@article{sandala_eichar_kuo_hahn_basak_huggins_woolard_melander_gunn_2020, title={A dual-therapy approach for the treatment of biofilm-mediated Salmonella gallbladder carriage}, volume={16}, ISSN={["1553-7374"]}, DOI={10.1371/journal.ppat.1009192}, abstractNote={Asymptomatic carriage of Salmonella Typhi continues to facilitate the transmission of typhoid fever, resulting in 14 million new infections and 136,000 fatalities each year. Asymptomatic chronic carriage of S. Typhi is facilitated by the formation of biofilms on gallstones that protect the bacteria from environmental insults and immune system clearance. Here, we identified two unique small molecules capable of both inhibiting Salmonella biofilm growth and disrupting pre-formed biofilm structures without affecting bacterial viability. In a mouse model of chronic gallbladder Salmonella carriage, treatment with either compound reduced bacterial burden in the gallbladder by 1–2 logs resulting in bacterial dissemination to peripheral organs that was associated with increased mortality. Co-administration of either compound with ciprofloxacin not only enhanced compound efficacy in the gallbladder by a further 1–1.5 logs for a total of 3–4.5 log reduction, but also prevented bacterial dissemination to peripheral organs. These data suggest a dual-therapy approach targeting both biofilm and planktonic populations can be further developed as a safe and efficient treatment of biofilm-mediated chronic S. Typhi infections.}, number={12}, journal={PLOS PATHOGENS}, author={Sandala, Jenna L. and Eichar, Bradley W. and Kuo, Laura G. and Hahn, Mark M. and Basak, Akash K. and Huggins, William M. and Woolard, Katherine and Melander, Christian and Gunn, John S.}, year={2020}, month={Dec} }
 @article{huggins_nguyen_hahn_baker_kuo_kaur_melander_gunn_melander_2018, title={2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium}, volume={9}, ISSN={["2040-2511"]}, DOI={10.1039/c8md00298c}, abstractNote={Serovars within the species Salmonella enterica are some of the most common food and water-borne pathogens worldwide.}, number={9}, journal={MEDCHEMCOMM}, author={Huggins, William M. and Nguyen, T. Vu and Hahn, Nicholas A. and Baker, James T. and Kuo, Laura G. and Kaur, Darpan and Melander, Roberta J. and Gunn, John S. and Melander, Christian}, year={2018}, month={Sep}, pages={1547–1552} }
 @article{yuen_walper_melde_daniele_stenger_2017, title={Electrolyte-sensing transistor decals enabled by ultrathin microbial nanocellulose}, volume={7}, journal={Scientific Reports}, author={Yuen, J. D. and Walper, S. A. and Melde, B. J. and Daniele, M. A. and Stenger, D. A.}, year={2017} }