Victoria Adams

College of Agriculture and Life Sciences

Works (3)

Updated: April 25th, 2025 18:00

2024 article

Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells

Lodge, M., Scheidemantle, G., Adams, V. R., Cottam, M. A., Richard, D., Breuer, D., … Kennedy, A. (2024, February 18). Scientific Reports, Vol. 14.

By: M. Lodge n, G. Scheidemantle  n, V. Adams n, M. Cottam *, D. Richard n, D. Breuer  n, P. Thompson n , K. Shrestha n, X. Liu n, A. Kennedy n 

MeSH headings : Child; Humans; Kupffer Cells / metabolism; Fructose / metabolism; Pentose Phosphate Pathway; Matrix Metalloproteinase 12 / metabolism; Liver / metabolism; Non-alcoholic Fatty Liver Disease / pathology; Fibrosis; Phenotype
topics (OpenAlex): Diet, Metabolism, and Disease; Liver Disease Diagnosis and Treatment; Diet and metabolism studies
TL;DR: It is demonstrated that chronic fructose diet decreased Kupffer cell populations while increasing transitioning monocytes and upregulating resolution and anti-inflammatory associated genes in Kupffer cells. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2024 article

Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis

Adams, V. R., Collins, L. B., Williams, T. I., Holmes, J., Hess, P., Atkins, H. M., … Kennedy, A. (2024, January 11). (T. I. Williams, L. B. Collins, & A. Kennedy, Eds.). Frontiers in Immunology, Vol. 14.

By: V. Adams n, L. Collins n , T. Williams n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Contributors: T. Williams n , V. Adams n, L. Collins n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n , L. Collins n  & A. Kennedy n 

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
MeSH headings : Animals; Mice; Non-alcoholic Fatty Liver Disease / pathology; CD8-Positive T-Lymphocytes; Inflammation; Myeloid Cells / metabolism; Mice, Transgenic; Fibrosis; Cytokines / metabolism
topics (OpenAlex): Immune Cell Function and Interaction; Liver Disease Diagnosis and Treatment; Immune cells in cancer
TL;DR: Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2024

2021 article

Beneficial effects of eicosapentaenoic acid on the metabolic profile of obese female mice entails upregulation of HEPEs and increased abundance of enteric Akkermansia muciniphila

Pal, A., Sun, S., Armstrong, M., Manke, J., Reisdorph, N., Adams, V. R., … Shaikh, S. R. (2021, October 4). Biochimica Et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1.

By: A. Pal *, S. Sun *, M. Armstrong*, J. Manke *, N. Reisdorph*, V. Adams n, A. Kennedy n , Y. Zu * ...

author keywords: N-3 polyunsaturated fatty acids; bacteria; Microbial; Lipidomics
MeSH headings : Akkermansia / genetics; Akkermansia / growth & development; Animals; Cardiometabolic Risk Factors; Cell Differentiation / drug effects; Diet, High-Fat / adverse effects; Eicosapentaenoic Acid / metabolism; Eicosapentaenoic Acid / pharmacology; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Glucose / metabolism; Humans; Hydroxyeicosatetraenoic Acids / biosynthesis; Hydroxyeicosatetraenoic Acids / blood; Male; Mass Spectrometry; Mice; Mice, Obese / genetics; Mice, Obese / microbiology; Phosphatidylinositol 3-Kinases / genetics; Proto-Oncogene Proteins c-akt / genetics; RNA, Ribosomal, 16S / genetics; Sex Characteristics; Th17 Cells / metabolism; Triglycerides / blood
topics (OpenAlex): Fatty Acid Research and Health; Diet and metabolism studies; Metabolomics and Mass Spectrometry Studies
TL;DR: Results show that EPA ethyl esters prevent some of the deleterious effects of a high fat diet in female mice, which may be mediated mechanistically through 8-HEPE and the upregulation of intestinal Akkermansia muciniphila. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021

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