Works (47)

2021 article

A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase

Chen, T.-Y., & Chang, W.-chen. (2021, July 13). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 7.

By: T. Chen & W. Chang

Sources: Web Of Science, ORCID
Added: August 23, 2021

2021 journal article

Current Understanding toward Isonitrile Group Biosynthesis and Mechanism

CHINESE JOURNAL OF CHEMISTRY, 39(2), 463–472.

By: T. Chen, J. Chen, Y. Tang, J. Zhou, Y. Guo & W. Chang

Sources: Web Of Science, ORCID
Added: March 1, 2021

2021 journal article

Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis

ACS CATALYSIS, 11(1), 278–282.

By: T. Chen, S. Xue, W. Tsai, T. Chien, Y. Guo & W. Chang

Sources: Web Of Science, ORCID
Added: January 11, 2021

2021 journal article

Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones

ACS CATALYSIS, 6.

By: H. Tang, Y. Tang, I. Kurnikov, H. Liao, N. Chan, M. Kurnikova, Y. Guo, W. Chang

Sources: Web Of Science, ORCID
Added: July 19, 2021

2020 journal article

Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

BIOCHEMISTRY, 59(21), 1961–1965.

By: L. Cha, S. Milikisiyants, M. Davidson, S. Xue, T. Smirnova, A. Smirnov, Y. Guo, W. Chang

Sources: Web Of Science, ORCID
Added: June 22, 2020

2020 article

An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2

Cha, L., & Chang, W.-chen. (2020, December). TRENDS IN CHEMISTRY, Vol. 2, pp. 1040–1042.

By: L. Cha & W. Chang

Sources: Web Of Science, ORCID
Added: January 4, 2021

2020 journal article

Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(13), 6268–6284.

By: J. Li, H. Liao, Y. Tang, J. Huang, L. Cha, T. Lin, J. Lee, I. Kurnikov ...

Sources: Web Of Science, ORCID
Added: May 26, 2020

2020 journal article

Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(19), 7367–7371.

By: T. Chen, J. Chen, Y. Tang, J. Zhou, Y. Guo & W. Chang

Sources: Web Of Science, ORCID
Added: May 8, 2020

2019 journal article

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases

BIOCHEMISTRY, 58(12), 1627–1647.

By: L. Rajkovich, M. Pandelia, A. Mitchell, W. Chang, B. Zhang, A. Boal, C. Krebs, J. Bollinger

Sources: Web Of Science, ORCID
Added: April 15, 2019

2019 journal article

Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation

Organic Letters, 21(1), 228–232.

By: W. Chang, Z. Yang, Y. Tu & T. Chien

Sources: NC State University Libraries, ORCID
Added: January 28, 2019

2019 journal article

Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(8), 3419–3423.

By: M. Davidson, M. McNamee, R. Fan, Y. Guo & W. Chang

Sources: Web Of Science, ORCID
Added: March 25, 2019

2019 article

Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships

NEW APPROACHES FOR FLAVIN CATALYSIS, pp. 167–188.

By: C. Thibodeaux, W. Chang & H. Liu

Sources: Web Of Science, ORCID
Added: December 30, 2019

2018 journal article

Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme

Journal of the American Chemical Society, 140(45), 15190–15193.

By: C. Yu, Y. Tang, L. Cha, S. Milikisiyants, T. Smirnova, A. Smirnov, Y. Guo, W. Chang

Sources: NC State University Libraries, ORCID
Added: December 10, 2018

2018 journal article

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

Angewandte Chemie - International Edition, 57(7), 1831–1835.

By: H. Liao, J. Li, J. Huang, M. Davidson, I. Kurnikov, T. Lin, J. Lee, M. Kurnikova ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions

Biochemistry, 57(14), 2074–2083.

By: J. Pan, M. Bhardwaj, B. Zhang, W. Chang, C. Schardl, C. Krebs, R. Grossman, J. Bollinger

Sources: Crossref, ORCID
Added: December 11, 2020

2018 journal article

Mechanistic Elucidation of Two Catalytically Versatile Iron(II)- and α-Ketoglutarate-Dependent Enzymes: Cases Beyond Hydroxylation

Comments on Inorganic Chemistry, 38(4), 127–165.

By: W. Chang, P. Liu & Y. Guo

Sources: NC State University Libraries, ORCID
Added: October 29, 2018

2018 journal article

Mechanistic Investigation of Oxidative Decarboxylation Catalyzed by Two Iron(II)- and 2-Oxoglutarate-Dependent Enzymes

Biochemistry, 57(12), 1838–1841.

By: J. Huang, Y. Tang, C. Yu, D. Sanyal, X. Jia, X. Liu, Y. Guo, W. Chang

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class i Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor

Biochemistry, 57(18), 2679–2693.

By: H. Rose, M. Ghosh, A. Maggiolo, C. Pollock, E. Blaesi, V. Hajj, Y. Wei, L. Rajakovich ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions

Journal of the American Chemical Society, 140(24), 7433–7436.

By: R. Ushimaru, M. Ruszczycky, W. Chang, F. Yan, Y. Liu & H. Liu

Sources: Crossref, ORCID
Added: December 11, 2020

2018 journal article

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

Journal of the American Chemical Society, 140(23), 7116–7126.

By: N. Dunham, W. Chang, A. Mitchell, R. Martinie, B. Zhang, J. Bergman, L. Rajakovich, B. Wang ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

In Vitro Stepwise Reconstitution of Amino Acid Derived Vinyl Isocyanide Biosynthesis: Detection of an Elusive Intermediate

Organic Letters, 19(5), 1208–1211.

By: W. Chang, D. Sanyal, J. Huang, K. Ittiamornkul, Q. Zhu & X. Liu

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Structure-Guided Reprogramming of a Hydroxylase to Halogenate Its Small Molecule Substrate

Biochemistry, 56(3), 441–444.

By: A. Mitchell, N. Dunham, J. Bergman, B. Wang, Q. Zhu, W. Chang, X. Liu, A. Boal

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase

Journal of the American Chemical Society, 139(39), 13830–13836.

By: A. Mitchell, N. Dunham, R. Martinie, J. Bergman, C. Pollock, K. Hu, B. Allen, W. Chang ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (-)-4′-Methoxycyclopenin Biosynthesis

Journal of the American Chemical Society, 138(33), 10390–10393.

By: W. Chang, J. Li, J. Lee, A. Cronican & Y. Guo

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Spectroscopic Evidence for the Two C–H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase

Journal of the American Chemical Society, 138(28), 8862–8874.

By: E. Tamanaha, B. Zhang, Y. Guo, W. Chang, E. Barr, G. Xing, J. St. Clair, S. Ye ...

Sources: ORCID, Crossref
Added: January 11, 2021

2015 journal article

Assembly of the unusual oxacycles in the orthosomycin antibiotics

Proceedings of the National Academy of Sciences, 112(39), 11989–11990.

By: A. Boal, J. Bollinger & W. Chang

Sources: ORCID, Crossref
Added: January 11, 2021

2015 journal article

Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2

Journal of the American Chemical Society, 137(21), 6912–6919.

By: R. Martinie, J. Livada, W. Chang, M. Green, C. Krebs, J. Bollinger, A. Silakov

Source: ORCID
Added: January 11, 2021

2015 chapter

Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond

In RSC Metallobiology: Vol. 2015-January (pp. 95–122).

By: J. Bollinger, W. Chang, M. Matthews, R. Martinie, A. Boal & C. Krebs

Source: ORCID
Added: January 11, 2021

2015 journal article

Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism

Journal of the American Chemical Society, 137(36), 11695–11709.

By: L. Rajakovich, H. Nørgaard, D. Warui, W. Chang, N. Li, S. Booker, C. Krebs, J. Bollinger, M. Pandelia

Sources: ORCID, Crossref
Added: January 11, 2021

2014 journal article

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Nature Chemical Biology, 10(3), 209–215.

By: M. Matthews, W. Chang, A. Layne, L. Miles, C. Krebs & J. Bollinger

Sources: ORCID, Crossref
Added: January 11, 2021

2014 journal article

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics

Science, 343(6175), 1140–1144.

Source: ORCID
Added: January 11, 2021

2014 journal article

Mechanistic Consequences of Chiral Radical Clock Probes: Analysis of the Mononuclear Non-Heme Iron Enzyme HppE with 2-Hydroxy-3-methylenecyclopropyl Radical Clock Substrates

Journal of the American Chemical Society, 136(8), 2944–2947.

By: H. Huang, W. Chang, G. Lin, A. Romo, P. Pai, W. Russell, D. Russell, H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2013 journal article

Current development in isoprenoid precursor biosynthesis and regulation

Current Opinion in Chemical Biology, 17(4), 571–579.

By: W. Chang, H. Song, H. Liu & P. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2013 journal article

Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase

Science, 342(6161), 991–995.

Source: ORCID
Added: January 11, 2021

2013 journal article

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

Nature, 496(7443), 114–118.

By: W. Chang, M. Dey, P. Liu, S. Mansoorabadi, S. Moon, Z. Zhao, C. Drennan, H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2013 book

Methylerythritol phosphate pathway of isoprenoid biosynthesis

In Annual Review of Biochemistry (Vol. 82, pp. 497–530).

By: L. Zhao, W. Chang, Y. Xiao, H. Liu & P. Liu

Source: ORCID
Added: January 11, 2021

2013 journal article

Reaction of HppE with Substrate Analogues: Evidence for Carbon–Phosphorus Bond Cleavage by a Carbocation Rearrangement

Journal of the American Chemical Society, 135(22), 8153–8156.

By: W. Chang, S. Mansoorabadi & H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2013 journal article

Substrate-Triggered Addition of Dioxygen to the Diferrous Cofactor of Aldehyde-Deformylating Oxygenase to Form a Diferric-Peroxide Intermediate

Journal of the American Chemical Society, 135(42), 15801–15812.

By: M. Pandelia, N. Li, H. Nørgaard, D. Warui, L. Rajakovich, W. Chang, S. Booker, C. Krebs, J. Bollinger

Sources: ORCID, Crossref
Added: January 11, 2021

2012 journal article

Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis

Chemical Reviews, 112(3), 1681–1709.

By: C. Thibodeaux, W. Chang & H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2012 journal article

Evidence for Only Oxygenative Cleavage of Aldehydes to Alk(a/e)nes and Formate by Cyanobacterial Aldehyde Decarbonylases

Biochemistry, 51(40), 7908–7916.

By: N. Li, W. Chang, D. Warui, S. Booker, C. Krebs & J. Bollinger

Sources: ORCID, Crossref
Added: January 11, 2021

2012 journal article

Evidence for Radical-Mediated Catalysis by HppE: A Study Using Cyclopropyl and Methylenecyclopropyl Substrate Analogues

Journal of the American Chemical Society, 134(39), 16171–16174.

By: H. Huang, W. Chang, P. Pai, A. Romo, S. Mansoorabadi, D. Russell, H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2012 journal article

Nucleophilic Participation of Reduced Flavin Coenzyme in Mechanism of UDP-galactopyranose Mutase

Journal of Biological Chemistry, 287(7), 4602–4608.

By: H. Sun, M. Ruszczycky, W. Chang, C. Thibodeaux & H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2011 journal article

Mechanistic Studies of an IspH-Catalyzed Reaction: Implications for Substrate Binding and Protonation in the Biosynthesis of Isoprenoids

Angewandte Chemie International Edition, 50(51), 12304–12307.

By: W. Chang, Y. Xiao, H. Liu & P. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2011 journal article

Study of IspH, a Key Enzyme in the Methylerythritol Phosphate Pathway Using Fluoro-Substituted Substrate Analogues

Organic Letters, 13(21), 5912–5915.

By: Y. Xiao, W. Chang, H. Liu & P. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2010 journal article

Linear Free Energy Relationships Demonstrate a Catalytic Role for the Flavin Mononucleotide Coenzyme of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase

Journal of the American Chemical Society, 132(29), 9994–9996.

By: C. Thibodeaux, W. Chang & H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2008 journal article

Evidence for the Involvement of Acid/Base Chemistry in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate/Dimethylallyl Diphosphate Isomerase fromStaphylococcus aureus

Biochemistry, 47(8), 2547–2558.

By: C. Thibodeaux, S. Mansoorabadi, W. Kittleman, W. Chang & H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

2008 journal article

Purification and Characterization of the Epoxidase Catalyzing the Formation of Fosfomycin from Pseudomonas syringae

Biochemistry, 47(33), 8726–8735.

By: J. Munos, S. Moon, S. Mansoorabadi, W. Chang, L. Hong, F. Yan, A. Liu, H. Liu

Sources: ORCID, Crossref
Added: January 11, 2021

Employment

2016 - present

North Carolina State University Raleigh, NC, US
Chemistry

2011 - 2015

Pennsylvania State University University Park, PA, US

2003 - 2005

mandatory Military Service Kinmen , TW

Education

2005 - 2011

University of Texas at Austin Austin, TX, US

1999 - 2003

National Taiwan University Taipei, TW