Works (3)

Updated: July 5th, 2023 15:40

2016 journal article

Secondary metabolites from fungal endophytes of Echinacea purpurea suppress cytokine secretion by macrophage-type cells

Natural Product Communications, 11(8), 1143–1146.

By: A. Kaur*, M. Oberhofer*, M. Juzumaite n, H. Raja*, T. Gulledge n, D. Kao*, S. Faeth*, S. Laster n, N. Oberlies*, N. Cech*

TL;DR: The results of this study are particularly interesting given that they show the presence of compounds with cytokine-suppressive activity in endophytes from a botanical used to treat inflammation. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria

PLOS ONE, 10(5).

By: D. Todd*, T. Gulledge n, E. Britton*, M. Oberhofer*, M. Leyte-Lugo*, A. Moody*, T. Shymanovich*, L. Grubbs* ...

MeSH headings : Amides / pharmacology; Animals; Bacteria / chemistry; Cell Death / drug effects; Chemical Fractionation; Chemokines / metabolism; Cytokines / metabolism; Echinacea / chemistry; Echinacea / growth & development; Endophytes / chemistry; Ethanol / chemistry; Mice; Plant Extracts / pharmacology; Pyrans / chemistry; Pyrans / pharmacology; RAW 264.7 Cells; Seeds / drug effects; Structure-Activity Relationship; Tumor Necrosis Factor-alpha / biosynthesis; Xanthines / chemistry; Xanthines / pharmacology
TL;DR: It is shown that ethanolic extracts prepared from E. purpurea plants grown under sterile conditions and from sterilized seeds, do not contain LPS and do not stimulate Macrophage production of TNF-α, supporting the hypothesis that the macrophage-stimulating activity in E. Purpurea extracts can originate from endophytic bacteria. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Synthesis and biological evaluation of a series of fatty acid amides from Echinacea


By: Y. Moazami n, T. Gulledge n, S. Laster n & J. Pierce n

author keywords: Echinacea; Alkylamide; TNF-alpha; Anti-inflammatory; Cytokine
MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Animals; Cell Line; Echinacea / chemistry; Echinacea / metabolism; Fatty Acids / chemistry; Lipopolysaccharides / toxicity; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Extracts / chemistry; Tumor Necrosis Factor-alpha / metabolism
TL;DR: The SAR of simple alkylamides found in Echinacea extracts with respect to their ability to decrease the production of the pro-inflammatory mediator TNF-α is explored. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.