@article{jing_jordan_li_burette_yang_marinkovich_diaz_googe_thomas_feng_et al._2024, title={Anti-NC16A IgA from Patients with Linear IgA Bullous Dermatosis Induce Neutrophil-Dependent Subepidermal Blistering in Mice}, volume={144}, ISSN={["1523-1747"]}, DOI={10.1016/j.jid.2023.05.027}, abstractNote={Linear IgA bullous dermatosis (LABD) is an acquired autoimmune subepidermal blistering skin disease characterized by circulating and tissue-bound IgA autoantibodies that recognize epitopes within the hemidesmosomal protein BP180, including its NC16A domain. Histologically, LABD has long been defined by neutrophil infiltration and dermal-epidermal separation. However, the pathogenic roles of anti-NC16A IgA and neutrophils in LABD, as well as their interactions, have not been thoroughly studied. We show that passive transfer of patient-derived anti-NC16A IgA induce clinical and histologic LABD pathology in humanized NC16A mice that are reconstituted locally or systemically with human neutrophils. The lesional skin of mice exhibits significantly elevated levels of the neutrophil chemoattractants CXCL-1 and CXCL-2. Furthermore, we show significantly increased levels of the neutrophil chemoattractant IL-8 in blister fluids of LABD patients. This study provides direct evidence that anti-NC16A IgA in LABD patients are pathogenic and interact with neutrophils to mediate tissue injury and subepidermal blister formation. This study further corroborates the importance of neutrophil-mediated tissue injury in LABD disease physiology and establishes a clinically relevant in vivo model system that can be used to systematically dissect the immunopathogenesis of LABD.}, number={1}, journal={JOURNAL OF INVESTIGATIVE DERMATOLOGY}, author={Jing, Ke and Jordan, Tyler J. M. and Li, Ning and Burette, Susan and Yang, Baoqi and Marinkovich, M. Peter and Diaz, Luis A. and Googe, Paul and Thomas, Nancy E. and Feng, Suying and et al.}, year={2024}, month={Jan} }
 @article{jordan_chen_li_burette_wan_chen_culton_geng_googe_thomas_et al._2023, title={The Eotaxin-1/CCR3 Axis and Matrix Metalloproteinase-9 Are Critical in Anti-NC16A IgE-Induced Bullous Pemphigoid}, volume={211}, ISSN={["1550-6606"]}, DOI={10.4049/jimmunol.2300080}, abstractNote={Abstract}, number={8}, journal={JOURNAL OF IMMUNOLOGY}, author={Jordan, Tyler J. M. and Chen, Jinbo and Li, Ning and Burette, Susan and Wan, Li and Chen, Liuqing and Culton, Donna A. and Geng, Songmei and Googe, Paul and Thomas, Nancy E. and et al.}, year={2023}, month={Oct}, pages={1216–1223} }