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Works (33)
Updated: April 4th, 2024 22:20
2022 article
IgD(+) age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged
Kugler-Umana, O., Zhang, W., Kuang, Y., Liang, J., Castonguay, C. H., Tonkonogy, S. L., … Swain, S. L. (2022, September 2). AGING CELL.
author keywords: adaptive immunity; age-associated B cells; aging; influenza; TLR signals
MeSH headings : Animals; Humans; Mice; Antibodies, Viral; Immunoglobulin D; Immunoglobulin G; Immunoglobulin M; Influenza Vaccines; Influenza, Human; Toll-Like Receptor 7; Toll-Like Receptor 9; Vaccines, Inactivated; B-Lymphocytes; T-Lymphocytes
TL;DR:
It is found that in response to influenza, IgD+CD21-CD23-ABC are the precursors of iABC, which is likely the naïve B cells with the potential to become Ab-secreting cells and to provide protection from infection in the aged.
(via Semantic Scholar)
open access via doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 12, 2022
2022 journal article
Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes
BIOMEDICINES, 10(12).
author keywords: E; coli; germ-free; gnotobiotic; T cell receptor repertoire; thymus; CD4+CD8+ T cell
TL;DR:
Results illustrate how gut bacteria shape the TCR repertoire, not simply among mature T cells, but among immature CD4+CD8+ thymocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: January 17, 2023
2018 journal article
Murine Adherent and Invasive E. coli Induces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10(-/-) Mice Independent of Long Polar Fimbriae Adhesin
INFLAMMATORY BOWEL DISEASES, 25(5), 875–885.
author keywords: ileitis; colitis; cytokines; T cells; adherent invasive E. coli
MeSH headings : Animals; Bacterial Adhesion; Escherichia coli / immunology; Escherichia coli Infections / immunology; Escherichia coli Infections / metabolism; Escherichia coli Infections / microbiology; Escherichia coli Infections / pathology; Escherichia coli Proteins / metabolism; Fimbriae Proteins / metabolism; Fimbriae, Bacterial / immunology; Fimbriae, Bacterial / pathology; Inflammation / etiology; Inflammation / metabolism; Inflammation / pathology; Interleukin-10 / physiology; Intestine, Large / immunology; Intestine, Large / metabolism; Intestine, Large / microbiology; Intestine, Large / pathology; Intestine, Small / immunology; Intestine, Small / metabolism; Intestine, Small / microbiology; Intestine, Small / pathology; Mice; Mice, Knockout
TL;DR:
Mice monoassociated with murine AIEC irrespective of LpfA expression developed chronic inflammation accompanied by IL-12/23 p40 production in the small and large intestines and IFN-γ/IL-17 production by CD4 T cells that model the interplay between enteric pathosymbionts, host susceptibility, and enhanced immune responses in people with IBD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 15, 2019
2016 journal article
Transient activation of mucosal effector immune responses by resident intestinal bacteria in normal hosts is regulated by interleukin-10 signalling
IMMUNOLOGY, 148(3), 304–314.
author keywords: germ-free mice; interleukin-10; resident bacteria
MeSH headings : Animals; Antigens, Bacterial / immunology; B-Lymphocytes / immunology; Cells, Cultured; Colitis / etiology; Colitis / immunology; Disease Models, Animal; Escherichia coli / immunology; Escherichia coli Infections / complications; Escherichia coli Infections / immunology; Immunity, Mucosal; Interferon-gamma / metabolism; Interleukin-10 / genetics; Interleukin-10 / metabolism; Intestines / immunology; Intestines / microbiology; Lymphocyte Activation; Mice; Mice, 129 Strain; Mice, Knockout; Signal Transduction; Th1 Cells / immunology
TL;DR:
Findings show that a resident E. coli that induces chronic colitis in monoassociated IL‐10‐deficient mice rapidly but transiently activates the effector immune system in normal hosts, in parallel with induction of protective IL-10 produced by B cells and CD4+ cells that subsequently suppresses this response to mediate mucosal homeostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Molecular detection of bacterial contamination in gnotobiotic rodent units
Gut Microbes, 4(5), 361–370.
MeSH headings : Animal Feed / analysis; Animal Feed / microbiology; Animals; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; DNA, Bacterial / genetics; Feces / microbiology; Germ-Free Life; Mice / microbiology; Polymerase Chain Reaction / methods; RNA, Ribosomal, 16S / genetics; Random Amplified Polymorphic DNA Technique / methods
TL;DR:
These molecular techniques can be utilized to more definitively screen GF and selectively colonized animals for bacterial contamination when Gram stain and/or culture results are un-interpretable or inconsistent.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2011 journal article
Antigen-Presenting Cell Production of IL-10 Inhibits T-Helper 1 and 17 Cell Responses and Suppresses Colitis in Mice
GASTROENTEROLOGY, 141(2), 653–U764.
author keywords: Mouse Model; Inflammatory Bowel Disease; Immune Response; Microbiota
MeSH headings : Adaptive Immunity; Animals; Antigen-Presenting Cells / drug effects; Antigen-Presenting Cells / metabolism; Antigens, Bacterial / immunology; CD11b Antigen / metabolism; CD4-Positive T-Lymphocytes / metabolism; Cells, Cultured; Colitis / immunology; DNA-Binding Proteins / deficiency; DNA-Binding Proteins / genetics; Forkhead Transcription Factors / metabolism; Germ-Free Life; Immunity, Innate; Interferon-gamma / metabolism; Interleukin-10 / deficiency; Interleukin-10 / genetics; Interleukin-10 / immunology; Interleukin-10 / metabolism; Interleukin-10 / pharmacology; Interleukin-12 / metabolism; Interleukin-17 / metabolism; Mice; Mice, Knockout; RNA, Messenger / metabolism; Signal Transduction; Smad Proteins; T-Box Domain Proteins / metabolism; T-Lymphocytes, Regulatory / cytology; Th1 Cells / immunology; Th17 Cells / immunology; Transforming Growth Factor beta / metabolism; Tretinoin / physiology
TL;DR:
IL-10 produced by APCs regulates homeostatic T-cell responses to commensal bacteria and induced more severe colitis and higher levels of inflammatory cytokines in IL-10(-/-), Rag2-replete, Rag2(-/-) mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation
GASTROENTEROLOGY, 141(3), 959–971.
author keywords: IBD; Bacteria-Host Interactions; Bacterial Protease; Intestinal Barrier Function
MeSH headings : Animals; CD4-Positive T-Lymphocytes / physiology; Cadherins / metabolism; Cell Membrane Permeability / physiology; Colitis / etiology; Colitis / metabolism; Colitis / physiopathology; Disease Models, Animal; Enterococcus faecalis / metabolism; Gelatinases / metabolism; Gram-Positive Bacterial Infections / complications; Gram-Positive Bacterial Infections / metabolism; Gram-Positive Bacterial Infections / physiopathology; Interleukin-10 / genetics; Interleukin-10 / metabolism; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Metalloproteases / metabolism; Mice; Mice, Knockout; Mice, Mutant Strains; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The metalloprotease GelE, produced by commensal strains of E faecalis, contributes to development of chronic intestinal inflammation in mice that are susceptible to intestinal inflammation (IL-10(-/-) and TNF(ΔARE/Wt) mice) by impairing epithelial barrier integrity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Adaptation in a Mouse Colony Monoassociated with Escherichia coli K-12 for More than 1,000 Days
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(14), 4655–4663.
MeSH headings : Animals; Escherichia coli K12 / genetics; Escherichia coli K12 / growth & development; Gastrointestinal Tract / microbiology; Longitudinal Studies; Mice; Restriction Mapping
TL;DR:
The results suggest that monoassociated mice might be used as a tool for characterizing niches occupied by the intestinal flora and potentially as a method of targeting the evolution of bacteria for applications in biotechnology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 conference paper
Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-lO-deficient mice
Inflammatory Bowel Diseases, 15(7), 1022–1031.
MeSH headings : Animals; Antigens, Bacterial / immunology; Bifidobacteriales Infections / complications; Bifidobacteriales Infections / immunology; Bifidobacteriales Infections / pathology; Bifidobacterium / immunology; Colitis / immunology; Colitis / microbiology; Colitis / pathology; Dendritic Cells / immunology; Dendritic Cells / microbiology; Dendritic Cells / pathology; Disease Models, Animal; Duodenitis / immunology; Duodenitis / microbiology; Duodenitis / pathology; Epitopes / immunology; Interleukin-10 / genetics; Interleukin-10 / immunology; Interleukin-12 / immunology; Interleukin-23 / immunology; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Severity of Illness Index; Th1 Cells / immunology; Th1 Cells / microbiology; Th1 Cells / pathology
TL;DR:
B. animalis, a traditional probiotic species that is expanded in experimental colitis in this model, induces marked duodenal and mild colonic inflammation and TH1/TH17 immune responses when introduced alone into GF IL‐10−/− mice, suggesting a potential pathogenic role for this commensal bacterial species in a susceptible host.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria
IMMUNOLOGY LETTERS, 123(1), 77–87.
author keywords: Cytokine regulation; Antigen presenting cells; IL-10 deficient mice
MeSH headings : Animals; Antigen-Presenting Cells / drug effects; Antigen-Presenting Cells / immunology; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / microbiology; Coculture Techniques; Colitis / immunology; Colitis / microbiology; Colon / immunology; Colon / microbiology; Enterobacteriaceae / immunology; Interferon-gamma / biosynthesis; Interferon-gamma / immunology; Interleukin-10 / genetics; Interleukin-10 / immunology; Interleukin-10 / pharmacology; Interleukin-12 / biosynthesis; Interleukin-12 / immunology; Interleukin-17 / biosynthesis; Interleukin-17 / immunology; Interleukin-23 / biosynthesis; Interleukin-23 / immunology; Mice; Mice, Knockout
TL;DR:
The results show that endogenous IL-10 produced by APC inhibits responses to commensal bacteria and influences the ability of APC to stimulate IFN-gamma-producing effector lymphocytes, which reciprocally, induce IL- 10 production byAPC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Aberrant Innate Immune Responses in TLR-ligand Activated HLA-B27 Transgenic Rat Cells
INFLAMMATORY BOWEL DISEASES, 14(10), 1358–1365.
author keywords: HLA-B27 transgenic rats; bacterial adjuvants; Toll-like receptors; innate immune responses; splenocytes
MeSH headings : Animals; Bacteria / immunology; Colitis / genetics; Colitis / immunology; Flow Cytometry; Gene Expression; Germ-Free Life / immunology; HLA-B27 Antigen / genetics; Humans; Immunity, Innate; Interleukin-10 / metabolism; Rats; Rats, Inbred F344; Rats, Transgenic; Specific Pathogen-Free Organisms / immunology; Spleen / cytology; T-Lymphocyte Subsets / immunology; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / metabolism; Toll-Like Receptors / genetics; Toll-Like Receptors / metabolism; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
HLA‐B27 TG rats have an aberrant cell composition, altered functional TLR expression, and an intrinsic defect in IL‐10 production in response to TLR ligands, which may result in exaggerated proinflammatory responses to commensal enteric bacteria and uncontrolled inflammation in this colitis model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Reduced responsiveness of HLA-B27 transgenic rat cells to TGF-beta and IL-10-mediated regulation of IFN-gamma production
INFLAMMATORY BOWEL DISEASES, 14(7), 921–930.
author keywords: HLA-B27 transgenic rats; cytokines; defective regulation
MeSH headings : Animals; Animals, Genetically Modified; Bacteria / immunology; Blotting, Western; Cells, Cultured; Colitis / physiopathology; Down-Regulation; Enzyme-Linked Immunosorbent Assay; HLA-B27 Antigen / genetics; Interferon-gamma / biosynthesis; Interleukin-10 / biosynthesis; Interleukin-10 / pharmacology; Interleukin-12 / pharmacology; Lymph Nodes / drug effects; Mesentery; Rats; Specific Pathogen-Free Organisms; Transforming Growth Factor beta / pharmacology
TL;DR:
An attenuated response to regulatory signals leads to uncontrolled potentiated induction of effector IFN‐&ggr; responses to commensal bacteria in HLA‐B27 TG rats that spontaneously develop chronic intestinal inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling
American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(4), G780–G787.
author keywords: bacterial colonization; fucosylation
MeSH headings : Animals; Colon / microbiology; Extracellular Signal-Regulated MAP Kinases / physiology; Fucosyltransferases / physiology; Germ-Free Life; Intestinal Mucosa / microbiology; JNK Mitogen-Activated Protein Kinases / physiology; Mice; Signal Transduction / physiology; Symbiosis
TL;DR:
Pioneer-mutualist symbiotic bacteria may utilize the ERK and JNK signaling cascade to induce the high degree of fucosylation characteristic of adult mammalian colon, and it is speculated that this fucOSylation facilitates colonization by adult microbiota.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 20, 2019
2007 journal article
Dual-association of gnotobiotic IL-10-/- mice vith 2 nonpathogenic commensal bacteria induces aggressive pancolitis
INFLAMMATORY BOWEL DISEASES, 13(12), 1457–1466.
author keywords: gnotobiotic IL-10-/- mice; pancolitis; commensal bacteria
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Colitis / immunology; Colitis / microbiology; Colon / chemistry; Colon / pathology; Colony Count, Microbial; Duodenitis / immunology; Duodenitis / microbiology; Enterococcus faecalis / growth & development; Escherichia coli / growth & development; Escherichia coli Infections / immunology; Escherichia coli Infections / microbiology; Germ-Free Life; Gram-Positive Bacterial Infections / immunology; Gram-Positive Bacterial Infections / microbiology; Interferon-gamma / analysis; Interleukin-10 / deficiency; Interleukin-12 / genetics; Interleukin-23 / genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B / biosynthesis; Up-Regulation
TL;DR:
Two commensal bacteria that individually induce phenotypically distinct colitis in gnotobiotic IL‐10−/− mice act additively to induce aggressive pancolitis and duodenal inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Adoptive transfer of nontransgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 143(3), 474–483.
author keywords: T cells; HLA-B27; nude; transgenic rats; commensal bacteria
MeSH headings : Adoptive Transfer; Animals; Animals, Genetically Modified; Bacteria / immunology; Cecum / immunology; Cecum / microbiology; Cell Extracts / immunology; Cell Proliferation; Colitis / etiology; Colitis / immunology; Colitis / microbiology; Colitis / pathology; Cytokines / biosynthesis; Disease Models, Animal; HLA-B27 Antigen / genetics; HLA-B27 Antigen / metabolism; Interleukin-1 / immunology; Lymphocyte Activation; Lymphocyte Transfusion; Mesentery; Peroxidase / metabolism; Rats; Rats, Inbred F344; Rats, Nude
TL;DR:
Interestingly, proliferating donor TG T cells were detectable one week after adoptive transfer into rnu/rnu TG recipients but not after transfer into non‐TG recipients, suggesting that activation of effector T cells by other cell types that express HLA‐B27 is pivotal for the pathogenesis of colitis in this model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
CD4(+) T lymphocytes mediate colitis in HLA-B27 transgenic rats monoassociated with nonpathogenic Bacteroides vulgatus
INFLAMMATORY BOWEL DISEASES, 13(3), 317–324.
author keywords: Bacteroides vulgatus; cytokines; HLA-B27; transgenic rats
MeSH headings : Animals; Bacteroides; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / microbiology; Colitis / immunology; HLA-B27 Antigen / immunology; Interferon-gamma / metabolism; Interleukin-10 / metabolism; Organisms, Genetically Modified; Rats; Rats, Nude
TL;DR:
These results implicate CD4+ T cells in the development of colitis in HLA‐B27 TG rats monoassociated with the nonpathogenic bacterial strain B. vulgatus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Dysregulated luminal bacterial antigen-specific T-cell responses and antigen-presenting cell function in HLA-B27 transgenic rats with chronic colitis
IMMUNOLOGY, 116(1), 112–121.
author keywords: antigen-presenting cells; CD4(+) T lymphocytes; enteric bacterial antigens; HLA-B27 transgenic rats
MeSH headings : Animals; Animals, Genetically Modified; Antigen-Presenting Cells / immunology; Antigens, Bacterial / immunology; CD4-Positive T-Lymphocytes / immunology; Cecum / immunology; Cecum / microbiology; Cells, Cultured; Chronic Disease; Coculture Techniques; Colitis / immunology; Colitis / microbiology; Female; Germ-Free Life; HLA-B27 Antigen / analysis; HLA-B27 Antigen / genetics; Interferon-gamma / biosynthesis; Interferon-gamma / immunology; Interleukin-10 / biosynthesis; Interleukin-10 / immunology; Lymph Nodes / immunology; Male; Rats; Rats, Inbred F344; T-Lymphocyte Subsets / immunology
TL;DR:
It is concluded that commensal luminal bacterial components induce exaggerated in vitro IFN‐γ responses in HLA‐B27 TG T cells, which may in turn inhibit the production of regulatory molecules, such as IL‐10.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Luminal bacterial antigen-specific CD4(+) T-cell responses in HLA-B27 transgenic rats with chronic colitis are mediated by both major histocompatibility class II and HLA-B27 molecules
IMMUNOLOGY, 117(3), 319–328.
author keywords: CD4(+) T-cell responses; HLA-B27; MHC class II; enteric bacterial antigens; transgenic rats
MeSH headings : Animals; Animals, Genetically Modified; Antigen-Presenting Cells / immunology; Antigens, Bacterial / immunology; CD4-Positive T-Lymphocytes / immunology; Cells, Cultured; Chronic Disease; Coculture Techniques; Colitis / immunology; Enterobacteriaceae / immunology; Female; HLA-B27 Antigen / genetics; HLA-B27 Antigen / immunology; Histocompatibility Antigens Class II / immunology; Interferon-gamma / biosynthesis; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Male; Rats
TL;DR:
Data implicate both native rat MHC class II and TG HLA‐B27 in CD4+ MLN T‐cell IFN‐γ responses to commensal enteric microflora in this colitis model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
GASTROENTEROLOGY, 128(4), 891–906.
MeSH headings : Animals; Antibody Formation; Antigens, Bacterial / immunology; CD4-Positive T-Lymphocytes / immunology; Cecal Diseases / microbiology; Cecal Diseases / pathology; Chronic Disease; Colitis / microbiology; Colitis / pathology; Colony Count, Microbial; Cytokines / biosynthesis; Disease Progression; Enterococcus faecalis / immunology; Enterocolitis / genetics; Enterocolitis / metabolism; Enterocolitis / microbiology; Enterocolitis / pathology; Escherichia coli / immunology; Escherichia coli Infections / microbiology; Gastroenteritis / microbiology; Gastroenteritis / pathology; Gram-Positive Bacterial Infections / microbiology; Interleukin-10 / deficiency; Intestinal Mucosa / metabolism; Lymph Nodes / immunology; Mice; Mice, Knockout; Phenotype
TL;DR:
Different commensal bacterial species selectively initiate immune-mediated intestinal inflammation with distinctly different kinetics and anatomic distribution in the same host.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Reduced ratio of protective versus proinflammatory cytokine responses to commensal bacteria in HLA-B27 transgenic rats
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 136(1), 30–39.
author keywords: cytokines; HLA-B27; transgenic rats; commensal bacteria
MeSH headings : Animals; Animals, Genetically Modified; Antigen-Presenting Cells / immunology; B-Lymphocytes / immunology; Bacteria / immunology; Cecum / microbiology; Cecum / pathology; Cells, Cultured; Colitis / genetics; Colitis / immunology; Colitis / microbiology; Cytokines / biosynthesis; Cytokines / genetics; Gene Expression; Germ-Free Life; HLA-B27 Antigen / genetics; Lymph Nodes / immunology; RNA, Messenger / genetics; Rats; Rats, Inbred F344; T-Lymphocyte Subsets / immunology
TL;DR:
Colitis that develops in SPF HLA‐B27 TG rats is accompanied by activation of IFN‐γ‐producing CD4+ T cells that respond to commensal bacteria, which indicates that B cell cytokine production in response to components of commensals intestinal microorganisms occurs in the absence of intestinal inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice
INFLAMMATORY BOWEL DISEASES, 8(2), 71–80.
author keywords: probiotics; experimental colitis; interleukin-10 knockout mice
MeSH headings : Administration, Oral; Animals; Colitis / immunology; Colitis / microbiology; Colitis / pathology; Colitis / prevention & control; Disease Models, Animal; Interleukin-10 / deficiency; Interleukin-10 / genetics; Lactobacillus / classification; Lactobacillus / physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Probiotics / administration & dosage; Probiotics / therapeutic use; Specific Pathogen-Free Organisms
TL;DR:
Results demonstrate that L. plantarum can attenuate immune-mediated colitis and suggest a potential therapeutic role for this agent in clinical inflammatory bowel diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 article
Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg is an element of 26 mice
Veltkamp, C., Tonkonogy, S. L., De Jong, Y. P., Albright, C., Grenther, W. B., Balish, E., … Sartor, R. B. (2001, March). GASTROENTEROLOGY, Vol. 120, pp. 900–913.
MeSH headings : Animals; Bacterial Physiological Phenomena; Bone Marrow Transplantation; Colitis / microbiology; Colitis / pathology; Colitis / prevention & control; Colon / microbiology; Colon / pathology; Germ-Free Life; Immunocompetence / physiology; Intestinal Mucosa / cytology; Lymph Nodes / cytology; Mesentery; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Phenotype; T-Lymphocytes / physiology; T-Lymphocytes / transplantation; Wasting Syndrome / prevention & control
TL;DR:
Activated T cells are present in the mucosa of BM-->GF Tg(epsilon26) mice but are incapable of inducing disease unless colonic bacteria are present, and pathogenic T cells require the continuous presence of Colonic bacteria to sustain colitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Disrupted B-lymphocyte development and survival in interleukin-2-deficient mice
IMMUNOLOGY, 104(2), 127–134.
MeSH headings : Animals; Ascitic Fluid / immunology; B-Lymphocytes / immunology; B-Lymphocytes / pathology; Bone Marrow Cells / immunology; Cell Differentiation / immunology; Cell Survival / immunology; Flow Cytometry; Hematopoietic Stem Cells / immunology; Immunoglobulin G / biosynthesis; Immunoglobulin G / blood; Interleukin-2 / deficiency; Interleukin-2 / immunology; Mice; Mice, Inbred C57BL; Spleen / immunology; T-Lymphocyte Subsets / immunology
TL;DR:
It is concluded that conventional B cells in older IL‐2−/− mice are lost by attrition owing to a derangement in B‐cell development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice
INFECTION AND IMMUNITY, 68(9), 5107–5113.
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Colitis / etiology; Germ-Free Life; Helicobacter / pathogenicity; Interleukin-10 / deficiency; Interleukin-10 / physiology; Lymphocyte Activation; Mice; Mice, Inbred C57BL
TL;DR:
It was found that IL-10−/− mice monoassociated with H. hepaticus for up to 16 weeks showed almost no histologic colitis or increased IL-12 production, and therefore is not required to induce colitis in genetically susceptible hosts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Natural killer cell-dependent immunoglobulin G2a anti-bovine serum albumin (BSA) response elicited by high molecular weight dextran-BSA conjugates associated with dextran-mediated macrophage-natural killer cell interaction
IMMUNOLOGY, 101(4), 474–483.
MeSH headings : Adjuvants, Immunologic; Animals; Cell Communication / immunology; Cell Culture Techniques; Dextrans / immunology; Dose-Response Relationship, Immunologic; Immunization / methods; Immunoglobulin G / biosynthesis; Interferon-gamma / biosynthesis; Interleukin-12 / biosynthesis; Killer Cells, Natural / immunology; Macrophages / immunology; Male; Mice; Mice, Inbred BALB C; Molecular Weight; Serum Albumin, Bovine / immunology; Spleen / immunology
TL;DR:
The results indicate an IL‐12‐dependent positive feedback interaction between NK cells and Mφ that supports a NK cell/IFN‐γ‐dependent mechanism for enhancement of anti‐BSA IgG2a antibody responses in mice immunized with HMW‐DEX–BSA protein conjugates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Quantitation of thymic and bursal lymphocytes populations in normal and PEMS affected turkeys
Proceedings of the ... Western Poultry Disease Conference, 49(2000), 95–97.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 276(6), G1461–G1472.
author keywords: interleukin-2-deficient mice; luminal flora; colitis; animal models
MeSH headings : Animals; Colitis / etiology; Colitis / pathology; Colon / metabolism; Digestive System / pathology; Gastritis / etiology; Gastritis / pathology; Germ-Free Life; Hepatitis, Animal / etiology; Immunoglobulins / biosynthesis; Interleukin-2 / deficiency; Interleukin-2 / genetics; Interleukin-2 / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout / genetics; Time Factors
TL;DR:
In contrast to other genetically engineered rodents, IL-2 -/- mice develop mild focal gastrointestinal and active portal tract inflammation in the absence of viable bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice
JOURNAL OF EXPERIMENTAL MEDICINE, 190(7), 1013–1023.
author keywords: T cell receptor transgenic; CD4 cells; aging; IL-2; gamma c-binding cytokines
MeSH headings : Aging / immunology; Animals; CD4-Positive T-Lymphocytes / cytology; CD4-Positive T-Lymphocytes / immunology; Cell Differentiation / drug effects; Cell Differentiation / immunology; Cells, Cultured; Cytokines / biosynthesis; Cytokines / pharmacology; H-2 Antigens / immunology; Interferon-gamma / biosynthesis; Interferon-gamma / pharmacology; Interleukin-2 / biosynthesis; Interleukin-2 / pharmacology; Interleukin-4 / biosynthesis; Interleukin-4 / pharmacology; Interleukin-5 / biosynthesis; Interleukin-5 / pharmacology; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Receptors, Antigen, T-Cell, alpha-beta / genetics; Receptors, Antigen, T-Cell, alpha-beta / immunology; Recombinant Proteins / pharmacology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; Th1 Cells / immunology; Th2 Cells / immunology
TL;DR:
The results indicate that responding naive CD4 cells from aged mice, compared with cells from young mice, make less interleukin (IL)-2, expand poorly between days 3 to 5, and give rise to fewer effectors with a less activated phenotype and reduced ability to produce cytokines, suggesting that the effect of aging on IL-2 production is reversible only in the presence of exogenous IL-1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Blockade of both L-selectin and alpha(4) integrins abrogates naive CD4 cell trafficking and responses in gut-associated lymphoid organs
INTERNATIONAL IMMUNOLOGY, 10(7), 961–968.
author keywords: adhesion molecules; CD4 T lymphocytes; homing; recirculation
MeSH headings : Animals; Antibodies, Monoclonal / pharmacology; Antigens, CD / physiology; CD4-Positive T-Lymphocytes / immunology; Endothelium, Lymphatic / immunology; Female; Integrin alpha4; L-Selectin / physiology; Lymph Nodes / cytology; Lymph Nodes / immunology; Lymphocyte Activation / physiology; Male; Mice; Mice, Inbred C57BL; Peyer's Patches / cytology; Peyer's Patches / immunology; Rats
TL;DR:
Recirculation of naive CD4 cells through tissues where entry is controlled through HEV is essential for the local generation of primary responses, and a blockade of both adhesion pathways on the recirculation is examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation ininterleukin-10-deficient mice
Infection and Immunity, 66(11), 5224–5231.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
L-selectin is not essential for naive CD4 cell trafficking or development of primary responses in Peyer's patches
EUROPEAN JOURNAL OF IMMUNOLOGY, 27(5), 1140–1146.
author keywords: CD4; Peyer's patch; L-selectin; trafficking
MeSH headings : Animals; Antibodies, Monoclonal / pharmacology; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; Cell Movement / immunology; L-Selectin / immunology; L-Selectin / physiology; Lymph Nodes / immunology; Lymphocyte Activation; Lymphocyte Depletion; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peyer's Patches / cytology; Peyer's Patches / immunology
TL;DR:
It is shown that anti‐L‐selectin antibody, MEL‐14, inhibited homing of a rigorously purified, homogenous population of naive CD4 cells into both of these tissues as well as peripheral lymph nodes, directly demonstrating a role for this receptor in regulating entry into gut‐associated sites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Sensitized liposomes as an antigen delivery system for the stimulation of mucosal immunity
JOURNAL OF DRUG TARGETING, 5(1), 15–24.
author keywords: cell proliferation; ELISA; liposomes; mucosal immunity; ovalbumin
MeSH headings : Administration, Rectal; Animals; Antigens / administration & dosage; Antigens / immunology; Bile / immunology; Cholera Toxin / administration & dosage; Cholera Toxin / immunology; Drug Carriers; Feces / chemistry; Ferritins / immunology; Immunity, Mucosal / immunology; Immunoglobulin A / biosynthesis; Immunoglobulin G / biosynthesis; Liposomes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Nitrophenols / chemistry; Nitrophenols / immunology; Ovalbumin / immunology; Peyer's Patches / immunology; Saliva / immunology
TL;DR:
The potential application of antigen-antibody complexes in the stimulation of mucosal immune responses and that MLA may play an important role in overcoming OVA tolerogenicity are supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1991 review
HELPER T-CELL SUBSETS - PHENOTYPE, FUNCTION AND THE ROLE OF LYMPHOKINES IN REGULATING THEIR DEVELOPMENT
[Review of ]. IMMUNOLOGICAL REVIEWS, 123, 115–144.
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Humans; Immunophenotyping; Lymphocyte Activation; Lymphokines / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Helper-Inducer / immunology
TL;DR:
The studies suggest these emerging memory cells may be phenotypically unique and postulate that they are specialized to become a "long-lived" population of memory cells that will persist indefinitely as a protective population of increased frequency for the antigen encountered and which is also able to respond more rapidly and effectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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