2017 journal article

Design, selection, and development of cyclic peptide ligands for human erythropoietin

JOURNAL OF CHROMATOGRAPHY A, 1500, 105–120.

By: W. Kish n, H. Sachi*, A. Naik n, M. Roach n, B. Bobay n, R. Blackburn n, S. Menegatti n, R. Carbonell n

author keywords: Erythropoietin; Cyclic peptide ligands; Ligand screening; Affinity chromatography; Affinity maturation; In-silico docking
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Erythropoietin / chemistry; Humans; Kinetics; Ligands; Molecular Sequence Data; Peptides, Cyclic / chemistry; Peptides, Cyclic / isolation & purification; Protein Binding
TL;DR: Mutagenesis studies performed on FSLLSH with natural and non-natural amino acid substitutions led to the identification of critical EPO-binding determinants, and the discovery of new peptide ligands that facilitate EPO recovery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Design of protease-resistant peptide ligands for the purification of antibodies from human plasma

Journal of Chromatography A, 1445, 93–104.

By: S. Menegatti n, B. Bobay n, K. Ward n, T. Islam n, W. Kish n, A. Naik n, R. Carbonell n

author keywords: Peptide affinity ligands; Polyclonal antibodies; Affinity chromatography; Proteolysis; Protease; Molecular docking
MeSH headings : Animals; Antibodies / isolation & purification; Binding Sites; Blood Chemical Analysis / methods; Chromatography, Affinity; Chymotrypsin / metabolism; Humans; Ligands; Peptides / chemistry; Protein Binding; Trypsin / metabolism
TL;DR: A strategy is presented for developing variants of peptide ligands with enhanced biochemical stability for the purification of antibodies from animal sera and higher selectivity than the original sequences, due to electrical neutrality. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Peptide-based affinity adsorbents with high binding capacity for the purification of monoclonal antibodies

Industrial & Engineering Chemistry Research, 52(26), 8800–8811.

By: W. Kish n, A. Naik n, S. Menegatti n & R. Carbonell n

TL;DR: The development of affinity resins based on hexapeptide ligand HWRGWV for recovering monoclonal antibodies from cell culture fluids and the reaction conditions of peptide coupling were optimized to maximize the binding capacity of the resulting adsorbents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Reversible cyclic peptide libraries for the discovery of affinity ligands

Analytical Chemistry, 85(19), 9229–9237.

By: S. Menegatti n, K. Ward n, A. Naik n, W. Kish n, R. Blackburn n & R. Carbonell n

MeSH headings : Ligands; Molecular Structure; Peptide Library; Peptides, Cyclic / analysis; Tandem Mass Spectrometry
TL;DR: A method is shown for synthesis of the irreversible cyclic peptide corresponding to the proposed depsipeptide structure, to make the ligand stable to the aqueous acid and alkaline conditions encountered in affinity chromatographic applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

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