Will Smith

College of Engineering

Works (3)

Updated: April 13th, 2024 05:01

2024 journal article

Novel multimodal cation-exchange membrane for the purification of a single-chain variable fragment from Pichia pastoris supernatant

JOURNAL OF CHROMATOGRAPHY A, 1718.

By: D. Pham *, M. Linova *, W. Smith n, H. Brown  n, D. Elhanafi n, J. Fan n, J. Lavoie n, J. Woodley *, R. Carbonell n

author keywords: Multimodal ligand; Membrane chromatography; Nonwoven membranes; Single-chain variable fragment (scFv); Pichia pastoris fermentation
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Source: Web Of Science
Added: April 8, 2024

2023 article

Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates

Chu, W., Shastry, S., Barbieri, E., Prodromou, R., Greback-Clarke, P., Smith, W., … Menegatti, S. (2023, July 12). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 7.

By: W. Chu n, S. Shastry n, E. Barbieri n, R. Prodromou n, P. Greback-Clarke n, W. Smith n, B. Moore n, R. Kilgore n ...

author keywords: adeno-associated virus; affinity chromatography; HEK 293 lysate; peptide ligands; virus purification
MeSH headings : Humans; Dependovirus / genetics; HEK293 Cells; Ligands; Peptides / genetics; Peptides / metabolism; Amino Acid Sequence; Genetic Vectors
TL;DR: Peptide ligands that selectively capture AAVs and release them under mild conditions are introduced, affording high recovery, high recovery of host cell proteins (HCPs), and high transduction activity of the purified viruses. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 7, 2023

2023 journal article

The downstream bioprocess toolbox for therapeutic viral vectors

JOURNAL OF CHROMATOGRAPHY A, 1709.

By: R. Kilgore n, A. Minzoni n, S. Shastry n, W. Smith n, E. Barbieri n, Y. Wu n, J. Lebarre n, W. Chu n, J. O'Brien n, S. Menegatti n 

author keywords: Viral vectors; Gene therapy; Affinity ligands; Chromatography; Adsorbents; AAV
TL;DR: This study presents a comprehensive overview of the downstream bioprocess toolbox for viral vectors established in the last decade, and discusses present efforts and future directions contributing to the success of this promising class of biological medicines. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 30, 2023

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