Thirumurugan Rathinasabapathy

Also known as: Thiru

https://orcid.org/0000-0002-7330-0552

Lead Optimization; Preclinical Candidate; Biomarker; Food Chemistry; Natural Product Chemistry

Works (36)

Updated: August 29th, 2023 11:24

2023 journal article

Gel formulated with Bryophyllum pinnatum leaf extract promotes skin wound healing in vivo by increasing VEGF expression: A novel potential active ingredient for pharmaceuticals

FRONTIERS IN PHARMACOLOGY, 13.

By: E. Dantas Araujo, J. Xavier-Santos*, V. Silva*, J. Lima*, J. Schlamb n, M. Fernandes-Pedrosa*, A. Silva Junior*, R. Araujo Junior* ...

co-author countries: Brazil 🇧🇷 United States of America 🇺🇸
author keywords: Crassulaceae; topical gel formulation; wound healing; stability study; analytical marker; phenolic compounds
Sources: Web Of Science, ORCID
Added: March 20, 2023

2022 review

All Polyphenols Are Not Created Equal: Exploring the Diversity of Phenolic Metabolites

[Review of ]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(7), 2077–2091.

By: C. Vong n, T. Rathinasabapathy n, M. Moncada n & S. Komarnytsky n

co-author countries: United States of America 🇺🇸

Contributors: C. Vong n, T. Rathinasabapathy n, M. Moncada n & S. Komarnytsky n

author keywords: (poly)phenols; phenolic acids; microbiome; microbial catabolism; methylation
MeSH headings : Antioxidants; Flavonoids / metabolism; Humans; Phenols / chemistry; Polyphenols / metabolism; Tannins
Sources: Web Of Science, ORCID
Added: February 12, 2022

2022 review

Plant-Based Support of Respiratory Health during Viral Outbreaks

[Review of ]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(7), 2064–2076.

By: T. Rathinasabapathy n, L. Sakthivel* & S. Komarnytsky n

co-author countries: India 🇮🇳 United States of America 🇺🇸

Contributors: T. Rathinasabapathy n, L. Sakthivel* & S. Komarnytsky n

author keywords: licorice; coneflower; ginger; mullein; horehound; elderberry; nettle; antiviral; anti-inflammatory; expectorant; COVID-19
MeSH headings : Disease Outbreaks; Humans; Phytotherapy; Plant Extracts / pharmacology; Respiratory System; Virus Diseases / drug therapy
Sources: Web Of Science, ORCID
Added: February 12, 2022

2021 review

Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils

[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(11).

By: S. Komarnytsky n, T. Rathinasabapathy n, C. Wagner n, B. Metzger*, C. Carlisle*, C. Panda*, S. Le Brun-Blashka*, J. Troup*, S. Varadharaj*

co-author countries: United States of America 🇺🇸

Contributors: S. Komarnytsky n, T. Rathinasabapathy n, C. Wagner n, B. Metzger*, C. Carlisle*, C. Panda*, S. Le Brun-Blashka*, J. Troup*, S. Varadharaj*

author keywords: ECS tone; phytocannabinoids; inflammation resolution; oxidative stress; systemic redox balance
MeSH headings : Adenosine / metabolism; Animals; Cannabinoids / metabolism; Cannabis / metabolism; Diet; Endocannabinoids / metabolism; Fatty Acids, Unsaturated / metabolism; Homeostasis / physiology; Humans; Inflammation / metabolism; Lipid Metabolism / physiology; Oxidative Stress / physiology; Plant Extracts / metabolism; Signal Transduction / physiology; TRPV Cation Channels / metabolism
Sources: Web Of Science, ORCID
Added: May 24, 2021

2021 journal article

Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3).

By: M. Wilson n, V. Konda*, K. Heidt n, T. Rathinasabapathy n, A. Desai* & S. Komarnytsky n

co-author countries: United States of America 🇺🇸

Contributors: M. Wilson n, V. Konda*, K. Heidt n, T. Rathinasabapathy n, A. Desai* & S. Komarnytsky n

author keywords: postmenopausal; estrogens; hot flashes; HRT; ERr 731
MeSH headings : Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / metabolism; Hot Flashes; Menopause / drug effects; Molecular Structure; Ovariectomy; Phytoestrogens / chemistry; Phytoestrogens / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Roots / chemistry; Postmenopause; Rats; Rheum / chemistry; Vasomotor System / drug effects
Sources: Web Of Science, ORCID
Added: January 21, 2021

2020 journal article

Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model

Food Chemistry, 331, 127279.

By: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸

Contributors: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Food matrix; By-product; Stability; Antioxidant; Anti-inflammatory
MeSH headings : Animals; Anthocyanins / analysis; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antioxidants / analysis; Blueberry Plants / chemistry; Digestion; Food-Processing Industry; Fruit / chemistry; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacokinetics; Plant Proteins, Dietary / chemistry; Polyphenols / pharmacokinetics; Proanthocyanidins / analysis; RAW 264.7 Cells; Vitis / chemistry
Source: ORCID
Added: June 19, 2020

2020 journal article

Spicing up gastrointestinal health with dietary essential oils

Phytochemistry Reviews, 19(2), 243–263.

co-author countries: Brazil 🇧🇷 Pakistan 🇵🇰 United States of America 🇺🇸

Contributors: M. Tanveer n, C. Wagner n, M. Haq*, N. Ribeiro n, T. Rathinasabapathy n, M. Butt*, A. Shehzad*, S. Komarnytsky n

author keywords: Essential oils; Indigestion; Gastroesophageal reflux; Dyspepsia; Gastritis
Source: ORCID
Added: March 5, 2020

2019 journal article

Distinct fractions of an Artemisia scoparia extract contain compounds with novel adipogenic bioactivity

Frontiers in Nutrition, 6.

By: A. Boudreau*, A. Poulev*, D. Ribnicky*, I. Raskin*, T. Rathinasabapathy*, A. Richard*, J. Stephens*

co-author countries: United States of America 🇺🇸

Contributors: A. Boudreau*, A. Poulev*, D. Ribnicky*, I. Raskin*, T. Rathinasabapathy*, A. Richard*, J. Stephens*

author keywords: adipocyte; plants-medicinal; botanical extract; adipogenesis; fat cell; activity-guided fractionation; 3T3-L1 adipocyte
Source: ORCID
Added: July 16, 2022

2018 journal article

Edible foxtail millet flour stabilises and retain the invitro activity of blueberry bioactive components

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 53(7), 1771–1780.

By: K. Mak*, T. Rathinasabapathy*, S. Sankaran*, M. Kandasamy*, E. Ling*, M. Balijepalli*, S. Sagineedu*, M. Pichika*

co-author countries: Malaysia 🇲🇾

Contributors: K. Mak*, T. Rathinasabapathy*, S. Sankaran*, M. Kandasamy*, E. Ling*, M. Balijepalli*, S. Sagineedu*, M. Pichika*

author keywords: -glucosidase enzyme; anthocyanins; antioxidant; blueberries; foxtail millet flour; polyphenols
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory

MOLECULAR NUTRITION & FOOD RESEARCH, 61(9).

By: K. Jackson n, T. Rathinasabapathy n, D. Esposito n & S. Komarnytsky n

co-author countries: Malaysia 🇲🇾 United States of America 🇺🇸

Contributors: K. Jackson n, T. Rathinasabapathy n, D. Esposito n & S. Komarnytsky n

author keywords: Blood glucose; Cell bioenergetics; Diabetes; Dietary supplementation; Metabolic syndrome
MeSH headings : Animals; Cell Line, Tumor; Chicory / chemistry; Gluconeogenesis / drug effects; Hypoglycemic Agents / pharmacology; MAP Kinase Signaling System; Pharmacogenetics; Phosphatidylinositol 3-Kinases / physiology; Plant Roots / chemistry; Quinic Acid / analogs & derivatives; Quinic Acid / pharmacology; Rats; Structure-Activity Relationship
Sources: ORCID, Web Of Science
Added: August 6, 2018

2017 journal article

Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity

Journal of Chemistry, 2017, 1–10.

By: T. Rathinasabapathy*, K. Palatini Jackson, Y. Thor n, A. Buru*, D. Esposito n, X. Li n, M. Pichika*, A. Hamzah*, S. Komarnytsky n

co-author countries: Malaysia 🇲🇾 United States of America 🇺🇸

Contributors: T. Rathinasabapathy*, K. Palatini Jackson, Y. Thor n, A. Buru*, D. Esposito n, X. Li n, M. Pichika*, A. Hamzah*, S. Komarnytsky n

Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2015 book

Effective waste water treatment and its management

In Toxicity and Waste Management Using Bioremediation (pp. 312–334).

By: S. Prabu*, T. Suriyaprakash, R. Kandasamy* & T. Rathinasabapathy*

co-author countries: India 🇮🇳 Malaysia 🇲🇾

Contributors: S. Prabu*, T. Suriyaprakash, R. Kandasamy* & T. Rathinasabapathy*

Source: ORCID
Added: December 9, 2019

2014 journal article

Process validation: A review

Pharma Times, 46(4), 12–15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943603029&partnerID=MN8TOARS

By: S. Prabu, T. Suriyaprakash, R. Thirumurugan & A. Shanmugarathinam

Contributors: S. Prabu, T. Suriyaprakash, R. Thirumurugan & A. Shanmugarathinam

Source: ORCID
Added: July 16, 2022

2013 journal article

Acceleration of cutaneous wound healing by brassinosteroids

WOUND REPAIR AND REGENERATION, 21(5), 688–696.

By: D. Esposito*, T. Rathinasabapathy*, B. Schmidt*, M. Shakarjian*, S. Komarnytsky n & I. Raskin*

co-author countries: Malaysia 🇲🇾 United States of America 🇺🇸

Contributors: D. Esposito*, T. Rathinasabapathy*, B. Schmidt*, M. Shakarjian*, S. Komarnytsky n & I. Raskin*

MeSH headings : Administration, Topical; Animals; Blotting, Western; Brassinosteroids / pharmacology; Cell Proliferation; Cells, Cultured; Intercellular Adhesion Molecule-1 / drug effects; Intercellular Adhesion Molecule-1 / metabolism; Male; Mice; Mice, Inbred C57BL; Signal Transduction / drug effects; Skin / injuries; Skin / pathology; Transforming Growth Factor beta / drug effects; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / drug effects; Tumor Necrosis Factor-alpha / metabolism; Wound Healing / drug effects
Sources: ORCID, Web Of Science
Added: August 6, 2018

2013 journal article

Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill

PHYTOCHEMISTRY, 87, 78–85.

By: R. Graziose, M. Grace*, T. Rathinasabapathy*, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila*, P. Smith, I. Raskin

Contributors: R. Graziose, M. Grace*, T. Rathinasabapathy*, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila*, P. Smith, I. Raskin

author keywords: Datisca glomerata; Cucurbitales; Datiscaceae; Durango root; Bioassay guided fractionation; Cucurbitacin; Antimalarial; Antileishmanial; Cytotoxicity
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / pharmacology; CHO Cells; Cell Line; Cricetinae; Glycosides / chemistry; Glycosides / pharmacology; Magnoliopsida / chemistry; Molecular Structure; Plants, Medicinal / chemistry; Plasmodium falciparum / drug effects; Rats; Triterpenes / chemistry; Triterpenes / pharmacology
Sources: ORCID, Web Of Science
Added: August 6, 2018

2013 journal article

Effects of Pregnane Glycosides on Food Intake Depend on Stimulation of the Melanocortin Pathway and BDNF in an Animal Model

Journal of Agricultural and Food Chemistry, 61(8), 1841–1849.

By: S. Komarnytsky n, D. Esposito n, T. Rathinasabapathy*, A. Poulev* & I. Raskin*

co-author countries: Ukraine 🇺🇦 United States of America 🇺🇸

Contributors: S. Komarnytsky n, D. Esposito n, T. Rathinasabapathy*, A. Poulev* & I. Raskin*

author keywords: appetite; satiety; body weight; milkweed; Asclepias
MeSH headings : Animals; Appetite / drug effects; Asclepias / chemistry; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; Cell Line, Tumor; Eating / drug effects; Female; Glycosides / administration & dosage; Humans; Male; Melanocortins / metabolism; Models, Animal; Plant Extracts / administration & dosage; Pregnanes / administration & dosage; Rats; Rats, Wistar
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae

JOURNAL OF ETHNOPHARMACOLOGY, 142(2), 456–461.

By: R. Graziose*, P. Rojas-Silva*, T. Rathinasabapathy*, C. Dekock*, M. Grace n, A. Poulev*, M. Lila n, P. Smith*, I. Raskin*

co-author countries: United States of America 🇺🇸 South Africa 🇿🇦

Contributors: R. Graziose*, P. Rojas-Silva*, T. Rathinasabapathy*, C. Dekock*, M. Grace n, A. Poulev*, M. Ann Lila n, P. Smith*, I. Raskin*

author keywords: Cornus; Antiplasmodial; Antileishmanial; Malaria; Cytotoxicity; Triterpene; Betulinic acid
MeSH headings : Animals; Antimalarials / isolation & purification; Antimalarials / pharmacology; Cell Line; Cornus / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmaniasis / drug therapy; Muscle, Skeletal / drug effects; Myoblasts / drug effects; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Plasmodium falciparum / drug effects; Rats; Trypanocidal Agents / isolation & purification; Trypanocidal Agents / pharmacology; Trypanocidal Agents / therapeutic use
Sources: ORCID, Web Of Science
Added: August 6, 2018

2011 journal article

Akt-Dependent Anabolic Activity of Natural and Synthetic Brassinosteroids in Rat Skeletal Muscle Cells

Journal of Medicinal Chemistry, 54(12), 4057–4066.

By: D. Esposito*, T. Rathinasabapathy*, A. Poulev*, S. Komarnytsky* & I. Raskin*

co-author countries: United States of America 🇺🇸

Contributors: D. Esposito*, T. Rathinasabapathy*, A. Poulev*, S. Komarnytsky* & I. Raskin*

MeSH headings : Anabolic Agents / chemical synthesis; Anabolic Agents / chemistry; Anabolic Agents / pharmacology; Animals; Cell Line; Cell Survival / drug effects; Cholestanones / chemical synthesis; Cholestanones / chemistry; Cholestanones / pharmacology; Mice; Muscle, Skeletal / cytology; Muscle, Skeletal / drug effects; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Rats; Stereoisomerism; Structure-Activity Relationship
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.

JOURNAL OF ETHNOPHARMACOLOGY, 133(1), 26–30.

By: R. Graziose*, T. Rathinasabapathy*, C. Lategan*, A. Poulev*, P. Smith*, M. Grace n, M. Lila n, I. Raskin*

co-author countries: United States of America 🇺🇸 South Africa 🇿🇦

Contributors: R. Graziose*, T. Rathinasabapathy*, C. Lategan*, A. Poulev*, P. Smith*, M. Grace n, M. Lila n, I. Raskin*

author keywords: Antimalarial; Aporphine alkaloids; Sesquiterpene lactones; Liriodendron tulipifera L.; Magnoliaceae; Cytotoxicity
MeSH headings : Alkaloids / chemistry; Alkaloids / isolation & purification; Alkaloids / pharmacology; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Aporphines / chemistry; Aporphines / isolation & purification; Aporphines / pharmacology; Lactones / chemistry; Lactones / isolation & purification; Lactones / pharmacology; Liriodendron / chemistry; Malaria / drug therapy; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Plant Leaves; Sesquiterpenes / chemistry; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; United States
Sources: ORCID, Web Of Science
Added: August 6, 2018

2011 journal article

Design and evaluation of buccoadhesive bi-layer tablet of atenolol

International Journal of Research in Pharmaceutical Sciences, 2(2), 100–103. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955369086&partnerID=MN8TOARS

By: K. Panneer, S. Ramkanth, R. Thirumurugan, K. Kumar & S. Raji

Contributors: K. Panneer, S. Ramkanth, R. Thirumurugan, K. Kumar & S. Raji

Source: ORCID
Added: July 16, 2022

2007 journal article

Antimycobacterial activity of novel 1-(5-cyclobutyl-1,3-oxazol-2-yl)-3-(sub)phenyl/pyridylthiourea compounds endowed with high activity toward multidrug-resistant Mycobacterium tuberculosis

J Antimicrob Chemother, 59(6), 1194–1196.

co-author countries: India 🇮🇳

Contributors: D. Sriram*, P. Yogeeswari*, M. Dinakaran* & R. Thirumurugan*

author keywords: antimycobacterial activity; antitubercular activity; thiourea derivatives; oxazole derivatives
MeSH headings : Animals; Antitubercular Agents / chemical synthesis; Antitubercular Agents / pharmacology; Antitubercular Agents / toxicity; Cell Survival / drug effects; Chlorocebus aethiops; Drug Resistance, Multiple, Bacterial / drug effects; Female; Isoniazid / pharmacology; Magnetic Resonance Spectroscopy; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis / drug effects; Pyridines / chemical synthesis; Pyridines / pharmacology; Pyridines / toxicity; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Thiourea / analogs & derivatives; Thiourea / chemical synthesis; Thiourea / pharmacology; Thiourea / toxicity; Tuberculosis / drug therapy; Tuberculosis / microbiology; Vero Cells
Source: ORCID
Added: December 9, 2019

2006 journal article

2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: synthesis and pharmacological evaluation

Bioorg Med Chem, 14(9), 3106–3112.

By: R. Thirumurugan*, D. Sriram*, A. Saxena*, J. Stables & P. Yogeeswari*

co-author countries: India 🇮🇳

Contributors: R. Thirumurugan*, D. Sriram*, A. Saxena*, J. Stables & P. Yogeeswari*

author keywords: aryl semicarbazones; anticonvulsant; 2,4-dimethoxy; GABA
MeSH headings : Animals; Anticonvulsants / chemical synthesis; Anticonvulsants / chemistry; Anticonvulsants / pharmacology; Central Nervous System / drug effects; Central Nervous System / metabolism; Disease Models, Animal; Male; Mice; Molecular Structure; Oxygen / chemistry; Rats; Seizures / metabolism; Seizures / prevention & control; Semicarbazones / chemical synthesis; Semicarbazones / chemistry; Semicarbazones / pharmacology; Structure-Activity Relationship; gamma-Aminobutyric Acid / metabolism
Source: ORCID
Added: December 9, 2019

2006 journal article

Discovery of new antitubercular oxazolyl thiosemicarbazones

J Med Chem, 49(12), 3448–3450.

co-author countries: India 🇮🇳
MeSH headings : Antibiotics, Antitubercular / chemical synthesis; Antibiotics, Antitubercular / chemistry; Antibiotics, Antitubercular / pharmacology; Drug Resistance, Multiple, Bacterial; Microbial Sensitivity Tests; Mycobacterium tuberculosis / drug effects; Structure-Activity Relationship; Thiosemicarbazones / chemical synthesis; Thiosemicarbazones / chemistry; Thiosemicarbazones / pharmacology
Source: ORCID
Added: December 9, 2019

2006 journal article

Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: an update

Nat Prod Res, 20(5), 497–505.

co-author countries: India 🇮🇳

Contributors: P. Yogeeswari*, D. Sriram*, T. Ratan Bal* & R. Thirumurugan*

author keywords: epibatidine; nicotinic acetylcholine receptor; analgesics; alkaloid
MeSH headings : Analgesics, Non-Narcotic / chemistry; Analgesics, Non-Narcotic / pharmacology; Analgesics, Non-Narcotic / therapeutic use; Analgesics, Non-Narcotic / toxicity; Animals; Anura; Bridged Bicyclo Compounds, Heterocyclic / chemistry; Bridged Bicyclo Compounds, Heterocyclic / pharmacology; Bridged Bicyclo Compounds, Heterocyclic / therapeutic use; Bridged Bicyclo Compounds, Heterocyclic / toxicity; Nicotinic Agonists / chemistry; Nicotinic Agonists / pharmacology; Nicotinic Agonists / therapeutic use; Nicotinic Agonists / toxicity; Pain / drug therapy; Phytotherapy; Pyridines / chemistry; Pyridines / pharmacology; Pyridines / therapeutic use; Pyridines / toxicity; Receptors, Nicotinic / drug effects; Skin / metabolism; Structure-Activity Relationship
Source: ORCID
Added: December 9, 2019

2006 journal article

Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones

Medicinal Chemistry, 2(1), 55–62.

By: P. Yogeeswari*, J. Ragavendran*, R. Thirumurugan, S. Induja*, D. Sriram* & J. Stables*

co-author countries: India 🇮🇳

Contributors: P. Yogeeswari*, J. Ragavendran*, R. Thirumurugan, S. Induja*, D. Sriram* & J. Stables*

MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / chemical synthesis; Anticonvulsants / therapeutic use; Binding Sites; Electroshock; Injections, Subcutaneous; Mice; Pentylenetetrazole / administration & dosage; Rats; Seizures / chemically induced; Seizures / drug therapy; Semicarbazones / administration & dosage; Semicarbazones / chemical synthesis; Semicarbazones / therapeutic use; Structure-Activity Relationship
Source: ORCID
Added: December 9, 2019

2006 journal article

Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors

Acta Pharm, 56(3), 259–272. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748855540&partnerID=MN8TOARS

By: P. Yogeeswari, D. Sriram, R. Thirumurugan, L. Jeewanlal, S. Jit, J. Ragavendran, R. Kavya, K. Rakhra, V. Saraswat

Contributors: P. Yogeeswari, D. Sriram, R. Thirumurugan, L. Jeewanlal, S. Jit, J. Ragavendran, R. Kavya, K. Rakhra, V. Saraswat

Source: ORCID
Added: December 9, 2019

2005 journal article

Camptothecin and its analogues: a review on their chemotherapeutic potential

Nat Prod Res, 19(4), 393–412.

By: D. Sriram, P. Yogeeswari, R. Thirumurugan & T. Bal

Contributors: D. Sriram, P. Yogeeswari, R. Thirumurugan & T. Bal

author keywords: camptothecin; anticancer; topoisomerase I inhibitors
MeSH headings : Animals; Antineoplastic Agents, Phytogenic / chemistry; Antineoplastic Agents, Phytogenic / pharmacology; Camptothecin / analogs & derivatives; Camptothecin / chemistry; Camptothecin / pharmacology; Humans; Molecular Structure; Structure-Activity Relationship
Source: ORCID
Added: December 9, 2019

2005 journal article

Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design

J Med Chem, 48(20), 6202–6211.

By: P. Yogeeswari*, D. Sriram*, R. Thirumurugan*, J. Raghavendran*, K. Sudhan*, R. Pavana*, J. Stables*

co-author countries: India 🇮🇳 United States of America 🇺🇸

Contributors: P. Yogeeswari*, D. Sriram*, R. Thirumurugan*, J. Raghavendran*, K. Sudhan*, R. Pavana*, J. Stables*

MeSH headings : 4-Aminobutyrate Transaminase / antagonists & inhibitors; Animals; Anticonvulsants / chemical synthesis; Anticonvulsants / pharmacology; Anticonvulsants / toxicity; Benzamides / chemical synthesis; Benzamides / pharmacology; Benzamides / toxicity; Chemical and Drug Induced Liver Injury / etiology; Drug Design; Female; Male; Mice; Models, Molecular; Motor Activity / drug effects; Rats; Seizures / drug therapy; Seizures / etiology; Semicarbazones / chemical synthesis; Semicarbazones / pharmacology; Semicarbazones / toxicity; Structure-Activity Relationship; gamma-Aminobutyric Acid / blood
Source: ORCID
Added: December 9, 2019

2005 journal article

Synthesis of aryl semicarbazones as potential anticonvulsant agents

Biomed Pharmacother, 59(1-2), 51–55.

By: P. Yogeeswari*, D. Sriram*, V. Veena*, R. Kavya*, K. Rakhra*, J. Ragavendran*, S. Mehta*, R. Thirumurugan*, J. Stables*

co-author countries: India 🇮🇳 United States of America 🇺🇸

Contributors: P. Yogeeswari*, D. Sriram*, V. Veena*, R. Kavya*, K. Rakhra*, J. Ragavendran*, S. Mehta*, R. Thirumurugan*, J. Stables*

author keywords: anticonvulsant; aryl semicarbazones; neurotoxicity
MeSH headings : Animals; Anticonvulsants / chemical synthesis; Anticonvulsants / pharmacology; Anticonvulsants / therapeutic use; Brain / drug effects; Brain / metabolism; Electroshock / methods; Male; Mice; Rats; Rats, Sprague-Dawley; Seizures / drug therapy; Seizures / metabolism; Semicarbazones / chemical synthesis; Semicarbazones / pharmacology; Semicarbazones / therapeutic use
Source: ORCID
Added: December 9, 2019

2004 journal article

3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity

Eur J Med Chem, 39(8), 729–734.

co-author countries: India 🇮🇳

Contributors: P. Yogeeswari*, R. Thirumurugan*, R. Kavya*, J. Samuel, J. Stables & D. Sriram*

author keywords: aryl semicarbazones; 3-Chloro-2-methyl substituted phenyl semicarbazones; anti convulsants; CNS depressants
MeSH headings : Animals; Anticonvulsants / chemical synthesis; Anticonvulsants / therapeutic use; Male; Mice; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures / prevention & control; Semicarbazones / chemical synthesis; Semicarbazones / therapeutic use
Source: ORCID
Added: December 9, 2019

2004 journal article

Antituberculous activity of some aryl semicarbazone derivatives

Bioorg Med Chem Lett, 14(15), 3923–3924.

co-author countries: India 🇮🇳
author keywords: antitubercular; aryl semicarbazones
MeSH headings : Antitubercular Agents / chemical synthesis; Antitubercular Agents / pharmacology; Microbial Sensitivity Tests; Molecular Conformation; Molecular Structure; Mycobacterium tuberculosis / drug effects; Semicarbazones / chemical synthesis; Semicarbazones / pharmacology; Structure-Activity Relationship
Source: ORCID
Added: December 9, 2019

2004 journal article

Ion channels as important targets for antiepileptic drug design

Current Drug Targets, 5(7), 589–602.

By: P. Yogeeswari*, J. Ragavendran, R. Thirumurugan*, A. Saxena & D. Sriram*

co-author countries: India 🇮🇳

Contributors: P. Yogeeswari*, J. Ragavendran, R. Thirumurugan*, A. Saxena & D. Sriram*

author keywords: epilepsy; voltage-gated ion channels; antiepileptic drugs; sodium ion channel; calcium ion channel; potassium ion channel; H-channels
MeSH headings : Anticonvulsants / chemistry; Anticonvulsants / pharmacology; Anticonvulsants / therapeutic use; Calcium Channels / drug effects; Calcium Channels / physiology; Chemistry, Pharmaceutical; Epilepsy / drug therapy; Epilepsy / metabolism; Humans; Ion Channels / drug effects; Ion Channels / physiology; Potassium Channels / drug effects; Potassium Channels / physiology; Sodium Channels / drug effects; Sodium Channels / physiology
Source: ORCID
Added: December 9, 2019

2003 journal article

Synthesis and anticonvulsant and neurotoxicity evaluation of N 4-phthalimido phenyl (thio) semicarbazides

European Journal of Pharmaceutical Sciences, 20(3), 341–346.

By: P. Yogeeswari*, D. Sriram*, V. Saraswat*, J. Ragavendran*, M. Kumar*, S. Murugesan*, R. Thirumurugan*, J. Stables

co-author countries: India 🇮🇳

Contributors: P. Yogeeswari*, D. Sriram*, V. Saraswat*, J. Ragavendran*, M. Kumar*, S. Murugesan*, R. Thirumurugan*, J. Stables

author keywords: phthalimides; semicarbazides; thiosemicarbazides; anticonvulsants; CNS depressants
MeSH headings : Animals; Anticonvulsants / chemical synthesis; Anticonvulsants / therapeutic use; Anticonvulsants / toxicity; Drug Evaluation, Preclinical / methods; Male; Mice; Rats; Rats, Sprague-Dawley; Seizures / drug therapy; Semicarbazides / chemical synthesis; Semicarbazides / toxicity
Source: ORCID
Added: July 16, 2022

2003 journal article

Synthesis and anticonvulsant and neurotoxicity evaluation of N4-phthalimido phenyl (thio) semicarbazides

Eur J Pharm Sci, 20(3), 341–346.

By: P. Yogeeswari, D. Sriram, V. Saraswat, J. Ragavendran, M. Kumar, S. Murugesan, R. Thirumurugan, J. Stables

Contributors: P. Yogeeswari, D. Sriram, V. Saraswat, J. Ragavendran, M. Kumar, S. Murugesan, R. Thirumurugan, J. Stables

Source: ORCID
Added: December 9, 2019

2003 journal article

Synthesis of novel aryl semicarbazones as anticonvulsants with GABA-mediated mechanism

Medicinal Chemistry Research, 12(2), 57–68. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347380971&partnerID=MN8TOARS

By: P. Yogeeswari, D. Sriram, A. Brahmandam, I. Sridharan, R. Thirumurugan & J. Stables

Contributors: P. Yogeeswari, D. Sriram, A. Brahmandam, I. Sridharan, R. Thirumurugan & J. Stables

Source: ORCID
Added: July 16, 2022

2000 journal article

Antitumour activity of Rhinacanthone against Dalton's ascitic lymphoma

Biological and Pharmaceutical Bulletin, 23(12), 1438–1440.

By: R. Thirumurugan, S. Kavimani & R. Srivastava

Contributors: R. Thirumurugan, S. Kavimani & R. Srivastava

MeSH headings : Animals; Antineoplastic Agents, Phytogenic / pharmacology; Ascitic Fluid / pathology; Benzopyrans / pharmacology; Lymphoma / drug therapy; Lymphoma / pathology; Male; Mice; Naphthoquinones / pharmacology; Neoplasm Transplantation; Plant Extracts / pharmacology; Plants, Medicinal / chemistry; Tumor Cells, Cultured
Source: ORCID
Added: December 9, 2019

Employment

Updated: December 19th, 2016 12:44

2016 - present

North Carolina State University Kannapolis, NC, US
Postdoctoral Research Scholar Plants for Human Health Institute, CALS

2012 - 2017

International Medical University Kuala Lumpur, Wilayah Persekutuan, MY
Assistant Professor Pharmaceutical Chemistry

2007 - 2012

Rutgers The State University of New Jersey New Brunswick, NJ, US
PostDoc Plant Biology and Pathology

2006 - 2007

Nycomed Pharma Private Ltd Mumbai, Maharashtra, IN
Research Scientist Lead Optimization

2005 - 2006

GVK Biosciences Private Limited Hyderabad, Telangana, IN
Senior Research Associate Medicinal Chemistry

2004 - present

Jubilant Chemsys Limited Noida, Uttar Pradesh, IN
Junior Research Scientist Medicinal Chemistry - CRO

2000 - 2001

Sami Labs Ltd Bangalore, Karnataka, IN
Research Chemist Natural Products

Education

Updated: December 19th, 2016 13:01

2011 - 2015

Birla Institute of Technology and Science Pilani, Rajasthan, IN
PhD School of Pharmacy

1998 - 2000

Banaras Hindu University Varanasi, Uttar Pradesh, IN
MPharmacy Department of Pharmaceutics

1993 - 1997

Madurai Medical College Madurai, Tamil Nadu, IN
BPharmacy School of Pharmacy

Funding History

Funding history based on the linked ORCID record. Updated: May 5th, 2016 07:12

grant January 1, 2015 - December 1, 2016
Efficacy of Andrographis paniculata in preventing the systemic inflammation, metabolic dysfunction and atherosclerosis induced by cholesterol-enriched high-fat diet in animal models
Ministry of Agriculture and Agro based Industry, Malaysia
grant July 1, 2014 - June 1, 2016
Swietenine, a natural wonder drug, potentiates the antidiabetic activity of metformin: Identification of molecular mechanisms involved
Ministry of Higher Education, Malaysia
grant July 1, 2014 - December 1, 2016
Identification of chemical probes with pancreatic β-cell-selective replication promoting activity: The new paradigm in anti-diabetic drug discovery
Ministry of Higher Education, Malaysia
grant June 1, 2013
Structure-based Optimisation of the novel lead compound Tetrahydrothiazolopyridine for the treatment of obesity: Design and synthesis of drug-like compounds; evaluation of their efficacy and toxicity in vivo
Ministry of Higher Education, Malaysia
grant January 1, 2010 - December 1, 2012
Artemisia Species and Insulin Signaling
National Center for Complementary and Alternative Medicine

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