Works (99)

Updated: April 4th, 2024 18:14

2015 journal article

A VALENTINE-SHAPED CARDIAC SILHOUETTE IN FELINE THORACIC RADIOGRAPHS IS PRIMARILY DUE TO LEFT ATRIAL ENLARGEMENT

VETERINARY RADIOLOGY & ULTRASOUND, 56(3), 245–250.

By: T. Oura n, A. Young*, B. Keene n, I. Robertson n, D. Jennings* & D. Thrall n

author keywords: atrium; cat; cardiomegaly; radiography; valentine shaped
MeSH headings : Animals; Cardiomegaly / diagnostic imaging; Cardiomegaly / etiology; Cardiomegaly / veterinary; Cat Diseases / diagnostic imaging; Cat Diseases / etiology; Cats; Cross-Sectional Studies; Echocardiography / veterinary; Female; Heart Atria / diagnostic imaging; Male; North Carolina; Radiography; Retrospective Studies
TL;DR: The hypothesis that a valentine-shaped cardiac silhouette in radiographs is due primarily to left atrial enlargement in cats is supported, with right atrial enlargeement only impacting the shape if concurrent with severe left atri enlargement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

COMPUTED TOMOGRAPHIC AND ULTRASONOGRAPHIC CHARACTERISTICS OF CAVERNOUS TRANSFORMATION OF THE OBSTRUCTED PORTAL VEIN IN SMALL ANIMALS

VETERINARY RADIOLOGY & ULTRASOUND, 56(5), 511–519.

By: S. Specchi*, P. Pey*, G. Ledda*, M. Lustgarten n, D. Thrall n & G. Bertolini*

author keywords: Cavernous transformation; CT-angiography; obstruction; portal collaterals; portal vein
MeSH headings : Angiography / veterinary; Animals; Cat Diseases / diagnostic imaging; Cats; Collateral Circulation; Cross-Sectional Studies; Dog Diseases / diagnostic imaging; Dogs; Female; Hypertension, Portal / diagnostic imaging; Hypertension, Portal / veterinary; Male; Multidetector Computed Tomography / veterinary; Portal Vein / abnormalities; Portal Vein / diagnostic imaging; Retrospective Studies
TL;DR: Describing MDCT and ultrasonographic characteristics of presumed cavernous transformation of the portal vein in small animals with portal vein obstruction using ultrasound and multidetector-row computed tomography (MDCT) was provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 article

What Is Your Diagnosis?

Jones, S. A., Rawlins, G., Arauz, M., Thrall, M.-A., Plessis, W. M., & Thrall, D. E. (2015, December 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 247, pp. 1237–1239.

By: S. Jones, G. Rawlins, M. Arauz, M. Thrall, W. Plessis & D. Thrall*

MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Radiography; Venereal Tumors, Veterinary / diagnosis; Venereal Tumors, Veterinary / diagnostic imaging; Venereal Tumors, Veterinary / pathology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

DCE-MRI: a review and applications in veterinary oncology

VETERINARY AND COMPARATIVE ONCOLOGY, 11(2), 87–100.

By: M. Boss n, N. Muradyan & D. Thrall n

author keywords: DCE-MRI; functional imaging; tumour imaging; MRI; perfusion
MeSH headings : Animals; Contrast Media / pharmacology; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Neoplasms / diagnostic imaging; Neoplasms / pathology; Neoplasms / veterinary; Radiography; Veterinary Medicine / methods
TL;DR: Given the importance of tumour perfusion with respect to tumour oxygenation and drug delivery, the use of DCE-MRI is a convenient and powerful way to gain basic information about a tumour. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

EVALUATION OF TWO OBJECTIVE METHODS TO OPTIMIZE KVP AND PERSONNEL EXPOSURE USING A DIGITAL INDIRECT FLAT PANEL DETECTOR AND SIMULATED VETERINARY PATIENTS

VETERINARY RADIOLOGY & ULTRASOUND, 54(1), 9–16.

By: C. Copple n, I. Robertson n, D. Thrall n & E. Samei*

author keywords: digital flat panel detector; FOM; figure of merit; kVp; SdNR; signal difference-to-noise ratio; small animal digital radiography; personnel exposure
MeSH headings : Animal Technicians; Animals; Humans; Occupational Exposure / prevention & control; Phantoms, Imaging / standards; Phantoms, Imaging / veterinary; Quality Control; Radiation Dosage; Radiation Monitoring / instrumentation; Radiation Monitoring / methods; Radiographic Image Enhancement / instrumentation; Radiographic Image Enhancement / methods; Reference Values; Signal-To-Noise Ratio
TL;DR: Evaluated methods for determining optimal kVp values for an indirect flat panel digital detector indicated that a single standard technique was only optimal for most medium-sized patients, and images of thinner patients should be made with a lower kVP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 book

Textbook of veterinary diagnostic radiology

St. Louis: Saunders Elsevier.

Donald Thrall

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

TWO ANATOMIC RESOURCES OF CANINE PELVIC LIMB MUSCLES BASED ON CT AND MRI

VETERINARY RADIOLOGY & ULTRASOUND, 53(3), 266–272.

By: S. Sunico n, C. Hamel*, M. Styner*, I. Robertson*, J. Kornegay*, C. Bettini n, J. Parks n, K. Wilber*, J. Smallwood n, D. Thrall n

author keywords: 3D Computer model; anatomic modeling; anatomy; muscle
MeSH headings : Animals; Computer Simulation; Dogs / anatomy & histology; Magnetic Resonance Imaging / veterinary; Muscle, Skeletal / anatomy & histology; Muscle, Skeletal / diagnostic imaging; Pelvis; Tomography, X-Ray Computed / veterinary
TL;DR: The Diagnostic Atlas is an interactive, multiplanar, web-based MR atlas of the canine pelvic limb musculature that was created by manually segmenting clinically analogous MR sequences and the 3D Model serves as a resource for students of gross anatomy, encouraging integrative learning with its highly interactive and selective display capabilities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Thermal dose fractionation affects tumour physiological response

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 28(5), 431–440.

By: D. Thrall n, P. Maccarini*, P. Stauffer*, J. Macfall*, M. Hauck n, S. Snyder n, B. Case n, K. Linder n ...

author keywords: thermal dosimetry; tumor oxygenation; microenvironment
MeSH headings : Animals; Antigens, Neoplasm / metabolism; Carbonic Anhydrases / metabolism; Caspase 3 / metabolism; Dogs; Hyperthermia, Induced; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Sarcoma / metabolism; Sarcoma / pathology; Sarcoma / therapy; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / therapy; Tumor Burden; Vascular Endothelial Growth Factor A / metabolism
TL;DR: There was a greater reduction in tumour volume and water diffusion at the end of therapy in tumours receiving one hyperthermia fraction per week, and response data pointed to a one per week prescription being superior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

USEFULNESS OF A HALF-FOURIER ACQUISITION SINGLE-SHOT TURBO SPIN-ECHO PULSE SEQUENCE IN IDENTIFYING ARACHNOID DIVERTICULA IN DOGS

VETERINARY RADIOLOGY & ULTRASOUND, 53(2), 157–161.

By: G. Seiler n, I. Robertson n, W. Mai*, W. Widmer*, J. Suran*, S. Nemanic*, C. Lamb*, J. Lang*, J. Johnson*, D. Thrall n

author keywords: acquisition; arachnoid diverticulum; magnetic resonance imaging; single-shot; turbo spin echo
MeSH headings : Animals; Arachnoid Cysts / diagnosis; Arachnoid Cysts / veterinary; Dog Diseases / diagnosis; Dogs; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary
TL;DR: Although sensitivity in this study was likely artificially low, the significantly increased detection rate of arachnoid diverticula when using HASTE imaging indicates that this sequence is a valuable addition to MR imaging protocols for the canine spine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics

CLINICAL CANCER RESEARCH, 17(8), 2549–2560.

By: J. Chi n, D. Thrall n, C. Jiang n, S. Snyder n, D. Fels n, C. Landon n, L. McCall n, L. Lan n ...

MeSH headings : Animals; Cluster Analysis; Combined Modality Therapy; Dogs; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics / methods; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging / methods; Oligonucleotide Array Sequence Analysis; Radiotherapy / methods; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma / genetics; Sarcoma / therapy
TL;DR: This is one of the first successful attempts to link changes in gene expression and functional imaging to understand the response heterogeneity and identify compounds enhancing thermoradiotherapy. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

IMAGING DIAGNOSIS-MAGNETIC RESONANCE IMAGING PULSATILITY ARTIFACT IN THE CANINE CERVICAL SPINE

VETERINARY RADIOLOGY & ULTRASOUND, 52(3), 313–316.

By: G. Seiler n, I. Robertson n, S. Mukundan* & D. Thrall n

author keywords: canine; cervical spine; MRI; pulsatility artifact
MeSH headings : Animals; Artifacts; Cervical Vertebrae; Dog Diseases / diagnosis; Dogs; Magnetic Resonance Imaging / veterinary; Pulsatile Flow; Spinal Cord / blood supply; Spinal Cord / pathology; Spinal Cord Diseases / diagnosis; Spinal Cord Diseases / veterinary
TL;DR: Care should be exercised to avoid misdiagnosing this pulsatility artifact seen in transverse T2-weighted images of the midcervical spine in large dogs as an intramedullary lesion when T1-images or phase-swap images are not available to confirm its artifactual origin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

IMAGING DOGS WITH SUSPECTED DISC HERNIATION: PROS AND CONS OF MYELOGRAPHY, COMPUTED TOMOGRAPHY, AND MAGNETIC RESONANCE

VETERINARY RADIOLOGY & ULTRASOUND, 52(1), S81–S84.

By: I. Robertson n & D. Thrall n

author keywords: computed tomography; dog; intervertebral disc disease; MR imaging; myelography
MeSH headings : Animals; Dog Diseases / diagnosis; Dogs; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Myelography / veterinary; Tomography, X-Ray Computed / methods; Tomography, X-Ray Computed / veterinary
TL;DR: Myelography is still considered adequate for diagnosis of disc herniation when MR and CT are unavailable, and CT myelography may be the next best option, particularly in nonchondrodystrophoid dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

CHEMOTHERAPY FOLLOWED BY ABDOMINAL CAVITY IRRADIATION FOR FELINE LYMPHOBLASTIC LYMPHOMA

VETERINARY RADIOLOGY & ULTRASOUND, 51(6), 681–687.

By: L. Williams n, A. Pruitt n & D. Thrall n

author keywords: feline; lymphoma; chemoradiotherapy
MeSH headings : Abdominal Neoplasms / blood; Abdominal Neoplasms / drug therapy; Abdominal Neoplasms / radiotherapy; Abdominal Neoplasms / veterinary; Animals; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cat Diseases / blood; Cat Diseases / drug therapy; Cat Diseases / radiotherapy; Cats; Combined Modality Therapy / veterinary; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / veterinary; Radiotherapy Dosage; Remission Induction / methods; Treatment Outcome
TL;DR: Results of this study suggest that 15 Gy total abdomen fractionated radiation therapy after induction chemotherapy is tolerated satisfactorily, and this protocol is suitable for further testing to quantify efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

CLINICAL, MAGNETIC RESONANCE, AND SONOGRAPHIC IMAGING FINDINGS IN HORSES WITH PROXIMAL PLANTAR METATARSAL PAIN

VETERINARY RADIOLOGY & ULTRASOUND, 51(1), 11–18.

By: R. Labens n, M. Schramme n, I. Robertson n, D. Thrall n & W. Redding n

author keywords: horse; MRI; proximal suspensory ligament; sonography; ultrasound
MeSH headings : Analysis of Variance; Animals; Female; Horse Diseases / diagnosis; Horse Diseases / diagnostic imaging; Horses; Lameness, Animal / diagnosis; Lameness, Animal / diagnostic imaging; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / standards; Magnetic Resonance Imaging / veterinary; Male; Metatarsal Bones / diagnostic imaging; Pain / diagnosis; Pain / diagnostic imaging; Pain / veterinary; Radiography; Retrospective Studies; Sensitivity and Specificity; Ultrasonography
TL;DR: In this retrospective study of 39 horses or 46 hind limbs with lameness due to proximal plantar metatarsal pain, the clinical and diagnostic findings are discussed and sonography and MR imaging compared for examination of the proximal part of the suspensory ligament. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

MRI FEATURES OF METACARPO(TARSO)PHALANGEAL REGION LAMENESS IN 40 HORSES

Veterinary Radiology & Ultrasound, 51(4), 404–414.

By: L. Gonzalez n, M. Schramme n, I. Robertson n, D. Thrall n & R. Redding n

author keywords: equine; fetlock; high-field magnetic resonance imaging; metacarpophalangeal joint; metatarsophalangeal joint
TL;DR: MRI provided information that was complementary to radiography, ultrasonography, and nuclear scintigraphy and that allowed for a comprehensive evaluation of all structures in the MP joint region and a diagnosis in all 40 horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2010 review

Magnetic resonance imaging: A potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer

[Review of ]. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 26(7), 625–637.

By: O. Craciunescu*, D. Thrall n, Z. Vujaskovic* & M. Dewhirst*

author keywords: imaging (DCE-MRI, DW-MRI); locally advanced breast cancer; physiological effects of hyperthermia; prediction and monitoring of tumour response
MeSH headings : Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Breast Neoplasms / drug therapy; Breast Neoplasms / pathology; Breast Neoplasms / therapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging / methods
TL;DR: The purpose of this review is to examine the potential role of magnetic resonance imaging (MRI) in early prediction of treatment response and prognosis of overall survival in locally advanced breast cancer patients enrolled on multi modality therapy trials that include hyperthermia. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

RADIATION THERAPY COMMUNICATION: NASAL PASSAGE AND PARANASAL SINUS LYMPHOMA IN A PONY

VETERINARY RADIOLOGY & ULTRASOUND, 51(1), 97–101.

By: M. Gerard n, A. Pruitt n & D. Thrall n

author keywords: equine; lymphoma; nasal passage; paranasal sinus; radiation therapy
MeSH headings : Animals; Euthanasia, Animal; Horse Diseases / pathology; Horse Diseases / radiotherapy; Horses; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / radiotherapy; Lymphoma, B-Cell / veterinary; Male; Palliative Care / methods; Paranasal Sinus Neoplasms / radiotherapy; Paranasal Sinus Neoplasms / veterinary; Radiation Dosage; Treatment Outcome
TL;DR: The results suggest that localized equine B-cell lymphoma is radiosensitive, and that palliative radiation therapy is a reasonable consideration for large tumors, even when tumor volume prevents all gross tumor from being irradiated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 26(3), 283–293.

By: M. Dewhirst*, D. Thrall n, G. Palmer*, T. Schroeder*, Z. Vujaskovic*, H. Charles*, J. Macfall*, T. Wong*

author keywords: MRI; PET; optical spectroscopy; prognosis; functional imaging; hyperthermia
MeSH headings : Combined Modality Therapy; Disease-Free Survival; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Microcirculation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / therapy; Positron-Emission Tomography; Predictive Value of Tests; ROC Curve; Thermography / methods
TL;DR: The roles that functional imaging may play in prediction of treatment response and determination of overall prognosis in patients who are enrolled in thermotherapy trials, either in combination with radiotherapy, chemotherapy or both are examined. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Dynamic Contrast-enhanced Magnetic Resonance Imaging as a Predictor of Clinical Outcome in Canine Spontaneous Soft Tissue Sarcomas Treated with Thermoradiotherapy

CLINICAL CANCER RESEARCH, 15(15), 4993–5001.

By: B. Viglianti n, M. Lora-Michiels n, J. Poulson n, L. Lan n, D. Yu n, L. Sanders n, O. Craciunescu n, Z. Vujaskovic n ...

MeSH headings : Animals; Combined Modality Therapy / veterinary; Dog Diseases / diagnosis; Dogs; Hyperthermia, Induced / veterinary; Image Enhancement; Kaplan-Meier Estimate; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Prognosis; Radiotherapy / veterinary; Radiotherapy Dosage / veterinary; Sarcoma / diagnosis; Sarcoma / pathology; Sarcoma / veterinary; Soft Tissue Neoplasms / diagnosis; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / veterinary; Treatment Outcome
TL;DR: DCE- MRI has utility predicting overall and metastasis-free survival in canine patients with soft tissue sarcomas, for the first time that DCE-MRI parameters are predictive of clinical outcome for soft tissue Sarcomas. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

EFFECT OF WETNESS LEVEL ON THE SUITABILITY OF WET GAUZE AS A SUBSTITUTE FOR SUPERFLAB((R)) AS A BOLUS MATERIAL FOR USE WITH 6 MV PHOTONS

VETERINARY RADIOLOGY & ULTRASOUND, 50(5), 555–559.

By: J. Benoit n, A. Pruitt n & D. Thrall n

author keywords: air gap; bolus; radiation therapy; Superflab((R)); surface dose
MeSH headings : Animals; Radiation Dosage; Radiotherapy, High-Energy / veterinary; Skin / radiation effects; Surgical Sponges; Water
TL;DR: If Superflab use leads to poor contact with the skin, wet gauze having a physical density of 1.02 g/cm3 can be used as a substitute, and the presence of an air gap under SuperFlab led to reduced surface dose, especially for small fields and large air gaps. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Expression of epidermal growth factor receptor and vascular endothelial growth factor in malignant canine epithelial nasal tumours

VETERINARY AND COMPARATIVE ONCOLOGY, 7(2), 106–114.

By: K. Shiomitsu n, C. Johnson n, D. Malarkey*, A. Pruitt n & D. Thrall n

author keywords: canine; EGFR; nasal tumour; radiosensitivity; VEGF
MeSH headings : Animals; Dog Diseases / metabolism; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dogs; ErbB Receptors / metabolism; Gene Expression Regulation, Neoplastic; Immunohistochemistry / veterinary; Neoplasms, Glandular and Epithelial / metabolism; Neoplasms, Glandular and Epithelial / pathology; Neoplasms, Glandular and Epithelial / radiotherapy; Neoplasms, Glandular and Epithelial / veterinary; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Treatment Outcome; Vascular Endothelial Growth Factor A / metabolism
TL;DR: Findings indicate that EGFR and VEGF proteins were present in some malignant epithelial nasal tumours in the dogs, and therefore, it may be beneficial to treat canine patients with tumours that overexpress EG FR and V EGF with specific inhibitors in conjunction with radiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

PROGNOSTIC SIGNIFICANCE OF TUMOR HISTOLOGY AND COMPUTED TOMOGRAPHIC STAGING FOR RADIATION TREATMENT RESPONSE OF CANINE NASAL TUMORS

VETERINARY RADIOLOGY & ULTRASOUND, 50(3), 330–335.

By: W. Adams*, M. Kleiter*, D. Thrall n, J. Klauer*, L. Forrest*, T. La Due, T. Havighurst*

author keywords: canine nasal tumor; predictive factors; tumor staging; veterinary radiation therapy
MeSH headings : Animals; Disease-Free Survival; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dogs; Nose Neoplasms / diagnostic imaging; Nose Neoplasms / pathology; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Prognosis; Radiotherapy Planning, Computer-Assisted / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: Prognostic significance of tumor histology and four computed tomography (CT) staging methods was tested retrospectively in dogs from three treatment centers that underwent intent-to-cure-radiotherapy for intranasal neoplasia and combined CT and histology statistically improved prognostic significance for both survival endpoints over the proposed CT staging method alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Characterization of normal tissue complications in 51 dogs undergoing definitive pelvic region irradiation

VETERINARY RADIOLOGY & ULTRASOUND, 49(1), 85–89.

By: J. Arthur n, M. Kleiter*, D. Thrall n & A. Pruitt n

author keywords: dog; radiation therapy; normal tissue complication; rectal toxicity
MeSH headings : Animals; Colonic Neoplasms / radiotherapy; Colonic Neoplasms / veterinary; Dog Diseases / epidemiology; Dog Diseases / radiotherapy; Dogs; Female; Male; Necrosis / pathology; Necrosis / veterinary; North Carolina / epidemiology; Pedigree; Pelvis / pathology; Prevalence; Radiation Injuries / epidemiology; Radiation Injuries / veterinary; Radiotherapy Dosage / veterinary; Retrospective Studies
TL;DR: The finding of an association of tumor site to complications may be a spurious finding and the association between field size and complications is not unexpected although absolute difference in field size between dogs with and without complications was small. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Diagnostic accuracy of magnetic resonance imaging for meniscal tears in dogs affected with naturally occuring cranial cruciate ligament rupture

VETERINARY RADIOLOGY & ULTRASOUND, 49(5), 425–431.

By: L. Blond n, D. Thrall n, S. Roe n, N. Chailleux n & I. Robertson n

author keywords: magnetic resonance imaging; canine; stifle; meniscus
MeSH headings : Animals; Anterior Cruciate Ligament / pathology; Anterior Cruciate Ligament Injuries; Dogs / injuries; False Positive Reactions; Female; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / standards; Magnetic Resonance Imaging / veterinary; Male; Menisci, Tibial / pathology; Rupture / diagnosis; Rupture / veterinary; Sensitivity and Specificity; Tibial Meniscus Injuries
TL;DR: High-field MR imaging is a reliable method to diagnose meniscal tears preoperatively and this may be useful in selecting the surgical approach to clinically abnormal joints and may decrease the need for arthrotomy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas

MOLECULAR CANCER THERAPEUTICS, 6(1), 380–389.

By: F. Siddiqui, C. Li*, S. LaRue, J. Poulson*, P. Avery*, A. Pruitt n, X. Zhang*, R. Ullrich ...

MeSH headings : Adenoviridae; Animals; Cats; Cytomegalovirus / genetics; Feasibility Studies; Genetic Therapy / adverse effects; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Hyperthermia, Induced; Interleukin-12 / blood; Interleukin-12 / genetics; Interleukin-12 / therapeutic use; Liver / pathology; Mice; Promoter Regions, Genetic / genetics; Recombinant Proteins / adverse effects; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Recombinant Proteins / therapeutic use; Sarcoma / drug therapy; Sarcoma / genetics; Sarcoma / radiotherapy; Sarcoma / veterinary
TL;DR: An adenoviral gene therapy vector with IL-12 controlled by a heat-inducible promoter (heat shock promoter 70B) was developed and tested in a phase I clinical trial in cats with spontaneously arising soft tissue sarcoma, finding it possible to localize gene expression and limit systemic toxicity of IL- 12 using the hyperthermia-induced gene therapy approach. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Comparison of isodose distributions in canine brain in heterogeneity-corrected versus uncorrected treatment plans using 6 MV photons

VETERINARY RADIOLOGY & ULTRASOUND, 48(3), 292–296.

By: J. Lyons n, D. Thrall n & A. Pruitt n

author keywords: heterogeneity correction; dog; radiation therapy; treatment planning
MeSH headings : Algorithms; Animals; Brain Neoplasms / radiotherapy; Brain Neoplasms / veterinary; Dog Diseases / radiotherapy; Dogs; Dose-Response Relationship, Radiation; Photons; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted / methods; Radiotherapy Planning, Computer-Assisted / veterinary; Radiotherapy, Conformal / methods; Radiotherapy, Conformal / veterinary; Tomography, Emission-Computed, Single-Photon / methods; Tomography, Emission-Computed, Single-Photon / veterinary
TL;DR: No clinically significant difference is found between CT-based radiotherapy plans without and with heterogeneity correction for brain tumors in small animals, which supports the use of MR-based treatment planning for radiotherapy of small animal brain tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Imaging diagnosis-synchronous primary brain tumors in a dog

VETERINARY RADIOLOGY & ULTRASOUND, 48(6), 550–553.

By: E. MacKillop n, D. Thrall n, R. Ranck n, K. Linder n & K. Munana n

Contributors: E. MacKillop n, D. Thrall n, R. Ranck n, K. Linder n & K. Munana n

MeSH headings : Animals; Astrocytoma / pathology; Astrocytoma / veterinary; Cerebellar Neoplasms / pathology; Cerebellar Neoplasms / veterinary; Diagnosis, Differential; Dog Diseases / cerebrospinal fluid; Dog Diseases / pathology; Dogs; Magnetic Resonance Imaging / veterinary; Male; Medulloblastoma / pathology; Medulloblastoma / veterinary; Neoplasms, Multiple Primary / pathology; Neoplasms, Multiple Primary / veterinary; Thalamic Diseases / pathology; Thalamic Diseases / veterinary
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 64(2), 592–602.

By: M. Kleiter n, D. Thrall n, D. Malarkey*, X. Ji*, D. Lee*, S. Chou*, J. Raleigh*

author keywords: hypoxia; pimonidazole; CCI-103F; differential metabolism; pH
MeSH headings : Administration, Oral; Animals; Area Under Curve; Cell Hypoxia; Cell Line; Cricetinae; Cricetulus; Dog Diseases / metabolism; Dogs; Feasibility Studies; Hydrogen-Ion Concentration; Injections, Intravenous; Neoplasms / metabolism; Neoplasms / veterinary; Nitroimidazoles / administration & dosage; Nitroimidazoles / pharmacokinetics
TL;DR: Oral pimonidazole HCl is effective as a hypoxia marker in spontaneously arising canine tumors and selective cellular uptake and concomitant higher levels of binding in regions of Hypoxia at the high end of pH gradients might account for the greater extent of pimonidsazole binding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral Doxil extravasation

CLINICAL CANCER RESEARCH, 12(22), 6800–6807.

By: M. Kleiter*, D. Yu, L. Mohammadian*, N. Niehaus, I. Spasojevic*, L. Sanders*, B. Viglianti*, P. Yarmolenko* ...

MeSH headings : Animals; Antibiotics, Antineoplastic / pharmacokinetics; Antibiotics, Antineoplastic / therapeutic use; Combined Modality Therapy / methods; Diagnostic Imaging / methods; Dose-Response Relationship, Drug; Doxorubicin / pharmacokinetics; Doxorubicin / therapeutic use; Drug Carriers / administration & dosage; Feasibility Studies; Female; Fibrosarcoma / therapy; Hyperthermia, Induced / methods; Liposomes / administration & dosage; Liposomes / pharmacokinetics; Radioactive Tracers; Rats; Technetium Tc 99m Exametazime / administration & dosage; Thigh / radiation effects; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
TL;DR: The use of a radiolabeled tracer has potential value to monitor drug delivery and estimate the effect of an intervention aimed to increase liposomal accumulation, such as local hyperthermia. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 22(5), 365–373.

By: D. Thrall n, S. Larue*, A. Pruitt n, B. Case n & M. DeWhirst*

author keywords: hyperthermia; radiation therapy; dog; oxygen measurements
MeSH headings : Animals; Cell Hypoxia / physiology; Cell Hypoxia / radiation effects; Combined Modality Therapy / methods; Combined Modality Therapy / veterinary; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Oxygen / analysis; Oxygen / metabolism; Sarcoma / metabolism; Sarcoma / therapy; Sarcoma / veterinary
TL;DR: There was an increase in oxygenation in tumours with low pre-treatment oxygenation that persisted throughout treatment, an advantageous hyperthermia effect as it may lead to increased radiation cell killing at each fraction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Epidermal growth factor receptor expression in feline oral squamous cell carcinomas

VETERINARY AND COMPARATIVE ONCOLOGY, 4(1), 33–40.

By: J. Looper n, D. Malarkey*, D. Ruslander n, D. Proulx n & D. Thrall n

author keywords: epidermal growth factor receptor; feline; immunohistochemistry; oral squamous cell carcinoma; tyrosine kinase inhibitors
TL;DR: Thirteen formalin-fixed paraffin wax-embedded biopsy samples from feline oral SCC were analysed and nine of 13 tumours were positive for EGFR expression, suggesting that altered EGFRexpression plays a role in feline Oral SCC and provides a rationale for a potential clinical benefit using EGFR inhibitors in combination with conventional treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy

CLINICAL CANCER RESEARCH, 12(19), 5733–5740.

By: M. Lora-Michiels*, D. Yu*, L. Sanders*, J. Poulson*, C. Azuma*, B. Case n, Z. Vujaskovic*, D. Thrall n, H. Charles*, M. Dewhirst*

MeSH headings : Animals; Combined Modality Therapy; Disease Models, Animal; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Female; Hydrogen-Ion Concentration; Hyperthermia, Induced; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphorus Isotopes; Prospective Studies; Radiotherapy Dosage; Sarcoma / pathology; Sarcoma / therapy; Sarcoma / veterinary; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / therapy; Soft Tissue Neoplasms / veterinary; Treatment Outcome
TL;DR: PHe was predictive of metastasis and OS in canine spontaneous sarcomas, the first time that pHe has been shown to be predictive of clinical outcome, and the results suggest that additional studies should be considered evaluating the prognostic significance of this variable. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Magnetic resonance imaging findings in a dog with caudal aortic thromboembolism and ischemic myopathy

VETERINARY RADIOLOGY & ULTRASOUND, 47(4), 334–338.

By: P. Brofman* & D. Thrall n

MeSH headings : Animals; Aorta, Thoracic / pathology; Aortic Diseases / complications; Aortic Diseases / pathology; Aortic Diseases / veterinary; Diagnosis, Differential; Dog Diseases / pathology; Dogs; Magnetic Resonance Imaging / veterinary; Male; Paresis / etiology; Paresis / veterinary; Thromboembolism / complications; Thromboembolism / pathology; Thromboembolism / veterinary
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors

CLINICAL CANCER RESEARCH, 12(13), 4004–4010.

By: M. Hauck n, S. LaRue*, W. Petros*, J. Poulson*, D. Yu, I. Spasojevic, A. Pruitt n, A. Klein n ...

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacokinetics; Carcinoma / therapy; Carcinoma / veterinary; Combined Modality Therapy; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Doxorubicin / pharmacokinetics; Drug Administration Schedule; Drug Delivery Systems; Female; Hyperthermia, Induced / methods; Liposomes; Male; Maximum Tolerated Dose; Microwaves / therapeutic use; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Treatment Outcome
TL;DR: LTSL-doxorubicin offers a novel approach to improving drug delivery to solid tumors and was well tolerated and resulted in favorable response profiles in these patients. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Value of a single-shot turbo spin-echo pulse sequence for assessing the architecture of the subarachnoid space and the constitutive nature of cerebrospinal fluid

VETERINARY RADIOLOGY & ULTRASOUND, 47(3), 254–259.

By: A. Pease n, S. Sullivan n, N. Olby n, H. Galano n, S. Cerda-Gonzalez n, I. Robertson n, P. Gavin*, D. Thrall n

author keywords: cervical; half-Fourier acquisition single-shot turbo spin echo; magnetic resonance imaging; myelogram; shot turbo spin echo
MeSH headings : Animals; Cat Diseases / cerebrospinal fluid; Cat Diseases / pathology; Cats; Diagnosis, Differential; Dog Diseases / cerebrospinal fluid; Dog Diseases / pathology; Dogs; Encephalitis / complications; Encephalitis / pathology; Encephalitis / veterinary; Female; Lameness, Animal / etiology; Lumbar Vertebrae / pathology; Lymphoma, Non-Hodgkin / complications; Lymphoma, Non-Hodgkin / pathology; Lymphoma, Non-Hodgkin / veterinary; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Male; Spinal Cord Neoplasms / complications; Spinal Cord Neoplasms / pathology; Spinal Cord Neoplasms / veterinary; Subarachnoid Space / pathology
TL;DR: Although the resolution of the single-shot turbo spin-echo pulse sequence images is relatively poor compared with more conventional sequences, the qualitative information about the subarachnoid space and cerebrospinal fluid and the rapid acquisition time, make it a useful sequence to include in standard protocols of spinal magnetic resonance imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 interview

An interview with... Dr. Donald E. Thrall

By: D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Re-setting the biologic rationale for thermal therapy

Dewhirst, M. W., Vujaskovic, Z., Jones, E., & Thrall, D. (2005, December). INTERNATIONAL JOURNAL OF HYPERTHERMIA, Vol. 21, pp. 779–790.

By: M. Dewhirst*, Z. Vujaskovic*, E. Jones* & D. Thrall n

author keywords: thermal dose; clinical trials; hypoxia; hyperthermia biology
MeSH headings : Cell Death / physiology; Clinical Trials as Topic; Hot Temperature; Humans; Hyperthermia, Induced; Neoplasms / therapy; Retrospective Studies
TL;DR: New knowledge about the biology of hyperthermia compels one to continue to move the field forward, but with thermal goals that are eminently achievable and tolerable by patients, as well as on an integrated biological, engineering and clinical level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy

Clinical Cancer Research, 11(14), 5206–5214.

By: D. Thrall, S. Larue, D. Yu, T. Samulski, L. Sanders, B. Case, G. Rosner, C. Azuma ...

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Use of radiography in combination with computed tomography for the assessment of noncardiac thoracic disease in the dog and cat

VETERINARY RADIOLOGY & ULTRASOUND, 46(2), 114–121.

By: A. Prather*, C. Berry* & D. Thrall n

author keywords: computed tomography; thoracic diseases; thoracic radiographs
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cats; Dog Diseases / diagnostic imaging; Dogs; Female; Male; Predictive Value of Tests; Radiography, Thoracic / veterinary; Thoracic Diseases / diagnostic imaging; Thoracic Diseases / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: Computed tomography is a valuable tool for evaluating intrathoracic disease because it provides additional cross-sectional anatomic information that can aid in anatomic localization and evaluation of the extent of the pathology in question. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Chemotherapy followed by half-body radiation therapy for canine lymphoma

JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(5), 703–709.

By: L. Williams n, J. Johnson*, M. Hauck n, D. Ruslander n, G. Price n & D. Thrall n

author keywords: cancer; dog; multimodality therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 20(5), 477–489.

By: J. Poulson*, Z. Vujaskovic*, A. Gaskin*, S. Larue*, R. Meyer n, D. Prescott, T. Samulski*, D. Thrall n, M. Dewhirst*

author keywords: tumours; hyperthermia; sodium nitroprusside; CGRP
MeSH headings : Animals; Blood Pressure / drug effects; Calcitonin Gene-Related Peptide / therapeutic use; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / physiopathology; Dog Diseases / radiotherapy; Dog Diseases / therapy; Dogs; Hyperthermia, Induced; Nitroprusside / therapeutic use; Sarcoma / drug therapy; Sarcoma / radiotherapy; Sarcoma / therapy; Sarcoma / veterinary; Soft Tissue Neoplasms / drug therapy; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / therapy; Soft Tissue Neoplasms / veterinary; Vasodilator Agents / therapeutic use
TL;DR: There is little justification for translation of this approach to human trials using conventional local hyperthermia treatment of SNP, and a significant increase was seen in tumour but not normal subcutaneous tissue temperatures, which was not sufficient to improve the likelihood of increased response rates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Expression of cyclooxygenase-2 in canine epithelial nasal tumors

VETERINARY RADIOLOGY & ULTRASOUND, Vol. 45, pp. 255–260.

By: M. Kleiter n, D. Malarkey*, D. Ruslander n & D. Thrall n

author keywords: canine; cyclooxygenase-2; nasal tumors; radiation therapy
MeSH headings : Adenocarcinoma / enzymology; Adenocarcinoma / veterinary; Animals; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / veterinary; Case-Control Studies; Combined Modality Therapy; Cyclooxygenase 2; Dog Diseases / drug therapy; Dog Diseases / enzymology; Dog Diseases / radiotherapy; Dogs; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Isoenzymes / metabolism; Nose Neoplasms / enzymology; Nose Neoplasms / veterinary; Prostaglandin-Endoperoxide Synthases / metabolism; Records / veterinary; Retrospective Studies
TL;DR: A combination therapy of irradiation and a selective COX-2 inhibitor appears worthy of clinical investigation in the treatment of canine epithelial nasal tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Malignant tumor formation in dogs previously irradiated for acanthomatous epulis

Veterinary Radiology & Ultrasound, 45(4), 357–361.

By: M. McEntee, R. Page, A. Theon, H. Erb & D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Use of photon fields with noncoincident isocenters to improve homogeneity of dose distribution

VETERINARY RADIOLOGY & ULTRASOUND, 45(5), 471–475.

By: A. Pruitt n & D. Thrall n

author keywords: boost fields; noncoincident isocenters; radiation therapy; dog
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / radiotherapy; Dogs; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Radiography; Radiotherapy Dosage / veterinary; Radiotherapy Planning, Computer-Assisted / veterinary
TL;DR: Improved tumor dose distribution was achieved with the addition of a smaller field having a different isocenter, and dose delivered to the mandible was lower in all dogs with the use of noncoincident fields, as it was possible to reduce the dose delivered from the ventral field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

A retrospective analysis of 140 dogs with oral melanoma treated with external beam radiation

VETERINARY RADIOLOGY & ULTRASOUND, 44(3), 352–359.

By: D. Proulx n, D. Ruslander n, R. Dodge*, M. Hauck n, L. Williams n, B. Horn, G. Price, D. Thrall n

author keywords: dog; oral malignant melanoma; radiation therapy; prognostic factors
MeSH headings : Animals; Disease-Free Survival; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Dose Fractionation, Radiation; Female; Male; Melanoma / mortality; Melanoma / veterinary; Mouth Neoplasms / mortality; Mouth Neoplasms / veterinary; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / veterinary; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Survival Analysis; Treatment Outcome
TL;DR: External beam radiation therapy is effective in local disease control of canine oral malignant melanoma; however, the optimal fractionation scheme has yet to be determined and further investigation into novel therapies is warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Images from the 2002 ACVR Certification Examination: Small animal diagnosis elective

VETERINARY RADIOLOGY & ULTRASOUND, 44(1), 118–121.

By: D. Thrall n

MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / diagnostic imaging; Cats; Certification; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dogs; Male; Radiography; Veterinary Medicine
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Radiographic features of aortic bulb/valve mineralization in 20 dogs

VETERINARY RADIOLOGY & ULTRASOUND, 44(1), 20–27.

By: J. Douglass n, C. Berry n, D. Thrall n, D. Malarkey n & K. Spaulding n

author keywords: canine; aortic bulb mineralization; radiography
MeSH headings : Animals; Aortic Valve / diagnostic imaging; Aortic Valve / pathology; Calcification, Physiologic; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Male; Radiography
TL;DR: Based on the histologic findings in one dog, the mineralization seen in the aortic root is similar to a form of dystrophic mineralization called Monckeberg's calcific arteriosclerosis in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

CT findings of intracranial blastomycosis in a dog

VETERINARY RADIOLOGY & ULTRASOUND, 43(1), 16–21.

By: M. Saito*, N. Sharp, K. Munana*, B. Troan*, M. Tokuriki n & D. Thrall n

Contributors: M. Saito*, N. Sharp, K. Munana*, B. Troan*, M. Tokuriki n & D. Thrall n

MeSH headings : Animals; Blastomycosis / diagnostic imaging; Blastomycosis / pathology; Blastomycosis / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Male; Tomography, X-Ray Computed
TL;DR: Computed tomography findings in a dog with intracranial blastomycosis were marked periventricular contrast enhancement of the lateral ventricles, the 3rd ventricle, and the mesencephalic aqueduct. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

Images from the 2001 ACVR Certifying Examination - CT/MR elective section

VETERINARY RADIOLOGY & ULTRASOUND, 43(1), 68–69.

By: D. Thrall n

MeSH headings : Animals; Arachnoid Cysts / diagnostic imaging; Arachnoid Cysts / veterinary; Certification; Dog Diseases / diagnostic imaging; Dogs; Male; Tomography, X-Ray Computed; Veterinary Medicine
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos

VETERINARY RADIOLOGY & ULTRASOUND, 43(4), 331–337.

By: M. Saito n, N. Sharp n, G. Kortz*, A. Lahunta*, R. Leventer*, M. Tokuriki*, D. Thrall n

MeSH headings : Animals; Brain / abnormalities; Brain / pathology; Breeding; Diagnosis, Differential; Dog Diseases / pathology; Dogs; Female; Humans; Magnetic Resonance Imaging / veterinary
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Preoperative radiotherapy for vaccine associated sarcoma in 92 cats

VETERINARY RADIOLOGY & ULTRASOUND, 43(5), 473–479.

By: T. Kobayashi n, M. Hauck n, R. Dodge*, R. Page*, G. Price, L. Williams n, E. Hardie n, K. Mathews n, D. Thrall n

author keywords: cat; vaccine-associated sarcoma; radiation therapy; preoperative irradiation
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Carboplatin / administration & dosage; Carboplatin / therapeutic use; Cat Diseases / chemically induced; Cat Diseases / drug therapy; Cat Diseases / radiotherapy; Cat Diseases / surgery; Cats; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; Female; Male; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / prevention & control; Neoplasm Recurrence, Local / veterinary; North Carolina; Preoperative Care / veterinary; Records / veterinary; Retrospective Studies; Sarcoma / chemically induced; Sarcoma / mortality; Sarcoma / radiotherapy; Sarcoma / surgery; Sarcoma / veterinary; Soft Tissue Neoplasms / chemically induced; Soft Tissue Neoplasms / mortality; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / surgery; Soft Tissue Neoplasms / veterinary; Treatment Outcome; Vaccination / adverse effects; Vaccination / veterinary
TL;DR: Preoperative irradiation is an effective treatment for cats with vaccine associated sarcoma, especially if complete excision can be accomplished following irradiation, and outcome in cats receiving carboplatin was better than all other treatment groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Results of radiation therapy in 19 dogs with cutaneous mast cell tumor and regional lymph node metastasis

VETERINARY RADIOLOGY & ULTRASOUND, 43(4), 392–395.

By: K. Chaffin n & D. Thrall n

author keywords: canine; mast cell tumor; megavoltage radiation
MeSH headings : Animals; Combined Modality Therapy; Disease-Free Survival; Dog Diseases / mortality; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dog Diseases / surgery; Dogs; Dose-Response Relationship, Radiation; Female; Forelimb; Hindlimb; Lymphatic Metastasis / radiotherapy; Male; Mast-Cell Sarcoma / mortality; Mast-Cell Sarcoma / radiotherapy; Mast-Cell Sarcoma / secondary; Mast-Cell Sarcoma / surgery; Mast-Cell Sarcoma / veterinary; Neoplasm Recurrence, Local / pathology; Neoplasm Recurrence, Local / veterinary; North Carolina; Records / veterinary; Severity of Illness Index; Skin Neoplasms / mortality; Skin Neoplasms / pathology; Skin Neoplasms / radiotherapy; Skin Neoplasms / surgery; Skin Neoplasms / veterinary; Treatment Outcome
TL;DR: The disease-free survival in dogs with stage 2 mast cell tumor suggests that the combination of surgery, irradiation, and prednisone for the primary tumor along with irradiation of the positive lymph node is effective. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 book

Textbook of veterinary diagnostic radiology

Philadelphia, Pa.: W.B. Saunders.

By: D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Computed tomographic imaging of infiltrative lipoma in 22 dogs

VETERINARY RADIOLOGY & ULTRASOUND, 42(3), 221–225.

By: M. McEntee* & D. Thrall n

author keywords: infiltrative or infiltrating lipoma; computed tomography; canine
MeSH headings : Animals; Contrast Media / administration & dosage; Dog Diseases / diagnostic imaging; Dogs; Female; Forelimb; Head; Hindlimb; Injections, Intravenous / veterinary; Lipoma / diagnostic imaging; Lipoma / veterinary; Male; Records / veterinary; Retrospective Studies; Shoulder; Soft Tissue Neoplasms / diagnostic imaging; Soft Tissue Neoplasms / veterinary; Thorax; Tomography, X-Ray Computed / veterinary
TL;DR: CT imaging allows adequate discrimination of tumor with the caveat that differentiation of normal fat from infiltrative lipoma can be problematic, and tumors tended to be less well-defined in regions where the infiltrate interdigitated with normal body fat. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Images from the 2001 ACVR certifying examination - CT/MR elective section

VETERINARY RADIOLOGY & ULTRASOUND, 42(6), 594–594.

By: D. Thrall n

MeSH headings : Animals; Certification; Dog Diseases / pathology; Dogs; Femoral Neuropathy / complications; Femoral Neuropathy / pathology; Femoral Neuropathy / veterinary; Lameness, Animal / etiology; Male; Veterinary Medicine
Source: Web Of Science
Added: August 6, 2018

2001 article

Retrospective analysis of axial skeleton osteosarcoma in 22 large-breed dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 15, pp. 120–124.

By: M. Dickerson n, R. Page n, T. LaDue n, M. Hauck n, D. Thrall n, M. Stebbins n, G. Price n

author keywords: canine; metastasis; radiation therapy; retriever
TL;DR: Prevalence of metastasis and median survival for large-breed dogs with axial skeleton OSA seems to be similar to that reported for large and purebred dogs with appendicular skeletons OSA, and definitive radiation therapy may have a role in the treatment of axialkeleton osteosarcoma. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 article

Semiquantitative immunohistochemical analysis for hypoxia in human tumors

Raleigh, J. A., Chou, S. C., Bono, E. L., Thrall, D. E., & Varia, M. A. (2001, February 1). INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 49, pp. 569–574.

By: J. Raleigh*, S. Chou*, E. Bono*, D. Thrall n & M. Varia*

author keywords: immunohistochemical assay; pimonidazole; quantitation
MeSH headings : Calibration; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / physiopathology; Cell Hypoxia; Female; Head and Neck Neoplasms / metabolism; Head and Neck Neoplasms / physiopathology; Humans; Immunohistochemistry; Nitroimidazoles / metabolism; Observer Variation; Radiation-Sensitizing Agents / metabolism; Uterine Cervical Neoplasms / metabolism; Uterine Cervical Neoplasms / physiopathology
TL;DR: The calibrated, semiquantitative assay shows promise as an approach to simplifying the quantitation of human tumor hypoxia by immunohistochemical techniques. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs

In Vivo (Athens, Greece), 14(6), 709–714.

By: J. Poulson, M. Dewhirst, A. Gaskin, Z. Vujaskovic, T. Samulski, D. Prescott, R. Meyer, R. Page, D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Dynamic CT measurement of contrast medium washin kinetics in canine nasal tumors

Veterinary Radiology & Ultrasound, 41(5), 403–408.

By: S. Van Camp n, P. Fisher n & D. Thrall n

MeSH headings : Animals; Contrast Media / pharmacokinetics; Dog Diseases / radiotherapy; Dogs; Female; Male; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Perfusion / veterinary; Tomography, X-Ray Computed
TL;DR: Measurement of perfusion in canine nasal tumors using dynamic CT is possible and further study of this parameter as it relates to radiation response is reasonable. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas

Clinical Cancer Research, 6(9), 3748–3755.

By: M. Matteucci, G. Anyarambhatla, G. Rosner, C. Azuma, P. Fisher, M. Dewhirst, D. Needham, D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Primary irradiation of canine intracranial masses

VETERINARY RADIOLOGY & ULTRASOUND, 41(4), 377–380.

By: E. Spugnini n, D. Thrall n, G. Price n, N. Sharp n, K. Munana n & R. Page n

Contributors: E. Spugnini n, D. Thrall n, G. Price n, N. Sharp n, K. Munana n & R. Page n

author keywords: dog; brain tumor; radiation therapy
MeSH headings : Animals; Brain Neoplasms / diagnostic imaging; Brain Neoplasms / mortality; Brain Neoplasms / radiotherapy; Brain Neoplasms / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Glioma / diagnostic imaging; Glioma / mortality; Glioma / radiotherapy; Glioma / veterinary; Male; Meningeal Neoplasms / diagnostic imaging; Meningeal Neoplasms / mortality; Meningeal Neoplasms / radiotherapy; Meningeal Neoplasms / veterinary; Radiography; Radiotherapy / veterinary
TL;DR: Radiation therapy is superior to medical treatment of brain tumors in dogs with steroids, is useful for tumors that are not currently operable and may be preferable to surgical resection in dogs if the mass appears infiltrative, however, 22/29 (76%) dogs died of recurrent progressive neuropathy suggestive of tumor regrowth or progression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Results of irradiation of infiltrative lipoma in 13 dogs

VETERINARY RADIOLOGY & ULTRASOUND, 41(6), 554–556.

By: M. McEntee*, R. Page n, G. Mauldin* & D. Thrall n

author keywords: infiltrating or infiltrative lipoma; radiation therapy; canine
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Lipoma / mortality; Lipoma / radiotherapy; Lipoma / veterinary; Male; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Survival Analysis; Tomography, X-Ray Computed / veterinary; Treatment Outcome
TL;DR: It appears that dogs with infiltrative lipomas can benefit from external beam irradiation alone or in combination with surgery to effect long-term local tumor control. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 46(1), 179–185.

By: Z. Vujaskovic*, J. Poulson*, A. Gaskin*, D. Thrall n, R. Page n, H. Charles*, . MacFall*, D. Brizel* ...

author keywords: tumors; hyperthermia blood how; pO(2); pH; thermal dose
MeSH headings : Animals; Combined Modality Therapy; Dogs; Female; Hydrogen-Ion Concentration; Hyperthermia, Induced / methods; Male; Oxygen / metabolism; Partial Pressure; Sarcoma, Experimental / blood supply; Sarcoma, Experimental / metabolism; Sarcoma, Experimental / radiotherapy; Sarcoma, Experimental / therapy; Soft Tissue Neoplasms / blood supply; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / therapy
TL;DR: This study suggests that hyperthermia has biphasic effects on tumor physiologic parameters, and suggests that the thermal threshold for vascular damage is higher in spontaneous tumors than in more rapidly growing rodent tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

The computed tomographic appearance of acute thoracolumbar intervertebral disk herniations in dogs.

Veterinary Radiology Ultrasound, 41(5), 396–402.

By: N. Olby n, K. Muntana, N. Sharp n & D. Thrall n

Contributors: N. Olby n, K. Muñana n, N. Sharp n & D. Thrall n

author keywords: intervertebral disc herniation; computed tomography; myelography; epidural hemorrhage; dog
MeSH headings : Animals; Diskectomy; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Hematoma, Epidural, Cranial / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Myelography; Spinal Cord / pathology; Tomography, X-Ray Computed
TL;DR: In dogs with a long standing history of disc herniations, disc material identified in the vertebral canal had a more hyperattenuating and homogeneous appearance than recently herniated disc material. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2000 journal article

The relationship between intracellular and extracellular pH in spontaneous canine tumors

Clinical Cancer Research, 6(6), 2501–2505.

By: D. Prescott, H. Charles, J. Poulson, R. Page, D. Thrall, Z. Vujaskovic, M. Dewhirst

Source: NC State University Libraries
Added: August 6, 2018

2000 review

The role of liposomes in drug delivery and diagnostic imaging: A review

[Review of ]. VETERINARY RADIOLOGY & ULTRASOUND, 41(2), 100–107.

By: M. Matteucci n & D. Thrall n

MeSH headings : Animal Diseases / diagnostic imaging; Animals; Contrast Media / administration & dosage; Diagnostic Imaging / methods; Diagnostic Imaging / veterinary; Drug Carriers; Drug Delivery Systems / veterinary; Liposomes; Radiography; Veterinary Drugs / administration & dosage
TL;DR: Because of their unique properties liposomes will continue to be investigated in drug delivery and imaging systems, and very likely will be incorporated into the discipline of veterinary medicine as the clinical applications of liposome technology continue to expand. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 personal communication

Untitled - Reply

By: D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Using units of CEM 43 degrees C T-90, local hyperthermia thermal dose can be delivered as prescribed

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 16(5), 415–428.

By: D. Thrall n, G. Rosner*, C. Azuma n, S. Larue*, B. Case n, T. Samulski*, M. Dewhirst*

author keywords: dog; hyperthermia; thermal dose
MeSH headings : Animals; Catheterization; Combined Modality Therapy; Dogs; Dose-Response Relationship, Radiation; Hyperthermia, Induced / methods; Radiotherapy / methods; Sarcoma / pathology; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Time Factors
TL;DR: Relatively simple but accurate methods of delivering prescribed thermal dose as described herein will aid the translation of clinicalhyperthermia from the research setting into more general practice once the characteristics of the relationship between hyperthermia dose and outcome are understood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Factors influencing survival after radiotherapy of nasal tumors in 130 dogs

VETERINARY RADIOLOGY & ULTRASOUND, 40(3), 312–317.

By: T. LaDue n, R. Dodge n, R. Page n, G. Price n, M. Hauck n & D. Thrall n

author keywords: dog; nasal tumor; radiation therapy; cobalt; predictive factors
MeSH headings : Animals; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Multivariate Analysis; Nose Neoplasms / mortality; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Prognosis; Radiotherapy Dosage; Survival Rate
TL;DR: In a subset of dogs that received cobalt radiation, after adjusting for age, dogs treated with a boost technique had decreased survival and in general, local control of canine nasal tumors following aggressive radiation therapy is poor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Osteosarcoma at the site of bone infarction associated with total hip arthroplasty in a dog

VETERINARY SURGERY, 28(1), 54–60.

By: D. Marcellin-Little n, D. DeYoung n, D. Thrall n & C. Merrill n

MeSH headings : Animals; Arthroplasty, Replacement, Hip / adverse effects; Arthroplasty, Replacement, Hip / veterinary; Dog Diseases / etiology; Dogs; Femoral Neoplasms / etiology; Femoral Neoplasms / veterinary; Femur / blood supply; Infarction / complications; Infarction / etiology; Infarction / veterinary; Male; Osteosarcoma / etiology; Osteosarcoma / veterinary
TL;DR: Bilateral medullary bone infarction was visible in the femoral canals 1 year after THA and remained visible on subsequent evaluations, and an osteosarcoma developed in the right distal femoral metaphysis at the site ofinfarction, 5 years after ThA and was found to have metastasized widely throughout the body. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 article

Palliative radiotherapy of appendicular osteosarcoma in 95 dogs

VETERINARY RADIOLOGY & ULTRASOUND, Vol. 40, pp. 517–522.

By: O. Ramirez, R. Dodge, R. Page*, G. Price, M. Hauck*, T. LaDue, F. Nutter*, D. Thrall*

author keywords: canine; osteosarcoma; palliative radiotherapy
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / radiotherapy; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / radiotherapy; Dogs; Dose-Response Relationship, Radiation; Female; Male; Multivariate Analysis; Osteosarcoma / drug therapy; Osteosarcoma / radiotherapy; Osteosarcoma / veterinary; Palliative Care; Probability
TL;DR: Ninety-five dogs with either a presumptive or biopsy confirmed diagnosis of osteosarcoma received palliative radiotherapy using 60Co photons and seventy-three of the 95 dogs experienced pain relief following treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Radiographic diagnosis: Effect of right vs. left lateral recumbency on myelographic appearance of a lateralized extradural mass

VETERINARY RADIOLOGY & ULTRASOUND, 40(4), 351–352.

By: M. Matteucci n, O. Ramirez n & D. Thrall n

MeSH headings : Animals; Calcinosis / diagnostic imaging; Calcinosis / veterinary; Cervical Vertebrae / diagnostic imaging; Dog Diseases / diagnostic imaging; Dogs; Hemiplegia / diagnostic imaging; Hemiplegia / veterinary; Intervertebral Disc / diagnostic imaging; Male; Myelography / methods; Myelography / veterinary; Neck Pain / diagnostic imaging; Neck Pain / veterinary; Posture; Spinal Cord Compression / diagnostic imaging; Spinal Cord Compression / veterinary; Spinal Diseases / diagnostic imaging; Spinal Diseases / veterinary
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Tumour cell kinetics as predictors of response in canine lymphoma treated with chemotherapy alone or combined with whole body hyperthermia

International Journal of Hyperthermia, 15(6), 475–486.

By: S. Larue*, M. Fox, G. Ogilvie, R. Page*, D. Getzy, D. Thrall*, J. Johnson, M. Dewhirst*, E. Gillette

MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Cycle; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Doxorubicin / administration & dosage; Hyperthermia, Induced; Indazoles / administration & dosage; Lymphoma / drug therapy; Lymphoma / therapy; Lymphoma / veterinary; Prognosis
TL;DR: Kinetic parameters including potential doubling time (Tpot), duration of S phase (Ts), labelling index (LI), and DNA index (DI) were obtained from 42 dogs with previously untreated lymphoma and dogs treated only with chemotherapy had significantly longer remission duration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses

International Journal of Hyperthermia, 15(5), 383–398.

By: D. Thrall, S. Larue, B. Powers, R. Page, J. Johnson, S. George, J. Kornegay, M. McEntee ...

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

A review of imaging techniques for canine cauda equina syndrome

VETERINARY RADIOLOGY & ULTRASOUND, 39(4), 283–296.

By: O. Ramirez n & D. Thrall n

author keywords: cauda equina syndrome; dog; contrast radiography; myelography; epidurography; discography; computed tomography; magnetic resonance imaging
MeSH headings : Animals; Cauda Equina / diagnostic imaging; Cauda Equina / pathology; Diagnostic Imaging / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dogs; Dura Mater / diagnostic imaging; Dura Mater / pathology; Epidural Space; Female; Intervertebral Disc / diagnostic imaging; Lumbar Vertebrae / diagnostic imaging; Lumbar Vertebrae / pathology; Magnetic Resonance Imaging / veterinary; Male; Myelography / veterinary; Nerve Compression Syndromes / diagnosis; Nerve Compression Syndromes / diagnostic imaging; Nerve Compression Syndromes / veterinary; Phlebography / veterinary; Sacrum / diagnostic imaging; Sacrum / pathology; Sensitivity and Specificity; Spinal Canal / diagnostic imaging; Spinal Canal / pathology; Tomography / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: Computed tomography and magnetic resonance imaging have become valuable in evaluating the lumbosacral region in dogs and have proven to be both sensitive and specific for determining cauda equina compression in both humans and in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 chapter

Biologic principles of radiation therapy

In Cancer in dogs and cats: Medical and surgical management (pp. 399–413). Baltimore: Williams & Wilkins.

By: D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Bt resistance management

NATURE BIOTECHNOLOGY, 16(2), 144–146.

By: W. McGaughey*, F. Gould n & W. Gelernter*

MeSH headings : Bacillus thuringiensis; Bacillus thuringiensis Toxins; Bacterial Proteins / administration & dosage; Bacterial Proteins / genetics; Bacterial Toxins; Crops, Agricultural / genetics; Endotoxins / administration & dosage; Endotoxins / genetics; Genetic Engineering; Hemolysin Proteins; Insecticide Resistance; Insecticides / administration & dosage; Pest Control, Biological; Plants, Genetically Modified
TL;DR: A plan for reconciling the needs of the many stakeholders in Bacillus thuringiensis endotoxin-based products (including transgenic plants) is considered under the following headings: the problem of resistance, general strategies, a national forum, need for more research, funding, coordination and education, implementation of resistance management plans and conclusions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 journal article

Computed tomographic diagnosis: Use of computed tomography to distinguish a pulmonary mass from alveolar disease

VETERINARY RADIOLOGY & ULTRASOUND, 39(6), 532–535.

By: D. Spann n, R. Sellon n, D. Thrall n, A. Bostian n & G. Boston*

MeSH headings : Animals; Diagnosis, Differential; Dog Diseases / diagnostic imaging; Dogs; Female; Lung Diseases, Interstitial / diagnostic imaging; Lung Diseases, Interstitial / veterinary; Lung Neoplasms / diagnostic imaging; Lung Neoplasms / veterinary; Mast-Cell Sarcoma / diagnostic imaging; Mast-Cell Sarcoma / veterinary; Pulmonary Alveoli / diagnostic imaging; Tomography, X-Ray Computed / veterinary
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 review

Imaging basilar skull fractures in the horse: A review

[Review of ]. VETERINARY RADIOLOGY & ULTRASOUND, 39(5), 391–395.

By: O. Ramirez n, J. Jorgensen n & D. Thrall n

author keywords: basisphenoid; basilar skull; fracture; guttural pouch; equine
MeSH headings : Animals; Horses / injuries; Occipital Bone / anatomy & histology; Occipital Bone / diagnostic imaging; Occipital Bone / injuries; Radiography; Skull Fractures / diagnostic imaging; Skull Fractures / physiopathology; Skull Fractures / veterinary
TL;DR: When available and when the patient will accommodate the equipment, computed tomography may give a definitive diagnosis owing to its superior resolution and differentiation of soft tissue structures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Potential complications associated with normothermic lonidamine infusion and with systemic acidosis in dogs receiving lonidamine during whole body hyperthermia (WBH)

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 14(3), 271–283.

By: G. Price n, J. Cline*, R. Page n, J. Riviere n & D. Thrall n

author keywords: lonidamine; whole body hyperthermia; vascular toxicosis; systemic pH; haemorrhage
MeSH headings : Acidosis; Animals; Dogs; Hyperthermia, Induced; Indazoles / adverse effects; Radiation-Sensitizing Agents / adverse effects; Thrombosis / chemically induced; Vasculitis / chemically induced
TL;DR: The observations confirm the results of in vitro studies which suggest that the combined effect of lonidamine and hyperthermia is enhanced under acidic conditions and indicate that acid-base status of patients receiving l onidamine during WBH must be monitored carefully to avoid serious complications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Radiation therapy for incompletely resected canine mast cell tumors

VETERINARY RADIOLOGY & ULTRASOUND, 39(1), 57–62.

By: T. LaDue n, G. Price n, R. Dodge n, R. Page n & D. Thrall n

author keywords: canine; mast cell neoplasia; megavoltage radiation
MeSH headings : Adrenal Cortex Hormones / therapeutic use; Age Factors; Animals; Cobalt Radioisotopes / therapeutic use; Disease-Free Survival; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dog Diseases / surgery; Dogs; Dose Fractionation, Radiation; Female; Follow-Up Studies; Lymph Nodes / radiation effects; Lymphatic Metastasis / radiotherapy; Male; Mast-Cell Sarcoma / pathology; Mast-Cell Sarcoma / radiotherapy; Mast-Cell Sarcoma / secondary; Mast-Cell Sarcoma / surgery; Mast-Cell Sarcoma / veterinary; Neoplasm Recurrence, Local / pathology; Neoplasm Recurrence, Local / veterinary; Neoplasm Staging / veterinary; Neoplasm, Residual / radiotherapy; Neoplasm, Residual / veterinary; Neoplasms, Second Primary / pathology; Neoplasms, Second Primary / veterinary; Radiopharmaceuticals / therapeutic use; Radiotherapy Dosage / veterinary; Radiotherapy, High-Energy / veterinary; Retrospective Studies; Sex Factors; Skin Neoplasms / pathology; Skin Neoplasms / radiotherapy; Skin Neoplasms / surgery; Skin Neoplasms / veterinary; Survival Rate; Time Factors
TL;DR: Data presented herein support megavoltage radiation as an effective treatment for canine mast cell neoplasia, and suggest that disease free interval in dogs treated with daily fractions may be longer than that achieved with alternating day fractions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 book

Textbook of veterinary diagnostic radiology

Philadelphia: W. B. Saunders.

Donald Thrall

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Biologic basis of radiation therapy

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 27(1), 21-&.

By: D. Thrall n

MeSH headings : Animals; Cat Diseases / radiotherapy; Cats; Dog Diseases / radiotherapy; Dogs; Neoplasms / physiopathology; Neoplasms / radiotherapy; Neoplasms / veterinary; Radiation Effects; Radiation Oncology; Radiobiology / methods; Radiotherapy / methods; Radiotherapy / veterinary; Radiotherapy Dosage
TL;DR: When evaluating historic data regarding the response of canine and feline tumors to irradiation, the time-dose scheme used must be considered, and the response rates published must be tempered by the fact that it may be possible to obtain better tumor control rates using smaller doses per fraction and a larger total dose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Correlation between thoracic radiographic changes and remission/survival duration in 270 dogs with lymphosarcoma

VETERINARY RADIOLOGY & ULTRASOUND, 38(6), 411–418.

By: G. Starrak, C. Berry*, R. Page n, J. Johnson* & D. Thrall*

author keywords: lymphosarcoma; dog; thoracic radiography; phenotype; cranial mediastinal lymphadenomegaly
MeSH headings : Animals; Disease-Free Survival; Dog Diseases / diagnostic imaging; Dogs; Female; Lung Neoplasms / diagnostic imaging; Lung Neoplasms / pathology; Lung Neoplasms / veterinary; Lymphocyte Subsets; Lymphoma, Non-Hodgkin / diagnostic imaging; Lymphoma, Non-Hodgkin / mortality; Lymphoma, Non-Hodgkin / pathology; Lymphoma, Non-Hodgkin / veterinary; Male; Multivariate Analysis; Neoplasm Metastasis / diagnostic imaging; Phenotype; Prognosis; Radiography, Thoracic / veterinary; Remission Induction; Retrospective Studies; Sex Factors; Survival Rate
TL;DR: A retrospective study was undertaken wherein the medical records and thoracic radiographs of 270 dogs with lymphosarcoma were reviewed and only T-cell phenotype and the presence of cranial mediastinal lymphadenomegaly were identified as having a significant negative correlation to both primary remission and survival duration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Hypoxia marker labeling in tumor biopsies: quantification of labeling variation and criteria for biopsy sectioning

RADIOTHERAPY AND ONCOLOGY, 44(2), 171–176.

By: D. Thrall n, G. Rosner*, C. Azuma n, M. McEntee n & J. Raleigh*

author keywords: hypoxia; canine tumors; nitroimidazole markers; hypoxia markers; CCI-103F; sampling error
MeSH headings : Animals; Biopsy; Cell Hypoxia; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Neoplasms / metabolism; Neoplasms / pathology; Neoplasms / veterinary; Nitroimidazoles
TL;DR: Comparing the intrabiopsy distribution of CCI-103F, a 2-nitroimidazole hypoxia marker, in dogs bearing spontaneous solid tumors found quantification of the labeled area in four randomly selected slides from a biopsy can provide an estimate of the labeling area in the biopsy within an absolute range of +/-0.05. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime

RADIATION RESEARCH, 148(1), 35–42.

By: C. Azuma*, J. Raleigh* & D. Thrall*

TL;DR: The longevity of pimonidazole adducts in tumors was quantified as an estimate of the lifetime of hypoxic cells and there was no relationship in individual tumors between the relative change in antigen concentration and therelative change in labeled area fraction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 37(4), 897–905.

By: A. Kennedy*, J. Raleigh*, G. Perez*, D. Calkins*, D. Thrall*, D. Novotny n, M. Varia*

author keywords: hypoxia; proliferation; hypoxia marker; pimonidazole; MIB-1; PCNA; cervix carcinoma
MeSH headings : Adult; Antigens, Nuclear; Biomarkers; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Carcinoma, Squamous Cell / physiopathology; Cell Division; Cell Hypoxia / physiology; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Nitroimidazoles / metabolism; Nuclear Proteins / metabolism; Proliferating Cell Nuclear Antigen / metabolism; Radiation-Sensitizing Agents / metabolism; Uterine Cervical Neoplasms / metabolism; Uterine Cervical Neoplasms / pathology; Uterine Cervical Neoplasms / physiopathology
TL;DR: Investigation of immunohistochemical staining for pimonidazole binding in primary squamous cell carcinoma of the cervix uteri found it consistent with the presence of hypoxic cells in human tumors and may be useful for estimating tumor hypoxia before radiation therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Quantification of CCI-103F labeling heterogeneity in canine solid tumors

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 37(3), 655–662.

By: J. Cline n, G. Rosner*, J. Raleigh* & D. Thrall n

author keywords: hypoxia; canine tumors; nitroimidazole markers; hypoxia markers; CCI-103F; sampling error
MeSH headings : Analysis of Variance; Animals; Biomarkers; Cell Hypoxia; Dog Diseases / pathology; Dogs; Neoplasms / pathology; Neoplasms / veterinary; Nitroimidazoles; Oxygen / analysis; Reproducibility of Results
TL;DR: Despite intratumor variation, acceptable estimates of nitroimidazole-labeled cells in a tumor may be obtained from a clinically feasible number of biopsies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Hypoxia in canine tumors

Veterinary Cancer Society Newsletter, 20(3), 6.

By: D. Thrall, J. Cline, M. McEntee, C. Azuma & J. Raleigh

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 38(2), 129–135.

By: G. Price n, R. Page n, J. Riviere n, J. Cline n & D. Thrall n

author keywords: lonidamine; pharmacokinetics; dog
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Dogs; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Injections, Intravenous; Kinetics; Liver / drug effects; Liver / pathology; Male; Testis / drug effects; Testis / pathology; Vomiting / chemically induced
TL;DR: The findings suggest that lonidamine is hepatotoxic in dogs, and the dose and route appears to be a viable and controllable method for prospective quantification of l onidamine interaction with systemic chemotherapy and/or hyperthermia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 12(3), 309–320.

By: M. Hauck*, G. Price n, G. Ogilvie*, J. Johnson*, E. Gillette*, D. Thrall n, M. Dewhirst*, R. Page*

author keywords: hyperthermia; mitoxanthrone; lymphoma; canine
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Blood Cell Count / veterinary; Dogs; Female; Fever / veterinary; Lymphoma / metabolism; Lymphoma / therapy; Lymphoma / veterinary; Male; Mitoxantrone / therapeutic use; Mitoxantrone / toxicity; Neutropenia / complications; Neutropenia / veterinary; Neutrophils / metabolism; Regression Analysis; Thrombocytopenia / complications; Thrombocytopenia / veterinary
TL;DR: It is concluded that MX may be administered without dose reduction to dogs undergoing WBH and that MX should be evaluated more thoroughly in future thermochemotherapy studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1995 journal article

EFFECT OF WHOLE-BODY HYPERTHERMIA ON LONIDAMINE AND DOXORUBICIN PHARMACOKINETICS AND TOXICITY IN DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11(4), 545–559.

By: G. Price n, R. Page n, J. Riviere n, J. Cline n, D. Frazier* & D. Thrall n

author keywords: LONIDAMINE; DOXORUBICIN; WHOLE BODY HYPERTHERMIA; PHARMACOKINETICS; TOXICITY
MeSH headings : Animals; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Bile Acids and Salts / blood; Blood Chemical Analysis; Dogs; Doxorubicin / blood; Doxorubicin / pharmacokinetics; Doxorubicin / toxicity; Hyperthermia, Induced; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Liver / drug effects; Liver / ultrastructure; Metabolic Clearance Rate; Microscopy, Electron; Myocardial Contraction / drug effects; Myocardium / ultrastructure; Vacuoles / drug effects; Vacuoles / ultrastructure
TL;DR: WBH did not decrease the maximum tolerable dose of doxorubicin when given with lonidamine, and that the antitumour activity of this combination should be assessed, but the biochemical and haematologic toxicities observed did not appear to differ in character or severity from that reported in dogs receiving lonIDamine +/- WBH or doxorbicin +/-WBH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1995 journal article

EFFECT OF WHOLE-BODY HYPERTHERMIA ON THE PHARMACOKINETICS AND TOXICITY OF LONIDAMINE IN DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11(4), 531–544.

By: G. Price n, R. Page n, J. Riviere n, J. Cline n & D. Thrall n

author keywords: LONIDAMINE; WHOLE-BODY HYPERTHERMIA; PHARMACOKINETICS; TOXICITY; DOG
MeSH headings : Alanine Transaminase / blood; Alkaline Phosphatase / blood; Amylases / blood; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Bilirubin / blood; Blood Glucose / metabolism; Carbon Dioxide / blood; Creatine Kinase / blood; Dogs; Hyperthermia, Induced; Hypokalemia / etiology; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Liver / drug effects; Liver / pathology; Sialorrhea / etiology; Urea / blood
TL;DR: The pharmacokinetics and toxicity of intravenous lonidamine were investigated in dogs receiving four cycles of lonidsamine and 400 mg/m2 was identified as the maximum tolerable dose to be administered intravenously to dogs during whole-body hyperthermia (WBH). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1995 journal article

Palliative radiation therapy

Seminars in Veterinary Medicine and Surgery (Small Animal), 10(3), 205.

By: D. Thrall & S. LaRue

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

EFFECT OF WHOLE-BODY HYPERTHERMIA ON CARBOPLATIN DISPOSITION AND TOXICITY IN DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(6), 807–816.

MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / toxicity; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Female; Hematopoietic System / drug effects; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary
TL;DR: A randomized phase II evaluation should be initiated to determine if a therapeutic gain can be achieved using combined CBDCA and WBH and further refinement of the CBDCA dose in such a trial should be based on both pharmacokinetic parameters and normal tissue response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1993 journal article

A BOOST TECHNIQUE FOR IRRADIATION OF MALIGNANT CANINE NASAL TUMORS

VETERINARY RADIOLOGY & ULTRASOUND, 34(4), 295–300.

By: D. Thrall n, M. Mcentee n, C. Novotney n, M. Hauck n & R. Page n

author keywords: BOOST IRRADIATION; RADIATION THERAPY; DOG; NASAL TUMOR
TL;DR: Although there is justification for assessing more aggressive radiation protocols in canine nasal tumor patients, total doses approximating 60 Gy can not be given as described because of the inability of acutely responding normal tissues to compensate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1992 journal article

QUANTITATIVE ESTIMATION OF THE THERMAL DOSE-MODIFYING FACTOR FOR CIS-DIAMMINEDICHLOROPLATINUM (CDDP) IN TUMOR-BEARING DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 8(6), 761–769.

By: R. Page n, D. Thrall n, S. George*, G. Price n, G. Heidner n, M. Mcentee n, C. Novotney n, M. Hauck n, M. Dewhirst n

MeSH headings : Animals; Bone Marrow / drug effects; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Drug Tolerance; Female; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Kidney / drug effects; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary; Organoplatinum Compounds / administration & dosage; Organoplatinum Compounds / adverse effects
TL;DR: A statistical method for estimating clinical toxicity was used to determine a theoretical isoeffect dose-modifying factor for dogs with disseminated or refractory neoplasia treated with cis-diammine dichloroplatinum (II) plus whole-body hyperthermia or CDDP alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1989 conference paper

Effect of temperature on cisplatin (CDDP) and carboplatin (CBDCA) pharmacokinetic disposition in dogs

Conference Proceedings, 2, 499–501.

Source: NC State University Libraries
Added: August 6, 2018

1986 journal article

Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs

International Journal of Hyperthermia, 2, 351–358.

By: J. Riviere n, R. Page n, M. Dewhirst*, K. Tyczkowska n & D. Thrall n

MeSH headings : Animals; Biotransformation; Cisplatin / blood; Cisplatin / metabolism; Dogs; Half-Life; Hyperthermia, Induced / methods; Kinetics; Platinum / blood; Spectrophotometry, Atomic; Ultrafiltration
TL;DR: Data from in vitro and in vivo cisplatin pharmacokinetic studies in dogs would indicate that at the elevated temperatures encountered in whole body hyperthermia, the rate of formation of reactive metabolites from parent cisPlatin is increased. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

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