Works (3)
Updated: July 5th, 2023 15:40
2016 journal article
Secondary metabolites from fungal endophytes of Echinacea purpurea suppress cytokine secretion by macrophage-type cells
Natural Product Communications, 11(8), 1143–1146.
TL;DR:
The results of this study are particularly interesting given that they show the presence of compounds with cytokine-suppressive activity in endophytes from a botanical used to treat inflammation.
(via Semantic Scholar)
open access via journals.sagepub.com (publisher PDF)
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria
PLOS ONE, 10(5).
MeSH headings : Amides / pharmacology; Animals; Bacteria / chemistry; Cell Death / drug effects; Chemical Fractionation; Chemokines / metabolism; Cytokines / metabolism; Echinacea / chemistry; Echinacea / growth & development; Endophytes / chemistry; Ethanol / chemistry; Mice; Plant Extracts / pharmacology; Pyrans / chemistry; Pyrans / pharmacology; RAW 264.7 Cells; Seeds / drug effects; Structure-Activity Relationship; Tumor Necrosis Factor-alpha / biosynthesis; Xanthines / chemistry; Xanthines / pharmacology
TL;DR:
It is shown that ethanolic extracts prepared from E. purpurea plants grown under sterile conditions and from sterilized seeds, do not contain LPS and do not stimulate Macrophage production of TNF-α, supporting the hypothesis that the macrophage-stimulating activity in E. Purpurea extracts can originate from endophytic bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Synthesis and biological evaluation of a series of fatty acid amides from Echinacea
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(16), 3091–3094.
author keywords: Echinacea; Alkylamide; TNF-alpha; Anti-inflammatory; Cytokine
MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Animals; Cell Line; Echinacea / chemistry; Echinacea / metabolism; Fatty Acids / chemistry; Lipopolysaccharides / toxicity; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Extracts / chemistry; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The SAR of simple alkylamides found in Echinacea extracts with respect to their ability to decrease the production of the pro-inflammatory mediator TNF-α is explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018