Thomas Jackson

Works (7)

Updated: April 27th, 2024 05:00

2024 article

Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes

Starnes, H. M., Jackson, T. W., Rock, K. D., & Belcher, S. M. (2024, March 20). Toxicological Sciences, Vol. 3.

By: H. Starnes n, T. Jackson n, K. Rock n & S. Belcher n 

author keywords: binding affinity; differential scanning fluorimetry; in vitro; PFAS; species extrapolation
MeSH headings : Animals; Cattle; Humans; Rats; Fluorocarbons / chemistry; Fluorocarbons / toxicity; Fluorocarbons / metabolism; Protein Binding; Serum Albumin / metabolism; Serum Albumin / chemistry; Serum Albumin, Human / metabolism; Serum Albumin, Human / chemistry; Species Specificity; Swine
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Methemoglobinemia and Tumor Lysis Syndrome; Microbial metabolism and enzyme function
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 22, 2024

2022 article

Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina

Guillette, T. C., Jackson, T. W., Guillette, M., McCord, J., & Belcher, S. M. (2022, October 20). Frontiers in Toxicology, Vol. 4.

By: T. Guillette n, T. Jackson n, M. Guillette n, J. McCord* & S. Belcher n 

author keywords: autoantibodies; autoimmune; crocodilian; immune toxicity; lupus; one health; PFAS
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Chemical Analysis and Environmental Impact; Toxic Organic Pollutants Impact
TL;DR: The association of increased PFAS exposure with disrupted immune functions is interpreted to suggest that PFAS broadly alters immune activities resulting in autoimmune-like pathology in American alligators. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 6, 2023

2022 article

Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis

Jackson, T. W., Baars, O., & Belcher, S. M. (2022, February 24). Toxicological Sciences, Vol. 2.

By: T. Jackson n, O. Baars n  & S. Belcher n 

author keywords: gestation; epigenetic; essential metals; metallothionein; placenta
MeSH headings : Animals; Cadmium / toxicity; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Female; Homeostasis; Iron / metabolism; Liver / metabolism; Male; Manganese / metabolism; Manganese / toxicity; Metallothionein / genetics; Metallothionein / metabolism; Mice; Placenta / metabolism; Pregnancy; Zinc / toxicity
topics (OpenAlex): Heavy Metal Exposure and Toxicity; Trace Elements in Health; Mercury impact and mitigation studies
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 26, 2022

2021 article

Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry

Jackson, T. W., Scheibly, C. M., Polera, M. E., & Belcher, S. M. (2021, September 8). Environmental Science & Technology, Vol. 9.

By: T. Jackson n, C. Scheibly n, M. Polera n & S. Belcher n 

author keywords: alcohols; carboxylic acids; fluorocarbons; perfluorocarbons; protein; sulfonic acids; telomer; thermal stability; toxicokinetic
MeSH headings : Alkanesulfonic Acids; Carboxylic Acids; Fluorocarbons; Fluorometry; Humans; Serum Albumin, Human; Sulfonic Acids
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Effects and risks of endocrine disrupting chemicals
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 9, 2021

2020 article

Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring

Jackson, T. W., Ryherd, G. L., Scheibly, C. M., Sasser, A. L., Guillette, T. C., & Belcher, S. M. (2020, October 14). Toxicological Sciences, Vol. 178, pp. 264–280.

By: T. Jackson n, G. Ryherd n, C. Scheibly n, A. Sasser n , T. Guillette  n & S. Belcher n 

Contributors: T. Jackson n, G. Ryherd n, C. Scheibly n, A. Sasser n , T. Guillette  n & S. Belcher n 

author keywords: cadmium; diabetes mellitus type 2; endocrine disruption; insulin resistance; metabolic; nonalcoholic fatty liver disease; retinoic acid
MeSH headings : Animals; Cadmium / toxicity; Cadmium Chloride / toxicity; Diabetes Mellitus, Type 2 / chemically induced; Female; Insulin Resistance; Liver / physiopathology; Male; Metabolic Syndrome / chemically induced; Mice; Obesity / chemically induced; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Heavy Metal Exposure and Toxicity; Birth, Development, and Health
TL;DR: The observed steatosis and metabolic syndrome-like phenotypes resulting from exposure to 500 ppb CdCl2 during the pre- and perinatal period of development equivalent to human gestation indicate that Cd acts developmentally as a sex-specific delayed obesogen. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2021

2020 article

Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice

Jackson, T. W., Bendfeldt, G. A., Beam, K. A., Rock, K. D., & Belcher, S. M. (2020, February 27). Neurotoxicology and Teratology, Vol. 78.

By: T. Jackson n, G. Bendfeldt  n, K. Beam n, K. Rock n & S. Belcher n 

Contributors: T. Jackson n, G. Bendfeldt  n, K. Beam n, K. Rock n & S. Belcher n 

author keywords: Cerebellum; Cortex; Holoprosencephaly; Hyperactivity; Medial prefrontal cortex; Medulloblastoma; Sex differences
MeSH headings : Animals; Cerebellum / anatomy & histology; Cerebellum / physiology; Cerebral Cortex / anatomy & histology; Cerebral Cortex / physiology; Female; Heterozygote; Hippocampus / anatomy & histology; Hippocampus / physiology; Mice, Knockout; Mutation; Patched-1 Receptor / genetics; Patched-1 Receptor / physiology; Sex Characteristics; Signal Transduction; Social Behavior
topics (OpenAlex): Hedgehog Signaling Pathway Studies; Congenital Ear and Nasal Anomalies; Epigenetics and DNA Methylation
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2020

2018 article

Duality of estrogen receptor β action in cancer progression

Guillette, T. C., Jackson, T. W., & Belcher, S. M. (2018, May 14). Current Opinion in Pharmacology, Vol. 41, pp. 66–73.

By: T. Guillette n, T. Jackson n & S. Belcher n 

Contributors: T. Guillette n, T. Jackson n & S. Belcher n 

MeSH headings : Animals; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cerebellar Neoplasms / metabolism; Cerebellar Neoplasms / pathology; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / metabolism; Female; Humans; Male; Medulloblastoma / metabolism; Medulloblastoma / pathology; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology
topics (OpenAlex): Estrogen and related hormone effects; Retinoids in leukemia and cellular processes; Cytokine Signaling Pathways and Interactions
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018

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