Rahima R. Benhabbour

Works (12)

Updated: April 5th, 2024 11:08

2023 journal article

Injectable pH and Thermo-Responsive Hydrogel Scaffold with Enhanced Osteogenic Differentiation of Preosteoblasts for Bone Regeneration

PHARMACEUTICS, 15(9).

By: J. King *, R. Shrivastava  n, P. Shah n, P. Maturavongsadit  n & S. Benhabbour  n

author keywords: chitosan-based hydrogel; cellulose nanocrystals; injectable hydrogels; osteogenic differentiation; osteogenesis; bone regeneration
TL;DR: Results suggest that this injectable hydrogel is suitable for cell survival, can promote osteogenic differentiation of preosteoblasts, and structurally support new bone growth. (via Semantic Scholar)
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Source: Web Of Science
Added: October 16, 2023

2023 journal article

Long-acting injectable multipurpose prevention technology for prevention of HIV and unplanned pregnancy

JOURNAL OF CONTROLLED RELEASE, 363, 606–620.

By: I. Young *, A. Pallerla*, M. Cottrell *, P. Maturavongsadit  n, A. Prasher n, R. Shrivastava  n, G. Cruz *, S. Montgomery* ...

author keywords: Contraception; Drug delivery; HIV; Injectable; Polymer
TL;DR: The ability to co-formulate antiretrovirals with contraceptives in an ISFI that is well-tolerated with sustained plasma concentrations up to 90 days is demonstrated. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: December 11, 2023

2023 review

Non-Hormonal Contraception

[Review of ]. JOURNAL OF CLINICAL MEDICINE, 12(14).

By: S. Howard * & S. Benhabbour  n

author keywords: contraceptive; non-hormonal; long-acting; reversible
TL;DR: Non-hormonal contraceptives can target a variety of critical reproductive processes discussed here, including permanent sterilization, copper intrauterine devices, as well as traditional family planning methods including withdrawal and the rhythm method. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 14, 2023

2023 review

The Current Landscape of Glioblastoma Biomarkers in Body Fluids

[Review of ]. CANCERS, 15(15).

By: S. Zanganeh n, E. Abbasgholinejad *, M. Doroudian *, N. Esmaelizad *, F. Farjadian * & S. Benhabbour  n

author keywords: glioblastoma; biomarkers; body fluids; circulating tumor cells (CTCs); cell-free DNA (cfDNA); cell-free RNA (cfRNA); microRNA (miRNA); extracellular vesicles (EV); exosomes
TL;DR: The article highlights the potential of liquid biopsies as valuable tools for personalized GBM management but underscores the need for standardized protocols and further research to optimize their clinical utility. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 21, 2023

2023 journal article

Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

NATURE COMMUNICATIONS, 14(1).

By: I. Young *, I. Massud*, M. Cottrell *, R. Shrivastava  n, P. Maturavongsadit  n, A. Prasher n, A. Wong-Sam *, C. Dinh* ...

MeSH headings : Humans; Female; Animals; Mice; Macaca; Pyridones; HIV Integrase Inhibitors / therapeutic use; Rectum; Pre-Exposure Prophylaxis / methods; HIV Infections / prevention & control; HIV Infections / drug therapy; Anti-HIV Agents / therapeutic use
TL;DR: The results support the clinical advancement of CAB ISFIs for ultra-long-acting PrEP in humans and are well-tolerated in female mice and female macaques showing no signs of toxicity or chronic inflammation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 28, 2023

2022 journal article

Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics

PHARMACEUTICS, 14(3).

By: J. Joiner *, J. King *, R. Shrivastava  n, S. Howard *, M. Cottrell *, A. Kashuba *, P. Dayton n, S. Benhabbour  n

author keywords: long-acting; in situ; injectable; biodegradable; implants; PLGA; controlled release; drug delivery; ultrasound; pharmacokinetics
TL;DR: There was no statistical difference in drug exposure regardless of the route of administration or number of injections, and dolutegravir-loaded ISFIs along the range of injection volumes tested were present at 90 days post-injection, suggesting that DTG can prolong ISFI degradation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 18, 2022

2021 journal article

Biodegradable polymeric solid implants for ultra-long-acting delivery of single or multiple antiretroviral drugs

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 605.

By: P. Maturavongsadit  n, R. Shrivastava  n, C. Sykes*, M. Cottrell *, S. Montgomery *, A. Kashuba *, S. Benhabbour  n

author keywords: Polymeric solid implants; Long-acting drug delivery; Poly(lactic-co-glycolic acid) (PLGA); Dolutegravir; Rilpivirine; HIV prevention
MeSH headings : Anti-Retroviral Agents; HIV Infections / drug therapy; Humans; Pharmaceutical Preparations; Polymers / therapeutic use; Rilpivirine / therapeutic use
TL;DR: Results showed that in a single or bilayer dual-drug PSI, DTG and RPV exhibited physicochemical properties similar to their pure drug analogues, which makes this technology attractive as an ULA drug delivery platform for HIV and various therapeutic applications. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 20, 2021

2021 journal article

Cell-Laden Nanocellulose/Chitosan-Based Bioinks for 3D Bioprinting and Enhanced Osteogenic Cell Differentiation

ACS APPLIED BIO MATERIALS, 4(3), 2342–2353.

By: P. Maturavongsadit  n, L. Narayanan n, P. Chansoria n, R. Shirwaiker n  & S. Benhabbour  n

author keywords: chitosan-based hydrogel; cellulose nanocrystal; bioink; osteogenic differentiation; bioprinting
MeSH headings : 3T3 Cells; Animals; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Bioprinting; Cell Differentiation / drug effects; Cells, Cultured; Cellulose / chemistry; Cellulose / pharmacology; Chitosan / chemistry; Chitosan / pharmacology; Ink; Materials Testing; Mice; Nanoparticles / chemistry; Osteogenesis / drug effects; Particle Size
TL;DR: The versatility of this CNCs-incorporated chitosan hydrogel makes it attractive as a bioink for 3D bioprinting to engineer scaffolds for bone tissue engineering and other therapeutic applications. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 19, 2021

2021 review

Glioblastoma Multiforme-A Look at the Past and a Glance at the Future

[Review of ]. PHARMACEUTICS, 13(7).

By: J. King  n & S. Benhabbour  n

author keywords: glioblastoma; blood-brain barrier (BBB); blood-brain tumor barrier (BBTB); surgery; radiation; chemotherapy; immune checkpoint inhibitors (ICIs); stem cell-based therapy; stem cell engineering; hydrogels; smart hydrogels; focused ultrasound (FUS)
TL;DR: A comprehensive overview of the latest advances in treatment of glioblastoma multiforme is given with emphasis on the significant advances in immunotherapy and novel therapeutic delivery strategies to enhance treatment for GBM. (via Semantic Scholar)
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Source: Web Of Science
Added: August 2, 2021

2021 review

Multipurpose Prevention Technologies: Oral, Parenteral, and Vaginal Dosage Forms for Prevention of HIV/STIs and Unplanned Pregnancy

[Review of ]. POLYMERS, 13(15).

By: I. Young * & S. Benhabbour  n

author keywords: contraceptives; drug delivery; HIV; implants; injectables; intravaginal rings; multipurpose prevention technologies; sexually transmitted infections; sustained release
TL;DR: A comprehensive overview of the latest oral, parenteral, and vaginally delivered MPTs in development as well as drug delivery formulations with the potential to advance as an MPT, and implementation studies regarding MPT user acceptability and adherence are given. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 16, 2021

2021 journal article

Steroid Eluting Esophageal-Targeted Drug Delivery Devices for Treatment of Eosinophilic Esophagitis

POLYMERS, 13(4).

By: A. Prasher  n, R. Shrivastava  n, D. Dahl n, P. Sharma-Huynh*, P. Maturavongsadit  n, T. Pridgen n, A. Schorzman*, W. Zamboni * ...

author keywords: eosinophilic esophagitis (EoE); esophageal drug delivery systems; drug-eluting string; 3D printing; photopolymerizable resins; Drug loading strategies; steroids; fluticasone
TL;DR: Two novel esophageal-specific drug delivery platforms are reported, including a fluticasone-eluting string that could be swallowed similar to the string test “entero-test” and used for overnight treatment, and a 3D printed ring for local and sustained release of flutic asone in the esophagus. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 18, 2021

2019 journal article

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

NATURE COMMUNICATIONS, 10.

By: S. Benhabbour  n, M. Kovarova *, C. Jones*, D. Copeland*, R. Shrivastava  n, M. Swanson*, C. Sykes*, P. Ho* ...

MeSH headings : Anti-Retroviral Agents / pharmacokinetics; Biodegradable Plastics / chemistry; Chemistry, Pharmaceutical; Delayed-Action Preparations / chemistry; Delayed-Action Preparations / pharmacology; Drug Delivery Systems / methods; Drug Liberation; HIV Infections / drug therapy; Humans; Kinetics; Materials Testing; Polymers / metabolism; Pyrrolidinones; Rheology; Solubility
TL;DR: An ultra-long-acting tunable, biodegradable, and removable polymer-based delivery system that offers sustained drug delivery for up to one year for HIV treatment or prophylaxis and optimize and demonstrate the release of 6 different drugs over a period of up to a year. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 7, 2019

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