Works (15)

Updated: April 4th, 2024 02:58

2014 journal article

Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 31(9), 1506–1521.

By: T. Leavens n, L. Tell*, L. Kissell n, G. Smith n, D. Smith*, S. Wagner*, W. Shelver*, H. Wu n ...

author keywords: flunixin; PBPK models; withdrawal intervals; route of administration; cattle (Bos taurus)
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Drug Residues; Liver / chemistry; Liver / metabolism; Milk / chemistry; Models, Biological; Sensitivity and Specificity; Software; Uncertainty
TL;DR: A physiologically based pharmacokinetic (PBPK) model was developed to predict plasma, liver and milk concentrations of flunixin in cattle following intravenous, intramuscular or subcutaneous administration for use as a tool to determine factors that may affect the withdrawal time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle

Journal of Veterinary Pharmacology and Therapeutics, 36(3), 248–257.

By: H. Wu n, R. Baynes n, T. Leavens n, L. Tell* & J. Riviere*

MeSH headings : Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Computer Simulation; Drug Administration Routes; Drug Residues / pharmacokinetics; Female; Liver / metabolism; Male; Models, Biological; Monte Carlo Method
TL;DR: This study questions the use of small groups of healthy animals to determine WDTs for drugs intended for administration to large diverse populations and may warrant a reevaluation of the current procedure for establishing WDT to prevent violative residues of flunixin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2012 journal article

Acute vascular effects of nanoparticle infusion in isolated perfused skin

Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.

By: J. Riviere n, T. Leavens n, J. Brooks n & N. Monteiro-Riviere n

Contributors: J. Riviere n, T. Leavens n, J. Brooks n & N. Monteiro-Riviere n

author keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
MeSH headings : Animals; Female; Perfusion; Quantum Dots; Skin / blood supply; Skin / pathology; Skin / physiopathology; Sus scrofa; Vascular Resistance / drug effects
TL;DR: Specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects, and these observations suggest certain nanoparticles infusions may beassociated with acute vascular physiologic effects that merit further attention. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2012 journal article

Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(2), 121–131.

By: T. Leavens n, L. Tell*, K. Clothier*, R. Griffith*, R. Baynes n & J. Riviere n

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Computer Simulation; Disaccharides / blood; Disaccharides / pharmacokinetics; Goats / blood; Goats / metabolism; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Models, Biological; Sensitivity and Specificity; Software; Tissue Distribution
TL;DR: The developed model and compilation of physiological parameters for goats provide initial tools that can be used as a basis for predicting withdrawal times of drugs in this minor species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps

JOURNAL OF APPLIED TOXICOLOGY, 32(11), 913–919.

By: T. Leavens n, N. Monteiro-Riviere n, A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

Contributors: T. Leavens n, N. Monteiro-Riviere n, A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
TL;DR: The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(10), 1634–1640.

By: J. Romanet*, G. Smith*, T. Leavens*, R. Baynes*, S. Wetzlich, J. Riviere*, L. Tell

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / blood; Disaccharides / pharmacokinetics; Female; Goats / blood; Goats / metabolism; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Injections, Subcutaneous / veterinary; Male; Tandem Mass Spectrometry / veterinary; Time Factors; Tissue Distribution
TL;DR: The tissue depletion profile of tulathromycin was determined and an appropriate slaughter withdrawal interval in meat goats after multiple SC injections of the drug was determined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

The Toxicology Education Summit: Building the Future of Toxicology Through Education

TOXICOLOGICAL SCIENCES, 127(2), 331–338.

By: A. Barchowsky*, L. Buckley*, G. Carlson*, V. Fitsanakis*, S. Ford*, M. Genter*, D. Germolec*, T. Leavens n ...

author keywords: toxicology; education
MeSH headings : Cooperative Behavior; Curriculum / trends; Education, Professional / trends; Fellowships and Scholarships / trends; Forecasting; Humans; Interinstitutional Relations; Needs Assessment / trends; Professional Competence; Research Support as Topic / trends; Toxicology / education; Toxicology / trends
TL;DR: This report summarizes the outcomes of the Toxicology Educational Summit, presents examples of successful programs that advance toxicology education, and concludes with strategies that will insure the future of toxicology through advanced educational initiatives. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Tulathromycin assay validation and tissue residues after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus)

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(2), 113–120.

By: K. Clothier*, T. Leavens n, R. Griffith*, S. Wetzlich*, R. Baynes n, J. Riviere n, L. Tell*

MeSH headings : Adipose Tissue; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Residues; Female; Goats / metabolism; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Infusions, Subcutaneous; Kidney; Liver; Lung; Male; Muscle, Skeletal; Reproducibility of Results; Tissue Distribution
TL;DR: It is demonstrated that tissue levels in goats are very similar to those seen in swine and cattle, and below limit of quantification in injection site and lung by day 18 and in liver, kidney, muscle, and fat at all time points. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus)

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 34(5), 448–454.

By: K. Clothier*, T. Leavens n, R. Griffith*, S. Wetzlich*, R. Baynes n, J. Riviere n, L. Tell*

MeSH headings : Aging; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Drug Administration Schedule; Female; Goats / blood; Half-Life; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Male
TL;DR: Overall, pharmacokinetic parameters in goats are similar to those reported in cattle and swine, and tulathromycin may prove a useful drug for treating respiratory disease in goats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats

RESEARCH IN VETERINARY SCIENCE, 90(3), 477–479.

By: G. Young n, G. Smith n, T. Leavens n, S. Wetzlich*, R. Baynes n, S. Mason n, J. Riviere n, L. Tell*

author keywords: Tulathromycin; Goats; Pharmacokinetics; Respiratory disease; Antibiotics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Goats / blood; Goats / metabolism; Half-Life; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Injections, Subcutaneous / veterinary; Tandem Mass Spectrometry / veterinary
TL;DR: The pharmacokinetics of tulathromycin after a single 2.5 mg/kg SC injection in goats were very similar to what has been previously reported in cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles

TOXICOLOGY LETTERS, 197(1), 1–6.

By: T. Leavens n, X. Xia n, H. Lee n, N. Monteiro-Riviere n, J. Brooks n & J. Riviere n

Contributors: T. Leavens n, X. Xia n, H. Lee n, N. Monteiro-Riviere n, J. Brooks n & J. Riviere n

author keywords: nC(60); Isolated perfused porcine skin flaps; Pharmacokinetics; In vitro; Nanoparticles; Skin
MeSH headings : Animals; Arteries / metabolism; Colloids; Female; Fullerenes / pharmacokinetics; Immunoglobulin G / metabolism; Models, Animal; Nanoparticles / ultrastructure; Skin / metabolism; Swine; Tissue Distribution; Veins / metabolism
TL;DR: Based on the apparent volume of distribution, the low extraction during the perfusion, and the high percentage recovery following the washout phase, there was limited distribution of fullerene nanoparticles from the vascular space into the extracellular space and negligible intracellular uptake of nC(60) in this system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Pharmacokinetics of radiolabeled tungsten (W-188) in male Sprague-Dawley rats following acute sodium tungstate inhalation

INHALATION TOXICOLOGY, 22(1), 69–76.

By: P. Radcliffe*, T. Leavens n, D. Wagner*, A. Olabisi*, M. Struve n, B. Wong*, E. Tewksbury*, G. Chapman*, D. Dorman n

author keywords: Inhalation; kinetics; tungsten
MeSH headings : Administration, Inhalation; Aerosols; Animals; Inhalation Exposure; Male; Metabolic Clearance Rate; Models, Biological; Radioisotopes; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / pharmacokinetics
TL;DR: Evaluated the pharmacokinetics of inhaled tungstate (WO4) in rats found the kidney, adrenal, spleen, femur, lymph nodes, and brain continued to accumulate small amounts of tungsten as reflected by tissue:blood activity ratios that increased throughout the 21-day period. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Physiologically based pharmacokinetic rat model for methyl tertiary-butyl ether; comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation

TOXICOLOGY, 275(1-3), 79–91.

By: S. Borghoff, H. Parkinson & T. Leavens*

author keywords: MTBE; TBA; PBPK
MeSH headings : Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical / methods; Female; Inhalation Exposure / adverse effects; Kidney / drug effects; Kidney / physiology; Male; Methyl Ethers / administration & dosage; Methyl Ethers / pharmacokinetics; Methyl Ethers / toxicity; Models, Animal; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar
TL;DR: This model can now be used to evaluate route-to-route extrapolation issues concerning MTBE exposures but also as a means of comparing potential dose metrics that may provide insight to differences in biological responses observed in rats following different routes of MTBE exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Acute sodium tungstate inhalation is associated with minimal olfactory transport of tungsten (W-188) to the rat brain

NEUROTOXICOLOGY, 30(3), 445–450.

By: P. Radcliffe*, A. Olabisi*, D. Wagner*, T. Leavens n, B. Wong*, M. Struve n, G. Chapman*, E. Wilfong*, D. Dorman n

author keywords: Inhalation; Olfactory transport; Brain; Tungsten; Single-dose; Rat
MeSH headings : Administration, Inhalation; Aerosols; Animals; Corpus Striatum / metabolism; Male; Olfactory Pathways / metabolism; Pituitary Gland / metabolism; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / administration & dosage; Tungsten Compounds / blood; Tungsten Compounds / pharmacokinetics
TL;DR: The data suggest that olfactory transport plays a minimal role in delivering tungsten to the rat brain, i.e., approximately 1-3% of the amount ofTungsten seen in the olf factory epithelium suggesting that o aroma transport plays an important role in transporting metals to the CNS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Physiologically Based Pharmacokinetic Model of Methyl Tertiary Butyl Ether and Tertiary Butyl Alcohol Dosimetry in Male Rats Based on Binding to alpha 2u-Globulin

TOXICOLOGICAL SCIENCES, 109(2), 321–335.

By: T. Leavens n & S. Borghoff*

author keywords: MTBE; TBA; alpha 2u-globulin; PBPK
MeSH headings : Algorithms; Alpha-Globulins / metabolism; Animals; Brain Chemistry; Computer Simulation; Dose-Response Relationship, Drug; Female; Inhalation Exposure; Kidney / metabolism; Liver / metabolism; Male; Methyl Ethers / administration & dosage; Methyl Ethers / metabolism; Methyl Ethers / pharmacokinetics; Methyl Ethers / toxicity; Models, Biological; Models, Chemical; Protein Binding; Rats; Rats, Inbred F344; Testis / metabolism; Toxicity Tests, Acute; Toxicity Tests, Chronic; tert-Butyl Alcohol / blood; tert-Butyl Alcohol / metabolism
TL;DR: The role of MTBE and TBA binding to the male rat-specific protein alpha2u-globulin as essential for predicting concentrations of these chemicals in the kidney following exposure is supported. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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