Wei-Chen Chang

Works (17)

2020 journal article

Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

BIOCHEMISTRY, 59(21), 1961–1965.

By: L. Cha, S. Milikisiyants, M. Davidson, S. Xue, T. Smirnova, A. Smirnov, Y. Guo, W. Chang

Source: Web Of Science
Added: June 22, 2020

2020 journal article

Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(13), 6268–6284.

By: J. Li, H. Liao, Y. Tang, J. Huang, L. Cha, T. Lin, J. Lee, I. Kurnikov ...

Source: Web Of Science
Added: May 26, 2020

2020 journal article

Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(19), 7367–7371.

By: T. Chen, J. Chen, Y. Tang, J. Zhou, Y. Guo & W. Chang

Source: Web Of Science
Added: May 8, 2020

2019 journal article

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases

BIOCHEMISTRY, 58(12), 1627–1647.

By: L. Rajkovich, M. Pandelia, A. Mitchell, W. Chang, B. Zhang, A. Boal, C. Krebs, J. Bollinger

Source: Web Of Science
Added: April 15, 2019

2019 journal article

Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation

ORGANIC LETTERS, 21(1), 228–232.

By: W. Chang, Z. Yang, Y. Tu & T. Chien

Source: NC State University Libraries
Added: January 28, 2019

2019 journal article

Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(8), 3419–3423.

By: M. Davidson, M. McNamee, R. Fan, Y. Guo & W. Chang

Source: Web Of Science
Added: March 25, 2019

2019 article

Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships

NEW APPROACHES FOR FLAVIN CATALYSIS, pp. 167–188.

By: C. Thibodeaux, W. Chang & H. Liu

Source: Web Of Science
Added: December 30, 2019

2018 journal article

Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 140(45), 15190–15193.

By: C. Yu, Y. Tang, L. Cha, S. Milikisiyants, T. Smirnova, A. Smirnov, Y. Guo, W. Chang

Source: NC State University Libraries
Added: December 10, 2018

2018 journal article

Insights into the desaturation of cyclopeptin and its C3 epimer catalyzed by a non-heme iron enzyme: Structural characterization and mechanism elucidation

Angewandte Chemie [International Edition in English], 57(7), 1831–1835.

By: H. Liao, J. Li, J. Huang, M. Davidson, I. Kurnikov, T. Lin, J. Lee, M. Kurnikova ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Mechanistic Elucidation of Two Catalytically Versatile Iron(II)- and -Ketoglutarate-Dependent Enzymes: Cases Beyond Hydroxylation

COMMENTS ON INORGANIC CHEMISTRY, 38(4), 127–165.

By: W. Chang, P. Liu & Y. Guo

Source: NC State University Libraries
Added: October 29, 2018

2018 journal article

Mechanistic investigation of oxidative decarboxylation catalyzed by two iron(II)- and 2-oxoglutarate-dependent enzymes

Biochemistry, 57(12), 1838–1841.

By: J. Huang, Y. Tang, C. Yu, D. Sanyal, X. Jia, X. Liu, Y. Guo, W. Chang

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Structural basis for superoxide activation of Flavobacterium johnsoniae Class I ribonucleotide reductase and for radical initiation by Its dimanganese cofactor

Biochemistry, 57(18), 2679–2693.

By: H. Rose, M. Ghosh, A. Maggiolo, C. Pollock, E. Blaesi, V. Hajj, Y. Wei, L. Rajakovich ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of alpha-Heteroatom Assistance

Journal of the American Chemical Society, 140(23), 7116–7126.

By: N. Dunham, W. Chang, A. Mitchell, R. Martinie, B. Zhang, J. Bergman, L. Rajakovich, B. Wang ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

In vitro stepwise reconstitution of amino acid derived vinyl isocyanide biosynthesis: Detection of an elusive intermediate

Organic Letters, 19(5), 1208–1211.

By: W. Chang, D. Sanyal, J. Huang, K. Ittiamornkui, Q. Zhu & X. Liu

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Structure-guided reprogramming of a hydroxylase to halogenate its small molecule substrate

Biochemistry, 56(3), 441–444.

By: A. Mitchell, N. Dunham, J. Bergman, B. Wang, Q. Zhu, W. Chang, X. Liu, A. Boal

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Visualizing the reaction cycle in an iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase

Journal of the American Chemical Society, 139(39), 13830–13836.

By: A. Mitchell, N. Dipham, R. Martinie, J. Bergman, C. Pollock, K. Hu, B. Allen, W. Chang ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Mechanistic investigation of a non-heme iron enzyme catalyzed epoxidation in (-)-4 '-methoxycyclopenin biosynthesis

Journal of the American Chemical Society, 138(33), 10390–10393.

By: W. Chang, J. Li, J. Lee, A. Cronican & Y. Guo

Source: NC State University Libraries
Added: August 6, 2018