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Works (20)
Updated: April 5th, 2024 09:54
2023 journal article
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 324(4), G262–G280.
author keywords: absorptive colonocyte monolayers; intestinal stem cells; permeability; toxicity
MeSH headings : Humans; Bacterial Toxins / toxicity; Bacterial Toxins / metabolism; Enterotoxins / toxicity; Enterotoxins / metabolism; Clostridioides difficile / metabolism; Caco-2 Cells; Diclofenac; Bacterial Proteins / metabolism; Colon / metabolism
doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 24, 2023
2023 journal article
Design of 8-mer peptides that block <i>Clostridioides difficile</i> toxin A in intestinal cells
COMMUNICATIONS BIOLOGY, 6(1).
TL;DR:
An approach that combines a Pep tide B inding D esign (PepBD) algorithm, molecular-level simulations, a rapid screening assay, and surface plasmon resonance (SPR) measurements to develop peptide inhibitors that block Toxin A in colon epithelial cells is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 27, 2023
2023 journal article
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 16(5), 823–846.
author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
TL;DR:
A new microphysiological system (MPS) is presented to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolongedHypoxia modulates how hISC respond to inflammation-associated interleukins (ILs) and has important implications for understanding intestinal epithelial regeneration mechanisms caused by inflammatory hypoxIA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023
2022 journal article
A Planar Culture Model of Human Absorptive Enterocytes Reveals Metformin Increases Fatty Acid Oxidation and Export
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 14(2), 409–434.
author keywords: Intestinal Stem Cells; Absorptive Enterocyte Mono-layers; Fatty Acid Oxidation; Drug Screening
MeSH headings : Caco-2 Cells; Diabetes Mellitus, Type 2 / metabolism; Enterocytes / metabolism; Fatty Acids / metabolism; Humans; Hypoglycemic Agents / metabolism; Hypoglycemic Agents / pharmacology; Metformin / pharmacology; RNA
TL;DR:
A high-throughput planar human absorptive enterocyte monolayer system is developed for investigating lipid handling and the role of fatty acid oxidation in fatty acid export, using etomoxir, C75, and the antidiabetic drug metformin to evaluate fatty acid handling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 6, 2022
2022 journal article
Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa
GASTROENTEROLOGY, 163(4), 875–890.
author keywords: Gastric Carcinogenesis; Dysplasia; Dysplastic Stem Cells; Kras; CK1 alpha; Pyrvinium
MeSH headings : Animals; Casein Kinase I / metabolism; Cell Plasticity; Cell Transformation, Neoplastic / pathology; Gastric Mucosa / pathology; Humans; Hyperplasia / pathology; Ligands; Mice; Precancerous Conditions / pathology; Proto-Oncogene Proteins p21(ras) / metabolism; Stem Cells / metabolism; Stomach Neoplasms / pathology; Tumor Microenvironment; beta Catenin / metabolism
TL;DR:
Findings indicate that the DSCs are de novo gastric cancer-initiating cells responsible for neoplastic transformation and a promising target for intervention in early induction of Gastric cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 30, 2023
2022 journal article
Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(18).
author keywords: PLAC8; coronavirus; CRISPR; swine acute diarrhea syndrome coronavirus
MeSH headings : Alphacoronavirus / genetics; Animals; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Coronavirus Infections / epidemiology; Swine; Swine Diseases
TL;DR:
Using genomewide CRISPR knockout screening, the placenta-associated 8 protein (PLAC8) is identified as an essential host factor for SADS-CoV infection, uncovering a novel antiviral target for CoV infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022
2021 article
In Silico Identification and Experimental Validation of Peptide-Based Inhibitors Targeting Clostridium difficile Toxin A
Xiao, X., Sarma, S., Menegatti, S., Crook, N., Magness, S. T., & Hall, C. K. (2021, December 29). ACS CHEMICAL BIOLOGY, Vol. 17.
MeSH headings : Bacterial Toxins / antagonists & inhibitors; Bacterial Toxins / chemistry; Computer Simulation; Drug Design; Enterotoxins / antagonists & inhibitors; Enterotoxins / chemistry; Models, Molecular; Peptides / chemistry; Peptides / pharmacology; Protein Binding; Protein Conformation; Protein Domains; Reproducibility of Results
TL;DR:
This work used a computational strategy that integrates a peptide binding design algorithm and explicit-solvent atomistic molecular dynamics simulation to determine promising toxin A-targeting peptides that can recognize and bind to the catalytic site of the TcdA glucosyltransferase domain (GTD).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 30, 2021
2021 journal article
The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut
MICROBIOME, 9(1).
author keywords: Gut microbiome; Prebiotics; Bifidobacterium; Intestinal permeability; Host-microbiota interactions; Diet; Antibiotics; Metagenomics; Transcriptomics; Organoids
MeSH headings : Aging / drug effects; Aging / genetics; Aging / physiology; Animals; Female; Gastrointestinal Microbiome / drug effects; Intestines / drug effects; Intestines / microbiology; Intestines / physiology; Mice; Mice, Inbred C57BL; Oligosaccharides / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Prebiotics; Proto-Oncogene Proteins c-akt / metabolism
TL;DR:
Stools from mice exhibiting variable bifidogenic response to GOS injected into colon organoids in the presence of prebiotics reproduced the response and non-response phenotypes observed in vivo suggesting that the composition and functionality of the microbiota are the main contributors to the phenotype.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 22, 2021
2021 article
The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut (vol 9, 31, 2021)
Arnold, J. W., Roach, J., Fabela, S., Moorfield, E., Ding, S., Blue, E., … Azcarate-Peril, M. A. (2021, February 26). MICROBIOME, Vol. 9.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 22, 2021
2020 journal article
Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation
DEVELOPMENT, 147(1).
author keywords: 5hmC; Id3; Chromatin; Differentiation; Intestinal stem cell
MeSH headings : Animals; Cell Differentiation / genetics; Chromatin / metabolism; Chromatin Assembly and Disassembly; DNA Methylation; Gene Expression Profiling; Gene Regulatory Networks; Genes, Reporter; Intestines / cytology; Male; Mice; Mice, Inbred C57BL; Organ Culture Techniques; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Stem Cells / metabolism; Stem Cells / physiology
TL;DR:
Analysis and quantification of chromatin accessibility and 5-hydroxymethylcytosine reveals cis-regulatory dynamics and associated transcription factors involved in intestinal stem cell differentiation and provides a chromatin roadmap for further dissecting cis regulation of cell fate in the intestine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 3, 2020
2019 journal article
IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 7(1), 1–17.
author keywords: Intestinal Stem Cells; Interleukin-22; Inflammatory Bowel Disease
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage / drug effects; Cell Proliferation / drug effects; Cell Self Renewal / drug effects; Cellular Microenvironment / drug effects; Computer Simulation; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ileum / cytology; Inflammatory Bowel Diseases / pathology; Interleukins / pharmacology; Mice, Inbred C57BL; Models, Biological; Organoids / cytology; Organoids / drug effects; Organoids / metabolism; Receptors, Interleukin / metabolism; Serum / metabolism; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism
TL;DR:
Increased IL22 limits ISC expansion in favor of increased TA progenitor cell expansion, and chronically increased IL22 levels, similar to predicted microenvironment levels, showed increases in proliferative cells in the TA zone with no increase in ISCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019
2019 journal article
Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems
BIOSENSORS & BIOELECTRONICS, 123, 131–140.
author keywords: Oxygen; Microdevice; Organs-on-chips; Oxygen biosensor; Biosensors; Hypoxia
MeSH headings : Biosensing Techniques; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Humans; Luminescent Measurements / methods; Oxygen / chemistry; Oxygen / metabolism; Photons
TL;DR:
The design and engineering of a system to remotely monitor and control oxygen concentration inside a device for 3D cell culture is reported, integrating a photonic oxygen biosensor into the 3D tissue scaffold and regulate oxygen concentration via the control of purging gas flow.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 3, 2018
2019 journal article
Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection
Cellular and Molecular Gastroenterology and Hepatology, 8(1), 1–20.
author keywords: Cryptosporidiosis; Cytokine; Enterocyte; Protozoa
MeSH headings : Animals; Cell Line; Cryptosporidiosis / genetics; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidium parvum / physiology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression Profiling; Intestinal Mucosa / immunology; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Swine; Up-Regulation
TL;DR:
These studies identify IFN-λ2/3 as a key epithelial defense mechanism against C parvum infection and Priming of IECs with recombinant human IFn-λ3 promoted cellular defense against CParvum infections and abrogated C parVum–induced loss of barrier function by decreasing paracellular permeability to sodium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: July 15, 2019
2018 journal article
A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies
ANALYTICAL CHEMISTRY, 90(22), 13331–13340.
MeSH headings : Animals; Atenolol / metabolism; Biological Transport / physiology; Caco-2 Cells; Chickens; Collagen / chemistry; Colon / physiology; Epithelium / physiology; Humans; Mice; Propranolol / metabolism; Rhodamine 123 / metabolism; Riboflavin / metabolism; Tissue Engineering / methods
TL;DR:
A collagen scaffold, in which the degree of collagen cross-linking was present as a gradient, was developed to support the proliferation of primary colonic cells, and it is anticipated that this platform of primary Colonic epithelium will find utility in drug development and physiological studies, since the tissue possesses high integrity and active transporters and metabolism similar to that in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 10, 2018
2018 review
Bioengineered systems and designer matrices that recapitulate the intestinal stem cell niche
[Review of ]. Cellular and Molecular Gastroenterology and Hepatology, 5(3), 440-.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 5(2), 113–130.
author keywords: Intestinal Epithelial Cells; Intestine-On-A-Chip; Stem Cell Niche; Polarized Crypt
TL;DR:
In vitro human colon crypt array accurately mimicked the architecture, luminal accessibility, tissue polarity, cell migration, and cellular responses of in vivo intestinal crypts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity
American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(6), G966–G979.
author keywords: adherens junction; chloride channel ClC-2; colonic homeostasis; colonic tumorigenicity; colonoids
MeSH headings : Adherens Junctions / metabolism; Adherens Junctions / pathology; Animals; CLC-2 Chloride Channels; Carcinogenesis / genetics; Carcinogenesis / metabolism; Chloride Channels / genetics; Chloride Channels / metabolism; Colitis, Ulcerative / complications; Colonic Neoplasms / etiology; HT29 Cells; Homeostasis; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Mice; Mice, Inbred C57BL; Signal Transduction; beta Catenin / metabolism
TL;DR:
Disruption of adherens junctions in the absence of chloride channel protein-2 revealed critical functions of these junctional structures, including maintenance of colonic homeostasis and differentiation as well as driving tumorigenicity by regulating β-catenin signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 31, 2018
2018 journal article
Nonsteroidal Anti-Inflammatory Drug -Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells
ACS INFECTIOUS DISEASES, 4(1), 46–52.
author keywords: small intestine; leaky gut; bacterial translocation; NSAIDs; mitochondria; superoxide
MeSH headings : Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Cell Membrane Permeability / drug effects; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Mitochondria / drug effects; Mitochondria / metabolism
TL;DR:
The utility of this novel platform, representative of the human small intestinal epithelium, to understand NSAID toxicity, which can be applied to study multiple aspects of gut barrier function including defense against infectious pathogens and host-microbiota interactions, is established.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium
BIOMATERIALS, 128, 44–55.
author keywords: Scaffold; Microfabrication; Intestine; Stem cell; Crypt; Villus
MeSH headings : Animals; Cell Compartmentation; Cell Differentiation / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Collagen / pharmacology; Cross-Linking Reagents / pharmacology; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiology; Intestine, Small / drug effects; Intestine, Small / physiology; Mice; Organoids / drug effects; Porosity; Rats; Tissue Culture Techniques; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
This new approach combining microengineered scaffolds, biophysical cues and chemical gradients to control the intestinal epithelium ex vivo can serve as a physiologically relevant mimic of the human small intestine, and is broadly applicable to model other tissues that rely on gradients for physiological function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Self-renewing monolayer of primary colonic or rectal epithelial cells
Cellular and Molecular Gastroenterology and Hepatology, 4(1), 165-.
Source: NC State University Libraries
Added: August 6, 2018
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