Tomasz J. Czernuszewicz

Works (16)

Updated: April 25th, 2025 12:46

2024 article

Noninvasive Monitoring of Steatotic Liver Disease in Western Diet‐Fed Obese Mice Using Automated Ultrasound and Shear Wave Elastography

Czernuszewicz, T. J., Wang, Y., Jiang, L., Kim, K., Mikulski, Z., Aji, A. M., … Schnabl, B. (2024, November 11). Liver International.

By: T. Czernuszewicz n, Y. Wang *, L. Jiang *, K. Kim *, Z. Mikulski *, A. Aji, J. Rojas, R. Gessner, B. Schnabl *

author keywords: fatty liver; liver echogenicity; liver stiffness; shear wave elastography; small animal imaging; Western diet model
MeSH headings : Animals; Elasticity Imaging Techniques; Mice, Inbred C57BL; Female; Diet, Western / adverse effects; Disease Models, Animal; Mice; Liver / diagnostic imaging; Liver / pathology; Obesity; Liver Cirrhosis / diagnostic imaging; Liver Cirrhosis / pathology; Liver Cirrhosis / etiology; Non-alcoholic Fatty Liver Disease / diagnostic imaging; Non-alcoholic Fatty Liver Disease / pathology; Fatty Liver / diagnostic imaging; Fatty Liver / pathology; Fatty Liver / etiology
topics (OpenAlex): Liver Disease Diagnosis and Treatment; Cardiovascular Disease and Adiposity; Infrared Thermography in Medicine
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Source: Web Of Science
Added: November 25, 2024

2022 article

Development of a Robotic Shear Wave Elastography System for Noninvasive Staging of Liver Disease in Murine Models

Czernuszewicz, T. J., Aji, A. M., Moore, C. J., Montgomery, S. A., Velasco, B., Torres, G., … Gessner, R. C. (2022, February 24). Hepatology Communications.

By: T. Czernuszewicz n, A. Aji n, C. Moore n, S. Montgomery  n, B. Velasco  n, G. Torres  n, K. Anand n, K. Johnson n ...

MeSH headings : Animals; Disease Models, Animal; Elasticity Imaging Techniques / methods; Female; Liver Cirrhosis / diagnostic imaging; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease / diagnostic imaging; Reproducibility of Results; Robotic Surgical Procedures
topics (OpenAlex): Liver Disease Diagnosis and Treatment; Ultrasound Imaging and Elastography; Ultrasound and Hyperthermia Applications
TL;DR: Robotic SWE in small animals is feasible and sensitive to small changes in liver disease state, facilitating in vivo staging of rodent liver disease with minimal sonographic expertise. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 7, 2022

2022 article

Validation of a combined ultrasound and bioluminescence imaging system with magnetic resonance imaging in orthotopic pancreatic murine tumors

Rojas, J. D., Joiner, J. B., Velasco, B., Bautista, K. J. B., Aji, A. M., Moore, C. J., … Czernuszewicz, T. J. (2022, January 7). Scientific Reports.

By: J. Rojas*, J. Joiner *, B. Velasco  n, K. Bautista  n, A. Aji*, C. Moore*, N. Beaumont *, Y. Pylayeva-Gupta * ...

MeSH headings : Animals; Cell Line, Tumor; Disease Progression; Early Detection of Cancer / methods; High-Throughput Screening Assays; Magnetic Resonance Imaging; Mice, Inbred C57BL; Multimodal Imaging; Optical Imaging; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / pathology; Predictive Value of Tests; Reproducibility of Results; Time Factors; Tumor Burden; Ultrasonography
topics (OpenAlex): 3D Printing in Biomedical Research; Cancer Research and Treatments; Cancer Cells and Metastasis
TL;DR: It is concluded that combining BLI with robotic US offers an efficient screening tool for orthotopic tumor models, and offers complementary advantages of detection sensitivity and quantification accuracy, while mitigating individual technological weaknesses. (via Semantic Scholar)
Source: Web Of Science
Added: February 7, 2022

2020 article

Carotid Plaque Fibrous Cap Thickness Measurement by ARFI Variance of Acceleration: In Vivo Human Results

Torres, G., Czernuszewicz, T. J., Homeister, J. W., Farber, M. A., Caughey, M. C., & Gallippi, C. M. (2020, August 24). IEEE Transactions on Medical Imaging.

By: G. Torres  n, T. Czernuszewicz n, J. Homeister *, M. Farber *, M. Caughey  n & C. Gallippi n

author keywords: Thickness measurement; Imaging; In vivo; Image segmentation; Acceleration; Atherosclerosis; Correlation; Atherosclerosis; carotid endarterectomy (CEA); carotid plaque; acoustic radiation force impulse (ARFI) imaging
MeSH headings : Acceleration; Atherosclerosis; Carotid Arteries / diagnostic imaging; Carotid Stenosis / diagnostic imaging; Endarterectomy, Carotid; Humans; Plaque, Atherosclerotic / diagnostic imaging
topics (OpenAlex): Cerebrovascular and Carotid Artery Diseases; Cardiovascular Health and Disease Prevention; Acute Ischemic Stroke Management
TL;DR: It is suggested that ARFI log(VoA) enables improved discrimination of fibrous cap thickness relative to ARFI PD and further contributes to the growing body of evidence demonstrating ARFI’s overall relevance to delineating the structure and composition of carotid atherosclerotic plaque for stroke risk prediction. (via Semantic Scholar)
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Source: Web Of Science
Added: January 4, 2021

2019 article

Abstract 1935: Tracking angiogenesis induced microvascular changes in a lymphoma model via a new high throughput non-invasive dual modality imaging platform

Rojas, J. D., Rajamahendiran, R., Czernuszewicz, T. J., Velasco, B., Perdomo, J., Harlacher, M., … Gessner, R. C. (2019, July 1). Cancer Research.

By: J. Rojas*, R. Rajamahendiran*, T. Czernuszewicz*, B. Velasco  n, J. Perdomo *, M. Harlacher*, G. O'Connell *, J. Butler * ...

topics (OpenAlex): Photodynamic Therapy Research Studies; bioluminescence and chemiluminescence research
TL;DR: It is demonstrated that non-invasive measurements of in vivo microvascular remodeling can be precisely mapped to changes in tumor growth with a hybrid modality system, and should prove valuable when using antiangiogenic therapies. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2019 article

Abstract 1955: A preclinical ultrasound platform for widefield 3D imaging of rodent tumors

Czernuszewicz, T., Papadopoulou, V., Rojas, J. D., Rajamahendiran, R., Perdomo, J., Butler, J., … Gessner, R. C. (2019, July 1). Cancer Research.

By: T. Czernuszewicz*, V. Papadopoulou  n, J. Rojas*, R. Rajamahendiran*, J. Perdomo *, J. Butler *, M. Harlacher*, G. O'Connell * ...

topics (OpenAlex): Cancer Research and Treatments; Cancer, Hypoxia, and Metabolism; Cancer Genomics and Diagnostics
TL;DR: A novel robotic preclinical US imaging system that can accurately and consistently evaluate tumors in rodent models is demonstrated and leverages cost-effective robotic technology, and a new scanning paradigm that allows for easy and reproducible data acquisition to enable wide-field, 3D, multi-parametric ultrasound imaging. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2019 article

Delineation of Human Carotid Plaque Features <italic>In Vivo</italic> by Exploiting Displacement Variance

Torres, G., Czernuszewicz, T. J., Homeister, J. W., Caughey, M. C., Huang, B. Y., Lee, E. R., … Gallippi, C. M. (2019, February 11). IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control.

By: G. Torres  n, T. Czernuszewicz n, J. Homeister *, M. Caughey *, B. Huang *, E. Lee *, C. Zamora *, M. Farber* ...

author keywords: Acoustic radiation force impulse (ARFI) imaging; atherosclerosis; carotid endarterectomy (CEA); carotid plaque characterization
MeSH headings : Aged; Carotid Arteries / diagnostic imaging; Carotid Arteries / pathology; Carotid Arteries / surgery; Carotid Stenosis / diagnostic imaging; Carotid Stenosis / pathology; Carotid Stenosis / surgery; Elasticity Imaging Techniques / methods; Endarterectomy, Carotid; Female; Humans; Image Interpretation, Computer-Assisted / methods; Male; Middle Aged; Plaque, Atherosclerotic / diagnostic imaging; Plaque, Atherosclerotic / pathology; Plaque, Atherosclerotic / surgery; Signal-To-Noise Ratio
topics (OpenAlex): Cardiovascular Health and Disease Prevention; Cerebrovascular and Carotid Artery Diseases; Ultrasound Imaging and Elastography
TL;DR: It is suggested that log(VoA) enhances the differentiation of LRNC, IPH, COL, and CAL in human carotid plaques, in vivo, which is clinically relevant to improving stroke risk prediction and medical management. (via Semantic Scholar)
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Source: Web Of Science
Added: April 2, 2019

2018 article

Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma

Rojas, J. D., Papadopoulou, V., Czernuszewicz, T. J., Rajamahendiran, R. M., Chytil, A., Chiang, Y.-C., … Dayton, P. A. (2018, July 27). IEEE Transactions on Biomedical Engineering.

By: J. Rojas n, V. Papadopoulou  n, T. Czernuszewicz*, R. Rajamahendiran*, A. Chytil*, Y. Chiang*, D. Chong*, V. Bautch * ...

author keywords: Microvasculature; angiogenesis; ultrasound; contrast agents; response to therapy; acoustic angiography
MeSH headings : Angiogenesis Inhibitors / pharmacology; Angiography / methods; Animals; Carcinoma, Renal Cell / blood supply; Carcinoma, Renal Cell / diagnostic imaging; Drug Monitoring; Female; Heterografts; Kidney / blood supply; Kidney / diagnostic imaging; Kidney Neoplasms / blood supply; Kidney Neoplasms / diagnostic imaging; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels / diagnostic imaging; Microvessels / drug effects; Microvessels / pathology; Ultrasonography / methods
topics (OpenAlex): MRI in cancer diagnosis; Renal cell carcinoma treatment; Angiogenesis and VEGF in Cancer
TL;DR: Results suggest that future applications utilizing ultrasound imaging to monitor tumor response to therapy may be able to provide earlier insight into tumor behavior from metrics of microvascular density rather than anatomical tumor size measurements. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 11, 2019

2017 article

Performance of acoustic radiation force impulse ultrasound imaging for carotid plaque characterization with histologic validation

Czernuszewicz, T. J., Homeister, J. W., Caughey, M. C., Wang, Y., Zhu, H., Huang, B. Y., … Gallippi, C. M. (2017, July 13). Journal of Vascular Surgery.

By: T. Czernuszewicz n, J. Homeister *, M. Caughey *, Y. Wang *, H. Zhu *, B. Huang *, E. Lee *, C. Zamora * ...

MeSH headings : Aged; Area Under Curve; Calcium / analysis; Carotid Arteries / chemistry; Carotid Arteries / diagnostic imaging; Carotid Arteries / pathology; Carotid Artery Diseases / diagnostic imaging; Carotid Artery Diseases / pathology; Collagen / analysis; Elasticity Imaging Techniques; Female; Fibrosis; Hemorrhage / diagnostic imaging; Hemorrhage / pathology; Humans; Male; Middle Aged; Necrosis; Observer Variation; Pilot Projects; Plaque, Atherosclerotic; Predictive Value of Tests; Prognosis; Prospective Studies; ROC Curve; Reproducibility of Results; Vascular Calcification / diagnostic imaging; Vascular Calcification / pathology
topics (OpenAlex): Cerebrovascular and Carotid Artery Diseases; Cardiovascular Health and Disease Prevention; Acute Ischemic Stroke Management
TL;DR: The performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation is suggested to be capable of distinguishing soft from stiff atherosclerotic plaque components and delineating FC thickness. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Carotid plaque characterization with ARFI imaging: Blinded reader study

Czernuszewicz, T. J., Homeister, J. W., Caughey, M. C., Huang, B. Y., Lee, E. R., Zamora, C. A., … Gallippi, C. M. (2016, September 1).

By: T. Czernuszewicz*, J. Homeister *, M. Caughey  n, B. Huang *, E. Lee *, C. Zamora *, M. Farber *, J. Fulton* ...

topics (OpenAlex): Cerebrovascular and Carotid Artery Diseases; Cardiovascular Health and Disease Prevention; Ultrasound Imaging and Elastography
TL;DR: It is suggested that ARFI is capable of distinguishing soft from stiff compositional elements of atherosclerotic plaques and may be relevant to improving plaque risk assessment. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2016 article

On the Feasibility of Quantifying Fibrous Cap Thickness With Acoustic Radiation Force Impulse (ARFI) Ultrasound

Czernuszewicz, T. J., & Gallippi, C. M. (2016, March 2). IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control.

By: T. Czernuszewicz n & C. Gallippi n

author keywords: Acoustic radiation force; acoustic radiation force impulse (ARFI); atherosclerosis; fibrous cap (FC); finite-element method (FEM); resolution; vulnerable plaque
MeSH headings : Carotid Arteries / diagnostic imaging; Elasticity Imaging Techniques; Humans; Motion; Plaque, Atherosclerotic / diagnostic imaging; Ultrasonography
topics (OpenAlex): Cerebrovascular and Carotid Artery Diseases; Cardiovascular Health and Disease Prevention; Coronary Interventions and Diagnostics
TL;DR: The results of this study demonstrate that tracking pulse frequencies around 12 MHz are necessary to resolve caps around 0.2 mm; large motion-tracking kernel sizes introduce bias into thickness measurements and overestimate the true cap thickness; and color saturation settings on ARFI peak displacement images can impact thickness measurement accuracy substantially. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 article

Design, Fabrication, and Characterization of a Bifrequency Colinear Array

Wang, Z., Li, S., Czernuszewicz, T. J., Gallippi, C. M., Liu, R., Geng, X., & Jiang, X. (2015, December 4). IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, Vol. 63, pp. 266–274.

By: Z. Wang n, S. Li n, T. Czernuszewicz n, C. Gallippi n, R. Liu *, X. Geng*, X. Jiang n 

Contributors: Z. Wang n, S. Li n, T. Czernuszewicz n, C. Gallippi n, R. Liu *, X. Geng*, X. Jiang n 

author keywords: Bifrequency ultrasound; colinear array; composite transducer
MeSH headings : Equipment Design; Phantoms, Imaging; Signal-To-Noise Ratio; Transducers; Ultrasonography / instrumentation
topics (OpenAlex): Ultrasound Imaging and Elastography; Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging
TL;DR: The results of this study suggest that bifrequency colinear arrays are potential aids for wideband fundamental imaging and harmonic/subharmonic imaging. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

Dual-frequency IVUS transducer for acoustic radiation force impulse (ARFI) imaging

Wang, Z., Jiang, X., Czernuszewicz, T. J., Gallippi, C. M., & IEEE. (2015, October 1). 2015 Ieee International Ultrasonics Symposium (Ius).

By: Z. Wang n, X. Jiang n , T. Czernuszewicz*, C. Gallippi* & Ieee

Contributors: Z. Wang n, X. Jiang n , T. Czernuszewicz*, C. Gallippi* & Ieee

author keywords: dual frequency ultrasound; ultrasound transducer; intravascular ultrasound; IVUS; acoustic radiation force; ARFI
topics (OpenAlex): Ultrasound Imaging and Elastography; Ultrasonics and Acoustic Wave Propagation; Photoacoustic and Ultrasonic Imaging
TL;DR: A dual-frequency IVUS transducer, consisting of a 6.5 MHz “pushing” element and a 26 MHz ‘tracking’ element, was designed and fabricated for ARFI application and suggests great potential of this dual- frequencies for intravascular ARFI imaging. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Acoustic radiation force (ARF) generation with a novel dual-frequency intravascular transducer

Czernuszcwicz, T. J., Gallippi, C. M., Wang, Z., Ma, J., Jiang, X., & IEEE. (2014, September 1). 2014 Ieee International Ultrasonics Symposium (Ius), pp. 2284–2287.

By: T. Czernuszcwicz*, C. Gallippi n, Z. Wang n, J. Ma n, X. Jiang n  & Ieee

Contributors: T. Czernuszcwicz*, C. Gallippi n, Z. Wang n, J. Ma n, X. Jiang n  & Ieee

author keywords: ultrasound transducer; dual frequency; acoustic radiation force; ARFI; intravascular; IVUS
topics (OpenAlex): Photoacoustic and Ultrasonic Imaging; Ultrasound Imaging and Elastography; Ultrasound and Hyperthermia Applications
TL;DR: The results of this study show that ARF generation and high-resolution tracking is feasible on a small-aperture transducer fit for IVUS implementation, and is also shown to demonstrate backscatter sensitivity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Displacement underestimation correction using shear waves in VisR ultrasound

Selzo, M. R., Czernuszewicz, T. J., & Gallippi, C. M. (2014, September 1).

By: M. Selzo*, T. Czernuszewicz* & C. Gallippi n

author keywords: Viscoelastic Response (VisR) ultrasound; Acoustic Radiation Force (ARF); finite element model; optical tracking
topics (OpenAlex): Ultrasound Imaging and Elastography; Elasticity and Material Modeling; Ultrasound and Hyperthermia Applications
TL;DR: It is hypothesized that by utilizing shear waves to generate displacement and monitoring tissue displacement outside the region of excitation the authors can better estimate axial displacements and generate τ measurements that more closely represent the material. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

Acoustic radiation force beam sequence performance for detection and material characterization of atherosclerotic plaques: preclinical, ex vivo results

Behler, R. H., Czernuszewicz, T. J., Wu, C.-da, Nichols, T. C., Zhu, H., Homeister, J. W., … Gallippi, C. M. (2013, December 1). IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control.

By: R. Behler n, T. Czernuszewicz n, C. Wu *, T. Nichols *, H. Zhu *, J. Homeister *, E. Merricks*, C. Gallippi n

MeSH headings : Algorithms; Animals; Elasticity Imaging Techniques / methods; Femoral Artery / diagnostic imaging; Femoral Artery / pathology; Image Processing, Computer-Assisted; Phantoms, Imaging; Plaque, Atherosclerotic / diagnostic imaging; ROC Curve; Swine
topics (OpenAlex): Ultrasound Imaging and Elastography; Photoacoustic and Ultrasonic Imaging; Coronary Interventions and Diagnostics
TL;DR: Results suggest ARF-based imaging is relevant to detecting and characterizing plaques and support its use for diagnosing and monitoring atherosclerosis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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