Thaddeus Paulsel

Works (4)

Updated: April 25th, 2025 08:46

2025 article

Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation

Cossin, J. R., Paulsel, T. Q., Castelli, K., Wcisel, B., Malico, A. A., & Williams, G. J. (2025, April 3). ACS Chemical Biology, Vol. 4.

By: J. Cossin n , T. Paulsel n, K. Castelli n, B. Wcisel n, A. Malico n & G. Williams n 

MeSH headings : Substrate Specificity; Protein Engineering; Acetate-CoA Ligase / metabolism; Acetate-CoA Ligase / genetics; Acetate-CoA Ligase / chemistry; Acyl Coenzyme A / metabolism; Acyl Coenzyme A / chemistry; Pseudomonas / enzymology; Polyketide Synthases / metabolism
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Plant biochemistry and biosynthesis; Microbial Natural Products and Biosynthesis
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 3, 2025

2024 article

Engineering of a Malonyl‐CoA Ligase for Production of Fluorinated Polyketide Extender Units

Paulsel, T. Q., & Williams, G. J. (2024, July 22). ChemBioChem, Vol. 25.

By: T. Paulsel n & G. Williams n 

author keywords: Fluorination; Biocatalysis; Enzyme engineering; Chemoenzymatic; Polyketides
MeSH headings : Polyketides / metabolism; Polyketides / chemistry; Halogenation; Coenzyme A Ligases / metabolism; Coenzyme A Ligases / genetics; Malonyl Coenzyme A / metabolism; Protein Engineering; Molecular Structure; Bacterial Proteins
topics (OpenAlex): Microbial Natural Products and Biosynthesis; 14-3-3 protein interactions; Fluorine in Organic Chemistry
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 15, 2024

2023 article

Current State‐of‐the‐Art Toward Chemoenzymatic Synthesis of Polyketide Natural Products

Paulsel, T. Q., & Williams, G. J. (2023, August 24). ChemBioChem, Vol. 9.

By: T. Paulsel n & G. Williams n 

author keywords: bioorganic chemistry; biosynthesis; enzymes; polyketides; synthetic biology
MeSH headings : Humans; Polyketides / chemistry; Biological Products / metabolism; Polyketide Synthases / metabolism; Secondary Metabolism; Substrate Specificity
topics (OpenAlex): Microbial Natural Products and Biosynthesis; Fungal Biology and Applications; Phytochemical compounds biological activities
TL;DR: These synthetic strategies have successfully yielded natural product derivatives while providing critical insights into enzymatic promiscuity and mechanistic activity and their contributions to the field of chemical biology are summarized. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 10, 2023

2022 article

Targeted enzyme modifications enable regioselective biosynthesis of fluorinated polyketides

Welch, S. D., Cossin, J., Paulsel, T. Q., & Williams, G. J. (2022, October 1). Chem Catalysis, Vol. 2, pp. 2440–2443.

By: S. Welch n, J. Cossin n , T. Paulsel n & G. Williams n 

topics (OpenAlex): Microbial Natural Products and Biosynthesis; Fluorine in Organic Chemistry; Carbohydrate Chemistry and Synthesis
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 17, 2023

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