Thomas Eric Ballard

Works (13)

Updated: July 5th, 2023 15:56

2014 article

Microwave-assisted extraction of betalains from red beet (Beta vulgaris)

Cardoso-Ugarte, G. A., Sosa-Morales, M. E., Ballard, T., Liceaga, A., & Martín-González, M. F. S. (2014, May 24). LWT.

By: G. Cardoso-Ugarte *, M. Sosa-Morales *, T. Ballard n, A. Liceaga * & M. Martín-González*

author keywords: Microwave-assisted extraction; Betalains; Red beet; Ascorbic acid; Factorial design
topics (OpenAlex): Botanical Research and Applications
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Source: Web Of Science
Added: August 6, 2018

2009 article

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

Richards, J. J., Reyes, S., Stowe, S. D., Tucker, A. T., Ballard, T. E., Mathies, L. D., … Melander, C. (2009, July 9). Journal of Medicinal Chemistry.

By: J. Richards n, S. Reyes n, S. Stowe n, A. Tucker n, T. Ballard n, L. Mathies n, J. Cavanagh n, C. Melander n

MeSH headings : Amides / chemical synthesis; Amides / pharmacology; Amides / toxicity; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Caenorhabditis elegans / drug effects; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / physiology; Pyrroles / chemical synthesis; Pyrroles / pharmacology; Pyrroles / toxicity; Structure-Activity Relationship; Sulfonamides / chemical synthesis; Sulfonamides / pharmacology; Thiourea / chemical synthesis; Thiourea / pharmacology; Urea / chemical synthesis; Urea / pharmacology
topics (OpenAlex): Bacterial biofilms and quorum sensing; Biocrusts and Microbial Ecology; Fungal Biology and Applications
TL;DR: The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described and the most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation

Ballard, T. E., Richards, J. J., Aquino, A., Reed, C. S., & Melander, C. (2009, January 8). The Journal of Organic Chemistry.

By: T. Ballard n, J. Richards n, A. Aquino  n, C. Reed n & C. Melander n

MeSH headings : Acylation; Biofilms / drug effects; Oxidation-Reduction; Proteobacteria / drug effects; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
topics (OpenAlex): Marine Sponges and Natural Products; Bacterial biofilms and quorum sensing; Microbial Natural Products and Biosynthesis
TL;DR: This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Evaluation of dihydrooroidin as an antifouling additive in marine paint

Melander, C., Moeller, P. D. R., Ballard, T. E., Richards, J. J., Huigens, R. W., & Cavanagh, J. (2009, February 10). International Biodeterioration & Biodegradation.

By: C. Melander n, P. Moeller*, T. Ballard n, J. Richards n, R. Huigens n & J. Cavanagh n

author keywords: Antifouling; Biofilms; Natural products
topics (OpenAlex): Marine Biology and Environmental Chemistry; Microplastics and Plastic Pollution; Marine Ecology and Invasive Species
TL;DR: Dihydrooroidin (DHO) is presented as an effective paint-based, non-cytotoxic, antifouling agent against marine biofouling processes in a marine mesocosm. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 article

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

Richards, J. J., Ballard, T. E., & Melander, C. (2008, January 1). Organic & Biomolecular Chemistry.

By: J. Richards n, T. Ballard n & C. Melander n

MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Humans; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / growth & development; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Antimicrobial agents and applications
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications (Cambridge, England), (14), 1698–1700.

By: J. Richards, R. Huigens, T. Ballard, A. Basso, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Inhibition of HIV Fusion with Multivalent Gold Nanoparticles

Bowman, M.-C., Ballard, T. E., Ackerson, C. J., Feldheim, D. L., Margolis, D. M., & Melander, C. (2008, May 13). Journal of the American Chemical Society.

By: M. Bowman n, T. Ballard n, C. Ackerson  n, D. Feldheim n, D. Margolis  n & C. Melander n

MeSH headings : Amides / chemistry; Amides / pharmacology; Gold / chemistry; Gold / pharmacology; HIV Fusion Inhibitors / chemistry; HIV Fusion Inhibitors / pharmacology; HIV Infections / drug therapy; HIV-1 / physiology; Metal Nanoparticles / chemistry; Metal Nanoparticles / therapeutic use; Quaternary Ammonium Compounds / chemistry; Quaternary Ammonium Compounds / pharmacology
topics (OpenAlex): HIV Research and Treatment; HIV/AIDS Research and Interventions; Nanocluster Synthesis and Applications
TL;DR: A fragment of the potent HIV inhibitor TAK-779 was synthesized and conjugated to 2.0 nm diameter gold nanoparticles, and the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of Tak-779, suggesting that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 article

Kinamycin-mediated DNA cleavage under biomimetic conditions

Ballard, T. E., & Melander, C. (2008, March 10). Tetrahedron Letters.

By: T. Ballard n & C. Melander n

topics (OpenAlex): Cancer therapeutics and mechanisms; DNA and Nucleic Acid Chemistry; Synthesis and Biological Evaluation
TL;DR: Kinamycin D has been shown to potently cleave DNA under mild biomimetic conditions and use of the endogenously abundant reductant glutathione effectively cleaved DNA in a concentration, temperature, and time-dependent fashion. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Synthesis and Antibiofilm Activity of a Second‐Generation Reverse‐Amide Oroidin Library: A Structure–Activity Relationship Study

Ballard, T. E., Richards, J. J., Wolfe, A. L., & Melander, C. (2008, October 22). Chemistry - A European Journal.

By: T. Ballard n, J. Richards n, A. Wolfe n & C. Melander n

author keywords: amino acids; biological activity; drug design; medicinal chemistry; structure-activity relationships
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Drug Design; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / growth & development; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
topics (OpenAlex): Synthetic Organic Chemistry Methods; Chemical Synthesis and Analysis; Microbial Natural Products and Biosynthesis
TL;DR: A second-generation library of 2-aminoimidazole-based derivatives incorporating a "reversed amide" (RA) motif in comparison to the marine natural product oroidin were synthesized and subsequently assayed for antibiofilm activity against the medically relevant Gram-negative proteobacteria P. aeruginosa and A. baumannii. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 article

Synthesis and Screening of an Oroidin Library against Pseudomonas aeruginosa Biofilms

Richards, J. J., Ballard, T. E., Huigens, R. W., & Melander, C. (2008, April 22). ChemBioChem.

By: J. Richards n, T. Ballard n, R. Huigens n & C. Melander n

author keywords: biological activity; drug design; medicinal chemistry; natural products; structure-activity relationships
MeSH headings : Biofilms; Cross-Linking Reagents / chemistry; Databases, Factual; Drug Design; Drug Evaluation, Preclinical; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Structure-Activity Relationship
topics (OpenAlex): Bacterial biofilms and quorum sensing; Marine Sponges and Natural Products; Microbial Natural Products and Biosynthesis
TL;DR: The synthesis and determined biological activity of this unique class of compounds as inhibitors of biofilm formation that have no direct antibiotic effect are disclosed. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues

Journal of the American Chemical Society, 129(22), 6966-.

By: R. Huigens, J. Richards, G. Parise, T. Ballard, W. Zeng, R. Deora, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V. A., Feldheim, D. L., & Melander, C. (2006, July 26). Bioorganic & Medicinal Chemistry Letters.

By: W. Zeng n, T. Ballard n, A. Tkachenko n, V. Burns n, D. Feldheim n & C. Melander n

author keywords: kinamycins; lomaiviticins; DNA cleavage; diazofluorenes; antiproliferative activity
MeSH headings : Animals; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Carbazoles / pharmacology; Cell Proliferation / drug effects; DNA Damage / drug effects; Fluorenes / chemical synthesis; Fluorenes / pharmacology; HeLa Cells; Humans; Molecular Mimicry; Structure-Activity Relationship
topics (OpenAlex): Organic Chemistry Cycloaddition Reactions; Click Chemistry and Applications; Fluorine in Organic Chemistry
TL;DR: Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions, key to anticancer activity. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Tuning the oxidation properties of vanadium(V) through ligand stoichiometry

Zeng, W., Ballard, T. E., & Melander, C. (2006, July 4). Tetrahedron Letters.

By: W. Zeng n, T. Ballard n & C. Melander n

topics (OpenAlex): Vanadium and Halogenation Chemistry; Oxidative Organic Chemistry Reactions; Chemical Synthesis and Reactions
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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