Scott Thomas Magness

Works (20)

Updated: November 11th, 2023 05:00

2023 journal article

A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 324(4), G262–G280.

By: M. Ok n, J. Liu n, R. Bliton n, C. Hinesley n, E. Pedro n, K. Breau*, I. Gomez-Martinez*, J. Burclaff n, S. Magness n

co-author countries: United States of America 🇺🇸
author keywords: absorptive colonocyte monolayers; intestinal stem cells; permeability; toxicity
MeSH headings : Humans; Bacterial Toxins / toxicity; Bacterial Toxins / metabolism; Enterotoxins / toxicity; Enterotoxins / metabolism; Clostridioides difficile / metabolism; Caco-2 Cells; Diclofenac; Bacterial Proteins / metabolism; Colon / metabolism
Source: Web Of Science
Added: April 24, 2023

2023 journal article

Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells

COMMUNICATIONS BIOLOGY, 6(1).

By: S. Sarma n, C. Catella n, E. San Pedro*, X. Xiao n, D. Durmusoglu n, S. Menegatti n, N. Crook n, S. Magness*, C. Hall n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 27, 2023

2023 journal article

Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 16(5), 823–846.

By: K. Rivera n, R. Bilton, J. Burclaff n, M. Czerwinski*, J. Liu*, J. Trueblood*, C. Hinesley*, K. Breau* ...

co-author countries: United States of America 🇺🇸
author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
Sources: Web Of Science, ORCID
Added: November 6, 2023

2022 journal article

A Planar Culture Model of Human Absorptive Enterocytes Reveals Metformin Increases Fatty Acid Oxidation and Export

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 14(2), 409–434.

co-author countries: United States of America 🇺🇸
author keywords: Intestinal Stem Cells; Absorptive Enterocyte Mono-layers; Fatty Acid Oxidation; Drug Screening
MeSH headings : Caco-2 Cells; Diabetes Mellitus, Type 2 / metabolism; Enterocytes / metabolism; Fatty Acids / metabolism; Humans; Hypoglycemic Agents / metabolism; Hypoglycemic Agents / pharmacology; Metformin / pharmacology; RNA
Source: Web Of Science
Added: September 6, 2022

2022 journal article

Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa

GASTROENTEROLOGY, 163(4), 875–890.

By: J. Min*, C. Zhang*, R. Bliton n, B. Caldwell*, L. Caplan*, K. Presentation*, D. Park*, S. Kong ...

co-author countries: Korea (Republic of) 🇰🇷 United States of America 🇺🇸
author keywords: Gastric Carcinogenesis; Dysplasia; Dysplastic Stem Cells; Kras; CK1 alpha; Pyrvinium
MeSH headings : Animals; Casein Kinase I / metabolism; Cell Plasticity; Cell Transformation, Neoplastic / pathology; Gastric Mucosa / pathology; Humans; Hyperplasia / pathology; Ligands; Mice; Precancerous Conditions / pathology; Proto-Oncogene Proteins p21(ras) / metabolism; Stem Cells / metabolism; Stomach Neoplasms / pathology; Tumor Microenvironment; beta Catenin / metabolism
Source: Web Of Science
Added: January 30, 2023

2022 journal article

Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(18).

By: L. Tse*, R. Meganck*, K. Araba*, B. Yount*, K. Shaffer*, Y. Hou*, J. Munt*, L. Adams* ...

co-author countries: United States of America 🇺🇸
author keywords: PLAC8; coronavirus; CRISPR; swine acute diarrhea syndrome coronavirus
MeSH headings : Alphacoronavirus / genetics; Animals; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Coronavirus Infections / epidemiology; Swine; Swine Diseases
Sources: Web Of Science, ORCID
Added: June 13, 2022

2021 article

In Silico Identification and Experimental Validation of Peptide-Based Inhibitors Targeting Clostridium difficile Toxin A

Xiao, X., Sarma, S., Menegatti, S., Crook, N., Magness, S. T., & Hall, C. K. (2021, December 29). ACS CHEMICAL BIOLOGY, Vol. 17.

By: X. Xiao n, S. Sarma n, S. Menegatti n, N. Crook n, S. Magness* & C. Hall n

co-author countries: United States of America 🇺🇸
MeSH headings : Bacterial Toxins / antagonists & inhibitors; Bacterial Toxins / chemistry; Computer Simulation; Drug Design; Enterotoxins / antagonists & inhibitors; Enterotoxins / chemistry; Models, Molecular; Peptides / chemistry; Peptides / pharmacology; Protein Binding; Protein Conformation; Protein Domains; Reproducibility of Results
Sources: Web Of Science, ORCID
Added: December 30, 2021

2021 journal article

The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut

MICROBIOME, 9(1).

By: J. Arnold*, J. Roach*, S. Fabela*, E. Moorfield*, S. Ding*, E. Blue*, S. Dagher n, S. Magness n ...

co-author countries: United States of America 🇺🇸
author keywords: Gut microbiome; Prebiotics; Bifidobacterium; Intestinal permeability; Host-microbiota interactions; Diet; Antibiotics; Metagenomics; Transcriptomics; Organoids
MeSH headings : Aging / drug effects; Aging / genetics; Aging / physiology; Animals; Female; Gastrointestinal Microbiome / drug effects; Intestines / drug effects; Intestines / microbiology; Intestines / physiology; Mice; Mice, Inbred C57BL; Oligosaccharides / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Prebiotics; Proto-Oncogene Proteins c-akt / metabolism
Sources: Web Of Science, ORCID
Added: February 22, 2021

2021 article

The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut (vol 9, 31, 2021)

Arnold, J. W., Roach, J., Fabela, S., Moorfield, E., Ding, S., Blue, E., … Azcarate-Peril, M. A. (2021, February 26). MICROBIOME, Vol. 9.

By: J. Arnold*, J. Roach*, S. Fabela*, E. Moorfield*, S. Ding*, E. Blue*, S. Dagher n, S. Magness n ...

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: March 22, 2021

2020 journal article

Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation

DEVELOPMENT, 147(1).

By: J. Raab*, D. Tulasi*, K. Wager*, J. Morowitz*, S. Magness n & A. Gracz*

co-author countries: United States of America 🇺🇸
author keywords: 5hmC; Id3; Chromatin; Differentiation; Intestinal stem cell
MeSH headings : Animals; Cell Differentiation / genetics; Chromatin / metabolism; Chromatin Assembly and Disassembly; DNA Methylation; Gene Expression Profiling; Gene Regulatory Networks; Genes, Reporter; Intestines / cytology; Male; Mice; Mice, Inbred C57BL; Organ Culture Techniques; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Stem Cells / metabolism; Stem Cells / physiology
Source: Web Of Science
Added: February 3, 2020

2019 journal article

IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 7(1), 1–17.

By: B. Zwarycz*, A. Gracz*, K. Rivera n, I. Williamson n, L. Samsa*, J. Starmer*, M. Daniele n, L. Salter-Cid*, Q. Zhao*, S. Magness n

co-author countries: United States of America 🇺🇸
author keywords: Intestinal Stem Cells; Interleukin-22; Inflammatory Bowel Disease
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage / drug effects; Cell Proliferation / drug effects; Cell Self Renewal / drug effects; Cellular Microenvironment / drug effects; Computer Simulation; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ileum / cytology; Inflammatory Bowel Diseases / pathology; Interleukins / pharmacology; Mice, Inbred C57BL; Models, Biological; Organoids / cytology; Organoids / drug effects; Organoids / metabolism; Receptors, Interleukin / metabolism; Serum / metabolism; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism
Source: Web Of Science
Added: January 14, 2019

2019 journal article

Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems

BIOSENSORS & BIOELECTRONICS, 123, 131–140.

By: K. Rivera n, V. Pozdin n, A. Young n, P. Erb n, N. Wisniewski*, S. Magness n, M. Daniele n

co-author countries: United States of America 🇺🇸
author keywords: Oxygen; Microdevice; Organs-on-chips; Oxygen biosensor; Biosensors; Hypoxia
MeSH headings : Biosensing Techniques; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Humans; Luminescent Measurements / methods; Oxygen / chemistry; Oxygen / metabolism; Photons
Source: Web Of Science
Added: December 3, 2018

2019 journal article

Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection

Cellular and Molecular Gastroenterology and Hepatology, 8(1), 1–20.

By: S. Ferguson n, D. Foster n, B. Sherry n, S. Magness n, D. Nielsen n & J. Gookin n

co-author countries: United States of America 🇺🇸
author keywords: Cryptosporidiosis; Cytokine; Enterocyte; Protozoa
MeSH headings : Animals; Cell Line; Cryptosporidiosis / genetics; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidium parvum / physiology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression Profiling; Intestinal Mucosa / immunology; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Swine; Up-Regulation
Sources: Web Of Science, ORCID, Crossref
Added: July 15, 2019

2018 journal article

A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies

ANALYTICAL CHEMISTRY, 90(22), 13331–13340.

By: D. Gunasekara n, J. Speer*, Y. Wang*, D. Nguyen*, M. Reed*, N. Smiddy*, J. Parker*, J. Fallon* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Atenolol / metabolism; Biological Transport / physiology; Caco-2 Cells; Chickens; Collagen / chemistry; Colon / physiology; Epithelium / physiology; Humans; Mice; Propranolol / metabolism; Rhodamine 123 / metabolism; Riboflavin / metabolism; Tissue Engineering / methods
Source: Web Of Science
Added: December 10, 2018

2018 review

Bioengineered systems and designer matrices that recapitulate the intestinal stem cell niche

[Review of ]. Cellular and Molecular Gastroenterology and Hepatology, 5(3), 440-.

By: Y. Wang, R. Kim, S. Hinman, B. Zwarycz, S. Magness & N. Allbritton

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 5(2), 113–130.

By: Y. Wang*, R. Kim n, D. Gunasekara*, M. Reed*, M. DiSalvo n, D. Nguyen*, S. Bultman*, C. Sims*, S. Magness n, N. Allbritton n

co-author countries: United States of America 🇺🇸
author keywords: Intestinal Epithelial Cells; Intestine-On-A-Chip; Stem Cell Niche; Polarized Crypt
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity

American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(6), G966–G979.

By: Y. Jin n, D. Ibrahim n, S. Magness n & A. Blikslager n

co-author countries: United States of America 🇺🇸
author keywords: adherens junction; chloride channel ClC-2; colonic homeostasis; colonic tumorigenicity; colonoids
MeSH headings : Adherens Junctions / metabolism; Adherens Junctions / pathology; Animals; CLC-2 Chloride Channels; Carcinogenesis / genetics; Carcinogenesis / metabolism; Chloride Channels / genetics; Chloride Channels / metabolism; Colitis, Ulcerative / complications; Colonic Neoplasms / etiology; HT29 Cells; Homeostasis; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Mice; Mice, Inbred C57BL; Signal Transduction; beta Catenin / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: December 31, 2018

2018 journal article

Nonsteroidal Anti-Inflammatory Drug -Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells

ACS INFECTIOUS DISEASES, 4(1), 46–52.

By: A. Bhatt*, D. Gunasekara*, J. Speer*, M. Reed*, A. Pena*, B. Midkiff*, S. Magness n, S. Bultman*, N. Allbritton n, M. Redinbo*

co-author countries: United States of America 🇺🇸
author keywords: small intestine; leaky gut; bacterial translocation; NSAIDs; mitochondria; superoxide
MeSH headings : Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Cell Membrane Permeability / drug effects; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Mitochondria / drug effects; Mitochondria / metabolism
Source: Web Of Science
Added: August 6, 2018

2017 journal article

A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium

BIOMATERIALS, 128, 44–55.

By: Y. Wang*, D. Gunasekara*, M. Reed*, M. DiSalvo n, S. Bultman*, C. Sims*, S. Magness n, N. Allbritton n

co-author countries: United States of America 🇺🇸
author keywords: Scaffold; Microfabrication; Intestine; Stem cell; Crypt; Villus
MeSH headings : Animals; Cell Compartmentation; Cell Differentiation / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Collagen / pharmacology; Cross-Linking Reagents / pharmacology; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiology; Intestine, Small / drug effects; Intestine, Small / physiology; Mice; Organoids / drug effects; Porosity; Rats; Tissue Culture Techniques; Tissue Engineering / methods; Tissue Scaffolds / chemistry
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Self-renewing monolayer of primary colonic or rectal epithelial cells

Cellular and Molecular Gastroenterology and Hepatology, 4(1), 165-.

By: Y. Wang, M. DiSalvo, D. Gunasekara, J. Dutton, A. Proctor, M. Lebhar, I. Williamson, J. Speer ...

Source: NC State University Libraries
Added: August 6, 2018

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