Thirumurugan Rathinasabapathy

Also known as: Thiru

https://orcid.org/0000-0002-7330-0552

Lead Optimization; Preclinical Candidate; Biomarker; Food Chemistry; Natural Product Chemistry

Works (22)

2018 journal article

Edible foxtail millet flour stabilises and retain the invitro activity of blueberry bioactive components

International Journal of Food Science and Technology, 53(7), 1771–1780.

By: K. Mak, T. Rathinasabapathy, S. Sankaran, M. Kandasamy, E. Ling, M. Balijepalli, S. Sagineedu, M. Pichika

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2015 book

Effective waste water treatment and its management

In Toxicity and Waste Management Using Bioremediation (pp. 312–334).

By: S. Prabu, T. Suriyaprakash, R. Kandasamy & T. Rathinasabapathy

Source: ORCID
Added: December 9, 2019

2013 journal article

Acceleration of cutaneous wound healing by brassinosteroids

Wound Repair and Regeneration, 21(5), 688–696.

By: D. Esposito, T. Rathinasabapathy, B. Schmidt, M. Shakarjian, S. Komarnytsky & I. Raskin

Source: ORCID
Added: December 9, 2019

2013 journal article

Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill

Phytochemistry, 87, 78–85.

By: R. Graziose, M. Grace, T. Rathinasabapathy, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila, P. Smith, I. Raskin

Source: ORCID
Added: December 9, 2019

2013 journal article

Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and bdnf in an animal model

Journal of Agricultural and Food Chemistry, 61(8), 1841–1849.

By: S. Komarnytsky, D. Esposito, T. Rathinasabapathy, A. Poulev & I. Raskin

Source: ORCID
Added: December 9, 2019

2012 journal article

Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae

Journal of Ethnopharmacology, 142(2), 456–461.

By: R. Graziose, P. Rojas-Silva, T. Rathinasabapathy, C. Dekock, M. Grace, A. Poulev, M. Ann Lila, P. Smith, I. Raskin

Source: ORCID
Added: December 9, 2019

2011 journal article

Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells

Journal of Medicinal Chemistry, 54(12), 4057–4066.

By: D. Esposito, T. Rathinasabapathy, A. Poulev, S. Komarnytsky & I. Raskin

Source: ORCID
Added: December 9, 2019

2011 journal article

Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.

Journal of Ethnopharmacology, 133(1), 26–30.

By: R. Graziose, T. Rathinasabapathy, C. Lategan, A. Poulev, P. Smith, M. Grace, M. Lila, I. Raskin

Source: ORCID
Added: December 9, 2019

2007 journal article

Antimycobacterial activity of novel 1-(5-cyclobutyl-1,3-oxazol-2-yl)-3-(sub)phenyl/pyridylthiourea compounds endowed with high activity toward multidrug-resistant Mycobacterium tuberculosis

J Antimicrob Chemother, 59(6), 1194–1196.

By: D. Sriram, P. Yogeeswari, M. Dinakaran & R. Thirumurugan

Source: ORCID
Added: December 9, 2019

2006 journal article

2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: synthesis and pharmacological evaluation

Bioorg Med Chem, 14(9), 3106–3112.

By: R. Thirumurugan, D. Sriram, A. Saxena, J. Stables & P. Yogeeswari

Source: ORCID
Added: December 9, 2019

2006 journal article

Discovery of new antitubercular oxazolyl thiosemicarbazones

J Med Chem, 49(12), 3448–3450.

By: D. Sriram, P. Yogeeswari, R. Thirumurugan & R. Pavana

Source: ORCID
Added: December 9, 2019

2006 journal article

Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: an update

Nat Prod Res, 20(5), 497–505.

By: P. Yogeeswari, D. Sriram, T. Ratan Bal & R. Thirumurugan

Source: ORCID
Added: December 9, 2019

2006 journal article

Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones

Med Chem, 2(1), 55–62.

By: P. Yogeeswari, J. Ragavendran, R. Thirumurugan, S. Induja, D. Sriram & J. Stables

Source: ORCID
Added: December 9, 2019

2006 journal article

Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors

Acta Pharm, 56(3), 259–272.

By: P. Yogeeswari, D. Sriram, R. Thirumurugan, L. Jeewanlal, S. Jit, J. Ragavendran, R. Kavya, K. Rakhra, V. Saraswat

Source: ORCID
Added: December 9, 2019

2005 journal article

Camptothecin and its analogues: a review on their chemotherapeutic potential

Nat Prod Res, 19(4), 393–412.

By: D. Sriram, P. Yogeeswari, R. Thirumurugan & T. Bal

Source: ORCID
Added: December 9, 2019

2005 journal article

Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design

J Med Chem, 48(20), 6202–6211.

By: P. Yogeeswari, D. Sriram, R. Thirumurugan, J. Raghavendran, K. Sudhan, R. Pavana, J. Stables

Source: ORCID
Added: December 9, 2019

2005 journal article

Synthesis of aryl semicarbazones as potential anticonvulsant agents

Biomed Pharmacother, 59(1-2), 51–55.

By: P. Yogeeswari, D. Sriram, V. Veena, R. Kavya, K. Rakhra, J. Ragavendran, S. Mehta, R. Thirumurugan, J. Stables

Source: ORCID
Added: December 9, 2019

2004 journal article

3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity

Eur J Med Chem, 39(8), 729–734.

By: P. Yogeeswari, R. Thirumurugan, R. Kavya, J. Samuel, J. Stables & D. Sriram

Source: ORCID
Added: December 9, 2019

2004 journal article

Antituberculous activity of some aryl semicarbazone derivatives

Bioorg Med Chem Lett, 14(15), 3923–3924.

By: D. Sriram, P. Yogeeswari & R. Thirumurugan

Source: ORCID
Added: December 9, 2019

2004 journal article

Ion channels as important targets for antiepileptic drug design

Curr Drug Targets, 5(7), 589–602.

By: P. Yogeeswari, J. Ragavendran, R. Thirumurugan, A. Saxena & D. Sriram

Source: ORCID
Added: December 9, 2019

2003 journal article

Synthesis and anticonvulsant and neurotoxicity evaluation of N4-phthalimido phenyl (thio) semicarbazides

Eur J Pharm Sci, 20(3), 341–346.

By: P. Yogeeswari, D. Sriram, V. Saraswat, J. Ragavendran, M. Kumar, S. Murugesan, R. Thirumurugan, J. Stables

Source: ORCID
Added: December 9, 2019

2000 journal article

Antitumour activity of rhinacanthone against Dalton's ascitic lymphoma

Biol Pharm Bull, 23(12), 1438–1440.

By: R. Thirumurugan, S. Kavimani & R. Srivastava

Source: ORCID
Added: December 9, 2019

Employment

2016 - present

North Carolina State University Kannapolis, NC, US
Postdoctoral Research Scholar Plants for Human Health Institute, CALS

2012 - 2017

International Medical University Kuala Lumpur, Wilayah Persekutuan, MY
Assistant Professor Pharmaceutical Chemistry

2007 - 2012

Rutgers The State University of New Jersey New Brunswick, NJ, US
PostDoc Plant Biology and Pathology

2006 - 2007

Nycomed Pharma Private Ltd Mumbai, Maharashtra, IN
Research Scientist Lead Optimization

2005 - 2006

GVK Biosciences Private Limited Hyderabad, Telangana, IN
Senior Research Associate Medicinal Chemistry

2004 - present

Jubilant Chemsys Limited Noida, Uttar Pradesh, IN
Junior Research Scientist Medicinal Chemistry - CRO

2000 - 2001

Sami Labs Ltd Bangalore, Karnataka, IN
Research Chemist Natural Products

Education

2011 - 2015

Birla Institute of Technology and Science Pilani, Rajasthan, IN
PhD School of Pharmacy

1998 - 2000

Banaras Hindu University Varanasi, Uttar Pradesh, IN
MPharmacy Department of Pharmaceutics

1993 - 1997

Madurai Medical College Madurai, Tamil Nadu, IN
BPharmacy School of Pharmacy

Funding History

Funding history based on the linked ORCID record.

grant January 1, 2015 - December 1, 2016
Efficacy of Andrographis paniculata in preventing the systemic inflammation, metabolic dysfunction and atherosclerosis induced by cholesterol-enriched high-fat diet in animal models
Ministry of Agriculture and Agro based Industry, Malaysia
grant July 1, 2014 - June 1, 2016
Swietenine, a natural wonder drug, potentiates the antidiabetic activity of metformin: Identification of molecular mechanisms involved
Ministry of Higher Education, Malaysia
grant July 1, 2014 - December 1, 2016
Identification of chemical probes with pancreatic β-cell-selective replication promoting activity: The new paradigm in anti-diabetic drug discovery
Ministry of Higher Education, Malaysia
grant June 1, 2013
Structure-based Optimisation of the novel lead compound Tetrahydrothiazolopyridine for the treatment of obesity: Design and synthesis of drug-like compounds; evaluation of their efficacy and toxicity in vivo
Ministry of Higher Education, Malaysia
grant January 1, 2010 - December 1, 2012
Artemisia Species and Insulin Signaling
National Center for Complementary and Alternative Medicine