Works (33)

2022 article

IgD(+) age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged

Kugler-Umana, O., Zhang, W., Kuang, Y., Liang, J., Castonguay, C. H., Tonkonogy, S. L., … Swain, S. L. (2022, September 2). AGING CELL.

By: O. Kugler-Umana*, W. Zhang*, Y. Kuang*, J. Liang*, C. Castonguay*, S. Tonkonogy, A. Marshak-Rothstein*, P. Devarajan*, S. Swain*

author keywords: adaptive immunity; age-associated B cells; aging; influenza; TLR signals
Source: Web Of Science
Added: September 12, 2022

2022 journal article

Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes

BIOMEDICINES, 10(12).

By: S. Surman*, J. Crawford, P. Dash, S. Tonkonogy, P. Thomas & J. Hurwitz

author keywords: E; coli; germ-free; gnotobiotic; T cell receptor repertoire; thymus; CD4+CD8+ T cell
Source: Web Of Science
Added: January 17, 2023

2019 journal article

Murine Adherent and Invasive E. coli Induces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10(-/-) Mice Independent of Long Polar Fimbriae Adhesin

INFLAMMATORY BOWEL DISEASES, 25(5), 875–885.

By: J. Schmitz n, S. Tonkonogy, B. Dogan*, A. Leblond n, K. Whitehead n, S. Kim n, K. Simpson*, R. Sartor n

author keywords: ileitis; colitis; cytokines; T cells; adherent invasive E. coli
Source: Web Of Science
Added: July 15, 2019

2016 journal article

Transient activation of mucosal effector immune responses by resident intestinal bacteria in normal hosts is regulated by interleukin-10 signalling

IMMUNOLOGY, 148(3), 304–314.

By: C. Wu*, R. Sartor*, K. Huang* & S. Tonkonogy

author keywords: germ-free mice; interleukin-10; resident bacteria
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Molecular detection of bacterial contamination in gnotobiotic rodent units

Gut Microbes, 4(5), 361–370.

By: C. Packey*, M. Shanahan*, S. Manick*, M. Bower*, M. Ellermann*, S. Tonkonogy, I. Carroll*, R. Sartor*

Source: Crossref
Added: July 20, 2019

2011 journal article

Antigen-Presenting Cell Production of IL-10 Inhibits T-Helper 1 and 17 Cell Responses and Suppresses Colitis in Mice

GASTROENTEROLOGY, 141(2), 653–U764.

By: B. Liu*, S. Tonkonogy & R. Sartor*

author keywords: Mouse Model; Inflammatory Bowel Disease; Immune Response; Microbiota
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation

GASTROENTEROLOGY, 141(3), 959–971.

By: N. Steck*, M. Hoffmann*, I. Sava*, S. Kim*, H. Hahne*, S. Tonkonogy, K. Mair*, D. Krueger* ...

author keywords: IBD; Bacteria-Host Interactions; Bacterial Protease; Intestinal Barrier Function
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Adaptation in a Mouse Colony Monoassociated with Escherichia coli K-12 for More than 1,000 Days

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(14), 4655–4663.

By: S. Lee*, A. Wyse*, A. Lesher*, M. Everett*, L. Lou*, Z. Holzknecht*, J. Whitesides*, P. Spears ...

Source: Web Of Science
Added: August 6, 2018

2009 conference paper

Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-lO-deficient mice

Inflammatory Bowel Diseases, 15(7), 1022–1031.

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria

IMMUNOLOGY LETTERS, 123(1), 77–87.

By: C. Albright*, R. Sartor* & S. Tonkonogy

author keywords: Cytokine regulation; Antigen presenting cells; IL-10 deficient mice
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Aberrant Innate Immune Responses in TLR-ligand Activated HLA-B27 Transgenic Rat Cells

INFLAMMATORY BOWEL DISEASES, 14(10), 1358–1365.

By: B. Qian*, S. Tonkonogy & R. Sartor*

author keywords: HLA-B27 transgenic rats; bacterial adjuvants; Toll-like receptors; innate immune responses; splenocytes
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Reduced responsiveness of HLA-B27 transgenic rat cells to TGF-beta and IL-10-mediated regulation of IFN-gamma production

INFLAMMATORY BOWEL DISEASES, 14(7), 921–930.

By: B. Qian*, S. Tonkonogy & R. Sartor*

author keywords: HLA-B27 transgenic rats; cytokines; defective regulation
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling

American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(4), G780–G787.

By: D. Meng*, D. Newburg*, C. Young*, A. Baker*, S. Tonkonogy, R. Sartor*, W. Walker*, N. Nanthakumar*

author keywords: bacterial colonization; fucosylation
Source: Crossref
Added: July 20, 2019

2007 journal article

CD4(+) T lymphocytes mediate colitis in HLA-B27 transgenic rats monoassociated with nonpathogenic Bacteroides vulgatus

INFLAMMATORY BOWEL DISEASES, 13(3), 317–324.

By: F. Hoentjen*, S. Tonkonogy, B. Qian*, B. Liu*, L. Dieleman* & R. Sartor*

author keywords: Bacteroides vulgatus; cytokines; HLA-B27; transgenic rats
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Dual-association of gnotobiotic IL-10-/- mice vith 2 nonpathogenic commensal bacteria induces aggressive pancolitis

INFLAMMATORY BOWEL DISEASES, 13(12), 1457–1466.

By: S. Kim*, S. Tonkonogy, T. Karrasch*, C. Jobin* & R. Sartor*

author keywords: gnotobiotic IL-10-/- mice; pancolitis; commensal bacteria
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Adoptive transfer of nontransgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 143(3), 474–483.

By: F. Hoentjen*, S. Tonkonogy, B. Liu*, R. Sartor*, J. Taurog* & L. Dieleman*

author keywords: T cells; HLA-B27; nude; transgenic rats; commensal bacteria
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Luminal bacterial antigen-specific CD4(+) T-cell responses in HLA-B27 transgenic rats with chronic colitis are mediated by both major histocompatibility class II and HLA-B27 molecules

IMMUNOLOGY, 117(3), 319–328.

By: B. Qian*, S. Tonkonogy & R. Sartor*

author keywords: CD4(+) T-cell responses; HLA-B27; MHC class II; enteric bacterial antigens; transgenic rats
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Dysregulated luminal bacterial antigen-specific T-cell responses and antigen-presenting cell function in HLA-B27 transgenic rats with chronic colitis

IMMUNOLOGY, 116(1), 112–121.

By: B. Qian*, S. Tonkonogy, F. Hoentjen*, L. Dieleman* & R. Sartor n

author keywords: antigen-presenting cells; CD4(+) T lymphocytes; enteric bacterial antigens; HLA-B27 transgenic rats
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria

GASTROENTEROLOGY, 128(4), 891–906.

By: S. Kim*, S. Tonkonogy, C. Albright*, J. Tsang*, E. Balish*, J. Braun*, M. Huycke*, R. Sartor*

Source: Web Of Science
Added: August 6, 2018

2004 journal article

Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 136(1), 30–39.

By: L. Dieleman*, F. Hoentjen n, B. Qian n, D. Sprengers n, E. Tjwa n, M. Torres n, C. Torrice n, R. Sartor n, S. Tonkonogy

author keywords: cytokines; HLA-B27; transgenic rats; commensal bacteria
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice

INFLAMMATORY BOWEL DISEASES, 8(2), 71–80.

By: M. Schultz*, C. Veltkamp*, L. Dieleman*, W. Grenther, P. Wyrick*, S. Tonkonogy, R. Sartor*

author keywords: probiotics; experimental colitis; interleukin-10 knockout mice
Source: Web Of Science
Added: August 6, 2018

2001 article

Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg is an element of 26 mice

Veltkamp, C., Tonkonogy, S. L., De Jong, Y. P., Albright, C., Grenther, W. B., Balish, E., … Sartor, R. B. (2001, March). GASTROENTEROLOGY, Vol. 120, pp. 900–913.

By: C. Veltkamp*, S. Tonkonogy, Y. De Jong*, C. Albright*, W. Grenther, E. Balish*, C. Terhorst*, R. Sartor*

Source: Web Of Science
Added: August 6, 2018

2001 journal article

Disrupted B-lymphocyte development and survival in interleukin-2-deficient mice

IMMUNOLOGY, 104(2), 127–134.

By: M. Schultz*, S. Clarke*, L. Arnold*, R. Sartor* & S. Tonkonogy

Source: Web Of Science
Added: August 6, 2018

2000 journal article

Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice

INFECTION AND IMMUNITY, 68(9), 5107–5113.

By: L. Dieleman*, A. Arends*, S. Tonkonogy, M. Goerres*, D. Craft*, W. Grenther, R. Sellon, E. Balish*, R. Sartor*

Source: Web Of Science
Added: August 6, 2018

2000 journal article

Natural killer cell-dependent immunoglobulin G2a anti-bovine serum albumin (BSA) response elicited by high molecular weight dextran-BSA conjugates associated with dextran-mediated macrophage-natural killer cell interaction

IMMUNOLOGY, 101(4), 474–483.

By: C. Ediriwickrema n, S. Tonkonogy & B. Hammerberg

Source: Web Of Science
Added: August 6, 2018

2000 journal article

Quantitation of thymic and bursal lymphocytes populations in normal and PEMS affected turkeys

Proceedings of the ... Western Poultry Disease Conference, 49(2000), 95–97.

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 276(6), G1461–G1472.

By: M. Schultz*, S. Tonkonogy, R. Sellon, C. Veltkamp*, V. Godfrey*, J. Kwon n, W. Grenther, E. Balish*, I. Horak*, R. Sartor*

author keywords: interleukin-2-deficient mice; luminal flora; colitis; animal models
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice

JOURNAL OF EXPERIMENTAL MEDICINE, 190(7), 1013–1023.

By: L. Haynes*, P. Linton*, S. Eaton*, S. Tonkonogy & S. Swain*

author keywords: T cell receptor transgenic; CD4 cells; aging; IL-2; gamma c-binding cytokines
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Blockade of both L-selectin and alpha(4) integrins abrogates naive CD4 cell trafficking and responses in gut-associated lymphoid organs

INTERNATIONAL IMMUNOLOGY, 10(7), 961–968.

By: L. Bradley*, M. Malo, S. Fong, S. Tonkonogy & . Watson

author keywords: adhesion molecules; CD4 T lymphocytes; homing; recirculation
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation ininterleukin-10-deficient mice

Infection and Immunity, 66(11), 5224–5231.

By: R. Sellon, S. Tonkonogy, M. Schultz, L. Dieleman, W. Grenther, E. Balish, D. Rennick, R. Sartor

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

L-selectin is not essential for naive CD4 cell trafficking or development of primary responses in Peyer's patches

EUROPEAN JOURNAL OF IMMUNOLOGY, 27(5), 1140–1146.

By: L. Bradley*, M. Malo*, S. Tonkonogy & . Watson*

author keywords: CD4; Peyer's patch; L-selectin; trafficking
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Sensitized liposomes as an antigen delivery system for the stimulation of mucosal immunity

JOURNAL OF DRUG TARGETING, 5(1), 15–24.

By: C. Velez*, S. Tonkonogy, S. Lichtman* & M. Cho*

author keywords: cell proliferation; ELISA; liposomes; mucosal immunity; ovalbumin
Source: Web Of Science
Added: August 6, 2018

1991 review

HELPER T-CELL SUBSETS - PHENOTYPE, FUNCTION AND THE ROLE OF LYMPHOKINES IN REGULATING THEIR DEVELOPMENT

[Review of ]. IMMUNOLOGICAL REVIEWS, 123, 115–144.

By: S. Swain*, L. Bradley*, M. Croft*, S. Tonkonogy, G. Atkins*, A. Weinberg*, D. Duncan*, S. Hedrick*, R. Dutton*, G. Huston*

Source: Web Of Science
Added: August 6, 2018