Tyler Lee Harris

Works (4)

Updated: July 5th, 2023 15:45

2017 article

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria

Barker, W. T., Martin, S. E., Chandler, C. E., Nguyen, T. V., Harris, T. L., Goodell, C., … Melander, C. (2017, September 9). Bioorganic & Medicinal Chemistry.

By: W. Barker n, S. Martin n, C. Chandler *, T. Nguyen n, T. Harris n, C. Goodell*, R. Melander n, Y. Doi *, R. Ernst *, C. Melander n

MeSH headings : Acinetobacter baumannii / drug effects; Adjuvants, Pharmaceutic / chemistry; Adjuvants, Pharmaceutic / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Escherichia coli / drug effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Gram-Negative Bacteria / drug effects; Klebsiella pneumoniae / drug effects; Microbial Sensitivity Tests; Polymyxins / pharmacology; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
topics (OpenAlex): Antibiotic Resistance in Bacteria; Antibiotics Pharmacokinetics and Efficacy; Pharmaceutical and Antibiotic Environmental Impacts
TL;DR: This work reports successful reversion of mcr-1-driven colistin resistance in Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli with adjuvants reported as modulators of chromosomally-encoded colistIn resistance. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Gold Nanoparticles to Improve HIV Drug Delivery

Garrido, C., Simpson, C. A., Dahl, N. P., Bresee, J., Whitehead, D. C., Lindsey, E. A., … Margolis, D. M. (2015, July 1). Future Medicinal Chemistry.

By: C. Garrido *, C. Simpson*, N. Dahl*, J. Bresee*, D. Whitehead n, E. Lindsey n, T. Harris n, C. Smith * ...

MeSH headings : Animals; Anti-HIV Agents / administration & dosage; Anti-HIV Agents / chemical synthesis; Anti-HIV Agents / chemistry; Brain / metabolism; Drug Carriers / chemistry; Endothelial Cells / cytology; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Female; Gold / chemistry; HIV Core Protein p24 / antagonists & inhibitors; HIV Core Protein p24 / metabolism; HIV Infections / drug therapy; HIV-1 / physiology; Humans; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Mice; Mice, Inbred BALB C; Raltegravir Potassium / administration & dosage; Raltegravir Potassium / chemical synthesis; Raltegravir Potassium / chemistry; Tissue Distribution; Virus Replication / drug effects
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Gold and Silver Nanoparticles Synthesis and Applications; Nanoparticles: synthesis and applications
TL;DR: Gold nanoparticles prove to be a promising tool to use in HIV therapy by showing entry into different cell types, antiviral activity of an HIV integrase inhibitor conjugated in a gold nanoparticle and penetration into the brain in vivo without toxicity. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 article

Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance

Harris, T. L., Worthington, R. J., Hittle, L. E., Zurawski, D. V., Ernst, R. K., & Melander, C. (2013, October 16). ACS Chemical Biology.

By: T. Harris n, R. Worthington n, L. Hittle*, D. Zurawski *, R. Ernst * & C. Melander n

MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Colistin / chemistry; Colistin / pharmacology; Down-Regulation / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / drug effects; Gram-Negative Bacteria / genetics; Gram-Negative Bacteria / metabolism; Gram-Negative Bacterial Infections / drug therapy; Humans; Lipid A / metabolism; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Transcription Factors / genetics
topics (OpenAlex): Antibiotic Resistance in Bacteria; Cancer therapeutics and mechanisms; Antibiotics Pharmacokinetics and Efficacy
TL;DR: This report reports a small molecule adjuvant that suppresses colistin resistance in multidrug resistant Acinetobacter baumannii and Klebsiella pneumoniae by interfering with the expression of a two-component system. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 article

Potent Small‐Molecule Suppression of Oxacillin Resistance in Methicillin‐Resistant Staphylococcus aureus

Harris, T. L., Worthington, R. J., & Melander, C. (2012, October 9). Angewandte Chemie International Edition.

By: T. Harris n, R. Worthington n & C. Melander n

author keywords: 2-aminoimidazoles; adjuvants; antibiotics; antibiotic resistance; MRSA
MeSH headings : Anti-Bacterial Agents / pharmacology; Drug Resistance; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxacillin / pharmacology
topics (OpenAlex): Antimicrobial Resistance in Staphylococcus; Antibiotic Resistance in Bacteria; Bacterial biofilms and quorum sensing
TL;DR: A potent small molecule is pictured that, at sub-minimum inhibitory concentration levels, lowers the MIC of oxacillin against a number of MRSA strains by up to 512-fold. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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