Virginia A. Burns

Works (2)

Updated: August 2nd, 2023 21:16

2007 article

Targeting RNA with cysteine-constrained peptides

Burns, V. A., Bobay, B. G., Basso, A., Cavanagh, J., & Melander, C. (2007, December 5). Bioorganic & Medicinal Chemistry Letters.

By: V. Burns n, B. Bobay n, A. Basso n, J. Cavanagh n & C. Melander n

author keywords: RNA; cyclic peptides; HADDOCK
MeSH headings : Base Sequence; Cysteine / chemistry; Humans; Models, Molecular; Peptides, Cyclic / chemistry; RNA / chemistry
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA Interference and Gene Delivery; RNA modifications and cancer
TL;DR: This approach has successfully identified novel cyclic peptide constructs that can target bTAR RNA and RNA/peptide interactions were effectively modeled using the HADDOCK docking program. (via Semantic Scholar)
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Added: August 6, 2018

2006 article

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V. A., Feldheim, D. L., & Melander, C. (2006, July 26). Bioorganic & Medicinal Chemistry Letters.

By: W. Zeng n, T. Ballard n, A. Tkachenko n, V. Burns n, D. Feldheim n & C. Melander n

author keywords: kinamycins; lomaiviticins; DNA cleavage; diazofluorenes; antiproliferative activity
MeSH headings : Animals; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Carbazoles / pharmacology; Cell Proliferation / drug effects; DNA Damage / drug effects; Fluorenes / chemical synthesis; Fluorenes / pharmacology; HeLa Cells; Humans; Molecular Mimicry; Structure-Activity Relationship
topics (OpenAlex): Organic Chemistry Cycloaddition Reactions; Click Chemistry and Applications; Fluorine in Organic Chemistry
TL;DR: Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions, key to anticancer activity. (via Semantic Scholar)
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Added: August 6, 2018

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