Works (2)

Updated: August 2nd, 2023 21:16

2008 journal article

Targeting RNA with cysteine-constrained peptides


By: V. Burns n, B. Bobay n, A. Basso n, J. Cavanagh n & C. Melander n

author keywords: RNA; cyclic peptides; HADDOCK
MeSH headings : Base Sequence; Cysteine / chemistry; Humans; Models, Molecular; Peptides, Cyclic / chemistry; RNA / chemistry
TL;DR: This approach has successfully identified novel cyclic peptide constructs that can target bTAR RNA and RNA/peptide interactions were effectively modeled using the HADDOCK docking program. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs


By: W. Zeng n, T. Ballard n, A. Tkachenko, V. Burns n, D. Feldheim n & C. Melander n

author keywords: kinamycins; lomaiviticins; DNA cleavage; diazofluorenes; antiproliferative activity
MeSH headings : Animals; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Carbazoles / pharmacology; Cell Proliferation / drug effects; DNA Damage / drug effects; Fluorenes / chemical synthesis; Fluorenes / pharmacology; HeLa Cells; Humans; Molecular Mimicry; Structure-Activity Relationship
TL;DR: Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions, key to anticancer activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.