Works (10)
Updated: July 29th, 2023 21:14
2011 journal article
Localized Delivery of Interferon-beta by Lactobacillus Exacerbates Experimental Colitis
PLOS ONE, 6(2).
MeSH headings : Animals; Cells, Cultured; Colitis / chemically induced; Colitis / genetics; Colitis / microbiology; Dendritic Cells / immunology; Dendritic Cells / metabolism; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Transfer Techniques; Genetic Predisposition to Disease; Genetic Vectors; Interferon Type I / adverse effects; Interferon Type I / genetics; Interferon Type I / metabolism; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Organisms, Genetically Modified; Receptor, Interferon alpha-beta / genetics; Recombinant Proteins
TL;DR:
The data show that Lactobacillus secreting IFN-β has an immunological effect that in this model results in the exacerbation of colitis, which underscores that the selection of therapeutics delivered by a bacterial vehicle must take into consideration the simultaneous effects of the vehicle itself.
(via Semantic Scholar)
open access via journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Construction of vectors for inducible and constitutive gene expression in Lactobacillus
Microbial Biotechnology, 4(3), 357–367.
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Gene Expression; Gene Expression Regulation, Bacterial; Genetic Vectors / genetics; Genetic Vectors / metabolism; Lactobacillus / genetics; Lactobacillus / metabolism; Operon; Plasmids / genetics; Plasmids / metabolism
TL;DR:
Development of these expression vectors could support several novel applications, including the expression of enzymes, proteins, vaccines and biotherapeutics by intestinal lactobacilli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2009 patent
Compositions comprising promoter sequences and methods of use
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(11), 4331–4336.
author keywords: anthrax; lactic acid bacteria; mucosal immunity; oral; vaccine
MeSH headings : Administration, Oral; Animals; Anthrax / prevention & control; Anthrax Vaccines / administration & dosage; Anthrax Vaccines / immunology; Antibody Formation; Antigen Presentation; Antigens, Bacterial / administration & dosage; Antigens, Bacterial / genetics; Antigens, Bacterial / therapeutic use; Bacillus anthracis / immunology; Dendritic Cells / immunology; Immunity; Lactobacillus acidophilus / genetics; Mice
TL;DR:
Development of this strategy for oral delivery of DC-targeted antigens provides a safe and protective vaccine via a bacterial adjuvant that may potentiate mucosal immune responses against deadly pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 article
Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism
Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625.
MeSH headings : Adult; Bacterial Adhesion / genetics; Bacterial Adhesion / physiology; Bacterial Proteins / genetics; Child; DNA Primers; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Infant, Newborn; Intestines / microbiology; Lactobacillus / genetics; Lactobacillus / isolation & purification; Lactobacillus / pathogenicity; Open Reading Frames
TL;DR:
The results from this study indicated high intraspecies variability from a genome encoding traits important for survival and retention in the gastrointestinal tract.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 article
Functional genomics of probiotic Lactobacilli
Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162.
author keywords: Lactobacillus acidophilus; Lactobacillus johnsonii; Lactobacillus plantarum; Lactobacillus gasseri; genomics; probiotic cultures; lactic acid bacteria
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Evolution, Molecular; Genome, Bacterial; Genomics; Humans; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus / physiology; Probiotics / metabolism; Species Specificity
TL;DR:
A comparative genomic analysis of 4 completely sequenced Lactobacillus strains versus 25 lactic acid bacterial genomes present in the public database at thetime of analysis is conducted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 patent
Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
Source: NC State University Libraries
Added: August 6, 2018
2008 review
Targeting mucosal dendritic cells with microbial antigens from probiotic lactic acid bacteria
[Review of ]. EXPERT REVIEW OF VACCINES, 7(2), 163–174.
MeSH headings : Administration, Oral; Antigens, Bacterial / genetics; Antigens, Bacterial / immunology; Antigens, Bacterial / metabolism; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Genetic Vectors / metabolism; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Humans; Immunity, Mucosal; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Lactic Acid / metabolism; Probiotics / administration & dosage; Probiotics / metabolism
TL;DR:
This overview of mucosal immunity and how its cellular component(s), particularly dendritic cells, can be specifically targeted to deliver immunogenic subunits, such as the protective antigen from Bacillus anthracis (the causative agent of anthrax) is focused on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Characterization of the tre locus and analysis of trehalose cryoprotection in Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 72(2), 1218–1225.
MeSH headings : Amino Acid Sequence; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Cryoprotective Agents / metabolism; Cryoprotective Agents / pharmacology; DNA, Bacterial / genetics; Disaccharidases / genetics; Disaccharidases / metabolism; Fermentation; Genes, Bacterial; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Molecular Sequence Data; Mutagenesis, Insertional; Mutation; Phosphoenolpyruvate Sugar Phosphotransferase System / genetics; Phosphoenolpyruvate Sugar Phosphotransferase System / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Trehalose / metabolism; Trehalose / pharmacology
TL;DR:
Analysis of the Lactobacillus acidophilus NCFM genome revealed a putative trehalose utilization locus, which was found to be significantly reduced in the transporter mutant but unaffected in the hydrolase mutant, suggesting that intracellular transport and hydrolysis contribute significantly to cryoprotection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Genomic Perspectives on Probiotic Lactic Acid Bacteria
Bioscience and Microflora, 24(2), 31–33.
TL;DR:
The genomic content of probiotic Lactobacillus cultures is examined, compared to those lactic acid bacterial genomes that have appeared recently, to illustrate how environmental conditions encountered during biomanufacturing, fermentation, and the gastrointestinal tract can impact gene expression and culture functionality.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
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