Tomasz J. Czernuszewicz

Works (16)

Updated: November 28th, 2024 05:01

2024 article

Noninvasive Monitoring of Steatotic Liver Disease in Western Diet-Fed Obese Mice Using Automated Ultrasound and Shear Wave Elastography

Czernuszewicz, T. J., Wang, Y., Jiang, L., Kim, K., Mikulski, Z., Aji, A. M., … Schnabl, B. (2024, November 11). LIVER INTERNATIONAL.

By: T. Czernuszewicz n, Y. Wang *, L. Jiang *, K. Kim *, Z. Mikulski *, A. Aji, J. Rojas, R. Gessner, B. Schnabl *

author keywords: fatty liver; liver echogenicity; liver stiffness; shear wave elastography; small animal imaging; Western diet model
Source: Web Of Science
Added: November 25, 2024

2022 article

Development of a Robotic Shear Wave Elastography System for Noninvasive Staging of Liver Disease in Murine Models

Czernuszewicz, T. J., Aji, A. M., Moore, C. J., Montgomery, S. A., Velasco, B., Torres, G., … Gessner, R. C. (2022, February 24). HEPATOLOGY COMMUNICATIONS.

By: T. Czernuszewicz n, A. Aji n, C. Moore n, S. Montgomery  n, B. Velasco  n, G. Torres  n, K. Anand n, K. Johnson n ...

MeSH headings : Animals; Disease Models, Animal; Elasticity Imaging Techniques / methods; Female; Liver Cirrhosis / diagnostic imaging; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease / diagnostic imaging; Reproducibility of Results; Robotic Surgical Procedures
TL;DR: Robotic SWE in small animals is feasible and sensitive to small changes in liver disease state, facilitating in vivo staging of rodent liver disease with minimal sonographic expertise. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 7, 2022

2022 journal article

Validation of a combined ultrasound and bioluminescence imaging system with magnetic resonance imaging in orthotopic pancreatic murine tumors

SCIENTIFIC REPORTS, 12(1).

By: J. Rojas*, J. Joiner *, B. Velasco  n, K. Bautista  n, A. Aji*, C. Moore*, N. Beaumont *, Y. Pylayeva-Gupta * ...

MeSH headings : Animals; Cell Line, Tumor; Disease Progression; Early Detection of Cancer / methods; High-Throughput Screening Assays; Magnetic Resonance Imaging; Mice, Inbred C57BL; Multimodal Imaging; Optical Imaging; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / pathology; Predictive Value of Tests; Reproducibility of Results; Time Factors; Tumor Burden; Ultrasonography
TL;DR: It is concluded that combining BLI with robotic US offers an efficient screening tool for orthotopic tumor models, and offers complementary advantages of detection sensitivity and quantification accuracy, while mitigating individual technological weaknesses. (via Semantic Scholar)
Source: Web Of Science
Added: February 7, 2022

2020 journal article

Carotid Plaque Fibrous Cap Thickness Measurement by ARFI Variance of Acceleration: In Vivo Human Results

IEEE TRANSACTIONS ON MEDICAL IMAGING, 39(12), 4383–4390.

By: G. Torres  n, T. Czernuszewicz n, J. Homeister *, M. Farber *, M. Caughey  n & C. Gallippi n

author keywords: Thickness measurement; Imaging; In vivo; Image segmentation; Acceleration; Atherosclerosis; Correlation; Atherosclerosis; carotid endarterectomy (CEA); carotid plaque; acoustic radiation force impulse (ARFI) imaging
MeSH headings : Acceleration; Atherosclerosis; Carotid Arteries / diagnostic imaging; Carotid Stenosis / diagnostic imaging; Endarterectomy, Carotid; Humans; Plaque, Atherosclerotic / diagnostic imaging
TL;DR: It is suggested that ARFI log(VoA) enables improved discrimination of fibrous cap thickness relative to ARFI PD and further contributes to the growing body of evidence demonstrating ARFI’s overall relevance to delineating the structure and composition of carotid atherosclerotic plaque for stroke risk prediction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 4, 2021

2019 article

A preclinical ultrasound platform for widefield 3D imaging of rodent tumors

Czernuszewicz, T., Papadopoulou, V., Rojas, J. D., Rajamahendiran, R., Perdomo, J., Butler, J., … Gessner, R. C. (2019, July). CANCER RESEARCH, Vol. 79.

By: T. Czernuszewicz*, V. Papadopoulou  n, J. Rojas*, R. Rajamahendiran*, J. Perdomo *, J. Butler *, M. Harlacher*, G. O'Connell * ...

TL;DR: A novel robotic preclinical US imaging system that can accurately and consistently evaluate tumors in rodent models is demonstrated and leverages cost-effective robotic technology, and a new scanning paradigm that allows for easy and reproducible data acquisition to enable wide-field, 3D, multi-parametric ultrasound imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2019 journal article

Delineation of Human Carotid Plaque Features In Vivo by Exploiting Displacement Variance

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 66(3), 481–492.

By: G. Torres  n, T. Czernuszewicz n, J. Homeister *, M. Caughey *, B. Huang *, E. Lee *, C. Zamora *, M. Farber* ...

author keywords: Acoustic radiation force impulse (ARFI) imaging; atherosclerosis; carotid endarterectomy (CEA); carotid plaque characterization
MeSH headings : Aged; Carotid Arteries / diagnostic imaging; Carotid Arteries / pathology; Carotid Arteries / surgery; Carotid Stenosis / diagnostic imaging; Carotid Stenosis / pathology; Carotid Stenosis / surgery; Elasticity Imaging Techniques / methods; Endarterectomy, Carotid; Female; Humans; Image Interpretation, Computer-Assisted / methods; Male; Middle Aged; Plaque, Atherosclerotic / diagnostic imaging; Plaque, Atherosclerotic / pathology; Plaque, Atherosclerotic / surgery; Signal-To-Noise Ratio
TL;DR: It is suggested that log(VoA) enhances the differentiation of LRNC, IPH, COL, and CAL in human carotid plaques, in vivo, which is clinically relevant to improving stroke risk prediction and medical management. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: April 2, 2019

2019 article

Tracking angiogenesis induced microvascular changes in a lymphoma model via a new high throughput non-invasive dual modality imaging platform

Rojas, J. D., Rajamahendiran, R., Czernuszewicz, T. J., Velasco, B., Perdomo, J., Harlacher, M., … Gessner, R. C. (2019, July). CANCER RESEARCH, Vol. 79.

By: J. Rojas*, R. Rajamahendiran*, T. Czernuszewicz*, B. Velasco  n, J. Perdomo *, M. Harlacher*, G. O'Connell *, J. Butler * ...

TL;DR: It is demonstrated that non-invasive measurements of in vivo microvascular remodeling can be precisely mapped to changes in tumor growth with a hybrid modality system, and should prove valuable when using antiangiogenic therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2018 journal article

Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 66(3), 873–880.

By: J. Rojas n, V. Papadopoulou  n, T. Czernuszewicz*, R. Rajamahendiran*, A. Chytil*, Y. Chiang*, D. Chong*, V. Bautch ...

author keywords: Microvasculature; angiogenesis; ultrasound; contrast agents; response to therapy; acoustic angiography
MeSH headings : Angiogenesis Inhibitors / pharmacology; Angiography / methods; Animals; Carcinoma, Renal Cell / blood supply; Carcinoma, Renal Cell / diagnostic imaging; Drug Monitoring; Female; Heterografts; Kidney / blood supply; Kidney / diagnostic imaging; Kidney Neoplasms / blood supply; Kidney Neoplasms / diagnostic imaging; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels / diagnostic imaging; Microvessels / drug effects; Microvessels / pathology; Ultrasonography / methods
TL;DR: Results suggest that future applications utilizing ultrasound imaging to monitor tumor response to therapy may be able to provide earlier insight into tumor behavior from metrics of microvascular density rather than anatomical tumor size measurements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 11, 2019

2017 journal article

Performance of acoustic radiation force impulse ultrasound imaging for carotid plaque characterization with histologic validation

JOURNAL OF VASCULAR SURGERY, 66(6), 1749-+.

By: T. Czernuszewicz n, J. Homeister *, M. Caughey *, Y. Wang *, H. Zhu *, B. Huang *, E. Lee *, C. Zamora * ...

MeSH headings : Aged; Area Under Curve; Calcium / analysis; Carotid Arteries / chemistry; Carotid Arteries / diagnostic imaging; Carotid Arteries / pathology; Carotid Artery Diseases / diagnostic imaging; Carotid Artery Diseases / pathology; Collagen / analysis; Elasticity Imaging Techniques; Female; Fibrosis; Hemorrhage / diagnostic imaging; Hemorrhage / pathology; Humans; Male; Middle Aged; Necrosis; Observer Variation; Pilot Projects; Plaque, Atherosclerotic; Predictive Value of Tests; Prognosis; Prospective Studies; ROC Curve; Reproducibility of Results; Vascular Calcification / diagnostic imaging; Vascular Calcification / pathology
TL;DR: The performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation is suggested to be capable of distinguishing soft from stiff atherosclerotic plaque components and delineating FC thickness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 conference paper

Carotid plaque characterization with ARFI imaging: Blinded reader study

2016 ieee international ultrasonics symposium (ius).

By: T. Czernuszewicz*, J. Homeister *, M. Caughey  n, B. Huang *, E. Lee *, C. Zamora *, M. Farber *, J. Fulton* ...

TL;DR: It is suggested that ARFI is capable of distinguishing soft from stiff compositional elements of atherosclerotic plaques and may be relevant to improving plaque risk assessment. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

On the Feasibility of Quantifying Fibrous Cap Thickness With Acoustic Radiation Force Impulse (ARFI) Ultrasound

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 63(9), 1262–1275.

By: T. Czernuszewicz n & C. Gallippi n

author keywords: Acoustic radiation force; acoustic radiation force impulse (ARFI); atherosclerosis; fibrous cap (FC); finite-element method (FEM); resolution; vulnerable plaque
MeSH headings : Carotid Arteries / diagnostic imaging; Elasticity Imaging Techniques; Humans; Motion; Plaque, Atherosclerotic / diagnostic imaging; Ultrasonography
TL;DR: The results of this study demonstrate that tracking pulse frequencies around 12 MHz are necessary to resolve caps around 0.2 mm; large motion-tracking kernel sizes introduce bias into thickness measurements and overestimate the true cap thickness; and color saturation settings on ARFI peak displacement images can impact thickness measurement accuracy substantially. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Design, Fabrication, and Characterization of a Bifrequency Colinear Array

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 63(2), 266–274.

By: Z. Wang n, S. Li n, T. Czernuszewicz n, C. Gallippi n, R. Liu *, X. Geng*, X. Jiang n 

Contributors: Z. Wang n, S. Li n, T. Czernuszewicz n, C. Gallippi n, R. Liu *, X. Geng*, X. Jiang n 

author keywords: Bifrequency ultrasound; colinear array; composite transducer
TL;DR: The results of this study suggest that bifrequency colinear arrays are potential aids for wideband fundamental imaging and harmonic/subharmonic imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

Dual-frequency IVUS transducer for acoustic radiation force impulse (ARFI) imaging

2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS).

By: Z. Wang n, X. Jiang n , T. Czernuszewicz*, C. Gallippi* & Ieee

Contributors: Z. Wang n, X. Jiang n , T. Czernuszewicz*, C. Gallippi* & Ieee

author keywords: dual frequency ultrasound; ultrasound transducer; intravascular ultrasound; IVUS; acoustic radiation force; ARFI
TL;DR: A dual-frequency IVUS transducer, consisting of a 6.5 MHz “pushing” element and a 26 MHz ‘tracking’ element, was designed and fabricated for ARFI application and suggests great potential of this dual- frequencies for intravascular ARFI imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Acoustic radiation force (ARF) generation with a novel dual-frequency intravascular transducer.

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 2284–2287.

By: T. Czernuszcwicz, C. Gallippi n, Z. Wang n, J. Ma*, X. Jiang n  & Ieee

Contributors: T. Czernuszcwicz, C. Gallippi n, Z. Wang n, J. Ma*, X. Jiang n  & Ieee

author keywords: ultrasound transducer; dual frequency; acoustic radiation force; ARFI; intravascular; IVUS
TL;DR: The results of this study show that ARF generation and high-resolution tracking is feasible on a small-aperture transducer fit for IVUS implementation, and is also shown to demonstrate backscatter sensitivity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Displacement Underestimation Correction Using Shear Waves in VisR Ultrasound

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 1065–1068.

By: M. Selzo*, T. Czernuszewicz* & C. Gallippi n

author keywords: Viscoelastic Response (VisR) ultrasound; Acoustic Radiation Force (ARF); finite element model; optical tracking
TL;DR: It is hypothesized that by utilizing shear waves to generate displacement and monitoring tissue displacement outside the region of excitation the authors can better estimate axial displacements and generate τ measurements that more closely represent the material. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Acoustic Radiation Force Beam Sequence Performance for Detection and Material Characterization of Atherosclerotic Plaques: Preclinical, Ex Vivo Results

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 60(12), 2471–2487.

By: R. Behler n, T. Czernuszewicz n, C. Wu *, T. Nichols *, H. Zhu *, J. Homeister *, E. Merricks*, C. Gallippi n

MeSH headings : Algorithms; Animals; Elasticity Imaging Techniques / methods; Femoral Artery / diagnostic imaging; Femoral Artery / pathology; Image Processing, Computer-Assisted; Phantoms, Imaging; Plaque, Atherosclerotic / diagnostic imaging; ROC Curve; Swine
TL;DR: Results suggest ARF-based imaging is relevant to detecting and characterizing plaques and support its use for diagnosing and monitoring atherosclerosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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