Works (45)

2021 journal article

Current Understanding toward Isonitrile Group Biosynthesis and Mechanism

CHINESE JOURNAL OF CHEMISTRY, 39(2), 463–472.

By: T. Chen, J. Chen, Y. Tang, J. Zhou, Y. Guo & W. Chang

Source: Web Of Science
Added: March 1, 2021

2021 journal article

Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis

ACS CATALYSIS, 11(1), 278–282.

By: T. Chen, S. Xue, W. Tsai, T. Chien, Y. Guo & W. Chang

Sources: Web Of Science, ORCID
Added: January 11, 2021

2020 journal article

Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

BIOCHEMISTRY, 59(21), 1961–1965.

By: L. Cha, S. Milikisiyants, M. Davidson, S. Xue, T. Smirnova, A. Smirnov, Y. Guo, W. Chang

Sources: Web Of Science, ORCID
Added: June 22, 2020

2020 article

An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2

Cha, L., & Chang, W.-chen. (2020, December). TRENDS IN CHEMISTRY, Vol. 2, pp. 1040–1042.

By: L. Cha & W. Chang

Sources: Web Of Science, ORCID
Added: January 4, 2021

2020 journal article

Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(13), 6268–6284.

By: J. Li, H. Liao, Y. Tang, J. Huang, L. Cha, T. Lin, J. Lee, I. Kurnikov ...

Sources: Web Of Science, ORCID
Added: May 26, 2020

2020 journal article

Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(19), 7367–7371.

By: T. Chen, J. Chen, Y. Tang, J. Zhou, Y. Guo & W. Chang

Sources: Web Of Science, ORCID
Added: May 8, 2020

2019 journal article

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases

BIOCHEMISTRY, 58(12), 1627–1647.

By: L. Rajkovich, M. Pandelia, A. Mitchell, W. Chang, B. Zhang, A. Boal, C. Krebs, J. Bollinger

Sources: Web Of Science, ORCID
Added: April 15, 2019

2019 journal article

Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation

Organic Letters, 21(1), 228–232.

By: W. Chang, Z. Yang, Y. Tu & T. Chien

Sources: NC State University Libraries, ORCID
Added: January 28, 2019

2019 journal article

Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(8), 3419–3423.

By: M. Davidson, M. McNamee, R. Fan, Y. Guo & W. Chang

Sources: Web Of Science, ORCID
Added: March 25, 2019

2019 article

Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships

NEW APPROACHES FOR FLAVIN CATALYSIS, pp. 167–188.

By: C. Thibodeaux, W. Chang & H. Liu

Sources: Web Of Science, ORCID
Added: December 30, 2019

2018 journal article

Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme

Journal of the American Chemical Society, 140(45), 15190–15193.

By: C. Yu, Y. Tang, L. Cha, S. Milikisiyants, T. Smirnova, A. Smirnov, Y. Guo, W. Chang

Sources: NC State University Libraries, ORCID
Added: December 10, 2018

2018 journal article

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

Angewandte Chemie - International Edition, 57(7), 1831–1835.

By: H. Liao, J. Li, J. Huang, M. Davidson, I. Kurnikov, T. Lin, J. Lee, M. Kurnikova ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions

Biochemistry, 57(14), 2074–2083.

By: J. Pan, M. Bhardwaj, B. Zhang, W. Chang, C. Schardl, C. Krebs, R. Grossman, J. Bollinger

Sources: Crossref, ORCID
Added: December 11, 2020

2018 journal article

Mechanistic Elucidation of Two Catalytically Versatile Iron(II)- and α-Ketoglutarate-Dependent Enzymes: Cases Beyond Hydroxylation

Comments on Inorganic Chemistry, 38(4), 127–165.

By: W. Chang, P. Liu & Y. Guo

Sources: NC State University Libraries, ORCID
Added: October 29, 2018

2018 journal article

Mechanistic Investigation of Oxidative Decarboxylation Catalyzed by Two Iron(II)- and 2-Oxoglutarate-Dependent Enzymes

Biochemistry, 57(12), 1838–1841.

By: J. Huang, Y. Tang, C. Yu, D. Sanyal, X. Jia, X. Liu, Y. Guo, W. Chang

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class i Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor

Biochemistry, 57(18), 2679–2693.

By: H. Rose, M. Ghosh, A. Maggiolo, C. Pollock, E. Blaesi, V. Hajj, Y. Wei, L. Rajakovich ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions

Journal of the American Chemical Society, 140(24), 7433–7436.

By: R. Ushimaru, M. Ruszczycky, W. Chang, F. Yan, Y. Liu & H. Liu

Sources: Crossref, ORCID
Added: December 11, 2020

2018 journal article

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

Journal of the American Chemical Society, 140(23), 7116–7126.

By: N. Dunham, W. Chang, A. Mitchell, R. Martinie, B. Zhang, J. Bergman, L. Rajakovich, B. Wang ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

In Vitro Stepwise Reconstitution of Amino Acid Derived Vinyl Isocyanide Biosynthesis: Detection of an Elusive Intermediate

Organic Letters, 19(5), 1208–1211.

By: W. Chang, D. Sanyal, J. Huang, K. Ittiamornkul, Q. Zhu & X. Liu

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Structure-Guided Reprogramming of a Hydroxylase to Halogenate Its Small Molecule Substrate

Biochemistry, 56(3), 441–444.

By: A. Mitchell, N. Dunham, J. Bergman, B. Wang, Q. Zhu, W. Chang, X. Liu, A. Boal

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase

Journal of the American Chemical Society, 139(39), 13830–13836.

By: A. Mitchell, N. Dunham, R. Martinie, J. Bergman, C. Pollock, K. Hu, B. Allen, W. Chang ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (-)-4′-Methoxycyclopenin Biosynthesis

Journal of the American Chemical Society, 138(33), 10390–10393.

By: W. Chang, J. Li, J. Lee, A. Cronican & Y. Guo

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase

Journal of the American Chemical Society, 138(28), 8862–8874.

By: E. Tamanaha, B. Zhang, Y. Guo, W. Chang, E. Barr, G. Xing, J. St Clair, S. Ye ...

Source: ORCID
Added: January 11, 2021

2015 journal article

Assembly of the unusual oxacycles in the orthosomycin antibiotics

Proceedings of the National Academy of Sciences of the United States of America, 112(39), 11989–11990.

By: A. Boal, J. Bollinger & W. Chang

Source: ORCID
Added: January 11, 2021

2015 journal article

Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2

Journal of the American Chemical Society, 137(21), 6912–6919.

By: R. Martinie, J. Livada, W. Chang, M. Green, C. Krebs, J. Bollinger, A. Silakov

Source: ORCID
Added: January 11, 2021

2015 chapter

Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond

In RSC Metallobiology: Vol. 2015-January (pp. 95–122).

By: J. Bollinger, W. Chang, M. Matthews, R. Martinie, A. Boal & C. Krebs

Source: ORCID
Added: January 11, 2021

2015 journal article

Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism

Journal of the American Chemical Society, 137(36), 11695–11709.

By: L. Rajakovich, H. N?rgaard, D. Warui, W. Chang, N. Li, S. Booker, C. Krebs, J. Bollinger, M. Pandelia

Source: ORCID
Added: January 11, 2021

2014 journal article

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Nature Chemical Biology, 10(3), 209–215.

By: M. Matthews, W. Chang, A. Layne, L. Miles, C. Krebs & J. Bollinger

Source: ORCID
Added: January 11, 2021

2014 journal article

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics

Science, 343(6175), 1140–1144.

Source: ORCID
Added: January 11, 2021

2014 journal article

Mechanistic consequences of chiral radical clock probes: Analysis of the mononuclear non-heme iron enzyme HppE with 2-hydroxy-3-methylenecyclopropyl radical clock substrates

Journal of the American Chemical Society, 136(8), 2944–2947.

By: H. Huang, W. Chang, G. Lin, A. Romo, P. Pai, W. Russell, D. Russell, H. Liu

Source: ORCID
Added: January 11, 2021

2013 journal article

Current development in isoprenoid precursor biosynthesis and regulation

Current Opinion in Chemical Biology, 17(4), 571–579.

By: W. Chang, H. Song, H. Liu & P. Liu

Source: ORCID
Added: January 11, 2021

2013 journal article

Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase

Science, 342(6161), 991–995.

Source: ORCID
Added: January 11, 2021

2013 journal article

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

Nature, 496(7443), 114–118.

By: W. Chang, M. Dey, P. Liu, S. Mansoorabadi, S. Moon, Z. Zhao, C. Drennan, H. Liu

Source: ORCID
Added: January 11, 2021

2013 book

Methylerythritol phosphate pathway of isoprenoid biosynthesis

In Annual Review of Biochemistry (Vol. 82, pp. 497–530).

By: L. Zhao, W. Chang, Y. Xiao, H. Liu & P. Liu

Source: ORCID
Added: January 11, 2021

2013 journal article

Reaction of HppE with substrate analogues: Evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement

Journal of the American Chemical Society, 135(22), 8153–8156.

By: W. Chang, S. Mansoorabadi & H. Liu

Source: ORCID
Added: January 11, 2021

2013 journal article

Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate

Journal of the American Chemical Society, 135(42), 15801–15812.

By: M. Pandelia, N. Li, H. N?rgaard, D. Warui, L. Rajakovich, W. Chang, S. Booker, C. Krebs, J. Martin Bollinger

Source: ORCID
Added: January 11, 2021

2012 journal article

Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis

Chemical Reviews, 112(3), 1681–1709.

By: C. Thibodeaux, W. Chang & H. Liu

Source: ORCID
Added: January 11, 2021

2012 journal article

Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases

Biochemistry, 51(40), 7908–7916.

Source: ORCID
Added: January 11, 2021

2012 journal article

Evidence for radical-mediated catalysis by HppE: A study using cyclopropyl and methylenecyclopropyl substrate analogues

Journal of the American Chemical Society, 134(39), 16171–16174.

By: H. Huang, W. Chang, P. Pai, A. Romo, S. Mansoorabadi, D. Russell, H. Liu

Source: ORCID
Added: January 11, 2021

2012 journal article

Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase

Journal of Biological Chemistry, 287(7), 4602–4608.

By: H. Sun, M. Ruszczycky, W. Chang, C. Thibodeaux & H. Liu

Source: ORCID
Added: January 11, 2021

2011 journal article

Mechanistic studies of an isph-catalyzed reaction: Implications for substrate binding and protonation in the biosynthesis of isoprenoids

Angewandte Chemie - International Edition, 50(51), 12304–12307.

By: W. Chang, Y. Xiao, H. Liu & P. Liu

Source: ORCID
Added: January 11, 2021

2011 journal article

Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues

Organic Letters, 13(21), 5912–5915.

By: Y. Xiao, W. Chang, H. Liu & P. Liu

Source: ORCID
Added: January 11, 2021

2010 journal article

Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate: Dimethylallyl diphosphate isomerase

Journal of the American Chemical Society, 132(29), 9994–9996.

By: C. Thibodeaux, W. Chang & H. Liu

Source: ORCID
Added: January 11, 2021

2008 journal article

Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus

Biochemistry, 47(8), 2547–2558.

By: C. Thibodeaux, S. Mansoorabadi, W. Kittleman, W. Chang & H. Liu

Source: ORCID
Added: January 11, 2021

2008 journal article

Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae

Biochemistry, 47(33), 8726–8735.

By: J. Munos, S. Moon, S. Mansoorabadi, W. Chang, L. Hong, F. Yan, A. Liu, H. Liu

Source: ORCID
Added: January 11, 2021

Employment

2016 - present

North Carolina State University Raleigh, NC, US
Chemistry

2011 - 2015

Pennsylvania State University University Park, PA, US

2003 - 2005

mandatory Military Service Kinmen , TW

Education

2005 - 2011

University of Texas at Austin Austin, TX, US

1999 - 2003

National Taiwan University Taipei, TW