Sumit Dhole

Works (5)

Updated: July 5th, 2023 15:29

2022 journal article

Experimental demonstration of tethered gene drive systems for confined population modification or suppression

BMC BIOLOGY, 20(1).

By: M. Metzloff *, E. Yang *, S. Dhole n, A. Clark *, P. Messer * & J. Champer *

author keywords: Gene drive; CRISPR; Toxin-antidote confined; Drosophila melanogaster; Tethered gene drive; Population modification; Population suppression
MeSH headings : Animals; CRISPR-Cas Systems; Clustered Regularly Interspaced Short Palindromic Repeats; Drosophila / genetics; Gene Drive Technology / methods
TL;DR: The engineering of a tethered drive system in Drosophila is demonstrated, using a regionally confined CRISPR Toxin-Antidote Recessive Embryo (TARE) drive to support modification and suppression homing drives. (via Semantic Scholar)
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Source: Web Of Science
Added: June 20, 2022

2020 article

Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex

ANNUAL REVIEW OF ECOLOGY, EVOLUTION, AND SYSTEMATICS, VOL 51, 2020, Vol. 51, pp. 505–531.

By: S. Dhole n, A. Lloyd n  & F. Gould n 

author keywords: genetic pest management; underdominance; CRISPR; spatial dynamics; density dependence; population alteration
TL;DR: How different forms of density dependence, spatial heterogeneity, and mating behaviors can impact the spread of self-sustaining gene drives is reviewed. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2021

2019 journal article

Locally Fixed Alleles: A method to localize gene drive to island populations

SCIENTIFIC REPORTS, 9.

By: J. Sudweeks  n, B. Hollingsworth  n, D. Blondel n, K. Campbell, S. Dhole n, J. Eisemann*, O. Edwards *, J. Godwin n  ...

MeSH headings : Alleles; Animals; Biodiversity; Islands
TL;DR: This paper proposes the “Locally Fixed Alleles” approach as a novel means for localizing elimination by a drive to an island population that exhibits significant genetic isolation from neighboring populations and explores the feasibility and degree of localization that can be achieved. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2019

2019 article

Pest management by genetic addiction

Gould, F., Dhole, S., & Lloyd, A. L. (2019, March 26). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 116, pp. 5849–5851.

By: F. Gould n , S. Dhole n & A. Lloyd n 

MeSH headings : Gene Drive Technology; Pest Control
TL;DR: The work of Oberhofer et al. (1) adds substantially to a growing field within genetic engineering, often termed gene drive research, in which selfish genetic elements overcome the rules of Mendelian inheritance and push transgenes into a population. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 15, 2019

2019 journal article

Tethered homing gene drives: A new design for spatially restricted population replacement and suppression

EVOLUTIONARY APPLICATIONS, 12(8), 1688–1702.

By: S. Dhole n, A. Lloyd n  & F. Gould n 

author keywords: Cas; CRISPR; gene drive; genetic engineering; population alteration; underdominance
TL;DR: A new gene drive system, Tethered Homing (TH), is presented, with improved capacity for localized population alteration, especially for population suppression, and the ability to gradually adjust the genetic load in a population after the initial alteration, with minimal additional release effort. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 21, 2019

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