@article{konrade_clode_michau_roe_trumpatori_krug_gilger_2009, title={Surgical correction of severe strabismus and enophthalmos secondary to zygomatic arch fracture in a dog}, volume={12}, ISSN={1463-5216 1463-5224}, url={http://dx.doi.org/10.1111/j.1463-5224.2008.00689.x}, DOI={10.1111/j.1463-5224.2008.00689.x}, abstractNote={Abstract}, number={2}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Konrade, Kricket A. and Clode, Alison B. and Michau, Tammy M. and Roe, Simon C. and Trumpatori, Brian J. and Krug, William V. and Gilger, Brian C.}, year={2009}, month={Mar}, pages={119–124} } @article{mcmullen_clode_pandiri_malarkey_michau_gilger_2008, title={Epibulbar melanoma in a foal}, volume={11}, ISSN={1463-5216 1463-5224}, url={http://dx.doi.org/10.1111/j.1463-5224.2008.00637.x}, DOI={10.1111/j.1463-5224.2008.00637.x}, abstractNote={Abstract}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={McMullen, Richard J. and Clode, Alison B. and Pandiri, Arun Kumar R. and Malarkey, David E. and Michau, Tammy Miller and Gilger, Brian C.}, year={2008}, month={Sep}, pages={44–50} } @article{beale_salmon_michau_gilger_2006, title={Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in normal dog eyes}, volume={9}, ISSN={1463-5216 1463-5224}, url={http://dx.doi.org/10.1111/j.1463-5224.2006.00473.x}, DOI={10.1111/j.1463-5224.2006.00473.x}, abstractNote={Abstract}, number={5}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Beale, A. Brady and Salmon, Jacklyn and Michau, Tammy M. and Gilger, Brian C.}, year={2006}, month={Sep}, pages={335–340} } @article{clode_davis_salmon_michau_gilger_2006, title={Evaluation of concentration of voriconazole in aqueous humor after topical and oral administration in horses}, volume={67}, ISSN={0002-9645}, url={http://dx.doi.org/10.2460/ajvr.67.2.296}, DOI={10.2460/ajvr.67.2.296}, abstractNote={Abstract}, number={2}, journal={American Journal of Veterinary Research}, publisher={American Veterinary Medical Association (AVMA)}, author={Clode, Alison B. and Davis, Jennifer L. and Salmon, Jacklyn and Michau, Tammy Miller and Gilger, Brian C.}, year={2006}, month={Feb}, pages={296–301} } @article{gilger_michau_salmon_2005, title={Immune-mediated keratitis in horses: 19 cases (1998-2004)}, volume={8}, ISSN={1463-5216 1463-5224}, url={http://dx.doi.org/10.1111/j.1463-5224.2005.00393.x}, DOI={10.1111/j.1463-5224.2005.00393.x}, abstractNote={Abstract}, number={4}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Gilger, Brian C. and Michau, Tammy Miller and Salmon, Jacklyn H.}, year={2005}, month={Jul}, pages={233–239} } @article{michau_gilger_2004, title={Cosmetic globe surgery in the horse}, volume={20}, ISSN={0749-0739}, url={http://dx.doi.org/10.1016/j.cveq.2004.04.001}, DOI={10.1016/j.cveq.2004.04.001}, abstractNote={Effects of traumatic injury or inflammation on the equine eye can be catastrophic. These ocular conditions can frequently result in blindness or chronic pain. In addition to blindness and pain, permanent unsightly cosmetic defects can occur. This article addresses options available for improved cosmetic outcome in horses with ocular scars or requiring enucleation. Many of these options have been described in detail previously. New information has been added to the discussion of each option where pertinent.}, number={2}, journal={Veterinary Clinics of North America: Equine Practice}, publisher={Elsevier BV}, author={Michau, Tammy Miller and Gilger, Brian C}, year={2004}, month={Aug}, pages={467–484} } @article{gilger_michau_2004, title={Equine recurrent uveitis: new methods of management}, volume={20}, ISSN={0749-0739}, url={http://dx.doi.org/10.1016/j.cveq.2004.04.010}, DOI={10.1016/j.cveq.2004.04.010}, abstractNote={Equine recurrent uveitis (ERU) is a spontaneous, remitting-relapsing autoimmune disease driven by the adaptive immune system. Although T cells are described as the main effector cells in pathogenesis, granulocytes have also emerged as possible disease mediators. To explore the role of these innate immune cells, we investigated the whole cell proteome of granulocytes from equine recurrent uveitis cases and healthy controls. Among the 2362 proteins identified by mass spectrometry, we found 96 proteins with significantly changed abundance between groups (p < 0.05, fold change >1.2), representing 4.1% of total granulocyte proteome. Within these differential identifications, calgranulin B, a protein associated with pathogenesis in other autoimmune diseases, showed highest abundance in equine recurrent uveitis (18 fold).For a better interpretation of the results from our hypothesis-generating approach, we added a threshold for biological significance (ratio ERU/controls >2: 36 proteins) to the proteins with increased abundance in equine recurrent uveitis and analyzed their allocation to the subsets within the Immune System superpathway. The 36 differentially abundant proteins predominantly associated to RAF/MAP kinase cascade, MHC-I-mediated antigen presentation and neutrophil degranulation, suggesting a latently activated phenotype of these innate immune cells in disease. Raw data are available via ProteomeXchange with identifier PXD013648.Our study provides new insights into the protein repertoire of primary equine granulocytes and identifies protein abundance changes associated to equine recurrent uveitis (ERU), an organ specific, spontaneously occurring autoimmune disease. We show that granulocyte proteins with increased abundance in ERU strongly associate to RAF/MAP kinase signaling, MHC-I antigen presentation and neutrophil degranulation, pointing to a more activated state of these cells in ERU cases. Since cells were obtained in quiescent stage of disease, latent activation of granulocytes underlines the role of these innate immune cells in ERU.These findings are highly relevant for veterinary medicine, further establishing the importance of granulocytes in this T cell-driven autoimmune disease. Moreover, they have translational quality for autoimmune uveitis in man, due to strong similarity in disease occurrence, progression and pathogenesis.}, number={2}, journal={Veterinary Clinics of North America: Equine Practice}, publisher={Elsevier BV}, author={Gilger, Brian C and Michau, Tammy Miller}, year={2004}, month={Aug}, pages={417–427} } @article{michau_breitschwerdt_gilger_davidson_2003, title={Bartonella vinsonii subspecies berkhoffi as a possible cause of anterior uveitis and choroiditis in a dog}, volume={6}, ISSN={["1463-5224"]}, DOI={10.1111/j.1463-5224.2003.00310.x}, abstractNote={Abstract}, number={4}, journal={VETERINARY OPHTHALMOLOGY}, author={Michau, TM and Breitschwerdt, EB and Gilger, BC and Davidson, MG}, year={2003}, month={Dec}, pages={299–304} } @article{michau_proulx_rushton_olivry_dunston_gilger_davidson_2003, title={Intraocular extramedullary plasmacytoma in a cat}, volume={6}, ISSN={["1463-5224"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-0037629973&partnerID=MN8TOARS}, DOI={10.1046/j.1463-5224.2003.00277.x}, abstractNote={Abstract}, number={2}, journal={VETERINARY OPHTHALMOLOGY}, author={Michau, TM and Proulx, DR and Rushton, SD and Olivry, T and Dunston, SM and Gilger, BC and Davidson, MG}, year={2003}, month={Jun}, pages={177–181} } @article{michau_schwabenton_davidson_gilger_2003, title={Superficial, nonhealing corneal ulcers in horses: 23 cases (1989-2003)}, volume={6}, ISSN={["1463-5216"]}, DOI={10.1111/j.1463-5224.2003.00309.x}, abstractNote={Abstract}, number={4}, journal={VETERINARY OPHTHALMOLOGY}, author={Michau, TM and Schwabenton, B and Davidson, MG and Gilger, BC}, year={2003}, month={Dec}, pages={291–297} } @article{michau_gilger_maggio_davidson_2003, title={Use of thermokeratoplasty for treatment of ulcerative keratitis and bullous keratopathy secondary to corneal endothelial disease in dogs: 13 cases (1994-2001)}, volume={222}, ISSN={["0003-1488"]}, DOI={10.2460/javma.2003.222.607}, abstractNote={Abstract}, number={5}, journal={JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Michau, TM and Gilger, BC and Maggio, F and Davidson, MG}, year={2003}, month={Mar}, pages={607–612} }