Song Yun Zhu

Works (8)

Updated: July 13th, 2023 13:20

2011 article

C/EBPα Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBPα Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas

Thompson, E. A., Zhu, S., Hall, J. R., House, J. S., Ranjan, R., Burr, J. A., … Smart, R. C. (2011, February 24). Journal of Investigative Dermatology, Vol. 131, pp. 1339–1346.

By: E. Thompson n, S. Zhu n, J. Hall n , J. House n , R. Ranjan n, J. Burr n, Y. He *, D. Owens *, R. Smart n 

Contributors: E. Thompson n, S. Zhu n, J. Hall n , J. House n , R. Ranjan n, J. Burr n, Y. He *, D. Owens *, R. Smart n 

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / analysis; CCAAT-Enhancer-Binding Protein-alpha / physiology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / etiology; Cell Cycle; Cells, Cultured; Genes, p53; Humans; Keratosis, Actinic / metabolism; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mutation; Neoplasms, Radiation-Induced / etiology; Precancerous Conditions / chemistry; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / chemistry; Skin Neoplasms / etiology; Ultraviolet Rays / adverse effects
topics (OpenAlex): DNA Repair Mechanisms; Retinoids in leukemia and cellular processes; Cancer-related Molecular Pathways
TL;DR: It is observed that C/EBPα is induced in normal human epidermal keratinocytes and in the epidermis of human subjects exposed to UVB radiation, and loss of C/ EBPα confers susceptibility toUVB-induced skin SCCs involving defective cell cycle arrest in response to UVBs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 article

C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

House, J. S., Zhu, S., Ranjan, R., Linder, K., & Smart, R. C. (2010, March 22). PLoS ONE, Vol. 5.

By: J. House n , S. Zhu n, R. Ranjan n, K. Linder n & R. Smart n 

Contributors: J. House n , S. Zhu n, R. Ranjan n, K. Linder n & R. Smart n 

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / physiology; CCAAT-Enhancer-Binding Protein-beta / physiology; Cell Cycle; Cell Differentiation; Cell Proliferation; Epithelial Cells / cytology; Gene Expression Regulation; Genotype; Homozygote; Immunoblotting; Immunohistochemistry / methods; Keratinocytes / cytology; Mice; Sebaceous Glands / cytology; Skin / cytology
topics (OpenAlex): Skin and Cellular Biology Research; Hair Growth and Disorders; Skin Protection and Aging
TL;DR: Results indicate that in adult mouse skin, C/EBPα and C-EBPβ are critically involved in regulating sebocyte differentiation and epidermal homeostasis involving the basal to spinous keratinocyte transition and basal cell cycle withdrawal. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 article

C/EBPβ represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19Arf

Ewing, S. J., Zhu, S., Zhu, F., House, J. S., & Smart, R. C. (2008, July 18). Cell Death and Differentiation, Vol. 15, pp. 1734–1744.

By: S. Ewing n, S. Zhu n, F. Zhu n, J. House n  & R. Smart n 

Contributors: S. Ewing n, S. Zhu n, F. Zhu n, J. House n  & R. Smart n 

author keywords: apoptosis; p53; C/EBP beta; p19(Arf); DNA damage; keratinocytes
MeSH headings : Animals; Apoptosis / drug effects; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / metabolism; Carcinogens / toxicity; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cyclophosphamide / administration & dosage; Cyclophosphamide / pharmacology; DNA Damage; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Injections, Intraperitoneal; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Mice; Oncogene Protein p21(ras) / metabolism; Protein Processing, Post-Translational / drug effects; Repressor Proteins / metabolism; Transcriptional Activation / drug effects; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
topics (OpenAlex): Cancer-related Molecular Pathways; DNA Repair Mechanisms; Cell death mechanisms and regulation
TL;DR: Results suggest that inhibition of C/EBPβ may be a target for cancer cotherapy to increase the efficacy of alkylating chemotherapeutic agents and suggest that p19Arf represses p53 to promote cell survival downstream of DNA damage. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 article

Genetic Ablation of CCAAT/Enhancer Binding Protein α in Epidermis Reveals Its Role in Suppression of Epithelial Tumorigenesis

Loomis, K. D., Zhu, S., Yoon, K., Johnson, P. F., & Smart, R. C. (2007, July 15). Cancer Research, Vol. 67, pp. 6768–6776.

By: K. Loomis n, S. Zhu*, K. Yoon*, P. Johnson * & R. Smart n 

MeSH headings : Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-alpha / genetics; Cell Differentiation; Cell Proliferation; Epidermis / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Neoplastic; Keratinocytes / cytology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mutation; NIH 3T3 Cells; ras Proteins / metabolism
topics (OpenAlex): Genomics and Chromatin Dynamics; Retinoids in leukemia and cellular processes; Cancer-related Molecular Pathways
TL;DR: C/EBPalpha is dispensable for epidermal homeostasis and provides genetic evidence that C/EB Palpha is a suppressor of epithelial tumorigenesis, as well as proposed to block cell cycle progression through inhibition of E2F activity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Conditional ablation of C/EBPβ demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis

Sterneck, E., Zhu, S., Ramirez, A., Jorcano, J. L., & Smart, R. C. (2005, October 3). Oncogene, Vol. 25, pp. 1272–1276.

By: E. Sterneck *, S. Zhu n, A. Ramirez *, J. Jorcano * & R. Smart* 

author keywords: C/EBP; apoptosis; carcinogenesis
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens / toxicity; Female; Integrases / metabolism; Keratin-15; Keratin-5; Keratinocytes / metabolism; Keratinocytes / pathology; Keratins / genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / toxicity
topics (OpenAlex): Ubiquitin and proteasome pathways
TL;DR: It is demonstrated that C/EBPβ exerts an essential, keratinocyte-intrinsic role in cell survival in response to carcinogen treatment and the elimination of C/ EBPβ in keratinocytes is sufficient to confer complete resistance of the skin to chemical carcinogenesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Diminished expression of C/EBP alpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBP alpha in carcinoma cells inhibits proliferation

Cancer Research, 65(3), 861–867.

By: M. Shim, K. Powers, S. Ewing, S. Zhu & R. Smart 

Source: NC State University Libraries
Added: August 6, 2018

2004 article

Cell Cycle-Dependent Phosphorylation of C/EBPβ Mediates Oncogenic Cooperativity between C/EBPβ and H-RasV12

Shuman, J. D., Sebastian, T., Kaldis, P., Copeland, T. D., Zhu, S., Smart, R. C., & Johnson, P. F. (2004, August 16). Molecular and Cellular Biology, Vol. 24, pp. 7380–7391.

By: J. Shuman *, T. Sebastian *, P. Kaldis *, T. Copeland*, S. Zhu n, R. Smart n , P. Johnson *

MeSH headings : Amino Acid Sequence; Animals; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; CDC2-CDC28 Kinases / metabolism; Cell Cycle / physiology; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Enzyme Inhibitors / metabolism; Genes, ras; Mice; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; NIH 3T3 Cells; Phosphorylation; Proto-Oncogene Proteins c-raf / genetics; Proto-Oncogene Proteins c-raf / metabolism; Sequence Alignment; Serine / metabolism; Signal Transduction; Threonine / metabolism; ras Proteins / genetics; ras Proteins / metabolism
topics (OpenAlex): Melanoma and MAPK Pathways; Cancer-related Molecular Pathways; Protein Kinase Regulation and GTPase Signaling
TL;DR: It is shown that cell cycle-dependent phosphorylation of C/EBPβ on Ser64 and Thr189 is required to promote Ras-induced transformation of NIH 3T3 cells, and this support a role for C/ EBPβ as a nuclear effector of Ras signaling and transformation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 article

CCAAT/enhancer binding protein-β is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling

Zhu, S., Yoon, K., Sterneck, E., Johnson, P. F., & Smart, R. C. (2001, December 26). Proceedings of the National Academy of Sciences, Vol. 99, pp. 207–212.

By: S. Zhu n, K. Yoon n, E. Sterneck  n, P. Johnson  n & R. Smart n 

MeSH headings : 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Bromodeoxyuridine / pharmacology; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens; Cell Division; Cell Survival; Genes, Reporter; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Mutagens; Mutation; Oncogene Protein p21(ras) / genetics; Oncogene Protein p21(ras) / physiology; Phosphorylation; Signal Transduction; Skin Neoplasms / metabolism; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation
topics (OpenAlex): Retinoids in leukemia and cellular processes; Cancer-related Molecular Pathways
TL;DR: It is reported here that C/EBPβ-nullizygous mice are completely refractory to skin tumor development induced by a variety of carcinogens and carcinogenesis protocols, including 7,12-dimethylbenz[a]anthracene-initiation/12-O-tetradecanoylphorbol 13-acetate promotion, that produce tumors containing oncogenic Ras mutations. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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