Thaddeus Paulsel

Works (3)

Updated: November 25th, 2024 07:12

2024 journal article

Engineering of a Malonyl-CoA Ligase for Production of Fluorinated Polyketide Extender Units

CHEMBIOCHEM, 25(21).

By: T. Paulsel n & G. Williams n 

author keywords: Fluorination; Biocatalysis; Enzyme engineering; Chemoenzymatic; Polyketides
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 15, 2024

2023 article

Current State-of-the-Art Toward Chemoenzymatic Synthesis of Polyketide Natural Products

Paulsel, T. Q., & Williams, G. J. (2023, September 15). CHEMBIOCHEM, Vol. 9.

By: T. Paulsel n & G. Williams n 

author keywords: bioorganic chemistry; biosynthesis; enzymes; polyketides; synthetic biology
TL;DR: These synthetic strategies have successfully yielded natural product derivatives while providing critical insights into enzymatic promiscuity and mechanistic activity and their contributions to the field of chemical biology are summarized. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 10, 2023

2022 journal article

Targeted enzyme modifications enable regioselective biosynthesis of fluorinated polyketides

CHEM CATALYSIS, 2(10), 2440–2443.

By: S. Welch n, J. Cossin n , T. Paulsel n & G. Williams n 

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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 17, 2023

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