Works (4)
Updated: July 5th, 2023 15:44
2017 journal article
Design, selection, and development of cyclic peptide ligands for human erythropoietin
JOURNAL OF CHROMATOGRAPHY A, 1500, 105–120.
author keywords: Erythropoietin; Cyclic peptide ligands; Ligand screening; Affinity chromatography; Affinity maturation; In-silico docking
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Erythropoietin / chemistry; Humans; Kinetics; Ligands; Molecular Sequence Data; Peptides, Cyclic / chemistry; Peptides, Cyclic / isolation & purification; Protein Binding
TL;DR:
Mutagenesis studies performed on FSLLSH with natural and non-natural amino acid substitutions led to the identification of critical EPO-binding determinants, and the discovery of new peptide ligands that facilitate EPO recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Design of protease-resistant peptide ligands for the purification of antibodies from human plasma
Journal of Chromatography A, 1445, 93–104.
author keywords: Peptide affinity ligands; Polyclonal antibodies; Affinity chromatography; Proteolysis; Protease; Molecular docking
MeSH headings : Animals; Antibodies / isolation & purification; Binding Sites; Blood Chemical Analysis / methods; Chromatography, Affinity; Chymotrypsin / metabolism; Humans; Ligands; Peptides / chemistry; Protein Binding; Trypsin / metabolism
TL;DR:
A strategy is presented for developing variants of peptide ligands with enhanced biochemical stability for the purification of antibodies from animal sera and higher selectivity than the original sequences, due to electrical neutrality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Peptide-based affinity adsorbents with high binding capacity for the purification of monoclonal antibodies
Industrial & Engineering Chemistry Research, 52(26), 8800–8811.
TL;DR:
The development of affinity resins based on hexapeptide ligand HWRGWV for recovering monoclonal antibodies from cell culture fluids and the reaction conditions of peptide coupling were optimized to maximize the binding capacity of the resulting adsorbents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Reversible cyclic peptide libraries for the discovery of affinity ligands
Analytical Chemistry, 85(19), 9229–9237.
MeSH headings : Ligands; Molecular Structure; Peptide Library; Peptides, Cyclic / analysis; Tandem Mass Spectrometry
TL;DR:
A method is shown for synthesis of the irreversible cyclic peptide corresponding to the proposed depsipeptide structure, to make the ligand stable to the aqueous acid and alkaline conditions encountered in affinity chromatographic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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