Tyler Lee Harris

MeSH headings : Acinetobacter baumannii / drug effects; Adjuvants, Pharmaceutic / chemistry; Adjuvants, Pharmaceutic / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Escherichia coli / drug effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Gram-Negative Bacteria / drug effects; Klebsiella pneumoniae / drug effects; Microbial Sensitivity Tests; Polymyxins / pharmacology; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology

TL;DR: This work reports successful reversion of mcr-1-driven colistin resistance in Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli with adjuvants reported as modulators of chromosomally-encoded colistIn resistance. (via Semantic Scholar)

MeSH headings : Animals; Anti-HIV Agents / administration & dosage; Anti-HIV Agents / chemical synthesis; Anti-HIV Agents / chemistry; Brain / metabolism; Drug Carriers / chemistry; Endothelial Cells / cytology; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Female; Gold / chemistry; HIV Core Protein p24 / antagonists & inhibitors; HIV Core Protein p24 / metabolism; HIV Infections / drug therapy; HIV-1 / physiology; Humans; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Mice; Mice, Inbred BALB C; Raltegravir Potassium / administration & dosage; Raltegravir Potassium / chemical synthesis; Raltegravir Potassium / chemistry; Tissue Distribution; Virus Replication / drug effects

TL;DR: Gold nanoparticles prove to be a promising tool to use in HIV therapy by showing entry into different cell types, antiviral activity of an HIV integrase inhibitor conjugated in a gold nanoparticle and penetration into the brain in vivo without toxicity. (via Semantic Scholar)

MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Colistin / chemistry; Colistin / pharmacology; Down-Regulation / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / drug effects; Gram-Negative Bacteria / genetics; Gram-Negative Bacteria / metabolism; Gram-Negative Bacterial Infections / drug therapy; Humans; Lipid A / metabolism; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Transcription Factors / genetics

TL;DR: This report reports a small molecule adjuvant that suppresses colistin resistance in multidrug resistant Acinetobacter baumannii and Klebsiella pneumoniae by interfering with the expression of a two-component system. (via Semantic Scholar)

author keywords: 2-aminoimidazoles; adjuvants; antibiotics; antibiotic resistance; MRSA

MeSH headings : Anti-Bacterial Agents / pharmacology; Drug Resistance; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxacillin / pharmacology

TL;DR: A potent small molecule is pictured that, at sub-minimum inhibitory concentration levels, lowers the MIC of oxacillin against a number of MRSA strains by up to 512-fold. (via Semantic Scholar)