Works (44)

2011 journal article

Fozivudine Tidoxil as Single-Agent Therapy Decreases Plasma and Cell-Associated Viremia during Acute Feline Immunodeficiency Virus Infection

JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(3), 413–418.

By: J. Fogle, W. Tompkins, B. Campbell*, D. Sumner* & M. Tompkins

author keywords: Acquired immunodeficiency syndrome; Antiretroviral therapy; Lentivirus; Zidovudine
Source: Web Of Science
Added: August 6, 2018

2010 journal article

CD4(+)CD25(+) T Regulatory Cells Inhibit CD8(+) IFN-gamma Production During Acute and Chronic FIV Infection Utilizing a Membrane TGF-beta-Dependent Mechanism

AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(2), 201–216.

By: J. Fogle, A. Mexas, W. Tompkins & M. Tompkins

Source: Web Of Science
Added: August 6, 2018

2010 journal article

CD4(+)CD25(+) T regulatory cells from FIV+ cats induce a unique anergic profile in CD8(+) lymphocyte targets

RETROVIROLOGY, 7.

By: J. Fogle, W. Tompkins & M. Tompkins

Source: Web Of Science
Added: August 6, 2018

2008 journal article

CD4(+)CD25(+) regulatory T cells are infected and activated during acute FIV infection

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 126(3-4), 263–272.

By: A. Mexas, J. Fogle, W. Tompkins & M. Tompkins

author keywords: FIV; HIV; Regulatory T cells; Acute infection
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 122(1-2), 159–166.

By: S. Lankford, C. Petty n, A. La Voy n, S. Reckling, W. Tompkins & G. Dean

author keywords: Foxp3; feline; Treg; regulatory T cells; toll-like receptors
Source: Web Of Science
Added: August 6, 2018

2008 article

Lentivirus-induced immune dysregulation

Tompkins, M. B., & Tompkins, W. A. (2008, May 15). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 123, pp. 45–55.

By: M. Tompkins & W. Tompkins

author keywords: FIV; AIDS; immune suppression; immune regulation
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Transforming growth factor-beta/transforming growth factor-beta RII signaling may regulate CD4(+)CD25(+) T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 47(2), 148–160.

By: C. Petty n, M. Tompkins & W. Tompkins

author keywords: AIDS; immunodeficiency diseases; other animals; T lymphocytes
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Different thresholds of T cell activation regulate FIV infection of CD4(+)CD25(+) and CD4(+)CD25(-) cells

VIROLOGY, 335(2), 212–221.

By: A. Joshi, H. Garg, M. Tompkins & W. Tompkins

author keywords: treg cells; latency; activation; reservoirs; HIV; FIV; IL-2
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Preferential feline immunodeficiency virus (FIV) infection of CD4(+) CD25(+) T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors

JOURNAL OF VIROLOGY, 79(8), 4965–4976.

By: A. Joshi, H. Garg, M. Tompkins & W. Tompkins

Source: Web Of Science
Added: August 6, 2018

2005 article

The role of CD4(+)CD25(+) regulatory T cells in viral infections

Vahlenkamp, T. W., Tompkins, M. B., & Tompkins, W. A. F. (2005, October 18). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 108, pp. 219–225.

By: T. Vahlenkamp, M. Tompkins & W. Tompkins n

author keywords: regulatory T cells; viral infection; immune regulation; immunosuppression
Source: Web Of Science
Added: August 6, 2018

2004 journal article

B7(+)CTLA4(+) T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(3-4), 203–214.

By: T. Vahlenkamp, M. Bull, J. Dow, E. Collisson*, B. Winslow*, A. Phadke*, W. Tompkins n, M. Tompkins

author keywords: FIV; apoptosis; 137 costimulatory molecules; CTLA4
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Failure of FIV-infected cats to control Toxoplasma gondii correlates with reduced IL2, IL6, and IL12 and elevated IL10 expression by lymph node T cells

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(1-2), 101–111.

author keywords: FIV; cytokine; Toxoplasma gondii
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Feline immunodeficiency virus envelope glycoprotein mediates apoptosis in activated PBMC by a mechanism dependent on gp41 function

VIROLOGY, 330(2), 424–436.

By: H. Garg, A. Joshi & W. Tompkins

author keywords: FIV; envelope; apoptosis; fusion; syncytia; CD134; CXCR4
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4(+)CD25(+) T regulatory cells

JOURNAL OF IMMUNOLOGY, 172(8), 4752–4761.

By: T. Vahlenkamp, M. Tompkins & W. Tompkins n

Source: Web Of Science
Added: August 6, 2018

2004 journal article

Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion

VIROLOGY, 321(2), 274–286.

By: H. Garg, F. Fuller & W. Tompkins n

author keywords: feline immunodeficiency virus; glycoprotein-mediated fusion; lentiviruses
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation

VIROLOGY, 321(2), 307–322.

By: A. Joshi, T. Vahlenkamp, H. Garg, W. Tompkins n & M. Tompkins

author keywords: FIV; HIV; AIDS; latency; stimulation; anergy; apoptosis; reservoir
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 99(1-2), 25–37.

By: M. Bull, T. Vahlenkamp, J. Dow, E. Collisson*, B. Winslow*, A. Phadke*, M. Tompkins, W. Tompkins n

author keywords: FIV; apoptosis; IL2; B7 co-stimulatory molecules; CTLA4
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Evaluation of T lymphocytes in captive African lions (Panthera leo) infected with feline immunodeficiency virus

AMERICAN JOURNAL OF VETERINARY RESEARCH, 64(10), 1293–1300.

By: M. Bull, S. Kennedy-Stoskopf, J. Levine, M. Loomis, D. Gebhard* & W. Tompkins n

Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

C-terminal gp40 peptide analogs inhibit feline immunodeficiency virus: Cell fusion and virus spread

JOURNAL OF VIROLOGY, 76(18), 9079–9086.

By: R. Medinas, D. Lambert* & W. Tompkins

Source: Web Of Science
Added: August 6, 2018

2002 journal article

Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats

VACCINE, 21(3-4), 258–268.

By: M. Burkhard, L. Valenski, S. Leavell n, G. Dean & W. Tompkins n

author keywords: Venezuelan equine encephalitis (VEE) virus; VEE-replicon particles; feline immunodeficiency virus (FIV)
Source: Web Of Science
Added: August 6, 2018

2002 article

Feline immunodeficiency virus infection is characterized by B7(+)CTLA4(+) T cell apoptosis

Tompkins, M. B., Bull, M. E., Dow, J. L., Ball, J. M., Collisson, E. W., Winslow, B. J., … Tompkins, W. A. (2002, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 185, pp. 1077–1093.

By: M. Tompkins, M. Bull, J. Dow, J. Ball*, E. Collisson*, B. Winslow*, A. Phadke*, T. Vahlenkamp, W. Tompkins

Source: Web Of Science
Added: August 6, 2018

2002 journal article

Infection of the choroid plexus by feline immunodeficiency virus

JOURNAL OF NEUROVIROLOGY, 8(3), 211–224.

author keywords: human immunodeficiency virus; macrophages; brain; AIDS; neural culture
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Inhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro

JOURNAL OF VIROLOGY, 76(19), 9952–9961.

By: J. Ma n, S. Kennedy-Stoskopf, J. Jaynes*, L. Thurmond* & W. Tompkins

Source: Web Of Science
Added: August 6, 2018

2002 journal article

Polymorphic expression in the CD8 alpha chain surface receptor of African lions (Panthera leo)

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 84(3-4), 181–189.

By: M. Bull, D. Gebhard*, W. Tompkins n & S. Kennedy-Stoskopf

author keywords: African lion (Panthera leo); monoclonal antibody; cross-reactivity; CD8 alpha polymorphism
Source: Web Of Science
Added: August 6, 2018

2001 conference paper

B7.1/B7.2 and CTLA4 expression on feline T cells in vitro correlates with apoptosis

Journal of Leukocyte Biology, (2001), 255.

By: T. Vahlenkamp, M. Bull, J. Dow, J. Anderson, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Constitutive expression of types 1 and 2 cytokines by alveolar macrophages from feline immunodeficiency virus-infected cats

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 79(1-2), 83–100.

By: J. Ritchey n, J. Levy, S. Bliss n, W. Tompkins n & M. Tompkins

author keywords: FIV; macrophages; interleukins
Source: Web Of Science
Added: August 6, 2018

2001 conference paper

Feline immunodeficiency virus (FIV) infection induces B7(+)CTLA4(+) T cell apoptosis: A model for T cell depletion and immunodeficiency

Journal of Leukocyte Biology, (2001), 254.

By: M. Tompkins, M. Bull, J. Dow & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2001 patent

Nucleic acids obtained from the envelope coding region of feline immunodeficiency virus molecular clone designated JSY3

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins, M. Tompkins & J. Yang

Source: NC State University Libraries
Added: August 6, 2018

2001 conference paper

T cell apoptosis in FIV-infected cats is blocked by the addition of antibodies to B7.1 and B7.2

Journal of Leukocyte Biology, (2001), 256.

By: M. Bull, T. Vahlenkamp, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Cloning and sequencing hybrid striped bass (Morone saxatilis x M. chrysops) transforming growth factor-β (TGF-β), and development of a reverse transcription quantitative competitive polymerase chain reaction (RT-qcPCR) assay to measure TGF-β mRNA of teleost fish

Fish & Shellfish Immunology, 10(1), 61–85.

By: C. Harms, S. Kennedy-Stoskopf, W. Horne, F. Fuller & W. Tompkins n

author keywords: transforming growth factor-beta; TGF-beta; sequence; hybrid striped bass; Morone saxatilis X M-chrysops; quantitative PCR
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2000 journal article

T cells overexpressing interferon-gamma and interleukin-10 are found in both the thymus and secondary lymphoid tissues of feline immunodeficiency virus-infected cats

JOURNAL OF INFECTIOUS DISEASES, 181(2), 564–575.

Source: Web Of Science
Added: August 6, 2018

1999 review

Immunomodulation and therapeutic effects of the oral use of interferon-alpha: Mechanism of action

[Review of ]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 19(8), 817–828.

By: W. Tompkins

Source: Web Of Science
Added: August 6, 2018

1999 journal article

Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats

JOURNAL OF INFECTIOUS DISEASES, 180(5), 1503–1513.

Source: Web Of Science
Added: August 6, 2018

1999 journal article

Shedding of feline immunodeficiency virus in semen of domestic cats during acute infection

American Journal of Veterinary Research, 60(2), 211–215.

By: H. Jordan, Y. Liang, L. Hudson & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Biphasic thymus response by kittens inoculated with feline immunodeficiency virus during fetal development

VETERINARY PATHOLOGY, 35(3), 191–201.

By: C. Johnson*, G. Papadi*, W. Tompkins, R. Sellon, M. Orandle*, . Bellah*, L. Bubenik*

author keywords: animal models; lymphoid tissue; pediatrics; thymus
Source: Web Of Science
Added: August 6, 2018

1998 article

Elevated interleukin-10-to-interleukin-12 ratio in feline immunodeficiency virus-infected cats predicts loss of type 1 immunity to Toxoplasma gondii

Levy, J. K., Ritchey, J. W., Rottman, J. B., Davidson, M. G., Liang, Y. H., Jordan, H. L., … Tompkins, M. B. (1998, August). JOURNAL OF INFECTIOUS DISEASES, Vol. 178, pp. 503–511.

By: J. Levy, J. Ritchey n, J. Rottman n, M. Davidson, Y. Liang, H. Jordan n, W. Tompkins, M. Tompkins

Source: Web Of Science
Added: August 6, 2018

1998 journal article

Feline immunodeficiency virus is shed in semen from experimentally and naturally infected cats

AIDS RESEARCH AND HUMAN RETROVIRUSES, 14(12), 1087–1092.

By: H. Jordan*, J. Howard, M. Barr, S. Kennedy-Stoskopf, J. Levy & W. Tompkins

Source: Web Of Science
Added: August 6, 2018

1998 journal article

Horizontal transmission of feline immunodeficiency virus with semen from seropositive cats

Journal of Reproductive Immunology, 41(1-2), 341–357.

By: H. Jordan*, J. Howard*, J. Bucci, J. Butterworth n, R. English, S. Kennedy-Stoskopf, M. Tompkins, W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1998 chapter

Immunology of the cat: Nonspecific immunity in the cat

In Handbook of vertebrate immunology. San Diego: Academic Press.

By: J. Ritchey & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Lessons from the cat: Feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1

AIDS RESEARCH AND HUMAN RETROVIRUSES, 14(9), 797–801.

By: J. Elder*, G. Dean, E. Hoover*, J. Hoxie*, M. Malim*, L. Mathes*, J. Neil*, T. North* ...

Source: Web Of Science
Added: August 6, 2018

1998 article

Mucosally transmitted feline immunodeficiency virus induces a CD8(+) antiviral response that correlates with reduction of cell-associated virus

Bucci, J. G., English, R. V., Jordan, H. L., Childers, T. A., Tompkins, M. B., & Tompkins, W. A. F. (1998, January). JOURNAL OF INFECTIOUS DISEASES, Vol. 177, pp. 18–25.

By: J. Bucci n, R. English, H. Jordan, T. Childers, M. Tompkins & W. Tompkins

Source: Web Of Science
Added: August 6, 2018

1998 journal article

The CD8(+) cell phenotype mediating antiviral activity in feline immunodeficiency virus-infected cats is characterized by reduced surface expression of the CD8 beta chain

JOURNAL OF INFECTIOUS DISEASES, 178(4), 968–977.

By: J. Bucci n, D. Gebhard, T. Childers n, R. English, M. Tompkins & W. Tompkins n

Source: Web Of Science
Added: August 6, 2018

1997 patent

Feline immunodeficiency virus isolate NCSU.sub.1

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins & M. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1995 patent

Feline immunodeficiency virus isolate NCSU.sub.1Lb

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins & M. Tompkins

Source: NC State University Libraries
Added: August 6, 2018