Works (5)
Updated: July 5th, 2023 15:29
2022 journal article
Experimental demonstration of tethered gene drive systems for confined population modification or suppression
BMC BIOLOGY, 20(1).
author keywords: Gene drive; CRISPR; Toxin-antidote confined; Drosophila melanogaster; Tethered gene drive; Population modification; Population suppression
MeSH headings : Animals; CRISPR-Cas Systems; Clustered Regularly Interspaced Short Palindromic Repeats; Drosophila / genetics; Gene Drive Technology / methods
TL;DR:
The engineering of a tethered drive system in Drosophila is demonstrated, using a regionally confined CRISPR Toxin-Antidote Recessive Embryo (TARE) drive to support modification and suppression homing drives.
(via Semantic Scholar)
open access via bmcbiol.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 20, 2022
2020 article
Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex
ANNUAL REVIEW OF ECOLOGY, EVOLUTION, AND SYSTEMATICS, VOL 51, 2020, Vol. 51, pp. 505–531.
author keywords: genetic pest management; underdominance; CRISPR; spatial dynamics; density dependence; population alteration
TL;DR:
How different forms of density dependence, spatial heterogeneity, and mating behaviors can impact the spread of self-sustaining gene drives is reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2021
2019 journal article
Locally Fixed Alleles: A method to localize gene drive to island populations
SCIENTIFIC REPORTS, 9.
MeSH headings : Alleles; Animals; Biodiversity; Islands
TL;DR:
This paper proposes the “Locally Fixed Alleles” approach as a novel means for localizing elimination by a drive to an island population that exhibits significant genetic isolation from neighboring populations and explores the feasibility and degree of localization that can be achieved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2019
2019 article
Pest management by genetic addiction
Gould, F., Dhole, S., & Lloyd, A. L. (2019, March 26). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 116, pp. 5849–5851.
MeSH headings : Gene Drive Technology; Pest Control
TL;DR:
The work of Oberhofer et al. (1) adds substantially to a growing field within genetic engineering, often termed gene drive research, in which selfish genetic elements overcome the rules of Mendelian inheritance and push transgenes into a population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 15, 2019
2019 journal article
Tethered homing gene drives: A new design for spatially restricted population replacement and suppression
EVOLUTIONARY APPLICATIONS, 12(8), 1688–1702.
author keywords: Cas; CRISPR; gene drive; genetic engineering; population alteration; underdominance
TL;DR:
A new gene drive system, Tethered Homing (TH), is presented, with improved capacity for localized population alteration, especially for population suppression, and the ability to gradually adjust the genetic load in a population after the initial alteration, with minimal additional release effort.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 21, 2019
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