Works (4)
Updated: July 5th, 2023 15:44
2015 review
Recent progress and open questions in Drosophila dosage compensation
[Review of ]. FLY, 9(1), 29–35.
author keywords: chromatin; dosage compensation; Drosophila; epigenetics; male-specific lethal; MSL complex; review
MeSH headings : Animals; Biological Evolution; Dosage Compensation, Genetic; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Sex Chromosomes
topics (OpenAlex): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities; Insect Resistance and Genetics; Insect symbiosis and bacterial influences
TL;DR:
Recent progress in the field of Drosophila dosage compensation is synthesized as a means to highlight open questions, including how the MSL complex targets the X chromosome, how dosage compensation has shaped evolution of X-linked genes, and the degree to whichMSL complex-mediated dosage compensation varies in activity across somatic tissues.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
X-to-autosome expression and msl-2 transcript abundance correlate among Drosophila melanogaster somatic tissues
PEERJ, 3.
author keywords: H4K16Ac; Male-Specific Lethal complex; Drosophila melanogaster; Dosage compensation complex; Dosage compensation
topics (OpenAlex): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities; Genomics and Chromatin Dynamics; Invertebrate Immune Response Mechanisms
TL;DR:
It is hypothesize the degree, up to but not exceeding 2-fold, to which the MSL complex upregulates male X-linked genes varies quantitatively by tissue type, and finds X-to-autosome expression correlates with the tissue-specific expression of msl-2 which encodes an essential male-specific component of theMSL complex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
No Evidence for a Global Male-Specific Lethal Complex-Mediated Dosage Compensation Contribution to the Demasculinization of the Drosophila melanogaster X Chromosome
PLOS ONE, 9(8).
MeSH headings : Animals; Chromosomal Proteins, Non-Histone / metabolism; Chromosome Mapping; Chromosomes, Insect / physiology; DNA Helicases / metabolism; DNA-Binding Proteins / metabolism; Dosage Compensation, Genetic / genetics; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Genes, X-Linked / physiology; Histone Acetyltransferases / metabolism; Male; Multiprotein Complexes / metabolism; Multiprotein Complexes / physiology; Nuclear Proteins / metabolism; Sex Differentiation / genetics; Transcription Factors / metabolism; Transcriptional Activation; X Chromosome / physiology
topics (OpenAlex): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities; Invertebrate Immune Response Mechanisms; Genomics and Chromatin Dynamics
TL;DR:
The results do not corroborate previous observations supporting organismal-wide detrimental effects by dosage compensation on X-linked male-biased expressed genes and find no evidence that dosage compensation has played a role in the arrangement of dosage compensated male- biased genes on the X chromosome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Conservation and Sex-Specific Splicing of the transformer Gene in the Calliphorids Cochliomyia hominivorax, Cochliomyia macellaria and Lucilia sericata
PLoS ONE, 8(2), e56303.
Ed(s): G. Tear
MeSH headings : Animals; Base Sequence; Conserved Sequence / genetics; Diptera / genetics; Diptera / growth & development; Diptera / physiology; Female; Genes, Insect / genetics; Male; Molecular Sequence Data; Nucleotide Motifs / genetics; RNA Splicing / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sex Characteristics
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Insect Resistance and Genetics; Insect and Pesticide Research
TL;DR:
A model for sex specific regulation of tra splicing is proposed that incorporates the conserved features identified in this study and is proposed to facilitate the development of a “male-only” strain for genetic control programs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018