Tomoki Fukuyama
Works (8)
Updated: July 5th, 2023 15:40
2020 journal article
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
CELL REPORTS, 31(1).
co-author countries:
Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dogs; Female; Hypersensitivity / physiopathology; Integrin alpha5 / metabolism; Integrin beta3 / metabolism; Integrins / metabolism; Keratinocytes / metabolism; Male; Mice; Primates; Pruritus / metabolism; Pruritus / pathology; Sensory Receptor Cells / metabolism; Skin / metabolism
doi.org (publisher PDF)
Sources: Web Of Science, ORCID
Added: April 27, 2020
2019 journal article
Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons
Acta Dermato Venereologica, 99(6), 587–893.
author keywords: acute itch; dorsal root ganglia; mast cells; neuromedin B; allergic dermatitis.
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation; Cells, Cultured; Dermatitis, Allergic Contact / etiology; Female; Ganglia, Spinal / cytology; Ganglia, Spinal / metabolism; Gene Expression; Indoles / pharmacology; Injections, Intradermal; Macaca mulatta; Male; Mast Cells / metabolism; Mast Cells / physiology; Mice; Neurokinin B / administration & dosage; Neurokinin B / analogs & derivatives; Pruritus / chemically induced; Pyridines / pharmacology; RNA, Messenger / metabolism; Receptors, Bombesin / antagonists & inhibitors; Receptors, Bombesin / genetics; Receptors, Bombesin / metabolism; Sensory Receptor Cells / physiology; Single-Cell Analysis; Toluene 2,4-Diisocyanate
Sources: Web Of Science, Crossref, ORCID
Added: May 20, 2019
2017 journal article
Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib
EUROPEAN JOURNAL OF PHARMACOLOGY, 794, 20–26.
co-author countries:
United States of America 🇺🇸
author keywords: JAK-inhibitor; Oclacitinib; Itch; Rebound phenomenon; Allergic dermatitis; TRPV1
MeSH headings : Animals; Behavior, Animal / drug effects; CD11c Antigen / metabolism; Calcium / metabolism; Cytokines / metabolism; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dendritic Cells / pathology; Female; Ganglia, Spinal / drug effects; Ganglia, Spinal / pathology; Immunomodulation / drug effects; Intracellular Space / drug effects; Intracellular Space / metabolism; Janus Kinase 1 / antagonists & inhibitors; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use; Pruritus / drug therapy; Pruritus / immunology; Pruritus / pathology; Pyrimidines / pharmacology; Pyrimidines / therapeutic use; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / pathology; Skin / drug effects; Skin / immunology; Skin / metabolism; Sulfonamides / pharmacology; Sulfonamides / therapeutic use; Tumor Necrosis Factor-alpha / metabolism
Source: Web Of Science
Added: August 6, 2018
2017 personal communication
Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor
Fukuyama, T., Ganchingco, J. R., Mishra, S. K., Olivry, T., Rzagalinski, I., Volmer, D. A., & Baeumer, W. (2017, July).
co-author countries:
Germany 🇩🇪 United States of America 🇺🇸
Contributors: n, J. Ganchingco n, S. Mishra n, T. Olivry n , I. Rzagalinski*, D. Volmer *, W. Bäumer n
MeSH headings : Animals; Antipruritics / chemistry; Antipruritics / pharmacology; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Female; Humans; Janus Kinase Inhibitors / chemistry; Janus Kinase Inhibitors / pharmacology; Mice; Models, Molecular; Molecular Conformation; Molecular Imaging / methods; Protein Binding; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Structure-Activity Relationship; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / chemistry; TRPV Cation Channels / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Exon skipping of Fc epsilon RI beta eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(49), 14115–14120.
co-author countries:
United States of America 🇺🇸
Contributors: G. Cruse n , Y. Yin *, n, A. Desai*, G. Arthur n, W. Bäumer n, M. Beaven*, D. Metcalfe *
author keywords: mast cell; allergy; IgE receptor; oligonucleotides; dermatitis
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Cytokines / biosynthesis; Dermatitis, Allergic Contact / therapy; Disease Models, Animal; Female; Humans; Mast Cells / drug effects; Mast Cells / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotides, Antisense / pharmacology; Oligonucleotides, Antisense / therapeutic use; Passive Cutaneous Anaphylaxis / genetics; RNA Splicing / drug effects; Receptors, IgE / genetics; Receptors, IgE / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis
ARCHIVES OF DERMATOLOGICAL RESEARCH, 308(10), 711–721.
co-author countries:
United States of America 🇺🇸
author keywords: Superoxide dismutase mimics; BMX-010; BMX-001; Allergic dermatitis; Mice
MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Cell Line; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Allergic Contact / drug therapy; Disease Models, Animal; Ear; Female; Humans; Infant, Newborn; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-1beta / metabolism; Interleukin-4 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metalloporphyrins / administration & dosage; Metalloporphyrins / therapeutic use; Mice; Mice, Inbred BALB C; Pruritus / drug therapy; Skin / drug effects; Skin / metabolism; Skin Cream; Superoxide Dismutase / metabolism; Toluene 2,4-Diisocyanate / toxicity; p-Methoxy-N-methylphenethylamine / toxicity
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Aggression behaviour induced by oral administration of the Janus-kinase inhibitor tofacitinib, but not oclacitinib, under stressful conditions
European Journal of Pharmacology, 764, 278–282.
co-author countries:
Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Administration, Oral; Aggression / drug effects; Animals; Anti-Allergic Agents / adverse effects; Anti-Allergic Agents / pharmacokinetics; Anti-Allergic Agents / therapeutic use; Anti-Inflammatory Agents / adverse effects; Anti-Inflammatory Agents / pharmacokinetics; Anti-Inflammatory Agents / therapeutic use; Behavior, Animal / drug effects; Brain / metabolism; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / metabolism; Disease Models, Animal; Female; Janus Kinases / antagonists & inhibitors; Janus Kinases / metabolism; Male; Mice, Inbred BALB C; Piperidines / adverse effects; Piperidines / pharmacokinetics; Piperidines / therapeutic use; Protein Kinase Inhibitors / adverse effects; Protein Kinase Inhibitors / pharmacokinetics; Protein Kinase Inhibitors / therapeutic use; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / adverse effects; Pyrimidines / pharmacokinetics; Pyrimidines / therapeutic use; Pyrroles / adverse effects; Pyrroles / pharmacokinetics; Pyrroles / therapeutic use; Stress, Psychological; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use; Toluene 2,4-Diisocyanate
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 354(3), 394–405.
co-author countries:
United States of America 🇺🇸
MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents / administration & dosage; Antipruritics / administration & dosage; Cytokines / metabolism; Dermatitis, Allergic Contact / drug therapy; Dermatitis, Allergic Contact / metabolism; Disease Models, Animal; Female; Inflammation / drug therapy; Inflammation / metabolism; Janus Kinases / antagonists & inhibitors; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Piperidines / administration & dosage; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / administration & dosage; Pyrroles / administration & dosage; Skin / drug effects; Skin / metabolism; Sulfonamides / administration & dosage
Source: Web Of Science
Added: August 6, 2018
