2024 journal article
A survey of C-C bond formation strategies and mechanism deployed by iron-containing enzymes in natural products
TETRAHEDRON, 161.
2024 article
New Frontiers in Nonheme Enzymatic Oxyferryl Species
Paris, J. C., Cheung, Y. H., Zhang, T., Chang, W.-chen, Liu, P., & Guo, Y. (2024, August 7). CHEMBIOCHEM, Vol. 8.
2024 article
Optimized Substrate Positioning Enables Switches in the C-H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6<i>β</i>-Hydroxylase
Wenger, E. S., Martinie, R. J., Ushimaru, R., Pollock, C. J., Sil, D., Li, A., … Bollinger, J. M. (2024, August 22). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 8.
2024 journal article
Poly-γ-glutamylation of biomolecules
NATURE COMMUNICATIONS, 15(1).
2024 article
Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces
Chen, T.-Y., Chen, J., Ruszczycky, M. W., Hilovsky, D., Hostetler, T., Liu, X., … Chang, W.-chen. (2024, March 19). ACS CATALYSIS, Vol. 3.
2023 journal article
A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 8.
2023 article
An <i>S</i>=1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation
Paris, J. C., Hu, S., Wen, A., Weitz, A. C., Cheng, R., Gee, L. B., … Guo, Y. (2023, September 13). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 9.
2023 review
Current understanding of lignan biosynthesis
[Review of ]. ARKIVOC.
2023 journal article
Excision of a Protein-Derived Amine for <i>p</i>-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD
BIOCHEMISTRY, 62(22), 3276–3282.
2023 journal article
Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(44), 24210–24217.
2023 article
Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes
Cha, L., Paris, J. C., Zanella, B., Spletzer, M., Yao, A., Guo, Y., & Chang, W.-chen. (2023, March 13). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 3.
2023 article
Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration
Wang, B., Lu, Y., Cha, L., Chen, T.-Y., Palacios, P. M., Li, L., … Chen, C. (2023, September 6). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 9.
2022 journal article
Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis
ACS CATALYSIS, 12(4), 2270–2279.
2022 journal article
Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate
NATURE COMMUNICATIONS, 13(1).
2022 journal article
Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 144(18), 8257–8266.
2022 journal article
Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(39).
Contributors: T. Williams n
2021 article
A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase
Chen, T.-Y., & Chang, W.-chen. (2021, July 13). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 118.
2021 article
BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate
Manley, O. M., Tang, H., Xue, S., Guo, Y., Chang, W.-chen, & Makris, T. M. (2021, December 13). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 12.
2021 journal article
Current Understanding toward Isonitrile Group Biosynthesis and Mechanism
CHINESE JOURNAL OF CHEMISTRY, 39(2), 463–472.
2021 journal article
Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones
ACS CATALYSIS, 11(12), 7186–7192.
2021 article
Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes
Li, X., Shimaya, R., Dairi, T., Chang, W.-chen, & Ogasawara, Y. (2021, December 27). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 12.
2021 journal article
Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(1).
2020 journal article
Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring
BIOCHEMISTRY, 59(21), 1961–1965.
Contributors: L. Cha n , S. Milikisiyants n, M. Davidson n, S. Xue *, T. Smirnova n , A. Smirnov n , Y. Guo *, n
2020 article
An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2
Cha, L., & Chang, W.-chen. (2020, December). TRENDS IN CHEMISTRY, Vol. 2, pp. 1040–1042.
Contributors: L. Cha n & n
2020 journal article
Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis
ACS CATALYSIS, 11(1), 278–282.
2020 journal article
Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(13), 6268–6284.
2020 journal article
Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(19), 7367–7371.
2019 journal article
A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases
BIOCHEMISTRY, 58(12), 1627–1647.
Contributors: L. Rajakovich *, M. Pandelia *, A. Mitchell *, * , B. Zhang *, A. Boal *, C. Krebs *, J. Bollinger *
2019 journal article
Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(8), 3419–3423.
Contributors: M. Davidson n, M. McNamee n, R. Fan *, Y. Guo * & n
2019 article
Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships
NEW APPROACHES FOR FLAVIN CATALYSIS, Vol. 620, pp. 167–188.
Contributors: C. Thibodeaux *, n & H. Liu *
2018 journal article
Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 140(45), 15190–15193.
Contributors: C. Yu n, Y. Tang *, L. Cha n , S. Milikisiyants n, T. Smirnova n , A. Smirnov n , Y. Guo *, n
2018 journal article
Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57(7), 1831–1835.
Contributors: H. Liao*, J. Li *, J. Huang n, M. Davidson n, I. Kurnikov *, T. Lin *, J. Lee *, M. Kurnikova *
2018 journal article
Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions
Biochemistry, 57(14), 2074–2083.
Contributors: J. Pan *, M. Bhardwaj *, B. Zhang *, * , C. Schardl *, C. Krebs *, R. Grossman *, J. Martin Bollinger *
2018 journal article
Mechanistic Elucidation of Two Catalytically Versatile Iron(II)- and -Ketoglutarate-Dependent Enzymes: Cases Beyond Hydroxylation
COMMENTS ON INORGANIC CHEMISTRY, 38(4), 127–165.
2018 journal article
Mechanistic Investigation of Oxidative Decarboxylation Catalyzed by Two Iron(II)- and 2-Oxoglutarate-Dependent Enzymes
BIOCHEMISTRY, 57(12), 1838–1841.
2018 journal article
Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation
ORGANIC LETTERS, 21(1), 228–232.
Contributors: , Z. Yang*, Y. Tu* & T. Chien * n
2018 journal article
Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class i Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor
Biochemistry, 57(18), 2679–2693.
Contributors: H. Rose *, M. Ghosh*, A. Maggiolo *, C. Pollock *, E. Blaesi *, V. Hajj*, Y. Wei *, L. Rajakovich *
2018 journal article
Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions
Journal of the American Chemical Society, 140(24), 7433–7436.
Contributors: R. Ushimaru *, M. Ruszczycky*, * , F. Yan *, Y. Liu* & H. Liu *
2018 journal article
Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of alpha-Heteroatom Assistance
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 140(23), 7116–7126.
Contributors: N. Dunham *, * , A. Mitchell *, R. Martinie *, B. Zhang *, J. Bergman*, L. Rajakovich *, B. Wang *
2017 journal article
In Vitro Stepwise Reconstitution of Amino Acid Derived Vinyl Isocyanide Biosynthesis: Detection of an Elusive Intermediate
ORGANIC LETTERS, 19(5), 1208–1211.
2017 journal article
Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 139(39), 13830–13836.
Contributors: A. Mitchell *, N. Dunham *, R. Martinie *, J. Bergman*, C. Pollock *, K. Hu *, B. Allen *, *
2016 journal article
Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (-)-4 '-Methoxycyclopenin Biosynthesis
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138(33), 10390–10393.
2016 journal article
Spectroscopic Evidence for the Two C–H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase
Journal of the American Chemical Society, 138(28), 8862–8874.
Contributors: E. Tamanaha *, B. Zhang *, Y. Guo *, * , E. Barr*, G. Xing *, J. St Clair*, S. Ye *
2016 journal article
Structure-Guided Reprogramming of a Hydroxylase To Halogenate Its Small Molecule Substrate
BIOCHEMISTRY, 56(3), 441–444.
2015 journal article
Assembly of the unusual oxacycles in the orthosomycin antibiotics
Proceedings of the National Academy of Sciences, 112(39), 11989–11990.
Contributors: A. Boal *, J. Bollinger * & *
2015 journal article
Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2
Journal of the American Chemical Society, 137(21), 6912–6919.
Contributors: R. Martinie *, J. Livada*, * , M. Green *, C. Krebs *, J. Bollinger *, A. Silakov *
2015 chapter
Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond
In RSC Metallobiology: Vol. 2015-January (pp. 95–122).
Contributors: J. Bollinger *, * , M. Matthews *, R. Martinie *, A. Boal * & C. Krebs *
2015 journal article
Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism
Journal of the American Chemical Society, 137(36), 11695–11709.
Contributors: L. Rajakovich *, H. Nørgaard*, D. Warui *, * , N. Li *, S. Booker *, C. Krebs *, J. Bollinger *, M. Pandelia *
2014 journal article
Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase
Nature Chemical Biology, 10(3), 209–215.
Contributors: M. Matthews *, * , A. Layne*, L. Miles *, C. Krebs * & J. Bollinger *
2014 journal article
Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics
Science, 343(6175), 1140–1144.
Contributors: , Y. Guo *, C. Wang *, S. Butch*, A. Rosenzweig *, A. Boal *, C. Krebs *, J. Bollinger Jr. *
2014 journal article
Mechanistic Consequences of Chiral Radical Clock Probes: Analysis of the Mononuclear Non-Heme Iron Enzyme HppE with 2-Hydroxy-3-methylenecyclopropyl Radical Clock Substrates
Journal of the American Chemical Society, 136(8), 2944–2947.
Contributors: H. Huang *, * , G. Lin *, A. Romo*, P. Pai*, W. Russell *, D. Russell *, H. Liu *
2013 journal article
Current development in isoprenoid precursor biosynthesis and regulation
Current Opinion in Chemical Biology, 17(4), 571–579.
Contributors: , H. Song, H. Liu * & P. Liu *
2013 journal article
Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase
Science, 342(6161), 991–995.
Contributors: C. Wang *, * , Y. Guo *, H. Huang *, S. Peck *, M. Pandelia *, G. Lin *, H. Liu *, C. Krebs *, J. Bollinger Jr.
2013 journal article
Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction
Nature, 496(7443), 114–118.
Contributors: , M. Dey *, P. Liu *, S. Mansoorabadi *, S. Moon*, Z. Zhao *, C. Drennan *, H. Liu *
2013 book
Methylerythritol phosphate pathway of isoprenoid biosynthesis
In Annual Review of Biochemistry (Vol. 82, pp. 497–530).
2013 journal article
Reaction of HppE with Substrate Analogues: Evidence for Carbon–Phosphorus Bond Cleavage by a Carbocation Rearrangement
Journal of the American Chemical Society, 135(22), 8153–8156.
Contributors: , S. Mansoorabadi * & H. Liu * *
2013 journal article
Substrate-Triggered Addition of Dioxygen to the Diferrous Cofactor of Aldehyde-Deformylating Oxygenase to Form a Diferric-Peroxide Intermediate
Journal of the American Chemical Society, 135(42), 15801–15812.
Contributors: M. Pandelia *, N. Li *, H. Nørgaard*, D. Warui *, L. Rajakovich *, * , S. Booker *, C. Krebs *, J. Martin Bollinger *
2012 journal article
Evidence for Only Oxygenative Cleavage of Aldehydes to Alk(a/e)nes and Formate by Cyanobacterial Aldehyde Decarbonylases
Biochemistry, 51(40), 7908–7916.
Contributors: N. Li *, * , D. Warui *, S. Booker *, C. Krebs * & J. Bollinger Jr.
2012 journal article
Evidence for Radical-Mediated Catalysis by HppE: A Study Using Cyclopropyl and Methylenecyclopropyl Substrate Analogues
Journal of the American Chemical Society, 134(39), 16171–16174.
Contributors: H. Huang *, * , P. Pai*, A. Romo*, S. Mansoorabadi *, D. Russell *, H. Liu *
2012 journal article
Nucleophilic Participation of Reduced Flavin Coenzyme in Mechanism of UDP-galactopyranose Mutase
Journal of Biological Chemistry, 287(7), 4602–4608.
Contributors: H. Sun *, M. Ruszczycky*, * , C. Thibodeaux * & H. Liu
2011 journal article
Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis
Chemical Reviews, 112(3), 1681–1709.
Contributors: C. Thibodeaux *, * & H. Liu *
2011 journal article
Mechanistic Studies of an IspH-Catalyzed Reaction: Implications for Substrate Binding and Protonation in the Biosynthesis of Isoprenoids
Angewandte Chemie International Edition, 50(51), 12304–12307.
2011 journal article
Study of IspH, a Key Enzyme in the Methylerythritol Phosphate Pathway Using Fluoro-Substituted Substrate Analogues
Organic Letters, 13(21), 5912–5915.
2010 journal article
Linear Free Energy Relationships Demonstrate a Catalytic Role for the Flavin Mononucleotide Coenzyme of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase
Journal of the American Chemical Society, 132(29), 9994–9996.
Contributors: C. Thibodeaux *, * & H. Liu *
2008 journal article
Evidence for the Involvement of Acid/Base Chemistry in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate/Dimethylallyl Diphosphate Isomerase fromStaphylococcus aureus
Biochemistry, 47(8), 2547–2558.
Contributors: C. Thibodeaux *, S. Mansoorabadi *, W. Kittleman*, * & H. Liu *
2008 journal article
Purification and Characterization of the Epoxidase Catalyzing the Formation of Fosfomycin from Pseudomonas syringae
Biochemistry, 47(33), 8726–8735.
Contributors: J. Munos*, S. Moon*, S. Mansoorabadi *, * , L. Hong *, F. Yan *, A. Liu *, H. Liu *
Updated: September 1st, 2018 12:54
2016 - present
2011 - 2015
2003 - 2005
Updated: October 11th, 2019 13:50
2005 - 2011
1999 - 2003
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