Tomoki Fukuyama

Works (8)

Updated: July 5th, 2023 15:40

2020 article

Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch

Mishra, S. K., Wheeler, J. J., Pitake, S., Ding, H., Jiang, C., Fukuyama, T., … Olivry, T. (2020, April 1). Cell Reports, Vol. 31.

By: S. Mishra n, J. Wheeler n, S. Pitake n, H. Ding *, C. Jiang *, T. Fukuyama n, J. Paps n, P. Ralph n ...

Contributors: S. Mishra n, J. Wheeler n, S. Pitake n, H. Ding *, C. Jiang *, T. Fukuyama n, J. Paps n, P. Ralph n ...

MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dogs; Female; Hypersensitivity / physiopathology; Integrin alpha5 / metabolism; Integrin beta3 / metabolism; Integrins / metabolism; Keratinocytes / metabolism; Male; Mice; Primates; Pruritus / metabolism; Pruritus / pathology; Sensory Receptor Cells / metabolism; Skin / metabolism
topics (OpenAlex): Dermatology and Skin Diseases; Asthma and respiratory diseases; Urticaria and Related Conditions
TL;DR: A TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons is identified and the non-canonical functional role of an integrin in itch is characterized. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020

2019 journal article

Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons

Acta Dermato Venereologica, 99(6), 587–893.

By: S. Ehling n, T. Fukuyama n, M. Ko *, T. Olivry n  & W. Bäumer  n

Contributors: S. Ehling n, T. Fukuyama n, M. Ko *, T. Olivry n  & W. Bäumer  n

author keywords: acute itch; dorsal root ganglia; mast cells; neuromedin B; allergic dermatitis.
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation; Cells, Cultured; Dermatitis, Allergic Contact / etiology; Female; Ganglia, Spinal / cytology; Ganglia, Spinal / metabolism; Gene Expression; Indoles / pharmacology; Injections, Intradermal; Macaca mulatta; Male; Mast Cells / metabolism; Mast Cells / physiology; Mice; Neurokinin B / administration & dosage; Neurokinin B / analogs & derivatives; Pruritus / chemically induced; Pyridines / pharmacology; RNA, Messenger / metabolism; Receptors, Bombesin / antagonists & inhibitors; Receptors, Bombesin / genetics; Receptors, Bombesin / metabolism; Sensory Receptor Cells / physiology; Single-Cell Analysis; Toluene 2,4-Diisocyanate
topics (OpenAlex): Dermatology and Skin Diseases; Asthma and respiratory diseases; Urticaria and Related Conditions
TL;DR: In vitro real time PCR analysis for neuromedin B and its receptor expression in murine mast cells and dorsal root ganglia as well as functional calcium imaging in the ganglia found that the peripheral signal is likely transmitted through the activation of dorsalRoot ganglia. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: May 20, 2019

2017 article

Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor

Fukuyama, T., Ganchingco, J. R., Mishra, S. K., Olivry, T., Rzagalinski, I., Volmer, D. A., & Bäumer, W. (2017, January 26). Journal of Allergy and Clinical Immunology, Vol. 140, pp. 306–309.e3.

By: T. Fukuyama n, J. Ganchingco n, S. Mishra n, T. Olivry n , I. Rzagalinski*, D. Volmer *, W. Bäumer n

Contributors: T. Fukuyama n, J. Ganchingco n, S. Mishra n, T. Olivry n , I. Rzagalinski*, D. Volmer *, W. Bäumer n

MeSH headings : Animals; Antipruritics / chemistry; Antipruritics / pharmacology; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Female; Humans; Janus Kinase Inhibitors / chemistry; Janus Kinase Inhibitors / pharmacology; Mice; Models, Molecular; Molecular Conformation; Molecular Imaging / methods; Protein Binding; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Structure-Activity Relationship; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / chemistry; TRPV Cation Channels / metabolism
topics (OpenAlex): Dermatology and Skin Diseases; Allergic Rhinitis and Sensitization; Urticaria and Related Conditions
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 article

Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib

Fukuyama, T., Ganchingco, J. R., & Bäumer, W. (2016, November 12). European Journal of Pharmacology.

By: T. Fukuyama n, J. Ganchingco n & W. Bäumer  n

author keywords: JAK-inhibitor; Oclacitinib; Itch; Rebound phenomenon; Allergic dermatitis; TRPV1
MeSH headings : Animals; Behavior, Animal / drug effects; CD11c Antigen / metabolism; Calcium / metabolism; Cytokines / metabolism; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dendritic Cells / pathology; Female; Ganglia, Spinal / drug effects; Ganglia, Spinal / pathology; Immunomodulation / drug effects; Intracellular Space / drug effects; Intracellular Space / metabolism; Janus Kinase 1 / antagonists & inhibitors; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use; Pruritus / drug therapy; Pruritus / immunology; Pruritus / pathology; Pyrimidines / pharmacology; Pyrimidines / therapeutic use; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / pathology; Skin / drug effects; Skin / immunology; Skin / metabolism; Sulfonamides / pharmacology; Sulfonamides / therapeutic use; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Dermatology and Skin Diseases; Contact Dermatitis and Allergies; Urticaria and Related Conditions
TL;DR: While oclacitinib significantly reduced itch during treatment the abrupt withdrawal led to a rapid rebound phenomenon which can be explained by an increase in pruritogenic cytokines and fast peripheral sensitization. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

Cruse, G., Yin, Y., Fukuyama, T., Desai, A., Arthur, G. K., Bäumer, W., … Metcalfe, D. D. (2016, November 21). Proceedings of the National Academy of Sciences, Vol. 113, pp. 14115–14120.

By: G. Cruse n , Y. Yin *, T. Fukuyama n, A. Desai*, G. Arthur n, W. Bäumer  n, M. Beaven*, D. Metcalfe *

Contributors: G. Cruse n , Y. Yin *, T. Fukuyama n, A. Desai*, G. Arthur n, W. Bäumer  n, M. Beaven*, D. Metcalfe *

author keywords: mast cell; allergy; IgE receptor; oligonucleotides; dermatitis
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Cytokines / biosynthesis; Dermatitis, Allergic Contact / therapy; Disease Models, Animal; Female; Humans; Mast Cells / drug effects; Mast Cells / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotides, Antisense / pharmacology; Oligonucleotides, Antisense / therapeutic use; Passive Cutaneous Anaphylaxis / genetics; RNA Splicing / drug effects; Receptors, IgE / genetics; Receptors, IgE / metabolism
topics (OpenAlex): Mast cells and histamine; Allergic Rhinitis and Sensitization; Asthma and respiratory diseases
TL;DR: An innovative approach for targeting mast cells in vitro and in vivo is described using antisense oligonucleotide-mediated exon skipping of the β-subunit of the high-affinity IgE receptor (FcεRIβ) to eliminate surface high-Affinity Ig E receptor expression and function, rendering mast cells unresponsive to IgE-mediated activation. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis

Archives of Dermatological Research, 308(10), 711–721.

By: K. Stover n, T. Fukuyama n, A. Young n, M. Daniele n , R. Oberley*, J. Crapo *, W. Bäumer n

Contributors: K. Stover n, T. Fukuyama n, A. Young n, M. Daniele n , R. Oberley*, J. Crapo *, W. Baeumer n

author keywords: Superoxide dismutase mimics; BMX-010; BMX-001; Allergic dermatitis; Mice
MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Cell Line; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Allergic Contact / drug therapy; Disease Models, Animal; Ear; Female; Humans; Infant, Newborn; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-1beta / metabolism; Interleukin-4 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metalloporphyrins / administration & dosage; Metalloporphyrins / therapeutic use; Mice; Mice, Inbred BALB C; Pruritus / drug therapy; Skin / drug effects; Skin / metabolism; Skin Cream; Superoxide Dismutase / metabolism; Toluene 2,4-Diisocyanate / toxicity; p-Methoxy-N-methylphenethylamine / toxicity
topics (OpenAlex): Dermatology and Skin Diseases; Contact Dermatitis and Allergies; Skin Protection and Aging
TL;DR: Topical treatment with BMX cream resulted in a significant decrease in scratching behaviour in the compound 48/80 model, but not in the TDI model, and interestingly, the concentration of the cytokines IL-1β and IL-4 in inflamed skin was reduced by 80–90 % by all treatment options. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2015 article

Aggression behaviour induced by oral administration of the Janus-kinase inhibitor tofacitinib, but not oclacitinib, under stressful conditions

Fukuyama, T., Tschernig, T., Qi, Y., Volmer, D. A., & Bäumer, W. (2015, July 9). European Journal of Pharmacology.

By: T. Fukuyama n, T. Tschernig *, Y. Qi *, D. Volmer * & W. Bäumer n

MeSH headings : Administration, Oral; Aggression / drug effects; Animals; Anti-Allergic Agents / adverse effects; Anti-Allergic Agents / pharmacokinetics; Anti-Allergic Agents / therapeutic use; Anti-Inflammatory Agents / adverse effects; Anti-Inflammatory Agents / pharmacokinetics; Anti-Inflammatory Agents / therapeutic use; Behavior, Animal / drug effects; Brain / metabolism; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / metabolism; Disease Models, Animal; Female; Janus Kinases / antagonists & inhibitors; Janus Kinases / metabolism; Male; Mice, Inbred BALB C; Piperidines / adverse effects; Piperidines / pharmacokinetics; Piperidines / therapeutic use; Protein Kinase Inhibitors / adverse effects; Protein Kinase Inhibitors / pharmacokinetics; Protein Kinase Inhibitors / therapeutic use; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / adverse effects; Pyrimidines / pharmacokinetics; Pyrimidines / therapeutic use; Pyrroles / adverse effects; Pyrroles / pharmacokinetics; Pyrroles / therapeutic use; Stress, Psychological; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use; Toluene 2,4-Diisocyanate
topics (OpenAlex): Cytokine Signaling Pathways and Interactions; Pharmacological Effects of Natural Compounds; Computational Drug Discovery Methods
TL;DR: Results suggest that aggression was induced by tofacitinib under some kind of stressful environment, and indicates a possible role of the JAK-STAT pathway in modulation of aggression behaviour. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2015 article

Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis

Fukuyama, T., Ehling, S., Cook, E., & Bäumer, W. (2015, July 10). Journal of Pharmacology and Experimental Therapeutics.

By: T. Fukuyama n, S. Ehling n, E. Cook n & W. Bäumer n

MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents / administration & dosage; Antipruritics / administration & dosage; Cytokines / metabolism; Dermatitis, Allergic Contact / drug therapy; Dermatitis, Allergic Contact / metabolism; Disease Models, Animal; Female; Inflammation / drug therapy; Inflammation / metabolism; Janus Kinases / antagonists & inhibitors; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Piperidines / administration & dosage; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / administration & dosage; Pyrroles / administration & dosage; Skin / drug effects; Skin / metabolism; Sulfonamides / administration & dosage
topics (OpenAlex): Dermatology and Skin Diseases; Urticaria and Related Conditions; Allergic Rhinitis and Sensitization
TL;DR: Oral treatment with JAK inhibitors reduced itch behavior dramatically but had only little effect on the inflammatory response, whereas topical treatment improved both itch and inflammatory response. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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