Works (29)

Updated: September 27th, 2024 05:01

2024 review

A Review on the Development of Novel Heterocycles as α-Glucosidase Inhibitors for the Treatment of Type-2 Diabetes Mellitus

[Review of ]. MEDICINAL CHEMISTRY, 20(5), 503–536.

By: P. Patel*, D. Shah*, T. Bambharoliya n, V. Patel*, M. Patel*, D. Patel*, V. Bhavsar*, S. Padhiyar* ...

author keywords: Type 2 diabetes mellitus; alpha-glucosidase; heterocycles; hybrid molecules; synthesis; hyperglycemic
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 11, 2024

2024 article

Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies

Patel, V., Bambharoliya, T., Shah, D., Patel, D., Patel, M., Shah, U., … Patel, A. (2024, August 6). CURRENT TOPICS IN MEDICINAL CHEMISTRY.

By: V. Patel*, T. Bambharoliya n, D. Shah*, D. Patel*, M. Patel*, U. Shah*, M. Patel*, S. Patel* ...

author keywords: Chromene; Microwave synthesis; Green solvent; Ultrasound-assisted; Green chemistry
Source: Web Of Science
Added: September 16, 2024

2024 review

Unlocking the Potential: A Comprehensive Review for the Synthesis of Benzofuran Derivatives

[Review of ]. CURRENT GREEN CHEMISTRY, 11(1), 12–36.

By: K. Patel*, H. Patel*, D. Shah*, D. Patel*, N. Savaliya*, T. Bambharoliya n, A. Shah*, A. Mahavar*, A. Patel*

author keywords: Benzofuran; heterocyclic chemistry; synthetic methodologies; ubiquitous fragment; benzofuran-based molecules
Source: Web Of Science
Added: January 22, 2024

2023 article

Emerging green synthetic routes for thiazole and its derivatives: Current perspectives

Patel, M., Bambharoliya, T., Shah, D., Patel, K., Patel, M., Shah, U., … Patel, A. (2023, November 27). ARCHIV DER PHARMAZIE.

author keywords: green synthesis; heterocycles; thiazole
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 18, 2023

2023 article

Recent Progress for the Synthesis of ss-Carboline Derivatives - an Update

Patel, V., Bambharoliya, T., Shah, D., Patel, Y., Savaliya, N., Patel, Y., … Patel, A. (2023, February 20). POLYCYCLIC AROMATIC COMPOUNDS.

By: V. Patel*, T. Bambharoliya n, D. Shah*, Y. Patel*, N. Savaliya*, Y. Patel*, R. Patel*, V. Bhavsar* ...

author keywords: beta-Carboline; pictet-spengler cyclization; pyrido[34-b]indole; Heterocycle
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 20, 2023

2023 review

Sustainable Synthesis of Phenazines: A Review of Green Approaches

[Review of ]. CURRENT ORGANIC CHEMISTRY, 27(13), 1143–1163.

author keywords: Phenazine; heterocyclic scaffold; green synthesis; ubiquitous fragment; sustainable chemistry; active chemicals
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 12, 2024

2023 journal article

Ultrasound-Assisted Synthesis of Benzimidazole Derivatives: A Catalyst-Free Green Chemistry Approach

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 59(8), 1397–1406.

By: D. Shah*, A. Patel*, S. Patel*, M. Mehta*, Y. Patel*, B. Bhimani*, T. Bambharoliya n

author keywords: Benzimidazole; ultrasound-assisted synthesis; green chemistry; one-pot synthesis; catalyst-free
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 16, 2024

2022 review

A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase Inhibitor for the Treatment of Alzheimer's Disease

[Review of ]. CURRENT DRUG TARGETS, 24(3), 225–246.

author keywords: Alzheimer's disease (AD); Acetylcholinesterase (AChE); heterocyclic; scaffolds; CAS; peripheral anionic site (PAS)
MeSH headings : Humans; Cholinesterase Inhibitors / pharmacology; Cholinesterase Inhibitors / therapeutic use; Alzheimer Disease / drug therapy; Acetylcholinesterase / chemistry; Acetylcholinesterase / therapeutic use; Tacrine / pharmacology; Tacrine / therapeutic use; Tacrine / chemistry; Amyloid beta-Peptides
TL;DR: The results suggest that all the compounds constitute promising leads for the AChE targeted approach for Alzheimer's disease, and most of the compounds show a low toxicity profile during in vivo studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 17, 2023

2022 review

A review on synthetic investigation for quinoline- recent green approaches

[Review of ]. GREEN CHEMISTRY LETTERS AND REVIEWS, 15(2), 336–371.

By: A. Patel*, S. Patel*, M. Mehta*, Y. Patel*, R. Patel*, D. Shah*, D. Patel*, U. Shah* ...

Contributors: A. Patel*, S. Patel*, M. Mehta*, Y. Patel*, R. Patel*, D. Shah*, D. Patel*, U. Shah* ...

author keywords: Quinoline; green chemistry; microwave synthesis; solvent-free approach; multicomponent reaction
TL;DR: Light is shed on various reactions to produce quinolines and their derivatives using various green synthetic methods to decrease the use of chemicals, solvents, and catalysts which are detrimental to both humans and the environment. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 25, 2022

2022 journal article

In silico Study and Solvent-free one-pot Synthesis of Tetrahydropyrimidine derivatives by Mechanochemistry Approach for Targeting Human Neutrophil Elastase against Lung Cancer

CURRENT COMPUTER-AIDED DRUG DESIGN, 18(4), 293–306.

By: A. Patel*, K. Gandhi*, S. Shah*, D. Patel*, S. Chhatbar*, D. Shah*, S. Patel*, H. Patel*, T. Bambharoliya n

author keywords: Biginelii condensation; mechanochemistry; human neutrophil elastase; tetrahydropyrimidine; lung cancer; green chemistry
MeSH headings : Humans; Leukocyte Elastase / chemistry; Leukocyte Elastase / metabolism; Molecular Docking Simulation; Solvents; Lung Neoplasms / drug therapy
TL;DR: The tetrahydropyrimidine scaffold and its derivatives may serve as potential HNE inhibitors for the development of a promising anti-cancer agent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 14, 2022

2022 review

Mini Review on Cariprazine: A Promising Antipsychotic Agent

[Review of ]. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 22(2), 226–236.

By: A. Patel*, A. Patel*, D. Patel*, K. Patel* & T. Bambharoliya n

author keywords: Cariprazine; Dopamine(D-2; D-3) Receptor; DCAR; DDCAR; Schizophrenia; Bipolar I disorder
MeSH headings : Antipsychotic Agents / pharmacology; Antipsychotic Agents / therapeutic use; Serotonin
TL;DR: The potential benefits of cariprazine as a promising therapeutic alternative in addressing major clinical requirements for better therapy of such severe neuropsychiatric conditions were demonstrated in this summarized review study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: March 31, 2022

2022 journal article

Molecular Docking, <i>In silico</i> ADMET Study and Synthesis of Quinoline Derivatives as Dihydrofolate Reductase (DHFR) Inhibitors: A Solvent-free One-pot Green Approach through Sonochemistry

LETTERS IN DRUG DESIGN & DISCOVERY, 21(3), 504–519.

author keywords: Skraup synthesis; sonochemistry; dihydrofolate reductase (DHFR); quinoline; anti-microbial agent; green chemistry
TL;DR: This environmentally benign sonochemistry-based approach for synthesizing quinoline derivatives could be affordable for large-scale production and become a potential lead candidate for developing a new qu inoline-based antimicrobial agent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 12, 2024

2022 review

Recent Update on the Development of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors: A Promising Target for the Treatment of Parkinson's Disease

[Review of ]. MEDICINAL CHEMISTRY, 18(7), 757–771.

By: A. Patel*, S. Patel*, M. Mehta*, Y. Patel*, D. Langaliya*, S. Bhalodiya*, T. Bambharoliya n

Contributors: A. Patel*, S. Patel*, M. Mehta*, Y. Patel*, D. Langaliya*, S. Bhalodiya*, T. Bambharoliya n

author keywords: Leucine-rich repeat kinase 2 (LRRK2); Parkinson's disease (PD); brain penetrant LRKK2 inhibitors; G2019S-LRRK2 mutant; wild-type LRKK2; promising target
MeSH headings : Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / antagonists & inhibitors; Parkinson Disease / drug therapy; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use
TL;DR: Recent progress on the discovery and development of LRKK2 inhibitors as well as the bioactivity of several small-molecule LRRK2 inhibitors that have been used to inhibit L RRK2 kinase activity in vitro or in vivo are summarized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 27, 2022

2021 review

Development of Natural Bioactive Alkaloids: Anticancer Perspective

[Review of ]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 22(2), 200–212.

By: A. Patel*, R. Vanecha*, J. Patel*, D. Patel*, U. Shah* & T. Bambharoliya n

Contributors: A. Patel*, R. Vanecha*, J. Patel*, D. Patel*, U. Shah* & T. Bambharoliya n

author keywords: Natural alkaloids; anticancer agents; vinblastine; camptothecin; natural herbs; plant products
MeSH headings : Alkaloids / chemistry; Alkaloids / pharmacology; Alkaloids / therapeutic use; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Plants; Prospective Studies
TL;DR: This review focuses on the naturally-derived bioactive alkaloids with prospective anticancer properties based on the information in the literature, and widely formulated as anticancer medications, including camptothecin and vinblastine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 14, 2021

2021 journal article

Exploring the in-silico approach for assessing the potential of natural compounds as a SARS-CoV-2 main protease inhibitors

ORGANIC COMMUNICATIONS, 14(1), 58–72.

By: A. Patel*, A. Patel, R. Hemani*, R. Solanki*, J. Kansara*, G. Patel, S. Pradhan*, T. Bambharoliya n

Contributors: A. Patel*, A. Patel, R. Hemani*, R. Solanki*, J. Kansara*, G. Patel, S. Pradhan*, T. Bambharoliya n

author keywords: SARS-CoV-2; main protease; natural products; molecular docking; viral infection; drug-likeness
TL;DR: Good binding energy, drug-likeness, and efficient pharmacokinetics suggest the potential of NPs derivatives as SARS-CoV-2 main protease (Mpro) inhibitors However, further research is necessary to investigate the ability of these compounds as COVID-19 inhibitors. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: April 26, 2021

2021 review

Quinoxaline as Ubiquitous Structural Fragment: An Update on the Recent Develop-ment of its Green Synthetic Approaches

[Review of ]. CURRENT ORGANIC CHEMISTRY, 25(24), 3004–3016.

By: A. Patel*, D. Shah*, N. Patel*, K. Patel*, N. Soni*, A. Nagai*, U. Shah*, M. Patel* ...

Contributors: A. Patel*, D. Shah*, N. Patel*, K. Patel*, N. Soni*, A. Nagai*, U. Shah*, M. Patel* ...

author keywords: Quinoxaline; green chemistry; o-phenylenediamine; sustainable chemistry; conventional method; microwave irradiation
TL;DR: This review has attempted to shed light on various green synthetic strategies leading to the synthesis of quinoxaline scaffold and its derivatives, such as ultrasound irradiated, microwave irradiation, grindstone technique, environmentally benign solvents/catalysts based, and reactant immobilized on a solid support, etc. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2020 review

A Review on the Synthetic Approach of Marinopyrroles: A Natural Anti-tumor Agent from the Ocean

[Review of ]. LETTERS IN ORGANIC CHEMISTRY, 18(4), 251–264.

By: A. Patel*, H. Shah*, U. Shah*, T. Bambharoliya n, M. Patel*, I. Panchal*, V. Parikh*, A. Nagani* ...

Contributors: A. Patel*, H. Shah*, U. Shah*, T. Bambharoliya n, M. Patel*, I. Panchal*, V. Parikh*, A. Nagani* ...

author keywords: Marinopyrroles; bis-pyrrole; anti-tumor agents; new chemical entities; natural products; streptomycete
TL;DR: Various synthetic pathways of marinopyrroles possessing anti-cancer potential are elaborated on, which could encourage researchers to discover promising anti-tumor agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 10, 2021

2020 journal article

A hybrid vascular graft harnessing the superior mechanical properties of synthetic fibers and the biological performance of collagen filaments

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 118.

By: F. Zhang n, T. Bambharoliya n, Y. Xie n, L. Liu*, H. Celik*, L. Wang*, O. Akkus*, M. King n

Contributors: F. Zhang n, T. Bambharoliya n, Y. Xie n, L. Liu*, H. Celik*, L. Wang*, O. Akkus*, M. King n

author keywords: Tissue-engineered vascular graft; Biomaterial; Hybrid; Electrochemically aligned collagen; Poly (lactic acid)
MeSH headings : Biocompatible Materials / pharmacology; Blood Vessel Prosthesis; Collagen; Endothelial Cells; Tissue Engineering; Tissue Scaffolds
TL;DR: A hybrid tubular vascular tissue engineered scaffold has been circular-knitted using novel electrochemically aligned collagen (ELAC) filaments plied together with traditional poly(lactic acid) (PLA) yarn, which shows excellent mechanical and biological performance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 19, 2021

2020 journal article

Benzimidazole as Ubiquitous Structural Fragment: An Update on Development of its Green Synthetic Approaches

MINI-REVIEWS IN ORGANIC CHEMISTRY, 18(8).

By: A. Patel*, D. Shah*, N. Patel*, K. Patel*, N. Soni*, A. Nagani*, V. Parikh*, H. Shah*, T. Bambharoliya n

Contributors: A. Patel*, D. Shah*, N. Patel*, K. Patel*, N. Soni*, A. Nagani*, V. Parikh*, H. Shah*, T. Bambharoliya n

author keywords: Benzimidazole; green chemistry; o-phenylenediamine; aromatic aldehyde; synthesis; sustainable chemistry
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 16, 2020

2020 chapter

Coronary Artery Disease and The Evolution of Angioplasty Devices

In SpringerBriefs in Materials (pp. 1–62). http://www.scopus.com/inward/record.url?eid=2-s2.0-85127797918&partnerID=MN8TOARS

By: M. King, T. Bambharoliya, H. Ramakrishna & F. Zhang

Contributors: M. King, T. Bambharoliya, H. Ramakrishna & F. Zhang

Source: ORCID
Added: June 27, 2022

2020 chapter

Coronary Microvascular Dysfunction (CMD)

In SpringerBriefs in Materials (pp. 11–14).

By: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

Contributors: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

TL;DR: This chapter describes various pathogenic mechanisms of CMD and explains how CMD can result from functional and/or structural alterations to the vessel wall and lead to varying degrees of disruption to normal coronary physiology. (via Semantic Scholar)
Source: ORCID
Added: June 27, 2022

2020 chapter

Definitions and Basic Mechanism of Coronary Artery Disease (CAD)

In SpringerBriefs in Materials (pp. 3–10).

By: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

Contributors: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

TL;DR: The progression of atherosclerosis and its clinical findings are explained at various stages together with a description of the time course of inflammation and atherosclerotic calcification. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 27, 2022

2020 chapter

Diagnosis of Coronary Artery Disease (CAD)

In SpringerBriefs in Materials (pp. 15–20).

By: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

Contributors: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

TL;DR: This chapter includes a comprehensive approach to the diagnosis and treatment of patients with chest pain according to various clinical guidelines and lists the established and novel biomarkers for the diagnosis of chronic coronary arterial disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 27, 2022

2020 chapter

Epidemiology and Risk Factors

In SpringerBriefs in Materials (pp. 1–2).

By: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

Contributors: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

TL;DR: This chapter shows the data that CAD is and will continue to become a global burden of disease and, by 2035, nearly half of the US population will have some form of cardiovascular disease (CVD). (via Semantic Scholar)
Source: ORCID
Added: June 27, 2022

2020 chapter

Evolution of Angioplasty Devices

In SpringerBriefs in Materials (pp. 31–52).

By: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

Contributors: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

TL;DR: This chapter discusses the evolution in design and development of angioplasty devices including a list of currently available commercial products and experimental designs under research and development to get a glimpse of how the medical device sector is attempting to address this major healthcare problem. (via Semantic Scholar)
Source: ORCID
Added: June 27, 2022

2020 journal article

The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer’s Disease

CNS & Neurological Disorders - Drug Targets, 19(3), 184–194.

By: H. Shah*, A. Patel*, V. Parikh*, A. Nagani*, B. Bhimani*, U. Shah*, T. Bambharoliya n

Contributors: H. Shah*, A. Patel*, V. Parikh*, A. Nagani*, B. Bhimani*, U. Shah*, T. Bambharoliya n

author keywords: Alzheimer's disease; Amyloid Precursor Protein (APP); BACE1; Amyloid beta (A beta); beta-pathway; palmitoylation
MeSH headings : Alzheimer Disease / metabolism; Amyloid Precursor Protein Secretases / metabolism; Amyloid beta-Peptides / metabolism; Amyloid beta-Protein Precursor / metabolism; Animals; Aspartic Acid Endopeptidases / metabolism; Brain / metabolism; Humans; Protein Processing, Post-Translational
TL;DR: This β-secretase cleaves not only Amyloid precursor protein and its homologues but also small series of substrate including neuregulin and β subunit of voltage gated sodium channel that play a very important role in the development and normal function of the brain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: May 29, 2020

2020 chapter

Treatment of Coronary Artery Disease (CAD)

In SpringerBriefs in Materials (pp. 21–29).

By: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

Contributors: M. King n, T. Bambharoliya n, H. Ramakrishna n & F. Zhang n

TL;DR: This chapter presents the alternative therapies for stable ischemic heart disease (SIHD) and for acute coronary syndrome (ACS), such as drug therapy, invasive therapy and minimally invasive therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 27, 2022

2020 journal article

Ultrasound-Assisted One-Pot Synthesis of Tetrahydropyrimidne Derivatives through Biginelli Condensation: A Catalyst Free Green Chemistry Approach

LETTERS IN ORGANIC CHEMISTRY, 18(9), 749–756.

By: A. Patel*, J. Shah*, K. Patel*, K. Patel*, H. Patel*, D. Dobaria*, U. Shah*, M. Patel* ...

Contributors: A. Patel*, J. Shah*, K. Patel*, K. Patel*, H. Patel*, D. Dobaria*, U. Shah*, M. Patel* ...

author keywords: Biginelli condensation; catalyst free; sonochemistry; tetrahydropyrimidine; ultrasound-assisted; sustainable chemistry
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 16, 2021

2019 conference paper

Design and development of stent coated with novel cardiac stem cell-mimicking regenerative factors

Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, 40, 481. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065394023&partnerID=MN8TOARS

By: T. Bambharoliya, S. Hu, K. Cheng & M. King

Contributors: T. Bambharoliya, S. Hu, K. Cheng & M. King

Source: ORCID
Added: June 27, 2022

Employment

Updated: May 21st, 2023 18:31

2023 - present

BD Lexington, Massachusetts, US
Manager of Manufacturing

2020 - 2023

BD Lexington, Massachusetts, US
Extrusion Development Engineer

2015 - 2021

NC State University Raleigh, NC, US
Graduate Research Assistant Wilson College of Textiles

2011 - 2015

Nano Therapeutics Pvt Ltd Surat, Gujarat, IN
Sr. Executive Research and Developement

Education

Updated: January 8th, 2023 18:45

2015 - 2020

NC State University Raleigh, NC, US
PhD (Major- Fiber and Polymer Science and Minor- Biomedical Engineering) Wilson College of Textiles

2009 - 2011

Nirma University Ahmedabad, Gujarat, IN
Master in Pharmaceutical Technology and Biopharmaceutics College of Pharmacy

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