Wujin Sun

Works (34)

Updated: July 20th, 2023 21:13

2020 journal article

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

SCIENCE ADVANCES, 6(21).

By: W. Sun n, J. Wang n, Q. Hu n, X. Zhou *, A. Khademhosseini * & Z. Gu n

MeSH headings : CRISPR-Cas Systems; Cholesterol; DNA / genetics; DNA / metabolism; Gene Editing; Polymers / metabolism; Proprotein Convertase 9 / genetics; Proprotein Convertase 9 / metabolism; RNA / genetics; Ribonucleoproteins / genetics
TL;DR: A DNA nanoclew (NC)-based carrier for delivery of Cas12a/CRISPR RNA (crRNA) ribonucleoprotein (R NP) toward regulating serum cholesterol levels and significantly reducing the expression of PCSK9 and gaining the therapeutic benefit of cholesterol control. (via Semantic Scholar)
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Source: Web Of Science
Added: June 22, 2020

2019 journal article

Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

SCIENCE ADVANCES, 5(7).

By: J. Wang n, J. Yu n, Y. Zhang n, X. Zhang*, A. Kahkoska *, G. Chen*, Z. Wang *, W. Sun* ...

MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Drug Carriers / chemical synthesis; Drug Carriers / chemistry; Drug Delivery Systems; Insulin / administration & dosage; Mice; Molecular Structure; Polymers / chemical synthesis; Polymers / chemistry; Swine
TL;DR: A new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by electrostatic interaction achieves high insulin loading efficiency and loading capacity and promotes release under hyperglycemic conditions. (via Semantic Scholar)
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Added: August 19, 2019

2019 review

Non-transdermal microneedles for advanced drug delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 165-166, 41–59.

By: K. Lee *, M. Goudie *, P. Tebon *, W. Sun*, Z. Luo *, J. Lee *, S. Zhang *, K. Fetah * ...

author keywords: Microneedle; Implant; Drug delivery; Non-transdermal; Biocompatibility; Biodegradability
MeSH headings : Administration, Topical; Biological Transport; Drug Delivery Systems / methods; Equipment Design; Humans; Microinjections / instrumentation; Microinjections / methods; Microtechnology / methods; Polymers; Prostheses and Implants
TL;DR: The design and creation of modern MNs that aim to surpass the biological barriers of non-transdermal drug delivery in ocular, vascular, oral, and mucosal tissue are discussed. (via Semantic Scholar)
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Added: January 11, 2021

2018 journal article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

By: Q. Hu*, W. Sun*, J. Wang*, H. Ruan *, X. Zhang*, Y. Ye n, S. Shen *, C. Wang  n ...

MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
TL;DR: It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade. (via Semantic Scholar)
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Source: Web Of Science
Added: November 26, 2018

2018 article

Topical and Transdermal Nanomedicines for Cancer Therapy

NANOTHERANOSTICS FOR CANCER APPLICATIONS, Vol. 5, pp. 231–251.

By: Y. Ye n, J. Wang n, W. Sun n, H. Bomba n & Z. Gu n

TL;DR: This chapter summarizes the principles and the recent innovations in the field of transdermal nanomedicine together with opportunities and challenges in clinical translation. (via Semantic Scholar)
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Added: October 26, 2020

2017 journal article

Anaerobe-Inspired Anticancer Nanovesicles

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(10), 2588–2593.

By: C. Qian n, P. Feng *, J. Yu n, Y. Chen *, Q. Hu n, W. Sun n, X. Xiao*, X. Hu  n ...

author keywords: drug delivery; nanomedicines; photodynamic therapy
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Death / drug effects; Cell Proliferation / drug effects; Clostridium / chemistry; Clostridium / metabolism; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Hypoxia / metabolism; Imidazoles / chemistry; Imidazoles / pharmacology; Nanoparticles / chemistry; Prodrugs / chemistry; Prodrugs / pharmacology; Salmonella / chemistry; Salmonella / metabolism; Tirapazamine / chemistry; Tirapazamine / pharmacology
TL;DR: An anaerobe nanovesicle mimic that can not only be activated in THRs but also induce hypoxia in tumors by themselves is presented and provides a new strategy for engineering stimuli-responsive drug delivery systems in a bioinspired and synergistic fashion. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2017 review

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs

[Review of ]. THERANOSTICS, 7(14), 3504–3516.

By: C. Wang n, W. Sun n, Y. Ye n, H. Bomba  n & Z. Gu n

author keywords: artificial immune cells; lymphoid organs
MeSH headings : Animals; Antigen-Presenting Cells / immunology; Artificial Cells / chemistry; Artificial Cells / immunology; Biomimetic Materials / chemistry; Humans; Lymphoid Tissue / cytology; Lymphoid Tissue / immunology
TL;DR: This review surveys the latest studies on engineering biomimetic materials for immunotherapy, focusing on the perspectives of bioengineering artificial antigen presenting cells and lymphoid organs. (via Semantic Scholar)
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Added: August 6, 2018

2017 journal article

In vivo multienzyme complex coconstruction of N-Acetylneuraminic acid lyase and N-Acetylglucosamine-2-epimerase for Biosynthesis of N-Acetylneuraminic acid

Journal of Agricultural and Food Chemistry, 65(34), 7467–7475.

By: Z. Wang, W. Zhuang, J. Cheng, W. Sun, J. Wu, Y. Chen, H. Ying

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Insulin-responsive glucagon delivery for prevention of hypoglycemia

Small (Weinheim An Der Bergstrasse, Germany), 13(19).

By: J. Yu n, Y. Zhang n, W. Sun n, A. Kahkoska *, J. Wang n, J. Buse *, Z. Gu n

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Red Blood Cells for Glucose-Responsive Insulin Delivery

ADVANCED MATERIALS, 29(18).

By: C. Wang n, Y. Ye n, W. Sun n, J. Yu n, J. Wang  n, D. Lawrence *, J. Buse *, Z. Gu n

MeSH headings : Erythrocytes; Glucose; Insulin
TL;DR: This work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast responsiveness and the binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of BG level in vivo. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2017 journal article

Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy

ADVANCED MATERIALS, 29(13).

By: Q. Hu n, W. Sun n, C. Qian n, H. Bomba n, H. Xin n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Biomimetic Materials / chemistry; Blood Vessels / drug effects; Blood Vessels / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cells, Cultured; Dextrans / chemistry; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice, Nude; Microtubules / enzymology; Microtubules / metabolism; Nanostructures / chemistry; Neoplasm Transplantation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / metabolism; Oligopeptides / chemistry; Paclitaxel / administration & dosage; Paclitaxel / pharmacokinetics; Tumor Necrosis Factor-alpha / chemistry; Tumor Necrosis Factor-alpha / pharmacokinetics
TL;DR: A "relay drug delivery" system based on two distinct modules that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B that can accumulate at the tumor site by receiving the broadcasting signals generated by NCA is developed for amplifying active tumor targeting signal and enhancing antitumor therapy. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

ATP-Responsive Drug Delivery Systems

Sun, W., & Gu, Z. (2016, March 3). EXPERT OPINION ON DRUG DELIVERY, Vol. 13, pp. 311–314.

By: W. Sun n & Z. Gu n

MeSH headings : Adenosine Triphosphate / metabolism; Drug Carriers / chemistry; Drug Delivery Systems; Humans
TL;DR: An emerging strategy utilizing the “molecular unit of currency” in biological energy transfer - ATP - as a trigger for therapeutic delivery is discussed. (via Semantic Scholar)
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Added: August 6, 2018

2016 journal article

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

THERANOSTICS, 6(7), 1053–1064.

By: C. Qian n, Y. Chen, S. Zhu *, J. Yu n, L. Zhang *, P. Feng *, X. Tang *, Q. Hu n ...

author keywords: drug delivery; nanomedicine; stimuli-responsive; ATP-responsive; theranostics; conjugated polymers
MeSH headings : Adenosine Triphosphate / metabolism; Antineoplastic Agents / administration & dosage; Boronic Acids / metabolism; Doxorubicin / administration & dosage; Drug Carriers / administration & dosage; Hep G2 Cells; Humans; Liver Neoplasms / diagnostic imaging; Liver Neoplasms / drug therapy; Nanoparticles / administration & dosage; Optical Imaging / methods; Theranostic Nanomedicine / methods
TL;DR: In vivo studies validate that this adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging exhibits promising capability for inhibition of tumor growth. (via Semantic Scholar)
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Added: August 6, 2018

2016 journal article

Dual targeted nanocarrier for brain ischemic stroke treatment

JOURNAL OF CONTROLLED RELEASE, 233, 64–71.

By: Y. Zhao *, Y. Jiang *, W. Lv *, Z. Wang *, L. Lv *, B. Wang *, X. Liu *, Y. Liu* ...

author keywords: Stroke; Stroke homing peptide; Dual-targeting liposomes; ZL006; Neuroprotection
TL;DR: T7&SHp-P-LPs could be used as a safe and effective dual targeted nanocarrier for ischemic stroke treatment and could enhance the ability of in vivo anti-ischemic stroke of MCAO rats. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

ADVANCED MATERIALS, 28(43), 9573-+.

By: Q. Hu n, C. Qian n, W. Sun n, J. Wang n, Z. Chen n, H. Bomba n, H. Xin n, Q. Shen *, Z. Gu n

MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacokinetics; Biomimetics; Blood Platelets / cytology; Bone and Bones / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Cellular Microenvironment; Disease Models, Animal; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Humans; Mice; Multiple Myeloma / complications; Multiple Myeloma / drug therapy; Multiple Myeloma / metabolism; Multiple Myeloma / pathology; Nanoparticles / chemistry; Thrombosis / complications; Thrombosis / drug therapy
TL;DR: A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and Myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myelomas growth and simultaneously eradicating thrombus complication. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

ADVANCED MATERIALS, 28(40), 8912–8920.

By: C. Wang n, W. Sun n, G. Wright n, A. Wang  n & Z. Gu n

MeSH headings : Adjuvants, Immunologic; Animals; Antibodies; CpG Islands; Immunotherapy; Inflammation; Mice; Neoplasms / therapy; Programmed Cell Death 1 Receptor / immunology
TL;DR: Inflammation-triggered combination delivery of anti-PD-1 antibody and CpG oligodeoxynucleotides (CpG ODNs) has been demonstrated to prevent cancer relapse utilizing postsurgical inflammatory response. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

Internalized compartments encapsulated nanogels for targeted drug delivery

NANOSCALE, 8(17), 9178–9184.

By: J. Yu n, Y. Zhang n, W. Sun n, C. Wang n, D. Ranson n, Y. Ye n, Y. Weng *, Z. Gu n

MeSH headings : Doxorubicin / administration & dosage; Drug Delivery Systems; Ferrous Compounds; Hyaluronic Acid; Nanoparticles; Silicon Dioxide
TL;DR: This study illustrates the potential of utilizing an internalized compartments encapsulated formulation for targeted cancer therapy, and offers guidelines for developing a natural particulate-inspired drug delivery system. (via Semantic Scholar)
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Added: August 6, 2018

2016 journal article

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

ADVANCED MATERIALS, 28(17), 3313–3320.

By: C. Qian n, J. Yu n, Y. Chen *, Q. Hu n, X. Xiao*, W. Sun n, C. Wang n, P. Feng *, Q. Shen *, Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Hypoxia; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Drug Carriers / chemistry; HeLa Cells; Humans; Hydrogen-Ion Concentration; Light; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Neoplasms / diagnostic imaging; Neoplasms / drug therapy; Neoplasms / pathology; Optical Imaging; Polyvinyl Alcohol / chemistry; Singlet Oxygen / chemistry; Singlet Oxygen / metabolism; Transplantation, Heterologous
TL;DR: A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen and inducing hypoxide to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 review

Tailoring non-viral delivery vehicles for transporting genome-editing tools

[Review of ]. Science China-Materials, 60(6), 511–515.

By: W. Sun n & Z. Gu n

TL;DR: The recent advances in the development of non-viral delivery systems for CRISPR-Cas9 are surveyed and challenges and future directions in this field are discussed. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

BIOMATERIALS, 96, 1–10.

By: W. Sun n, W. Ji  n, Q. Hu n, J. Yu n, C. Wang n, C. Qian n, G. Hochu n, Z. Gu n

author keywords: Cancer; Protein delivery; DNA structures; Cytokine; Nanomedicine
TL;DR: A tumor microenvironment-responsive and transformable nanocarrier for cell membrane targeted delivery of cytokine using a phospholipase A2 degradable liposome as a shell and complementary DNA nanostructures decorated with cytokines as the cores is reported. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

NANO LETTERS, 16(2), 1118–1126.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang *, A. Isaacson *, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
TL;DR: Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 journal article

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

BIOMATERIALS, 50, 67–74.

By: R. Mo n, T. Jiang n, W. Sun n & Z. Gu n

author keywords: ATP responsive; Graphene oxide; DNA; Drug delivery; Nanomedicine
MeSH headings : Adenosine Triphosphate / pharmacology; Antineoplastic Agents / pharmacology; Cell Death / drug effects; DNA, Single-Stranded / chemistry; Doxorubicin / pharmacology; Drug Delivery Systems; Endocytosis / drug effects; Graphite / chemistry; HeLa Cells; Humans; Intracellular Space / metabolism; Nanoparticles / chemistry; Particle Size; Spectrometry, Fluorescence
TL;DR: This study applied adenosine-5'-triphosphate (ATP), the primary "energy molecule", as a trigger for enhanced release of preloaded drugs responding to the intracellular ATP concentration that is significantly higher than the extracellular level, for targeted on-demand delivery of anticancer drugs inside specific cells. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 journal article

Anticancer Platelet-Mimicking Nanovehicles

ADVANCED MATERIALS, 27(44), 7043-+.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
TL;DR: A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 journal article

Characterization of a novel N-acetylneuraminic acid lyase favoring N-acetylneuraminic acid synthesis

SCIENTIFIC REPORTS, 5.

By: W. Ji *, W. Sun*, J. Feng*, T. Song *, D. Zhang *, P. Ouyang *, Z. Gu*, J. Xie *

MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biocatalysis; Cloning, Molecular; Corynebacterium glutamicum / chemistry; Corynebacterium glutamicum / classification; Corynebacterium glutamicum / enzymology; Escherichia coli / enzymology; Escherichia coli / genetics; Gene Expression; Hexosamines / metabolism; Hydro-Lyases / chemistry; Hydro-Lyases / classification; Hydro-Lyases / genetics; Hydro-Lyases / metabolism; Kinetics; Molecular Sequence Data; N-Acetylneuraminic Acid / biosynthesis; Oxo-Acid-Lyases / chemistry; Oxo-Acid-Lyases / genetics; Oxo-Acid-Lyases / metabolism; Phylogeny; Pyruvic Acid / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Alignment; Substrate Specificity
TL;DR: The biochemical characterization of a novel NAL from a “GRAS” (General recognized as safe) strain C. glutamicum ATCC 13032 suggests that CgNal might have adopted a unique set of residues for substrates recognition and is a promising biocatalyst for industrial Neu5Ac biosynthesis. (via Semantic Scholar)
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Added: August 6, 2018

2015 review

Engineering DNA scaffolds for delivery of anticancer therapeutics

[Review of ]. BIOMATERIALS SCIENCE, 3(7), 1018–1024.

By: W. Sun n & Z. Gu n

MeSH headings : DNA / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / methods; Engineering; Humans; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Nanostructures / chemistry; Nanostructures / therapeutic use; Nanotechnology / methods; Neoplasms / chemistry; Neoplasms / drug therapy; Nucleic Acids / chemistry
TL;DR: In this mini-review, current advances in utilizing DNA scaffolds as drug carriers for cancer treatment were summarized and future challenges were also discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 journal article

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(27), 8260–8265.

By: J. Yu n, Y. Zhang*, Y. Ye*, R. DiSanto*, W. Sun*, D. Ranson n, F. Ligler*, J. Buse *, Z. Gu n

author keywords: diabetes; drug delivery; glucose-responsive; hypoxia-sensitive; microneedle
MeSH headings : Animals; Blood Glucose / analysis; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Glucose / metabolism; Glucose Oxidase / metabolism; Humans; Hyaluronic Acid / chemistry; Hyaluronic Acid / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Hypoxia / metabolism; Insulin / administration & dosage; Insulin / chemistry; Insulin / metabolism; Male; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Molecular Structure; Oxidation-Reduction; Reproducibility of Results
TL;DR: The “smart insulin patch” with a new enzyme-based glucose-responsive mechanism can regulate the blood glucose of type 1 diabetic mice to achieve normal levels, with faster responsiveness compared with the commonly used pH-sensitive formulations, and can avoid the risk of hypoglycemia. (via Semantic Scholar)
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Added: August 6, 2018

2015 review

Recent advances of cocktail chemotherapy by combination drug delivery systems

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 98, 19–34.

By: Q. Hu n, W. Sun n, C. Wang n & Z. Gu n

author keywords: Chemotherapy; Combination; Cancer; Nanocarriers; Drug delivery
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Drug Delivery Systems; Humans; Nanoparticles / administration & dosage; Nanoparticles / therapeutic use; Neoplasms / drug therapy
TL;DR: This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers and highlights the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. (via Semantic Scholar)
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Added: August 6, 2018

2015 journal article

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

Angewandte Chemie International Edition, 54(41), 12029–12033.

By: W. Sun n, W. Ji  n, J. Hall n, Q. Hu n, C. Wang  n, C. Beisel n, Z. Gu n

author keywords: CRISPR-Cas9; DNA; drug delivery; genome editing; nanoparticles
MeSH headings : Animals; CRISPR-Associated Proteins / administration & dosage; CRISPR-Associated Proteins / chemistry; CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / administration & dosage; DNA / chemistry; DNA / genetics; Green Fluorescent Proteins / genetics; Humans; Mice, Nude; Nanoparticles / chemistry; Neoplasms / genetics; Neoplasms / therapy; RNA, Guide, Kinetoplastida / administration & dosage; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; Streptococcus pyogenes / chemistry; Streptococcus pyogenes / genetics
TL;DR: The biologically inspired vehicles were efficiently loaded with Cas9/sgRNA complexes and delivered the complexes to the nuclei of human cells, thus enabling targeted gene disruption while maintaining cell viability. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Transformable liquid-metal nanomedicine

NATURE COMMUNICATIONS, 6(1).

By: Y. Lu n, Q. Hu n, Y. Lin n, D. Pacardo n, C. Wang n, W. Sun n, F. Ligler n, M. Dickey n , Z. Gu*

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Gallium / chemistry; Humans; Indium / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Nanomedicine / instrumentation; Nanomedicine / methods; Neoplasms / drug therapy
TL;DR: A transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell, providing a new strategy for engineering theranostic agents with low toxicity. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Advances in Anticancer Protein Delivery using Micro-/Nanoparticles

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 31(12), 1204–1222.

By: W. Sun n, Y. Lu n & Z. Gu n

TL;DR: Recent advances in delivering anticancer proteins directly to tumor tissue for inducing apoptosis/necrosis or indirectly to antigen presenting cells for provoking immune responses are surveyed. (via Semantic Scholar)
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Added: August 6, 2018

2014 journal article

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(42), 14722–14725.

By: W. Sun*, T. Jiang*, Y. Lu*, M. Reiff*, R. Mo* & Z. Gu*

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; DNA / chemistry; DNA / metabolism; Deoxyribonucleases / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Liberation; Humans; MCF-7 Cells; Models, Molecular; Molecular Conformation; Nanoparticles / chemistry
TL;DR: In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Engineered cytidine triphosphate synthetase with reduced product inhibition

Protein Engineering Design & Selection, 27(7), 225–233.

By: M. Zhu, W. Sun, Y. Wang, J. Meng, D. Zhang, T. Guo, P. Ouyang, H. Ying, J. Xie

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

CHEMICAL COMMUNICATIONS, 50(95), 15105–15108.

By: Y. Lu n, R. Mo n, W. Tai n, W. Sun n, D. Pacardo n, C. Qian  n, Q. Shen *, F. Ligler n, Z. Gu n

MeSH headings : Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / administration & dosage; Drug Carriers / chemistry; Folic Acid / administration & dosage; Folic Acid / chemistry; Glutathione / chemistry; HeLa Cells; Humans; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Oxidation-Reduction; Peptides / chemistry; Polyethylene Glycols / chemistry
TL;DR: Self-folded redox/acid dual-responsive nanocarriers developed for physiologically triggered delivery of anticancer drugs suggest their potential as a promising formulation for tumor-targeted chemotherapy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

journal article

Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene

Jiang, T. Y., Sun, W. J., Zhu, Q. W., Burns, N. A., Khan, S. A., Mo, R., & Gu, Z. Advanced Materials, 27(6), 1021–1028.

By: T. Jiang, W. Sun, Q. Zhu, N. Burns, S. Khan , R. Mo, Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

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