Works (8)
Updated: July 5th, 2023 15:40
2020 journal article
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
CELL REPORTS, 31(1).
Contributors: S. Mishra n, J. Wheeler n, S. Pitake n, H. Ding *, C. Jiang *, n, J. Paps n, P. Ralph n
MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dogs; Female; Hypersensitivity / physiopathology; Integrin alpha5 / metabolism; Integrin beta3 / metabolism; Integrins / metabolism; Keratinocytes / metabolism; Male; Mice; Primates; Pruritus / metabolism; Pruritus / pathology; Sensory Receptor Cells / metabolism; Skin / metabolism
TL;DR:
A TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons is identified and the non-canonical functional role of an integrin in itch is characterized.
(via Semantic Scholar)
open access via doi.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020
2019 journal article
Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons
Acta Dermato Venereologica, 99(6), 587–893.
Contributors: S. Ehling n, n, M. Ko *, T. Olivry n & W. Bäumer n
author keywords: acute itch; dorsal root ganglia; mast cells; neuromedin B; allergic dermatitis.
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation; Cells, Cultured; Dermatitis, Allergic Contact / etiology; Female; Ganglia, Spinal / cytology; Ganglia, Spinal / metabolism; Gene Expression; Indoles / pharmacology; Injections, Intradermal; Macaca mulatta; Male; Mast Cells / metabolism; Mast Cells / physiology; Mice; Neurokinin B / administration & dosage; Neurokinin B / analogs & derivatives; Pruritus / chemically induced; Pyridines / pharmacology; RNA, Messenger / metabolism; Receptors, Bombesin / antagonists & inhibitors; Receptors, Bombesin / genetics; Receptors, Bombesin / metabolism; Sensory Receptor Cells / physiology; Single-Cell Analysis; Toluene 2,4-Diisocyanate
TL;DR:
In vitro real time PCR analysis for neuromedin B and its receptor expression in murine mast cells and dorsal root ganglia as well as functional calcium imaging in the ganglia found that the peripheral signal is likely transmitted through the activation of dorsalRoot ganglia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: May 20, 2019
2017 journal article
Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib
EUROPEAN JOURNAL OF PHARMACOLOGY, 794, 20–26.
author keywords: JAK-inhibitor; Oclacitinib; Itch; Rebound phenomenon; Allergic dermatitis; TRPV1
MeSH headings : Animals; Behavior, Animal / drug effects; CD11c Antigen / metabolism; Calcium / metabolism; Cytokines / metabolism; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dendritic Cells / pathology; Female; Ganglia, Spinal / drug effects; Ganglia, Spinal / pathology; Immunomodulation / drug effects; Intracellular Space / drug effects; Intracellular Space / metabolism; Janus Kinase 1 / antagonists & inhibitors; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / therapeutic use; Pruritus / drug therapy; Pruritus / immunology; Pruritus / pathology; Pyrimidines / pharmacology; Pyrimidines / therapeutic use; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / pathology; Skin / drug effects; Skin / immunology; Skin / metabolism; Sulfonamides / pharmacology; Sulfonamides / therapeutic use; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
While oclacitinib significantly reduced itch during treatment the abrupt withdrawal led to a rapid rebound phenomenon which can be explained by an increase in pruritogenic cytokines and fast peripheral sensitization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 personal communication
Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor
Fukuyama, T., Ganchingco, J. R., Mishra, S. K., Olivry, T., Rzagalinski, I., Volmer, D. A., & Baeumer, W. (2017, July).
Contributors: n, J. Ganchingco n, S. Mishra n, T. Olivry n , I. Rzagalinski*, D. Volmer *, W. Bäumer n
MeSH headings : Animals; Antipruritics / chemistry; Antipruritics / pharmacology; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Female; Humans; Janus Kinase Inhibitors / chemistry; Janus Kinase Inhibitors / pharmacology; Mice; Models, Molecular; Molecular Conformation; Molecular Imaging / methods; Protein Binding; Sensory Receptor Cells / drug effects; Sensory Receptor Cells / metabolism; Structure-Activity Relationship; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / chemistry; TRPV Cation Channels / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Exon skipping of Fc epsilon RI beta eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(49), 14115–14120.
Contributors: G. Cruse n , Y. Yin *, n, A. Desai*, G. Arthur n, W. Bäumer n, M. Beaven*, D. Metcalfe *
author keywords: mast cell; allergy; IgE receptor; oligonucleotides; dermatitis
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Cytokines / biosynthesis; Dermatitis, Allergic Contact / therapy; Disease Models, Animal; Female; Humans; Mast Cells / drug effects; Mast Cells / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotides, Antisense / pharmacology; Oligonucleotides, Antisense / therapeutic use; Passive Cutaneous Anaphylaxis / genetics; RNA Splicing / drug effects; Receptors, IgE / genetics; Receptors, IgE / metabolism
TL;DR:
An innovative approach for targeting mast cells in vitro and in vivo is described using antisense oligonucleotide-mediated exon skipping of the β-subunit of the high-affinity IgE receptor (FcεRIβ) to eliminate surface high-Affinity Ig E receptor expression and function, rendering mast cells unresponsive to IgE-mediated activation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis
ARCHIVES OF DERMATOLOGICAL RESEARCH, 308(10), 711–721.
author keywords: Superoxide dismutase mimics; BMX-010; BMX-001; Allergic dermatitis; Mice
MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Cell Line; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Allergic Contact / drug therapy; Disease Models, Animal; Ear; Female; Humans; Infant, Newborn; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-1beta / metabolism; Interleukin-4 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metalloporphyrins / administration & dosage; Metalloporphyrins / therapeutic use; Mice; Mice, Inbred BALB C; Pruritus / drug therapy; Skin / drug effects; Skin / metabolism; Skin Cream; Superoxide Dismutase / metabolism; Toluene 2,4-Diisocyanate / toxicity; p-Methoxy-N-methylphenethylamine / toxicity
TL;DR:
Topical treatment with BMX cream resulted in a significant decrease in scratching behaviour in the compound 48/80 model, but not in the TDI model, and interestingly, the concentration of the cytokines IL-1β and IL-4 in inflamed skin was reduced by 80–90 % by all treatment options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Aggression behaviour induced by oral administration of the Janus-kinase inhibitor tofacitinib, but not oclacitinib, under stressful conditions
European Journal of Pharmacology, 764, 278–282.
MeSH headings : Administration, Oral; Aggression / drug effects; Animals; Anti-Allergic Agents / adverse effects; Anti-Allergic Agents / pharmacokinetics; Anti-Allergic Agents / therapeutic use; Anti-Inflammatory Agents / adverse effects; Anti-Inflammatory Agents / pharmacokinetics; Anti-Inflammatory Agents / therapeutic use; Behavior, Animal / drug effects; Brain / metabolism; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / metabolism; Disease Models, Animal; Female; Janus Kinases / antagonists & inhibitors; Janus Kinases / metabolism; Male; Mice, Inbred BALB C; Piperidines / adverse effects; Piperidines / pharmacokinetics; Piperidines / therapeutic use; Protein Kinase Inhibitors / adverse effects; Protein Kinase Inhibitors / pharmacokinetics; Protein Kinase Inhibitors / therapeutic use; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / adverse effects; Pyrimidines / pharmacokinetics; Pyrimidines / therapeutic use; Pyrroles / adverse effects; Pyrroles / pharmacokinetics; Pyrroles / therapeutic use; Stress, Psychological; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use; Toluene 2,4-Diisocyanate
TL;DR:
Results suggest that aggression was induced by tofacitinib under some kind of stressful environment, and indicates a possible role of the JAK-STAT pathway in modulation of aggression behaviour.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 354(3), 394–405.
MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents / administration & dosage; Antipruritics / administration & dosage; Cytokines / metabolism; Dermatitis, Allergic Contact / drug therapy; Dermatitis, Allergic Contact / metabolism; Disease Models, Animal; Female; Inflammation / drug therapy; Inflammation / metabolism; Janus Kinases / antagonists & inhibitors; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Piperidines / administration & dosage; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / administration & dosage; Pyrroles / administration & dosage; Skin / drug effects; Skin / metabolism; Sulfonamides / administration & dosage
TL;DR:
Oral treatment with JAK inhibitors reduced itch behavior dramatically but had only little effect on the inflammatory response, whereas topical treatment improved both itch and inflammatory response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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