Works (13)
Updated: July 5th, 2023 15:56
2014 journal article
Microwave-assisted extraction of betalains from red beet (Beta vulgaris)
LWT-FOOD SCIENCE AND TECHNOLOGY, 59(1), 276–282.
author keywords: Microwave-assisted extraction; Betalains; Red beet; Ascorbic acid; Factorial design
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity
JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582–4585.
MeSH headings : Amides / chemical synthesis; Amides / pharmacology; Amides / toxicity; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Caenorhabditis elegans / drug effects; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / physiology; Pyrroles / chemical synthesis; Pyrroles / pharmacology; Pyrroles / toxicity; Structure-Activity Relationship; Sulfonamides / chemical synthesis; Sulfonamides / pharmacology; Thiourea / chemical synthesis; Thiourea / pharmacology; Urea / chemical synthesis; Urea / pharmacology
TL;DR:
The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described and the most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation
JOURNAL OF ORGANIC CHEMISTRY, 74(4), 1755–1758.
MeSH headings : Acylation; Biofilms / drug effects; Oxidation-Reduction; Proteobacteria / drug effects; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
TL;DR:
This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Evaluation of dihydrooroidin as an antifouling additive in marine paint
INTERNATIONAL BIODETERIORATION & BIODEGRADATION, 63(4), 529–532.
author keywords: Antifouling; Biofilms; Natural products
TL;DR:
Dihydrooroidin (DHO) is presented as an effective paint-based, non-cytotoxic, antifouling agent against marine biofouling processes in a marine mesocosm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues
ORGANIC & BIOMOLECULAR CHEMISTRY, 6(8), 1356–1363.
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Humans; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / growth & development; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Inhibition and dispersion of proteobacterial biofilms
Chemical Communications (Cambridge, England), (14), 1698–1700.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Inhibition of HIV fusion with multivalent gold nanoparticles
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(22), 6896-+.
MeSH headings : Amides / chemistry; Amides / pharmacology; Gold / chemistry; Gold / pharmacology; HIV Fusion Inhibitors / chemistry; HIV Fusion Inhibitors / pharmacology; HIV Infections / drug therapy; HIV-1 / physiology; Metal Nanoparticles / chemistry; Metal Nanoparticles / therapeutic use; Quaternary Ammonium Compounds / chemistry; Quaternary Ammonium Compounds / pharmacology
TL;DR:
A fragment of the potent HIV inhibitor TAK-779 was synthesized and conjugated to 2.0 nm diameter gold nanoparticles, and the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of Tak-779, suggesting that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Kinamycin-mediated DNA cleavage under biomimetic conditions
TETRAHEDRON LETTERS, 49(19), 3157–3161.
TL;DR:
Kinamycin D has been shown to potently cleave DNA under mild biomimetic conditions and use of the endogenously abundant reductant glutathione effectively cleaved DNA in a concentration, temperature, and time-dependent fashion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study
CHEMISTRY-A EUROPEAN JOURNAL, 14(34), 10745–10761.
author keywords: amino acids; biological activity; drug design; medicinal chemistry; structure-activity relationships
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Drug Design; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / growth & development; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
TL;DR:
A second-generation library of 2-aminoimidazole-based derivatives incorporating a "reversed amide" (RA) motif in comparison to the marine natural product oroidin were synthesized and subsequently assayed for antibiofilm activity against the medically relevant Gram-negative proteobacteria P. aeruginosa and A. baumannii.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms
CHEMBIOCHEM, 9(8), 1267–1279.
author keywords: biological activity; drug design; medicinal chemistry; natural products; structure-activity relationships
MeSH headings : Biofilms; Cross-Linking Reagents / chemistry; Databases, Factual; Drug Design; Drug Evaluation, Preclinical; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Structure-Activity Relationship
TL;DR:
The synthesis and determined biological activity of this unique class of compounds as inhibitors of biofilm formation that have no direct antibiotic effect are disclosed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues
Journal of the American Chemical Society, 129(22), 6966-.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(19), 5148–5151.
author keywords: kinamycins; lomaiviticins; DNA cleavage; diazofluorenes; antiproliferative activity
MeSH headings : Animals; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Carbazoles / pharmacology; Cell Proliferation / drug effects; DNA Damage / drug effects; Fluorenes / chemical synthesis; Fluorenes / pharmacology; HeLa Cells; Humans; Molecular Mimicry; Structure-Activity Relationship
TL;DR:
Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions, key to anticancer activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Tuning the oxidation properties of vanadium(V) through ligand stoichiometry
TETRAHEDRON LETTERS, 47(33), 5923–5926.
Source: Web Of Science
Added: August 6, 2018
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