Works (41)

Updated: April 4th, 2024 18:57

2018 journal article

Long-term complications of glycogen storage disease type Ia in the canine model treated with gene replacement therapy

JOURNAL OF INHERITED METABOLIC DISEASE, 41(6), 965–976.

By: E. Brooks*, D. Landau*, J. Everitt*, T. Brown n, K. Grady*, L. Waskowicz*, C. Bass*, J. D'Angelo* ...

MeSH headings : Animals; Carcinoma, Hepatocellular / etiology; Dependovirus / genetics; Disease Models, Animal; Dogs; Female; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glycogen Storage Disease Type I / complications; Glycogen Storage Disease Type I / therapy; Hypoglycemia / genetics; Hypoglycemia / metabolism; Liver / pathology; Liver Neoplasms / etiology; Male
TL;DR: It is shown that the canine G SD Ia model demonstrates similar long-term complications as GSD Ia patients in spite of gene replacement therapy, and further development of gene therapy is needed to develop a more effective treatment to prevent long- term complications of GSDIa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: February 4, 2019

2012 journal article

Long-Term Efficacy Following Readministration of an Adeno-Associated Virus Vector in Dogs with Glycogen Storage Disease Type Ia

HUMAN GENE THERAPY, 23(4), 407–418.

By: A. Demaster*, X. Luo*, S. Curtis*, K. Williams*, D. Landau*, E. Drake*, D. Kozink n, A. Bird* ...

MeSH headings : Animals; Dependovirus / genetics; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glycogen Storage Disease Type I / genetics; Glycogen Storage Disease Type I / metabolism; Glycogen Storage Disease Type I / therapy; Hypoglycemia / genetics; Hypoglycemia / metabolism; Hypoglycemia / therapy; Liver / metabolism
TL;DR: Preclinical data support the further translation of AAV vector-mediated gene therapy in GSD-Ia and support the demonstrated risk for recurrent hypoglycemia and mortality from waning efficacy of the AAV2/9 vector. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia

GENE THERAPY, 19(4), 443–452.

By: B. Crane n, X. Luo*, A. Demaster*, K. Williams*, D. Kozink n, P. Zhang*, T. Brown n, C. Pinto n ...

author keywords: glycogen storage disease; von Gierke disease; glucose-6-phosphatase; adenovirus vector; renal dysfunction
MeSH headings : Adenoviridae / genetics; Animals; Body Weight; Dog Diseases / therapy; Dogs; Genetic Therapy / adverse effects; Genetic Therapy / methods; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / therapy; Glycogen Storage Disease Type I / veterinary; Hypoglycemia / complications; Hypoglycemia / prevention & control
TL;DR: Administration of a serotype 2 HDAd vector prolonged survival in one GSD-Ia dog to 12 years of age and 36 months of age in the other, but the persistence of long-term complications limited HDAd vectors in the canine model for GSD -Ia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Effect of dietary boron on physiological responses in growing steers inoculated with bovine herpesvirus type-1

RESEARCH IN VETERINARY SCIENCE, 90(1), 78–83.

By: R. Fry n, T. Brown n, K. Lloyd n, S. Hansen n, L. Legleiter n, W. Robarge n, J. Spears n

author keywords: Boron; Cattle; BHV-1; Acute phase proteins; Cytokines; Plasma B
MeSH headings : Acute-Phase Reaction; Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Body Temperature; Boron / pharmacology; Cattle; Cytokines / blood; Diet / veterinary; Dietary Supplements; Dose-Response Relationship, Drug; Eating / drug effects; Herpesvirus 1, Bovine; Infectious Bovine Rhinotracheitis / immunology; Male; Time Factors; Weight Gain / drug effects
TL;DR: Dairy B did not affect the duration and severity of clinical signs of BHV-1 and had minimal effects on plasma acute phase proteins and cytokines and Supplementation of B increased plasma B concentrations in a dose-responsive manner. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Hepatorenal Correction in Murine Glycogen Storage Disease Type I With a Double-stranded Adeno-associated Virus Vector

MOLECULAR THERAPY, 19(11), 1961–1970.

By: X. Luo*, G. Hall*, S. Li*, A. Bird*, P. Lavin*, M. Winn*, A. Kemper*, T. Brown n, D. Koeberl*

MeSH headings : Animals; Dependovirus / genetics; Disease Models, Animal; Female; Gene Expression Regulation; Genetic Therapy; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / genetics; Glycogen Storage Disease Type I / mortality; Glycogen Storage Disease Type I / therapy; Humans; Hypoglycemia / genetics; Hypoglycemia / therapy; Kaplan-Meier Estimate; Kidney / metabolism; Liver / metabolism; Male; Mice; Mice, Knockout
TL;DR: Hepatorenal correction in G6pase (-/-) mice demonstrates the potential of AAV vectors for the correction of inherited diseases of metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Gene Therapy for Inherited Metabolic Disorders in Companion Animals

ILAR JOURNAL, 50(2), 122–127.

By: D. Koeberl, C. Pinto*, T. Brown* & Y. Chen

author keywords: amino acid metabolism; large animal model; gene therapy; glycogen storage disease; inborn errors of metabolism; inherited metabolic disorders; mitochondrial disorder; organic acidemia
MeSH headings : Animals; Cats; Disease Models, Animal; Dogs; Genetic Therapy / methods; Metabolism, Inborn Errors / genetics; Metabolism, Inborn Errors / therapy
Source: Web Of Science
Added: August 6, 2018

2009 journal article

The addition of cottonseed hulls to the starter and supplementation of live yeast or mannanoligosaccharide in the milk for young calves

JOURNAL OF DAIRY SCIENCE, 92(2), 790–798.

author keywords: cottonseed hull; calf; yeast; mannanoligosaccharide
MeSH headings : Animals; Animals, Newborn; Cattle / growth & development; Cattle / physiology; Cottonseed Oil / metabolism; Dietary Supplements; Eating / physiology; Female; Male; Milk / chemistry; Milk / microbiology; Oligosaccharides / metabolism; Random Allocation; Rumen / growth & development; Time Factors; Yeasts / metabolism
TL;DR: Investigation of the effects of the addition of cottonseed hulls (CSH) to the starter and the supplementation of live yeast product (YST) or mannanoligosaccharide product (MOS) to milk, on growth, intake, rumen development, and health parameters in young calves found no significant effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia

MOLECULAR THERAPY, 16(4), 665–672.

By: D. Koeberl*, C. Pinto n, B. Sun*, S. Li*, D. Kozink n, D. Benjamin*, A. Demaster n, M. Kruse n ...

MeSH headings : Animals; Dependovirus / genetics; Disease Models, Animal; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / biosynthesis; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / therapy; Humans; Hypoglycemia / enzymology; Hypoglycemia / therapy; Liver Glycogen / metabolism; Mice; Mice, Knockout
TL;DR: The AAV2/8 vector uniquely prevented hypoglycemia during fasting and fully corrected liver G6Pase deficiency in GSD-Ia mice and dogs, and support the further preclinical development of AAV vector-mediated gene therapy for GSD -Ia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Correction of multiple striated muscles in murine Pompe diseasethrough adeno-associated virus-mediated gene therapy

MOLECULAR THERAPY, 16(8), 1366–1371.

By: B. Sun*, S. Young*, P. Li*, C. Di*, T. Brown n, M. Salva*, S. Li*, A. Bird* ...

MeSH headings : Animals; Creatine Kinase, MM Form / genetics; Creatine Kinase, MM Form / metabolism; Dependovirus / genetics; Enhancer Elements, Genetic / genetics; Female; Genetic Therapy / methods; Genetic Vectors / genetics; Glycogen / metabolism; Glycogen Storage Disease Type II / genetics; Glycogen Storage Disease Type II / therapy; Hindlimb / metabolism; Hindlimb / pathology; Mice; Mice, Knockout; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Muscle, Striated / enzymology; Muscle, Striated / metabolism; Muscle, Striated / pathology; Myocardium / metabolism; Myosin Heavy Chains / genetics; Promoter Regions, Genetic / genetics; Quadriceps Muscle / metabolism; Quadriceps Muscle / pathology; Transduction, Genetic; alpha-Glucosidases / genetics; alpha-Glucosidases / metabolism
TL;DR: AAV8 and AAV9-pseudotyped vectors containing the MHCK7 regulatory cassette achieved enhanced efficacy in Pompe disease mice, thereby correcting a myofiber type that is unresponsive to enzyme replacement therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Intramedullary cavernous malformation of the spinal cord in two dogs

VETERINARY PATHOLOGY, 44(4), 528–532.

By: E. Mackillop n, N. Olby n, K. Linder n & T. Brown n

author keywords: cavernous hemangioma; hemorrhage; spinal cord; vascular malformation
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Female; Male; Spinal Cord / abnormalities; Spinal Cord / blood supply; Spinal Cord / pathology
TL;DR: CVMs appear to be an uncommon cause of both acute and chronic spinal cord disease in the dog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia

GENE THERAPY, 13(17), 1281–1289.

By: D. Koeberl*, B. Sun*, T. Damodaran*, T. Brown n, D. Millington*, D. Benjamin*, A. Bird*, A. Schneider* ...

author keywords: adeno-associated virus; glycogen storage disease; growth failure; metabolism; hypoglycemia; glucose-6-phosphatase
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Dependovirus / genetics; Genetic Therapy / methods; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Genetic Vectors / immunology; Glucose-6-Phosphatase / analysis; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glyceraldehyde-3-Phosphate Dehydrogenases / genetics; Glycogen / analysis; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / immunology; Glycogen Storage Disease Type I / therapy; Immunohistochemistry; Injections, Intravenous; Kidney / chemistry; Kidney / enzymology; Kidney / immunology; Liver / chemistry; Liver / enzymology; Liver / immunology; Mice; Mice, Knockout; Models, Animal; RNA, Messenger / analysis; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transduction, Genetic / methods
TL;DR: The development of efficacious AAV vector-mediated gene therapy could significantly reduce the impact of long-term complications in GSD-Ia, including hypoglycemia, hyperlipidemia and growth failure. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II

MOLECULAR THERAPY, 14(6), 822–830.

By: B. Sun*, H. Zhang*, D. Benjamin*, T. Brown n, A. Bird*, S. Young*, A. McVie-Wylie, Y. Chen*, D. Koeberl*

author keywords: Pompe disease; gene therapy; adeno-associated virus vector; signal peptide; acid alpha-glucosidase; glycogen storage disease
MeSH headings : Animals; Blotting, Western; Cell Line; Cells, Cultured; Dependovirus / genetics; Fibroblasts / metabolism; Genetic Therapy / methods; Genetic Vectors / genetics; Glucan 1,4-alpha-Glucosidase / genetics; Glucan 1,4-alpha-Glucosidase / metabolism; Glycogen / metabolism; Glycogen Storage Disease Type II / genetics; Glycogen Storage Disease Type II / pathology; Glycogen Storage Disease Type II / therapy; Humans; Mice; Mice, Knockout; Protein Sorting Signals / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Transfection; Treatment Outcome
TL;DR: Chimeric, highly secreted GAA enhanced the efficacy of AAV vector-mediated gene therapy in GSD-II mice. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter

MOLECULAR THERAPY, 11(6), 889–898.

By: B. Sun*, H. Zhang*, L. Franco*, T. Brown n, A. Bird*, A. Schneider*, D. Koeberl*

author keywords: glycogen storage disease type II; gene therapy; adeno-associated virus; acid alpha-glucosidase; Pompe disease
MeSH headings : Animals; Antibodies / blood; Antibody Formation; Creatine Kinase / genetics; Creatine Kinase, MM Form; DNA, Viral / analysis; Dependovirus / genetics; Enhancer Elements, Genetic / genetics; Gene Transfer Techniques; Genetic Therapy / methods; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Glycogen / analysis; Glycogen Storage Disease Type II / genetics; Glycogen Storage Disease Type II / therapy; Humans; Injections, Intramuscular; Isoenzymes / genetics; Mice; Mice, Knockout; Muscle, Skeletal / chemistry; Muscle, Skeletal / enzymology; Myocardium / chemistry; Myocardium / enzymology; Promoter Regions, Genetic / genetics; alpha-Glucosidases / analysis; alpha-Glucosidases / genetics; alpha-Glucosidases / immunology
TL;DR: Persistent correction of muscle glycogen content was achieved with an AAV vector containing a muscle-specific promoter in GAA-KO mice, and this approach should be considered for muscle-targeted gene therapy in Pompe disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II

MOLECULAR THERAPY, 12(5), 876–884.

By: L. Franco*, B. Sun*, X. Yang*, A. Bird*, H. Zhang*, A. Schneider*, T. Brown n, S. Young* ...

MeSH headings : Animals; Antibody Formation; Creatine Kinase; Creatine Kinase, MM Form / metabolism; DNA, Viral; Dependovirus / genetics; Enhancer Elements, Genetic; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Glycogen / metabolism; Glycogen Storage Disease Type II / immunology; Glycogen Storage Disease Type II / metabolism; Glycogen Storage Disease Type II / therapy; Humans; Liver / metabolism; Mice; Mice, Knockout; Muscle, Skeletal / metabolism; Plasmids / genetics; Promoter Regions, Genetic; alpha-Glucosidases / biosynthesis; alpha-Glucosidases / immunology
TL;DR: Liver-restricted GAA expression with an AAV vector evaded immunity and enhanced efficacy in GSD-II mice and provoked cellular immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 review

Feline systemic reactive angioendotheliomatosis: Eight cases and literature review

[Review of ]. VETERINARY PATHOLOGY, 42(5), 608–617.

By: R. Fuji*, K. Patton*, T. Steinbach*, F. Schulman*, G. Bradley*, T. Brown n, E. Wilson, B. Summers*

author keywords: blood vessels; electron microscopy; endothelial cells; feline diseases; heart; immunohistochemistry
MeSH headings : Animals; Cat Diseases / pathology; Cats; Coronary Vessels / pathology; Endothelial Cells / pathology; Female; Kidney / blood supply; Kidney / pathology; Male; Spinal Cord / blood supply; Spinal Cord / pathology; Vascular Diseases / pathology; Vascular Diseases / veterinary
TL;DR: A rare, multisystemic intravascular proliferative disorder was identified postmortem in eight cats, and the name “feline systemic reactive angioendotheliomatosis” is proposed for this unique, idiopathic disorder of domestic cats. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Isolation of necrotoxigenic Escherichia coli from a dog with hemorrhagic pneumonia

Journal of the American Veterinary Medical Association, 226(12), 2016–2019.

By: E. Breitschwerdt n, C. DebRoy, A. Mexas n, T. Brown n & A. Remick n

MeSH headings : Animals; Bacterial Typing Techniques / veterinary; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dogs; Escherichia coli / isolation & purification; Escherichia coli / pathogenicity; Escherichia coli Infections / diagnosis; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; Fatal Outcome; Hemorrhage / diagnosis; Hemorrhage / microbiology; Hemorrhage / veterinary; Lung / microbiology; Lung / pathology; Male; Pneumonia, Bacterial / diagnosis; Pneumonia, Bacterial / microbiology; Pneumonia, Bacterial / veterinary; Virulence
TL;DR: A 7-month-old sexually intact male Cocker Spaniel was admitted to the North Carolina State University Veterinary Teaching Hospital for evaluation of lethargy, panting, and excessive salivation that had become progressively severe during a 5-hour period, and death was attributed to acute, severe, necrotizing pneumonia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2005 journal article

Technical note: Technique for dissection and analysis of the rumen in young calves

JOURNAL OF DAIRY SCIENCE, 88(1), 324–326.

By: . Hill n, B. Hopkins n, S. Davidson n, S. Bolt n, D. Diaz n, C. Brownie n, T. Brown n, G. Huntington n, L. Whitlow n

author keywords: calf; rumen; development; papilla
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Cattle / anatomy & histology; Diet; Dissection / methods; Dissection / veterinary; Microscopy, Electron, Scanning; Rumen / anatomy & histology; Rumen / growth & development; Software
TL;DR: A technique used to evaluate rumen development in young calves, including removal, dissection, and analysis of tissue is discussed, which allowed for examination of the different sacs of the rumen using scanning electron microscopy to measure papillae denseness and histology slides to measure Papillae length and width. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Cerebellar cortical degeneration in adult American Staffordshire Terriers

JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(2), 201–208.

By: N. Olby n, S. Blot*, J. Thibaud*, J. Phillips n, . DP O'Brien, J. Burr n, J. Berg, T. Brown n, M. Breen n

author keywords: cerebellar abiotrophy; dog; hereditary ataxia; Purkinje neuron
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Ultrasonographic appearance of Dandy Walker-like Syndrome in a Boston terrier

Veterinary Radiology & Ultrasound, 45(4), 336–339.

By: C. Noureddine, R. Harder, N. Olby, K. Spaulding & T. Brown

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2002 journal article

Delivery of glucose-6-phosphatase in a canine model for glycogen storage disease, type Ia, with adeno-associated virus (AAV) vectors

GENE THERAPY, 9(15), 1015–1022.

By: R. Beaty*, M. Jackson n, D. Peterson*, A. Bird*, T. Brown n, D. Benjamin*, T. Juopperi n, P. Kishnani* ...

author keywords: gene therapy; adeno-associated virus vectors; glycogen storage disease; disorders of metabolism; genetic disease; animal model
MeSH headings : Animals; Blood Glucose / metabolism; Cholesterol / blood; Dependovirus / genetics; Dogs; Genetic Therapy / methods; Genetic Vectors / administration & dosage; Glucose-6-Phosphatase / genetics; Glycogen / metabolism; Glycogen Storage Disease Type I / metabolism; Glycogen Storage Disease Type I / pathology; Glycogen Storage Disease Type I / therapy; Lactic Acid / blood; Liver / metabolism; Liver / pathology; Models, Animal; Time Factors; Transduction, Genetic / methods; Triglycerides / blood
TL;DR: AAV vector administration in the canine model for GSD Ia resulted in sustained G6Pase expression and improvement in liver histology and in biochemical parameters, consistent with variation in the efficiency of transduction within the liver. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus

VIROLOGY, 302(2), 363–372.

By: W. Feng n, M. Tompkins n, J. Xu n, T. Brown n, S. Laster n, H. Zhang*, M. McCaw n

author keywords: PRRSV; thymus; thymocyte; T lymphocyte
MeSH headings : Animals; Animals, Newborn; Female; Infectious Disease Transmission, Vertical; Leukocytes, Mononuclear / immunology; Lymphocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / immunology; Pregnancy; Pregnancy, Animal; Swine; Swine Diseases / immunology; Swine Diseases / virology; T-Lymphocyte Subsets / immunology; Thymus Gland / cytology; Thymus Gland / immunology; Uterus / virology
TL;DR: It is shown that the number of thymocytes undergoing apoptosis was increased twofold in piglets infected with PRRSV and this results help explain the dramatic immunosuppression observed in neonatal animals infected in utero withPRRSV. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Canine model and genomic structural organization of glycogen storage disease type Ia (GSD Ia)

VETERINARY PATHOLOGY, 38(1), 83–91.

By: P. Kishnani*, E. Faulkner*, S. VanCamp n, M. Jackson n, T. Brown n, A. Boney*, D. Koeberl*, Y. Chen*

author keywords: animal model; canine; genomic structure; glomerular sclerosis; glycogen; GSD Ia; hepatomegaly; hypoglycemia; lactic acidosis
MeSH headings : Animals; Base Sequence; Crosses, Genetic; DNA / chemistry; DNA / isolation & purification; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / enzymology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Electrophoresis, Agar Gel / veterinary; Female; Glucose-6-Phosphatase / blood; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / genetics; Glycogen Storage Disease Type I / pathology; Glycogen Storage Disease Type I / veterinary; Histocytochemistry / veterinary; Humans; Kidney / enzymology; Kidney / pathology; Liver / enzymology; Liver / pathology; Liver Glycogen / metabolism; Male; Microscopy, Electron / veterinary; Molecular Sequence Data; Point Mutation / genetics; Sequence Analysis, DNA
TL;DR: Establishment of this canine colony of GSD Ia that closely resembles human disease and isolation of the canine genomic gene provides an excellent model for studying pathophysiology and long-term complications and an opportunity to develop novel therapeutic approaches such as drug and gene therapy. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 article

Immunopathology of Bartonella vinsonii (berkhoffii) in experimentally infected dogs

Pappalardo, B. L., Brown, T. T., Tompkins, M., & Breitschwerdt, E. B. (2001, December). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 83, pp. 125–147.

By: B. Pappalardo n, T. Brown n, M. Tompkins n & E. Breitschwerdt n

author keywords: dog; Bartonella; immunosuppression
MeSH headings : Animals; Antigen Presentation / immunology; Apoptosis / immunology; Bartonella / genetics; Bartonella / growth & development; Bartonella Infections / immunology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; CD4-CD8 Ratio; Cytokines / biosynthesis; Cytokines / blood; DNA, Bacterial / chemistry; DNA, Bacterial / isolation & purification; Dog Diseases / immunology; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Flow Cytometry / veterinary; Histocytochemistry; Lymph Nodes / immunology; Lymph Nodes / pathology; Lymphocytes / immunology; Phagocytosis / immunology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; T-Lymphocyte Subsets / immunology
TL;DR: Results from this study indicate that B. vinsonii establishes chronic infection in dogs which may result in immune suppression characterized by defects in monocytic phagocytosis, an impaired subset of CD8+ T lymphocytes, and impaired antigen presentation within LN. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II

JOURNAL OF VIROLOGY, 75(10), 4889–4895.

MeSH headings : Animals; Cell Differentiation; Disease Susceptibility / immunology; Female; Infectious Disease Transmission, Vertical; Leukocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / physiopathology; Porcine Reproductive and Respiratory Syndrome / transmission; Porcine respiratory and reproductive syndrome virus / immunology; Porcine respiratory and reproductive syndrome virus / isolation & purification; Pregnancy; Pregnancy, Animal; Streptococcal Infections / complications; Streptococcal Infections / immunology; Streptococcal Infections / microbiology; Streptococcal Infections / pathology; Streptococcus suis / immunology; Streptococcus suis / isolation & purification; Streptococcus suis / physiology; Swine; Uterus / virology
TL;DR: In utero infection by PRRSV makes piglets more susceptible to infection and disease following challenge by S. suis type II, and this model may provide a useful model to study the interaction betweenPRRSV and bacterial coinfections in piglets. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Pyometra and uterine adenocarcinoma in a melengestrol acetate- implanted captive coati (Nasua nasua)

Journal of Zoo and Wildlife Medicine, 32(2), 245–251.

By: E. Chittick n, D. Rotstein*, T. Brown* & B. Wolfe

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2000 article

Cyclic CD8+lymphopenia in dogs experimentally infected with Bartonella vinsonii subsp berkhoffii

Pappalardo, B. L., Brown, T., Gebhardt, D., Sontakke, S., & Breitschwerdt, E. B. (2000, June 30). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 75, pp. 43–57.

By: B. Pappalardo n, T. Brown n, D. Gebhardt n, S. Sontakke n & E. Breitschwerdt n

author keywords: mAb, monoclonal antibody; FBS, fetal bovine serum; PID, post-inoculation day; PBL, peripheral blood lymphocytes; LN, lymph node
MeSH headings : Animals; Bartonella Infections / complications; Bartonella Infections / veterinary; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cell Separation / veterinary; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / microbiology; Dogs; Flow Cytometry / veterinary; Leukocyte Count / veterinary; Lymphopenia / etiology; Lymphopenia / microbiology; Lymphopenia / veterinary; Polymerase Chain Reaction / veterinary
TL;DR: Evidence supporting a potentially important association between B. vinsonii and Ehrlichia canis co-infection in dogs is found based on a seroepidemiologic survey of dogs from North Carolina and Virginia presenting for a variety of medical problems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Effect of dietary copper level on performance and copper status of growing meat goats

Sheep & Goat Research Journal, 16(2000), 65–71.

By: J. Luginbuhl, M. Poore, J. Spears & T. Brown

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection

Henry, S. C., Schmader, K., Brown, T. T., Miller, S. E., Howell, D. N., Daley, G. G., & Hamilton, J. D. (2000, September). JOURNAL OF VIROLOGICAL METHODS, Vol. 89, pp. 61–73.

By: S. Henry, K. Schmader*, T. Brown n, S. Miller*, D. Howell*, G. Daley, J. Hamilton*

author keywords: recombinant cytomegalovirus; green fluorescent protein; cytomegalovirus infection
MeSH headings : Acute Disease; Animals; Biomarkers; Blotting, Northern; Blotting, Southern; Cells, Cultured; DNA, Recombinant / analysis; DNA, Viral / analysis; Female; Fluorescein-5-isothiocyanate; Green Fluorescent Proteins; Herpesviridae Infections / virology; Immunohistochemistry; Luminescent Proteins / immunology; Luminescent Proteins / isolation & purification; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Microscopy, Fluorescence; Muromegalovirus / genetics; Muromegalovirus / growth & development; Muromegalovirus / ultrastructure; Promoter Regions, Genetic; Virus Activation; Virus Latency
TL;DR: The observations presented in this study demonstrate the usefulness of EGFP-expressing recombinants as tools for direct tracking of mCMV activity in vivo and in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Granulomatous disease associated with Bartonella infection in 2 dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 14, pp. 37–42.

By: B. Pappalardo n, T. Brown*, J. Gookin n, C. Morrill n & E. Breitschwerdt n

author keywords: canine; infectious; lymphadenopathy; pathology
TL;DR: This is the 1st report of granulomatous disease in dogs associated with Bartonella infection, and an 11-year-old mixed-breed dog was referred for evaluation of a 6-week history of serous nasal discharge. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Bartonella vinsonii subsp berkhoffi and related members of the alpha subdivision of the Proteobacteria in dogs with cardiac arrhythmias, endocarditis, or myocarditis

Journal of Clinical Microbiology, 37(11), 3618–3626.

By: E. Breitschwerdt, C. Atkins, T. Brown, D. Kordick & P. Snyder

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Clinical and pathologic evaluation of chronic Bartonella henselae or Bartonella clarridgeiae infection in cats

Journal of Clinical Microbiology, 37(5), 1536–1547.

By: D. Kordick, T. Brown, K. Shin & E. Breitschwerdt

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Dental wear and growth performance in steers fed sweetpotato cannery waste

Journal of the American Veterinary Medical Association, 214(5), 681–687.

By: G. Rogers, M. Poore, B. Ferko, T. Brown, T. Deaton & J. Bawden

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Effect of breed (Angus Vs Simmental) on immune function and response to a disease challenge in stressed steers and preweaned calves

Journal of Animal Science, 77(3), 516–521.

By: T. Engle n, J. Spears n, T. Brown n & K. Lloyd n

MeSH headings : Animals; Body Temperature; Breeding; Cattle / classification; Cattle / immunology; Eating; Erythrocytes / immunology; Female; Immunity, Innate; Immunoglobulins / biosynthesis; Male; Phytohemagglutinins / immunology; Stress, Physiological / immunology; Swine; Weight Gain
TL;DR: Results indicate that the immune response of Angus and Simmental calves may differ and breed did affect cell-mediated immune response to phytohemagglutinin (PHA). (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Species, interindividual, and tissue specificity in endocrine signaling

Environmental Health Perspectives, 107(1999 Aug.), 619–624.

By: C. Walker*, S. Ahmed*, T. Brown*, S. Ho*, L. Hodges*, G. Lucier*, J. Russo*, N. Weigel*, T. Weise*, J. Vandenbergh*

MeSH headings : Age Factors; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endocrine System / drug effects; Endocrine System / physiology; Environmental Pollutants / adverse effects; Humans; Menopause; Models, Theoretical; Receptors, Estrogen / drug effects; Receptors, Estrogen / physiology; Signal Transduction; Species Specificity; Transcription, Genetic; Xenobiotics / adverse effects
TL;DR: The use of animal model systems and development of appropriate mathematical models has the potential to yield additional valuable information for elucidating the role of these determinants of specificity at low-dose exposures and for improved risk assessments for the adverse health effects of endocrine-active compounds. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Cytologic and histologic features of a poorly differentiated glioma in a dog

VETERINARY CLINICAL PATHOLOGY, 26(4), 182–186.

By: F. Fernandez n, C. Grindem n, T. Brown n, N. Sharp n & M. Saulnier n

author keywords: cytology; immunocytochemistry; glioma; spinal cord; ependymoma; dog
TL;DR: A 5-year old female Boxer with a 1-week history of progressive paresis and paraplegia had a T10-13 subarachnoid filling defect on myelography, which was subsequently diagnosed as a poorly differentiated glioma, most likely an anaplastic ependymoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Effect of shipping and chromium supplementation on performance, immune response, and disease resistance of steers

Journal of Animal Science, 75(7), 1956–1964.

By: E. Kegley n, J. Spears n & T. Brown n

MeSH headings : Animals; Antibodies, Viral / biosynthesis; Antibodies, Viral / immunology; Blood Glucose / analysis; Body Temperature / physiology; Cattle / blood; Cattle / growth & development; Cattle / immunology; Chromium / administration & dosage; Chromium / pharmacology; Food Deprivation / physiology; Food, Fortified; Herpesvirus 1, Bovine / immunology; Hydrocortisone / blood; Immunity, Innate; Immunoglobulin G / blood; Immunoglobulin M / blood; Infectious Bovine Rhinotracheitis / immunology; Infectious Bovine Rhinotracheitis / prevention & control; Male; Random Allocation; Transportation; Water Deprivation / physiology
Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Effects of copper deficiency and copper deficiency coupled with high dietary iron or molybdenum on phagocytic cell function and response of calves to a respiratory disease challenge

Journal of Animal Science, 75(4), 1112–1118.

By: G. Gengelbach n, J. Ward n, J. Spears n & T. Brown n

MeSH headings : Aging / metabolism; Aging / physiology; Animals; Body Temperature / drug effects; Body Temperature / physiology; Cattle / blood; Cattle / metabolism; Cattle / physiology; Cattle Diseases / metabolism; Cattle Diseases / physiopathology; Ceruloplasmin / analysis; Ceruloplasmin / metabolism; Copper / blood; Copper / deficiency; Copper / pharmacology; Diet / veterinary; Eating / drug effects; Eating / physiology; Female; Herpesvirus 1, Bovine / physiology; Infectious Bovine Rhinotracheitis / metabolism; Infectious Bovine Rhinotracheitis / physiopathology; Iron, Dietary / pharmacology; Leukocyte Count / drug effects; Macrophages / drug effects; Macrophages / physiology; Mannheimia haemolytica / physiology; Molybdenum / pharmacology; Neutrophils / drug effects; Neutrophils / physiology; Pasteurella Infections / metabolism; Pasteurella Infections / physiopathology; Pasteurella Infections / veterinary; Phagocytes / drug effects; Phagocytes / physiology; Phagocytosis / drug effects; Phagocytosis / physiology; Pregnancy; Superoxide Dismutase / analysis; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
TL;DR: The data indicate that dietary levels of Mo and Cu can affect body temperature and feed intake responses to disease by affecting TNF and perhaps other cytokines. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Exocrine pancreatic insufficiency in a yellow-naped Amazon (Amazona ochrocephala) with pancreatic adenocarcinoma

VETERINARY PATHOLOGY, 34(1), 55–57.

By: J. Ritchey n, L. Degernes* & T. Brown*

author keywords: adenocarcinoma; pancreas; yellow-naped Amazon (Amazona ochrocephala)
MeSH headings : Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Animals; Bird Diseases / pathology; Exocrine Pancreatic Insufficiency / pathology; Exocrine Pancreatic Insufficiency / veterinary; Male; Pancreatic Neoplasms / pathology; Pancreatic Neoplasms / veterinary; Parrots
TL;DR: This report describes exocrine pancreatic insufficiency in a yellow-naped Amazon with complete effacement of the pancreas by a pancreatic adenocarcinoma with a poor prognosis, which was euthanatized. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1995 journal article

Detection of pseudorabies viral DNA in tonsillar epithelial cells of latently infected pigs

American Journal of Veterinary Research, 56(5), 587.

By: T. Brown, K. Shin & F. Fuller

Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

Effect of bovine herpesvirus-1 or parainfluenza-3 virus on immune receptor-mediated functions of bovine alveolar macrophages in the presence or absence of virus-specific serum or pulmonary lavage fluids collected after virus infection

American Journal of Veterinary Research, 51(10), 1616.

By: T. Brown & K. Shin

Source: NC State University Libraries
Added: August 6, 2018

1985 journal article

DOSE-RESPONSE STUDIES OF GENTAMICIN-NEPHROTOXICITY IN RATS WITH EXPERIMENTAL RENAL DYSFUNCTION .1. SUBTOTAL SURGICAL NEPHRECTOMY

TOXICOLOGY AND APPLIED PHARMACOLOGY, 80(2), 251–263.

By: M. Carver n, J. Shymodjeska n, T. Brown n, R. Rogers n & J. Riviere n

MeSH headings : Absorption; Analysis of Variance; Animals; Gentamicins / metabolism; Gentamicins / toxicity; Gentamicins / urine; Glomerular Filtration Rate / drug effects; Injections, Subcutaneous; Kidney / metabolism; Kidney / physiology; Kidney Diseases / chemically induced; Kidney Diseases / pathology; Kinetics; Male; Nephrectomy; Rats; Rats, Inbred Strains
TL;DR: The relatively lower nephrotoxicity in the FD regimen in rats agrees with results previously reported in dogs, thus indicating that the method of dose reduction in patients with compromised renal function may be a significant factor in lowering neph rotoxic potential. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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