@article{jin_garcia-lopez_chiang_kuwahara_tour_wang_2019, title={Enhancing Photostability of Fluorescent Dye-Attached Molecular Machines at Air-Glass Interface Using Cyclooctatetraene}, volume={123}, ISSN={["1932-7447"]}, DOI={10.1021/acs.jpcc.8b11592}, abstractNote={Single-molecule fluorescence microscopy at an air–solid interface severely suffers from photobleaching. In this study, we evaluated using a triplet-state quencher cyclooctatetraene (COT) group to enhance the photostability of cy5-attached molecular machines. For single-dye-modified nanocars, the photobleaching lifetime of the dye was extended by 2.1 times after the attachment of the COT group. For two-COT-two-dye-attached unimolecular submersible nanomachine (USN) molecules, both one-step and two-step photobleaching of the dyes were observed, similar to those cy5-USNs without COT protection. The fraction of one-step photobleaching events was nearly a constant under different laser powers, indicating that one-step photobleaching is a single-photon process and that the product of the first photobleaching event destroys the second dye. The COT-cy5-USNs showed a larger fraction of two-step photobleaching events as compared to cy5-USNs, indicating that the COT group provides further protection for the second d...}, number={5}, journal={JOURNAL OF PHYSICAL CHEMISTRY C}, author={Jin, Tao and Garcia-Lopez, Victor and Chiang, Pinn-Tsong and Kuwahara, Shunsuke and Tour, James M. and Wang, Gufeng}, year={2019}, month={Feb}, pages={3011–3018} }
 @article{liu_garcia-lopez_gunasekera_nilewski_alemany_aliyan_jin_wang_tour_pal_2019, title={Near-Infrared Light Activates Molecular Nanomachines to Drill into and Kill Cells}, volume={13}, ISSN={["1936-086X"]}, DOI={10.1021/acsnano.9b01556}, abstractNote={Using two-photon excitation (2PE), molecular nanomachines (MNMs) are able to drill through cell membranes and kill the cells. This avoids the use of the more damaging ultraviolet light that has been used formerly to induce this nanomechanical cell-killing effect. Since 2PE is inherently confocal, enormous precision can be realized. The MNMs can be targeted to specific cell surfaces through peptide addends. Further, the efficacy was verified through a controlled opening of synthetic bilayer vesicles using the 2PE excitation of MNM that had been trapped within the vesicles.}, number={6}, journal={ACS NANO}, author={Liu, Dongdong and Garcia-Lopez, Victor and Gunasekera, Richard S. and Nilewski, Lizanne Greer and Alemany, Lawrence B. and Aliyan, Amir and Jin, Tao and Wang, Gufeng and Tour, James M. and Pal, Robert}, year={2019}, month={Jun}, pages={6813–6823} }
 @article{jin_garcia-lopez_kuwahara_chiang_tour_wang_2018, title={Diffusion of Nanocars on an Air-Glass Interface}, volume={122}, ISSN={["1932-7447"]}, DOI={10.1021/acs.jpcc.8b05668}, abstractNote={At room temperature, four-adamantane-wheeled nanocars thermally diffuse on an air–glass interface. A line-scan imaging method was developed to improve the time resolution in tracking their surface movement. The fast imaging technique disclosed that the four-wheeled nanocars diffuse on glass surfaces in a quasi-random two-dimensional (2D) diffusion manner. That is, they have a high tendency to keep a linear diffusion trajectory at a short time scale, which is consistent with the wheel-rolling mode diffusion. The nanocar molecules lose the directionality over time, indicating that other diffusion modes, e.g., pivoted movement, may also contribute to their thermal diffusion at room temperature. The characteristic linear movement time for the two types of nanocar molecules in this study was ∼1.2 s, from which the activation energy for the nanocars to pivot away from the original direction was estimated to be ∼65 kJ mol–1. Finally, it was shown that using the line-scanning method the diffusion coefficient of q...}, number={33}, journal={JOURNAL OF PHYSICAL CHEMISTRY C}, author={Jin, Tao and Garcia-Lopez, Victor and Kuwahara, Shunsuke and Chiang, Pinn-Tsong and Tour, James M. and Wang, Gufeng}, year={2018}, month={Aug}, pages={19025–19036} }
 @article{jin_garcia-lopez_chen_tour_wang_2016, title={Imaging Single Molecular Machines Attached with Two BODIPY Dyes at the Air-Solid Interface: High Probability of Single-Step-Like Photobleaching and Nonscaling Intensity}, volume={120}, ISSN={["1932-7447"]}, DOI={10.1021/acs.jpcc.6b07518}, abstractNote={Single-molecule fluorescence microscopy (SMFM) is a powerful technique in monitoring single molecular machine actions at ambient conditions. To improve the fluorescence intensity and photostability, one strategy is to attach multiple dyes to the same single molecular machine. However, it is unclear how the fluorescence property of the dyes will change when multiple dyes are compacted into the same molecule within a distance between them of ∼2 nm. In this study, we investigated the photophysics of two types of single molecular machines that are each equipped with two BODIPY dyes with different distances. We found that at the air–glass interface, single molecules attached with two dyes have a high tendency to show a single-step-like photobleaching, making them to appear like a single dye. We propose that the product of the first photobleaching event, possibly a superoxide anion radical, is involved in the destruction of the neighboring dye. In addition, the fluorescence intensity of the two-dye system does ...}, number={46}, journal={JOURNAL OF PHYSICAL CHEMISTRY C}, author={Jin, Tao and Garcia-Lopez, Victor and Chen, Fang and Tour, James and Wang, Gufeng}, year={2016}, month={Nov}, pages={26522–26531} }
 @article{chen_garcia-lopez_jin_neupane_chu_tour_wang_2016, title={Moving Kinetics of Nanocars with Hydrophobic Wheels on Solid Surfaces at Ambient Conditions}, volume={120}, ISSN={["1932-7447"]}, DOI={10.1021/acs.jpcc.6b01249}, abstractNote={Motivated by “driving” nanoscopic nanocars on solid substrate surfaces at ambient conditions, we studied the moving kinetics of nanocars on differently modified surfaces. Single molecule fluorescence imaging was used to track the nanocar movement so that the molecules were minimally perturbed. On freshly cleaned, hydroxylated glass surfaces, nanocars with hydrophobic adamantane wheels can diffuse with a relatively large diffusion coefficient of 7.6 × 10–16 m2/s. Both the number of moving molecules and the mobility of the moving molecules decreased over time when the sample was exposed in the air. Similar declinations in movement were observed on a poly(ethylene glycol) (PEG)-modified glass surface, but the declination rate was lowered. The slowing of molecular surface diffusion is correlated to the hydrophobicity of the surface and is likely caused by the adsorption of hydrophobic molecules from the air. A proposed sticky-spots model explains the decreasing apparent diffusion coefficient of the hydrophobi...}, number={20}, journal={JOURNAL OF PHYSICAL CHEMISTRY C}, author={Chen, Fang and Garcia-Lopez, Victor and Jin, Tao and Neupane, Bhanu and Chu, Pin-Lei E. and Tour, James and Wang, Gufeng}, year={2016}, month={May}, pages={10887–10894} }
 @article{neupane_jin_mellor_loboa_ligler_wang_2015, title={Continuous-wave stimulated emission depletion microscope for imaging actin cytoskeleton in fixed and live cells}, volume={15}, number={9}, journal={Sensors (Basel, Switzerland)}, author={Neupane, B. and Jin, T. and Mellor, L. F. and Loboa, E. G. and Ligler, F. S. and Wang, G. F.}, year={2015}, pages={24178–24190} }