Sarah Y Gardner

Works (16)

Updated: April 5th, 2024 01:30

2007 journal article

Cardiovascular effects of acute pulmonary obstruction in horses with recurrent airway obstruction

JOURNAL OF VETERINARY INTERNAL MEDICINE, 21(2), 302–307.

By: A. Johansson*, S. Gardner*, C. Atkins*, D. LaFevers & B. Breuhaus* 

author keywords: cardiac; echocardiogram; equine; heaves
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

The effect of amlodipine and the combination of amlodipine and enalapril on the renin-angiotensin-aldosterone system in the dog

Journal of Veterinary Pharmacology and Therapeutics, 30(5), 394–400.

By: C. Atkins*, W. Rausch*, S. Gardner*, T. Defrancesco* , B. Keene* & J. Levine n 

MeSH headings : Administration, Oral; Aldosterone / urine; Amlodipine / administration & dosage; Amlodipine / blood; Amlodipine / pharmacology; Animals; Antihypertensive Agents / administration & dosage; Antihypertensive Agents / blood; Antihypertensive Agents / pharmacology; Blood Pressure / drug effects; Blood Urea Nitrogen; Dogs / metabolism; Drug Therapy, Combination; Enalapril / administration & dosage; Enalapril / blood; Enalapril / pharmacology; Heart Rate / drug effects; Male; Renin-Angiotensin System / drug effects
TL;DR: Renin-angiotensin-aldosterone system activation was increased by approximately threefold (P < 0.05) with amlodipine administration, but this effect was blunted by enalapril, such that aldosterone excretion was no longer different from that observed under control conditions, although values for 24-h ald testosterone excretion did not return to pretreament levels. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2005 journal article

Stringhalt associated with a pasture infested with Hypochoeris radicata

Equine Veterinary Education, 17(3), 118–122.

By: S. Gardner n, A. Cook*, B. Jortner *, B. Troan  n, N. Sharp n, N. Campbell n, C. Brownie n

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Characterization of the Pharmacokinetic and Pharmacodynamic Properties of the Angiotensin-Converting Enzyme Inhibitor, Enalapril, in Horses

Journal of Veterinary Internal Medicine, 18(2), 231–237.

By: S. Gardner n, C. Atkins n, R. Sams *, A. Schwabenton n & M. Papich n 

TL;DR: There was a tendency (P = .0625) toward a decrease in ACE activity 45-120 minutes after enalapril administration, but ACE activity suppression was never > 16%. (via Semantic Scholar)
Sources: NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018

2004 journal article

Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension

ENVIRONMENTAL HEALTH PERSPECTIVES, 112(8), 872–878.

By: S. Gardner n, J. McGee n, U. Kodavanti  n, A. Ledbetter n, J. Everitt n, D. Winsett n, D. Doerfler n, D. Costa n

author keywords: air pollution; cardiopulmonary; monocrotaline; particle; residual oil fly ash; ventilation
MeSH headings : Animals; Carbon / administration & dosage; Carbon / toxicity; Coal Ash; Disease Models, Animal; Hypertension, Pulmonary / complications; Inflammation; Inhalation Exposure; Lung / pathology; Lung / physiology; Male; Monocrotaline / administration & dosage; Particle Size; Particulate Matter; Rats; Rats, Sprague-Dawley; Respiratory Function Tests / veterinary
TL;DR: ROFA exposure induced histologic changes and abnormalities in several ventilatory parameters, many of which were enhanced by MCT treatment, which enhanced susceptibility to the adverse effects of ambient particulate matter. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

Moxifloxacin pharmacokinetics in horses and disposition into phagocytes after oral dosing

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(1), 57–60.

By: S. Gardner n, J. Davis*, S. Jones* , D. Lafevers*, M. Hoskins*, M. Mcarver*, M. Papich n 

MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / pharmacokinetics; Female; Fluoroquinolones; Horses / metabolism; Moxifloxacin; Phagocytes / metabolism; Quinolines / administration & dosage; Quinolines / blood; Quinolines / pharmacokinetics
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2004 journal article

Pharmacokinetics and pharmacodynamics of furosemide after oral administration to horses

JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(5), 739–743.

By: A. Johansson n, S. Gardner n, J. Levine n , M. Papich n , D. LaFevers n, R. Goldman n, M. Sheets n, C. Atkins n

author keywords: equine; frusemide; loop diuretic; oral bioavailability
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Furosemide continuous rate infusion in the horse: Evaluation of enhanced efficacy and reduced side effects

JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(6), 887–895.

By: A. Johansson n, S. Gardner n, J. Levine n , M. Papich n , D. LaFevers n, L. Fuquay n, V. Reagan n, C. Atkins n

author keywords: electrolyte; equine; fluid balance; frusemide; lasix; loop diuretic
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Hypomagnesemia in hospitalized horses

JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(6), 860–867.

By: A. Johansson n, S. Gardner n, S. Jones n , L. Fuquay n, V. Reagan n & J. Levine n 

author keywords: electrolyte; equine; fluid balance; magnesium
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina

EQUINE VETERINARY JOURNAL, 35(3), 246–251.

By: D. Little n, . Flowers n, B. Hammerberg n & S. Gardner n

author keywords: horse; cyathostome; resistant; benzimidazole; pyrantel
MeSH headings : Animals; Antinematodal Agents / pharmacology; Antinematodal Agents / therapeutic use; Drug Resistance; Drug Resistance, Multiple; Feces / parasitology; Female; Fenbendazole / pharmacology; Fenbendazole / therapeutic use; Horses; Intestinal Diseases, Parasitic / drug therapy; Intestinal Diseases, Parasitic / parasitology; Intestinal Diseases, Parasitic / veterinary; Ivermectin / pharmacology; Ivermectin / therapeutic use; North Carolina; Parasite Egg Count / veterinary; Parasitic Sensitivity Tests / veterinary; Pyrantel / pharmacology; Pyrantel / therapeutic use; Strongyle Infections, Equine / drug therapy; Strongyle Infections, Equine / parasitology; Strongyloidea / drug effects; Treatment Outcome
TL;DR: Targeted ivermectin treatment may be an economically viable method of managing multiple drug resistant cyathostome infection in consecutive foal crops and should be monitored closely for development of resistance. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 journal article

Congestive heart failure in horses: 14 cases (1984-2001)

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 220(10), 1512–1515.

By: J. Davis n, S. Gardner n, B. Schwabenton n & B. Breuhaus n 

MeSH headings : Animals; Echocardiography / veterinary; Female; Heart Failure / diagnosis; Heart Failure / mortality; Heart Failure / therapy; Heart Failure / veterinary; Horse Diseases / diagnosis; Horse Diseases / mortality; Horse Diseases / therapy; Horses; Male; Prognosis; Retrospective Studies; Tachycardia / diagnosis; Tachycardia / therapy; Tachycardia / veterinary; Treatment Outcome
TL;DR: It is suggested that congestive heart failure is rare in horses and echocardiography was useful in determining the underlying cause in affected horses. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 25(2), 99–104.

By: J. Davis n, S. Gardner n, S. Jones n , B. Schwabenton n & M. Papich n 

MeSH headings : Actinomycetales Infections / drug therapy; Actinomycetales Infections / veterinary; Administration, Oral; Animals; Animals, Newborn; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Area Under Curve; Azithromycin / administration & dosage; Azithromycin / blood; Azithromycin / pharmacokinetics; Azithromycin / therapeutic use; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid / veterinary; Female; Horse Diseases / drug therapy; Horses / metabolism; Infusions, Intravenous / veterinary; Macrophages, Alveolar / metabolism; Male; Phagocytes / metabolism; Rhodococcus equi
TL;DR: The properties of azithromycin suggest that it may be an alternative to erythromycin for treatment of Rhodococcus equi pneumonia in foals and its disposition in plasma, polymorphonuclear leukocytes (PMN), and alveolar cells was examined to investigate this possibility. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2001 journal article

Comparison of cefepime pharmacokinetics in neonatal foals and adult dogs

Journal of Veterinary Pharmacology and Therapeutics, 24(3), 187–192.

By: S. Gardner n & M. Papich n 

MeSH headings : Animals; Animals, Newborn; Body Weight; Cefepime; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Dogs / metabolism; Female; Horses / metabolism; Injections, Intravenous / veterinary; Male
TL;DR: D doses for cefepime, a potentially useful antibiotic for neonatal foals and dogs, are determined from the pharmacokinetic values. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2000 journal article

Oil fly ash-induced elevation of plasma fibrinogen levels in rats

TOXICOLOGICAL SCIENCES, 56(1), 175–180.

By: S. Gardner*, . Lehmann & D. Costa

author keywords: particle; air pollution; lung; plasma fibrinogen; plasma viscosity; coagulation; particulate matter; residual oil fly ash; Mt. Saint Helen's volcanic ash; alveolitis; coagulation
MeSH headings : Air Pollutants / toxicity; Animals; Blood Cell Count; Blood Coagulation Tests; Blood Viscosity; Carbon / administration & dosage; Carbon / toxicity; Coal Ash; Disease Models, Animal; Fibrinogen / metabolism; Intubation, Intratracheal; Lung / drug effects; Lung / metabolism; Male; Particulate Matter; Pulmonary Fibrosis / blood; Pulmonary Fibrosis / chemically induced; Rats; Rats, Sprague-Dawley; Volcanic Eruptions
TL;DR: Testing the hypothesis that exposure of rats to a toxic PM, like ROFA, would adversely alter hemostatic parameters and cardiovascular risk factors thought to be involved in human epidemiologic findings found that alteration of important hematologic parameters through PM induction of an inflammatory response may serve as biomarkers of cardiovascular risk in susceptible individuals. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertension

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 57(8), 543–563.

By: U. Kodavanti *, M. Jackson, A. Ledbetter, . Richards, S. Gardner*, W. Watkinson, M. Campen, D. Costa

MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Carbon / administration & dosage; Carbon / toxicity; Coal Ash; Cytokines / genetics; Cytokines / metabolism; DNA, Complementary / analysis; Disease Models, Animal; Hypertension, Pulmonary / chemically induced; Intubation, Intratracheal; Lung / drug effects; Lung / metabolism; Lung / pathology; Lung Diseases / chemically induced; Lung Diseases / mortality; Lung Diseases / pathology; Male; Monocrotaline / toxicity; Particulate Matter; RNA / metabolism; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Survival Rate
TL;DR: Only the bolus IT ROFA caused mortality in the rat model of lung injury/hypertension, and exacerbation of histological lesions and cytokine mRNA expression were most reflective of increased ROFA susceptibility in this model. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1994 article

PHARMACOKINETICS OF CEFTRIAXONE IN MARES

GARDNER, S. Y., & AUCOIN, D. P. (1994, April). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 17, pp. 155–156.

By: S. Gardner n & D. Aucoin  n

MeSH headings : Animals; Ceftriaxone / adverse effects; Ceftriaxone / blood; Ceftriaxone / pharmacokinetics; Chromatography, High Pressure Liquid; Female; Half-Life; Horses / metabolism; Injections, Intravenous / veterinary
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Source: Web Of Science
Added: August 6, 2018

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