Thirumurugan Rathinasabapathy

Also known as: Thiru

https://orcid.org/0000-0002-7330-0552

Lead Optimization; Preclinical Candidate; Biomarker; Food Chemistry; Natural Product Chemistry

Works (36)

Updated: April 11th, 2023 10:13

2023 journal article

Gel formulated with Bryophyllum pinnatum leaf extract promotes skin wound healing in vivo by increasing VEGF expression: A novel potential active ingredient for pharmaceuticals

FRONTIERS IN PHARMACOLOGY, 13.

By: E. Dantas Araujo, J. Xavier-Santos, V. Silva, J. Lima, J. Schlamb, M. Fernandes-Pedrosa, A. Silva Junior, R. Araujo Junior ...

author keywords: Crassulaceae; topical gel formulation; wound healing; stability study; analytical marker; phenolic compounds
Sources: Web Of Science, ORCID
Added: March 20, 2023

2022 review

All Polyphenols Are Not Created Equal: Exploring the Diversity of Phenolic Metabolites

[Review of ]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(7), 2077–2091.

By: C. Vong n, T. Rathinasabapathy, M. Moncada & S. Komarnytsky

author keywords: (poly)phenols; phenolic acids; microbiome; microbial catabolism; methylation
Sources: Web Of Science, ORCID
Added: February 12, 2022

2022 review

Plant-Based Support of Respiratory Health during Viral Outbreaks

[Review of ]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(7), 2064–2076.

By: T. Rathinasabapathy, L. Sakthivel* & S. Komarnytsky

author keywords: licorice; coneflower; ginger; mullein; horehound; elderberry; nettle; antiviral; anti-inflammatory; expectorant; COVID-19
Sources: Web Of Science, ORCID
Added: February 12, 2022

2021 review

Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils

[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(11).

By: S. Komarnytsky, T. Rathinasabapathy, C. Wagner, B. Metzger*, C. Carlisle*, C. Panda*, S. Le Brun-Blashka*, J. Troup*, S. Varadharaj*

author keywords: ECS tone; phytocannabinoids; inflammation resolution; oxidative stress; systemic redox balance
Sources: Web Of Science, ORCID
Added: May 24, 2021

2021 journal article

Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3).

By: M. Wilson, V. Konda*, K. Heidt n, T. Rathinasabapathy, A. Desai* & S. Komarnytsky

author keywords: postmenopausal; estrogens; hot flashes; HRT; ERr 731
Sources: Web Of Science, ORCID
Added: January 21, 2021

2020 journal article

Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model

Food Chemistry, 331, 127279.

By: J. Xiong, Y. Chan n, T. Rathinasabapathy, M. Grace, S. Komarnytsky & M. Lila

author keywords: Food matrix; By-product; Stability; Antioxidant; Anti-inflammatory
Source: ORCID
Added: June 19, 2020

2020 journal article

Spicing up gastrointestinal health with dietary essential oils

Phytochemistry Reviews, 19(2), 243–263.

By: M. Tanveer n, C. Wagner n, M. Haq*, N. Ribeiro n, T. Rathinasabapathy n, M. Butt*, A. Shehzad*, S. Komarnytsky

author keywords: Essential oils; Indigestion; Gastroesophageal reflux; Dyspepsia; Gastritis
Source: ORCID
Added: March 5, 2020

2019 journal article

Distinct fractions of an Artemisia scoparia extract contain compounds with novel adipogenic bioactivity

Frontiers in Nutrition, 6.

By: A. Boudreau*, A. Poulev*, D. Ribnicky*, I. Raskin*, T. Rathinasabapathy, A. Richard*, J. Stephens*

author keywords: adipocyte; plants-medicinal; botanical extract; adipogenesis; fat cell; activity-guided fractionation; 3T3-L1 adipocyte
Source: ORCID
Added: July 16, 2022

2018 journal article

Edible foxtail millet flour stabilises and retain the invitro activity of blueberry bioactive components

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 53(7), 1771–1780.

By: K. Mak*, T. Rathinasabapathy, S. Sankaran*, M. Kandasamy*, E. Ling*, M. Balijepalli*, S. Sagineedu*, M. Pichika*

author keywords: -glucosidase enzyme; anthocyanins; antioxidant; blueberries; foxtail millet flour; polyphenols
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory

MOLECULAR NUTRITION & FOOD RESEARCH, 61(9).

By: K. Jackson n, T. Rathinasabapathy, D. Esposito & S. Komarnytsky

author keywords: Blood glucose; Cell bioenergetics; Diabetes; Dietary supplementation; Metabolic syndrome
Sources: ORCID, Web Of Science
Added: August 6, 2018

2017 journal article

Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity

Journal of Chemistry, 2017, 1–10.

By: T. Rathinasabapathy, K. Palatini Jackson, Y. Thor n, A. Buru*, D. Esposito, X. Li, M. Pichika*, A. Hamzah*, S. Komarnytsky

Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2015 book

Effective waste water treatment and its management

In Toxicity and Waste Management Using Bioremediation (pp. 312–334).

By: S. Prabu*, T. Suriyaprakash*, R. Kandasamy* & T. Rathinasabapathy

Source: ORCID
Added: December 9, 2019

2014 journal article

Process validation: A review

Pharma Times, 46(4), 12–15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943603029&partnerID=MN8TOARS

By: S. Prabu, T. Suriyaprakash, R. Thirumurugan & A. Shanmugarathinam

Source: ORCID
Added: July 16, 2022

2013 journal article

Acceleration of cutaneous wound healing by brassinosteroids

WOUND REPAIR AND REGENERATION, 21(5), 688–696.

By: D. Esposito*, T. Rathinasabapathy, B. Schmidt*, M. Shakarjian*, S. Komarnytsky & I. Raskin*

Sources: ORCID, Web Of Science
Added: August 6, 2018

2013 journal article

Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill

PHYTOCHEMISTRY, 87, 78–85.

By: R. Graziose*, M. Grace, T. Rathinasabapathy, P. Rojas-Silva*, C. Dekock*, A. Poulev*, M. Lila, P. Smith*, I. Raskin*

author keywords: Datisca glomerata; Cucurbitales; Datiscaceae; Durango root; Bioassay guided fractionation; Cucurbitacin; Antimalarial; Antileishmanial; Cytotoxicity
Sources: ORCID, Web Of Science
Added: August 6, 2018

2013 journal article

Effects of Pregnane Glycosides on Food Intake Depend on Stimulation of the Melanocortin Pathway and BDNF in an Animal Model

Journal of Agricultural and Food Chemistry, 61(8), 1841–1849.

By: S. Komarnytsky, D. Esposito, T. Rathinasabapathy, A. Poulev* & I. Raskin*

author keywords: appetite; satiety; body weight; milkweed; Asclepias
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae

JOURNAL OF ETHNOPHARMACOLOGY, 142(2), 456–461.

By: R. Graziose*, P. Rojas-Silva*, T. Rathinasabapathy, C. Dekock*, M. Grace, A. Poulev*, M. Lila, P. Smith*, I. Raskin*

author keywords: Cornus; Antiplasmodial; Antileishmanial; Malaria; Cytotoxicity; Triterpene; Betulinic acid
Sources: ORCID, Web Of Science
Added: August 6, 2018

2011 journal article

Akt-Dependent Anabolic Activity of Natural and Synthetic Brassinosteroids in Rat Skeletal Muscle Cells

Journal of Medicinal Chemistry, 54(12), 4057–4066.

By: D. Esposito, T. Rathinasabapathy, A. Poulev*, S. Komarnytsky & I. Raskin*

Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.

JOURNAL OF ETHNOPHARMACOLOGY, 133(1), 26–30.

By: R. Graziose*, T. Rathinasabapathy, C. Lategan*, A. Poulev*, P. Smith*, M. Grace, M. Lila, I. Raskin*

author keywords: Antimalarial; Aporphine alkaloids; Sesquiterpene lactones; Liriodendron tulipifera L.; Magnoliaceae; Cytotoxicity
Sources: ORCID, Web Of Science
Added: August 6, 2018

2011 journal article

Design and evaluation of buccoadhesive bi-layer tablet of atenolol

International Journal of Research in Pharmaceutical Sciences, 2(2), 100–103. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955369086&partnerID=MN8TOARS

By: K. Panneer, S. Ramkanth, R. Thirumurugan, K. Kumar & S. Raji

Source: ORCID
Added: July 16, 2022

2007 journal article

Antimycobacterial activity of novel 1-(5-cyclobutyl-1,3-oxazol-2-yl)-3-(sub)phenyl/pyridylthiourea compounds endowed with high activity toward multidrug-resistant Mycobacterium tuberculosis

J Antimicrob Chemother, 59(6), 1194–1196.

By: D. Sriram*, P. Yogeeswari*, M. Dinakaran* & R. Thirumurugan*

author keywords: antimycobacterial activity; antitubercular activity; thiourea derivatives; oxazole derivatives
Source: ORCID
Added: December 9, 2019

2006 journal article

2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: synthesis and pharmacological evaluation

Bioorg Med Chem, 14(9), 3106–3112.

By: R. Thirumurugan*, D. Sriram*, A. Saxena*, J. Stables* & P. Yogeeswari*

author keywords: aryl semicarbazones; anticonvulsant; 2,4-dimethoxy; GABA
Source: ORCID
Added: December 9, 2019

2006 journal article

Discovery of new antitubercular oxazolyl thiosemicarbazones

J Med Chem, 49(12), 3448–3450.

By: D. Sriram*, P. Yogeeswari*, R. Thirumurugan* & R. Pavana*

Source: ORCID
Added: December 9, 2019

2006 journal article

Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: an update

Nat Prod Res, 20(5), 497–505.

By: P. Yogeeswari*, D. Sriram*, T. Ratan Bal* & R. Thirumurugan*

author keywords: epibatidine; nicotinic acetylcholine receptor; analgesics; alkaloid
Source: ORCID
Added: December 9, 2019

2006 journal article

Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones

Medicinal Chemistry, 2(1), 55–62.

By: P. Yogeeswari*, J. Ragavendran, R. Thirumurugan, S. Induja, D. Sriram* & J. Stables

Source: ORCID
Added: December 9, 2019

2006 journal article

Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors

Acta Pharm, 56(3), 259–272. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748855540&partnerID=MN8TOARS

By: P. Yogeeswari, D. Sriram, R. Thirumurugan, L. Jeewanlal, S. Jit, J. Ragavendran, R. Kavya, K. Rakhra, V. Saraswat

Source: ORCID
Added: December 9, 2019

2005 journal article

Camptothecin and its analogues: a review on their chemotherapeutic potential

Nat Prod Res, 19(4), 393–412.

By: D. Sriram, P. Yogeeswari, R. Thirumurugan & T. Bal

author keywords: camptothecin; anticancer; topoisomerase I inhibitors
Source: ORCID
Added: December 9, 2019

2005 journal article

Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design

J Med Chem, 48(20), 6202–6211.

By: P. Yogeeswari*, D. Sriram*, R. Thirumurugan*, J. Raghavendran*, K. Sudhan*, R. Pavana*, J. Stables*

Source: ORCID
Added: December 9, 2019

2005 journal article

Synthesis of aryl semicarbazones as potential anticonvulsant agents

Biomed Pharmacother, 59(1-2), 51–55.

By: P. Yogeeswari*, D. Sriram*, V. Veena*, R. Kavya*, K. Rakhra*, J. Ragavendran*, S. Mehta*, R. Thirumurugan*, J. Stables*

author keywords: anticonvulsant; aryl semicarbazones; neurotoxicity
Source: ORCID
Added: December 9, 2019

2004 journal article

3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity

Eur J Med Chem, 39(8), 729–734.

By: P. Yogeeswari*, R. Thirumurugan*, R. Kavya*, J. Samuel*, J. Stables* & D. Sriram*

author keywords: aryl semicarbazones; 3-Chloro-2-methyl substituted phenyl semicarbazones; anti convulsants; CNS depressants
Source: ORCID
Added: December 9, 2019

2004 journal article

Antituberculous activity of some aryl semicarbazone derivatives

Bioorg Med Chem Lett, 14(15), 3923–3924.

By: D. Sriram*, P. Yogeeswari* & R. Thirumurugan*

author keywords: antitubercular; aryl semicarbazones
Source: ORCID
Added: December 9, 2019

2004 journal article

Ion channels as important targets for antiepileptic drug design

Current Drug Targets, 5(7), 589–602.

By: P. Yogeeswari*, J. Ragavendran, R. Thirumurugan, A. Saxena & D. Sriram

author keywords: epilepsy; voltage-gated ion channels; antiepileptic drugs; sodium ion channel; calcium ion channel; potassium ion channel; H-channels
Source: ORCID
Added: December 9, 2019

2003 journal article

Synthesis and anticonvulsant and neurotoxicity evaluation of N 4-phthalimido phenyl (thio) semicarbazides

European Journal of Pharmaceutical Sciences, 20(3), 341–346.

By: P. Yogeeswari*, D. Sriram*, V. Saraswat*, J. Ragavendran*, M. Kumar*, S. Murugesan*, R. Thirumurugan*, J. Stables*

author keywords: phthalimides; semicarbazides; thiosemicarbazides; anticonvulsants; CNS depressants
Source: ORCID
Added: July 16, 2022

2003 journal article

Synthesis and anticonvulsant and neurotoxicity evaluation of N4-phthalimido phenyl (thio) semicarbazides

Eur J Pharm Sci, 20(3), 341–346.

By: P. Yogeeswari, D. Sriram, V. Saraswat, J. Ragavendran, M. Kumar, S. Murugesan, R. Thirumurugan, J. Stables

Source: ORCID
Added: December 9, 2019

2003 journal article

Synthesis of novel aryl semicarbazones as anticonvulsants with GABA-mediated mechanism

Medicinal Chemistry Research, 12(2), 57–68. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347380971&partnerID=MN8TOARS

By: P. Yogeeswari, D. Sriram, A. Brahmandam, I. Sridharan, R. Thirumurugan & J. Stables

Source: ORCID
Added: July 16, 2022

2000 journal article

Antitumour activity of Rhinacanthone against Dalton's ascitic lymphoma

Biological and Pharmaceutical Bulletin, 23(12), 1438–1440.

By: R. Thirumurugan, S. Kavimani & R. Srivastava

Source: ORCID
Added: December 9, 2019

Employment

Updated: December 19th, 2016 12:44

2016 - present

North Carolina State University Kannapolis, NC, US
Postdoctoral Research Scholar Plants for Human Health Institute, CALS

2012 - 2017

International Medical University Kuala Lumpur, Wilayah Persekutuan, MY
Assistant Professor Pharmaceutical Chemistry

2007 - 2012

Rutgers The State University of New Jersey New Brunswick, NJ, US
PostDoc Plant Biology and Pathology

2006 - 2007

Nycomed Pharma Private Ltd Mumbai, Maharashtra, IN
Research Scientist Lead Optimization

2005 - 2006

GVK Biosciences Private Limited Hyderabad, Telangana, IN
Senior Research Associate Medicinal Chemistry

2004 - present

Jubilant Chemsys Limited Noida, Uttar Pradesh, IN
Junior Research Scientist Medicinal Chemistry - CRO

2000 - 2001

Sami Labs Ltd Bangalore, Karnataka, IN
Research Chemist Natural Products

Education

Updated: December 19th, 2016 13:01

2011 - 2015

Birla Institute of Technology and Science Pilani, Rajasthan, IN
PhD School of Pharmacy

1998 - 2000

Banaras Hindu University Varanasi, Uttar Pradesh, IN
MPharmacy Department of Pharmaceutics

1993 - 1997

Madurai Medical College Madurai, Tamil Nadu, IN
BPharmacy School of Pharmacy

Funding History

Funding history based on the linked ORCID record. Updated: May 5th, 2016 07:12

grant January 1, 2015 - December 1, 2016
Efficacy of Andrographis paniculata in preventing the systemic inflammation, metabolic dysfunction and atherosclerosis induced by cholesterol-enriched high-fat diet in animal models
Ministry of Agriculture and Agro based Industry, Malaysia
grant July 1, 2014 - June 1, 2016
Swietenine, a natural wonder drug, potentiates the antidiabetic activity of metformin: Identification of molecular mechanisms involved
Ministry of Higher Education, Malaysia
grant July 1, 2014 - December 1, 2016
Identification of chemical probes with pancreatic β-cell-selective replication promoting activity: The new paradigm in anti-diabetic drug discovery
Ministry of Higher Education, Malaysia
grant June 1, 2013
Structure-based Optimisation of the novel lead compound Tetrahydrothiazolopyridine for the treatment of obesity: Design and synthesis of drug-like compounds; evaluation of their efficacy and toxicity in vivo
Ministry of Higher Education, Malaysia
grant January 1, 2010 - December 1, 2012
Artemisia Species and Insulin Signaling
National Center for Complementary and Alternative Medicine