William Randall Lampe

Works (2)

Updated: July 9th, 2023 21:19

2012 article

Calpain and MARCKS protein regulation of airway mucin secretion

Lampe, W. R., Park, J., Fang, S., Crews, A. L., & Adler, K. B. (2012, June 18). Pulmonary Pharmacology & Therapeutics.

By: W. Lampe n, J. Park n, S. Fang n, A. Crews n & K. Adler n

author keywords: Airway; Mucin; MARCKS; Calpain; Secretion
MeSH headings : Bronchi / cytology; Bronchi / metabolism; Calpain / antagonists & inhibitors; Calpain / metabolism; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells / metabolism; Fluorescence; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides / administration & dosage; Oligopeptides / pharmacology; Protein Kinase C / metabolism; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): RNA regulation and disease; Galectins and Cancer Biology; Lysosomal Storage Disorders Research
TL;DR: Cleavage of MARCKS by Calpain may have an important role in regulation of the PKC/MARCKS pathway regulating airway mucin secretion, as opposed to the original hypothesis, inactivating Calpain caused a decrease rather than an increase in secretion. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Protein Kinase Cδ Regulates Airway Mucin Secretion via Phosphorylation of MARCKS Protein

Park, J.-A., Crews, A. L., Lampe, W. R., Fang, S., Park, J., & Adler, K. B. (2007, November 30). American Journal Of Pathology.

By: J. Park n, A. Crews n, W. Lampe n, S. Fang n, J. Park n & K. Adler n

MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Bronchi / drug effects; Bronchi / enzymology; Bronchi / metabolism; Bryostatins / pharmacology; Cell Line; Enzyme Activation; Epithelial Cells / drug effects; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / genetics; Protein Kinase C-delta / physiology; Protein Kinase Inhibitors / pharmacology; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): Cystic Fibrosis Research Advances; Glycosylation and Glycoproteins Research; Proteoglycans and glycosaminoglycans research
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Source: Web Of Science
Added: August 6, 2018

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