostic imaging; Ductus Arteriosus, Patent / physiopathology; Ductus Arteriosus, Patent / therapy; Ductus Arteriosus, Patent / veterinary; Echocardiography / veterinary; Female; Hypertension, Pulmonary / veterinary; Male; Radiography, Thoracic / veterinary; Retrospective Studies; Survival Analysis; Vascular Fistula / veterinary
topics (OpenAlex): Cardiovascular Conditions and Treatments; Congenital Heart Disease Studies; Vascular anomalies and interventions
TL;DR: Cats with PDA often do not display clinical signs and may not have the characteristic physical examination findings typical of PDA in dogs, and Thoracic radiographs and echocardiogram may provide the most comprehensive information for making a diagnosis and treatment recommendations. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Pilot study to determine the feasibility of radiation therapy for dogs with right atrial masses and hemorrhagic pericardial effusion

Journal of Veterinary Cardiology, 19(2), 132–143.

By: M. Nolan n , M. Arkans n, D. LaVine n, T. DeFrancesco n , J. Myers *, E. Griffith n , L. Posner n, B. Keene n ...

author keywords: Heart-base tumor; Cardiac hemangiosarcoma; Canine
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / radiotherapy; Dogs; Echocardiography; Female; Heart Atria; Heart Neoplasms / complications; Heart Neoplasms / radiotherapy; Heart Neoplasms / veterinary; Hemangiosarcoma / complications; Hemangiosarcoma / radiotherapy; Hemangiosarcoma / veterinary; Hemorrhage / complications; Hemorrhage / veterinary; Male; Pericardial Effusion / complications; Pericardial Effusion / veterinary; Pilot Projects; Postoperative Complications / veterinary; Treatment Outcome
topics (OpenAlex): Veterinary Oncology Research; Sarcoma Diagnosis and Treatment; Cardiac tumors and thrombi
TL;DR: RT alone, or in combination with chemotherapy, may provide clinical benefit to dogs with presumptive diagnoses of cardiac hemangiosarcoma, and appears to have reduced the frequency of periacardial tamponade that necessitated pericardiocentesis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002-2014)

JOURNAL OF VETERINARY CARDIOLOGY, 18(3), 199–212.

By: J. Ward n, T. DeFrancesco n , S. Tou n , C. Atkins n, E. Griffith n  & B. Keene n

author keywords: Dog; Arrhythmia; Bradycardia; Sinus arrest; Pacemaker
MeSH headings : Animals; Dog Diseases / mortality; Dogs; Prognosis; Sick Sinus Syndrome / mortality; Sick Sinus Syndrome / veterinary; Sinoatrial Node / physiopathology; Survival Analysis; Treatment Outcome
topics (OpenAlex): Cardiovascular Conditions and Treatments; Cardiovascular Syncope and Autonomic Disorders; Cardiac Arrhythmias and Treatments
TL;DR: Sinus node dysfunction and SSS represent a spectrum of sinoatrial node disease, which for some dogs may also involve a component of autonomic dysfunction, and medical management is often useful, particularly in atropine responsive dogs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Suspected acute myocardial infarction in a dystrophin-deficient dog

Neuromuscular Disorders, 26(6), 361–366.

By: S. Schneider *, A. Coleman  n, L. Guo *, S. Tou n , B. Keene n & J. Kornegay *

author keywords: Muscular dystrophy; Duchenne muscular dystrophy; Golden retriever muscular dystrophy; Cardiomyopathy; Animal model; Myocardial infarction
MeSH headings : Animals; Biomarkers / blood; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Fatal Outcome; Female; Heart / diagnostic imaging; Heart / physiopathology; Muscular Dystrophy, Animal / complications; Muscular Dystrophy, Animal / diagnosis; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / physiopathology; Myocardial Infarction / complications; Myocardial Infarction / diagnostic imaging; Myocardial Infarction / physiopathology; Myocardial Infarction / veterinary; Myocardium / pathology
topics (OpenAlex): Muscle Physiology and Disorders; Congenital heart defects research; Cardiomyopathy and Myosin Studies
TL;DR: A 7-month-old GRMD dog with an apparent analogous episode of myocardial infarction is reported with acute signs of cardiac disease, including tachyarrhythmia, supraventricular premature complexes, and femoral pulse deficits. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Complication Rates Associated with Transvenous Pacemaker Implantation in Dogs with High-Grade Atrioventricular Block Performed During versus After Normal Business Hours

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(1), 157–163.

By: J. Ward n, T. DeFrancesco n , S. Tou n , C. Atkins n, E. Griffith n  & B. Keene n

author keywords: Canine; Heart block; Transvenous
MeSH headings : Animals; Atrioventricular Block / therapy; Atrioventricular Block / veterinary; Cardiovascular Surgical Procedures / adverse effects; Cardiovascular Surgical Procedures / veterinary; Dog Diseases / therapy; Dogs; Pacemaker, Artificial / veterinary; Postoperative Complications / veterinary; Retrospective Studies; Treatment Outcome
topics (OpenAlex): Cardiovascular Conditions and Treatments; Cardiac pacing and defibrillation studies; Mechanical Circulatory Support Devices
TL;DR: AH transvenous pacemaker placement is associated with a higher rate of major complications (especially infections) compared to BH placement, and this difference may be because of a variety of human factor differences AH versus BH. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Cor triatriatum

Veterinary Image-Guided Interventions, 604–609.

By: B. Keene & S. Tou 

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(5), 534–539.

By: Y. Reina-Doreste n, J. Stern* , B. Keene n, S. Tou n , C. Atkins n, T. DeFrancesco n , M. Ames n, T. Hodge n, K. Meurs n 

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / therapeutic use; Case-Control Studies; Cat Diseases / drug therapy; Cat Diseases / mortality; Cats; Female; Heart Failure / drug therapy; Heart Failure / mortality; Heart Failure / veterinary; Male; Pyridazines / therapeutic use; Retrospective Studies
topics (OpenAlex): Cardiovascular Conditions and Treatments; Congenital Heart Disease Studies; Cardiac Arrhythmias and Treatments
TL;DR: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM- affected cats withCHF. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(6), 1437–1440.

By: K. Meurs n , J. Stern n , D. Sisson*, M. Kittleson *, S. Cunningham *, M. Ames n, C. Atkins n, T. DeFrancesco n  ...

author keywords: Boxer; Dilated cardiomyopathy; Mutation; Striatin
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / veterinary; Case-Control Studies; Confidence Intervals; DNA / chemistry; DNA / genetics; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Female; Genotype; Male; Membrane Proteins / genetics; Polymerase Chain Reaction / veterinary; Sequence Deletion / genetics
topics (OpenAlex): Cardiovascular Effects of Exercise; Vector-Borne Animal Diseases; Cardiomyopathy and Myosin Studies
TL;DR: This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype, and suggests that there is at least 1 other cause of DCm in the boxer dog. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Hybrid cutting balloon dilatation for treatment of cor triatriatum sinister in a cat

JOURNAL OF VETERINARY CARDIOLOGY, 15(3), 205–210.

By: J. Stern n , S. Tou n , P. Barker *, K. Hill *, A. Lodge*, K. Mathews n , B. Keene n

author keywords: Sinistrum; Pulmonary venous anomaly; Feline; Congenital heart disease; Dilatation
MeSH headings : Angioplasty, Balloon, Coronary / methods; Angioplasty, Balloon, Coronary / veterinary; Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Cats; Cor Triatriatum / diagnosis; Cor Triatriatum / therapy; Cor Triatriatum / veterinary; Echocardiography, Transesophageal / veterinary; Female
topics (OpenAlex): Cardiovascular Conditions and Treatments; Congenital Heart Disease Studies; Coronary Artery Anomalies
TL;DR: Based upon the outcome of this case, balloon dilatation appears to be a viable treatment option for cats affected with cor triatriatum sinister. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies

Mammalian Genome, 23(1-2), 85–108.

By: J. Kornegay, J. Bogan, D. Bogan, M. Childers, J. Li, P. Nghiem, D. Detwiler, C. Larsen ...

Source: NC State University Libraries
Added: August 6, 2018

2011 article

ECG of the Month

Tou, S. P., DeFrancesco, T. C., & Keene, B. W. (2011, July 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 239, pp. 55–57.

By: S. Tou n , T. DeFrancesco*  & B. Keene*

MeSH headings : Animals; Bundle-Branch Block / diagnosis; Bundle-Branch Block / veterinary; Dog Diseases / diagnosis; Dogs; Electrocardiography / veterinary; Male; Tachycardia, Sinus / veterinary
topics (OpenAlex): Cardiac electrophysiology and arrhythmias; Cardiac Arrhythmias and Treatments; Cardiac pacing and defibrillation studies
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Employment

Updated: March 24th, 2025 08:07

North Carolina State University Raleigh, North Carolina, US
Veterinary Cardiologist College of Veterinary Medicine

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