Tiffany Aimee Garbutt

Works (2)

Updated: July 5th, 2023 15:34

2020 article

Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains

Garbutt, T. A., Konganti, K., Konneker, T., Hillhouse, A., Phelps, D., Jones, A., … Threadgill, D. W. (2020, October 4). Mammalian Genome, Vol. 31, pp. 263–286.

By: T. Garbutt n, K. Konganti*, T. Konneker n, A. Hillhouse *, D. Phelps n , A. Jones  n, D. Aylor n , D. Threadgill*

MeSH headings : Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Heterogeneity; Immunophenotyping; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Species Specificity; Transcriptome
topics (OpenAlex): Pluripotent Stem Cells Research; CRISPR and Genetic Engineering; 3D Printing in Biomedical Research
TL;DR: Heterogeneity is a naturally occurring, necessary quality of stem cells that allows for the maintenance of pluripotency and this study is the first study to derive stable ESC-like stem cells from the non-permissive NOD/ShiLtJ and WSB/EiJ strains, enabling easier and broader research possibilities into pluripOTency for these and similar non-Permissive mouse strains and species. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2020

2018 article

Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus

Garbutt, T. A., Konneker, T. I., Konganti, K., Hillhouse, A. E., Swift-Haire, F., Jones, A., … Threadgill, D. W. (2018, September 26). Scientific Reports, Vol. 8.

By: T. Garbutt n, T. Konneker n, K. Konganti*, A. Hillhouse *, F. Swift-Haire n, A. Jones  n, D. Phelps n , D. Aylor n , D. Threadgill*

MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
topics (OpenAlex): Pluripotent Stem Cells Research; CRISPR and Genetic Engineering; 3D Printing in Biomedical Research; Neuroethics, Human Enhancement, Biomedical Innovations
TL;DR: iPSC derived in 2iS are more transcriptionally similar to ESC than EpiSC, indicating that iPSC reprogramming acts to overcome genetic background constraints, and only some M. musculus strains are permissive under LIF culture conditions suggesting that this is an evolutionarily derived characteristic in the M.Mus musculus lineage. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018

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