Works (44)

Updated: July 25th, 2023 21:16

2011 journal article

Fozivudine Tidoxil as Single-Agent Therapy Decreases Plasma and Cell-Associated Viremia during Acute Feline Immunodeficiency Virus Infection

JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(3), 413โ€“418.

By: J. Fogle n, W. Tompkins n, B. Campbellโ€‰*, D. Sumner* & M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Acquired immunodeficiency syndrome; Antiretroviral therapy; Lentivirus; Zidovudine
MeSH headings : Animals; Antiviral Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / virology; Cats; Immunodeficiency Virus, Feline / drug effects; Lentivirus Infections / drug therapy; Lipids / therapeutic use; Male; Specific Pathogen-Free Organisms; Viremia / drug therapy; Viremia / veterinary; Zidovudine / analogs & derivatives; Zidovudine / therapeutic use
Source: Web Of Science
Added: August 6, 2018

2010 journal article

CD4(+)CD25(+) T Regulatory Cells Inhibit CD8(+) IFN-gamma Production During Acute and Chronic FIV Infection Utilizing a Membrane TGF-beta-Dependent Mechanism

AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(2), 201โ€“216.

By: J. Fogle n, A. Mexas*, W. Tompkins n & M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; CD4 Antigens / analysis; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / immunology; Cat Diseases / virology; Cats; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Interferon-gamma / antagonists & inhibitors; Interleukin-2 Receptor alpha Subunit / analysis; Lentivirus Infections / veterinary; Lentivirus Infections / virology; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / immunology
Source: Web Of Science
Added: August 6, 2018

2010 journal article

CD4(+)CD25(+) T regulatory cells from FIV+ cats induce a unique anergic profile in CD8(+) lymphocyte targets

RETROVIROLOGY, 7.

By: J. Fogle n, W. Tompkins n & M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; CD4 Antigens / immunology; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / metabolism; Cats; Cell Cycle / immunology; Clonal Anergy; Coculture Techniques; Down-Regulation; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline; Interleukin-2 Receptor alpha Subunit / immunology; T-Lymphocytes, Regulatory / immunology
Source: Web Of Science
Added: August 6, 2018

2008 journal article

CD4(+)CD25(+) regulatory T cells are infected and activated during acute FIV infection

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 126(3-4), 263โ€“272.

By: A. Mexas n, J. Fogle n, W. Tompkins n & M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: FIV; HIV; Regulatory T cells; Acute infection
MeSH headings : Animals; Cat Diseases / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Forkhead Transcription Factors / metabolism; Gene Expression Regulation / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes, Regulatory / virology; Viremia / veterinary
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 122(1-2), 159โ€“166.

By: S. Lankford n, C. Petty n, A. La Voy n, S. Reckling n, W. Tompkins n & G. Dean n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Foxp3; feline; Treg; regulatory T cells; toll-like receptors
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cats; Cloning, Molecular; Forkhead Transcription Factors / chemistry; Forkhead Transcription Factors / genetics; Humans; Molecular Sequence Data; RNA, Messenger / analysis; T-Lymphocytes, Regulatory / metabolism; Toll-Like Receptors / physiology
Source: Web Of Science
Added: August 6, 2018

2008 article

Lentivirus-induced immune dysregulation

Tompkins, M. B., & Tompkins, W. A. (2008, May 15). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 123, pp. 45โ€“55.

By: M. Tompkins n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: FIV; AIDS; immune suppression; immune regulation
MeSH headings : Animals; Antibody Formation / immunology; Apoptosis / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunity, Cellular / immunology; Immunodeficiency Virus, Feline / immunology
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Transforming growth factor-beta/transforming growth factor-beta RII signaling may regulate CD4(+)CD25(+) T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 47(2), 148โ€“160.

By: C. Petty n, M. Tompkins n & W. Tompkins n

co-author countries: Netherlands ๐Ÿ‡ณ๐Ÿ‡ฑ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: AIDS; immunodeficiency diseases; other animals; T lymphocytes
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Cats; Cells, Cultured; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry; Gene Expression Regulation; Homeostasis; Interleukin-2 Receptor alpha Subunit / analysis; Leukocytes, Mononuclear / immunology; Protein Serine-Threonine Kinases / immunology; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta / immunology; Reverse Transcriptase Polymerase Chain Reaction; Specific Pathogen-Free Organisms; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / immunology
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Different thresholds of T cell activation regulate FIV infection of CD4(+)CD25(+) and CD4(+)CD25(-) cells

VIROLOGY, 335(2), 212โ€“221.

By: A. Joshi n, H. Garg n, M. Tompkins n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: treg cells; latency; activation; reservoirs; HIV; FIV; IL-2
MeSH headings : Animals; Apoptosis; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD4-Positive T-Lymphocytes / virology; Cats; Cell Proliferation / drug effects; Cells, Cultured; Concanavalin A / pharmacology; Dose-Response Relationship, Drug; Immunodeficiency Virus, Feline / drug effects; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Interleukin-2 / pharmacology; Lymphocyte Activation / drug effects; Lymphocyte Activation / immunology; Mitogens / pharmacology; Receptors, Interleukin-2 / genetics; Receptors, Interleukin-2 / immunology; Receptors, Interleukin-2 / metabolism; Up-Regulation / drug effects; Virus Latency / drug effects; Virus Replication / drug effects
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Preferential feline immunodeficiency virus (FIV) infection of CD4(+) CD25(+) T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors

JOURNAL OF VIROLOGY, 79(8), 4965โ€“4976.

By: A. Joshi n, H. Garg n, M. Tompkins n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Benzylamines; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; Cats; Cells, Cultured; Cyclams; Feline Acquired Immunodeficiency Syndrome / immunology; Heterocyclic Compounds / pharmacology; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Lymph Nodes / immunology; Lymph Nodes / virology; Receptors, CXCR4 / antagonists & inhibitors; Receptors, CXCR4 / genetics; Receptors, Interleukin-2 / immunology; T-Lymphocytes / immunology; T-Lymphocytes / virology; Virus Replication
Source: Web Of Science
Added: August 6, 2018

2005 article

The role of CD4(+)CD25(+) regulatory T cells in viral infections

Vahlenkamp, T. W., Tompkins, M. B., & Tompkins, W. A. F. (2005, October 18). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 108, pp. 219โ€“225.

By: T. Vahlenkamp*, M. Tompkins n & W. Tompkins n

co-author countries: Germany ๐Ÿ‡ฉ๐Ÿ‡ช United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: regulatory T cells; viral infection; immune regulation; immunosuppression
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Herpesviridae Infections / immunology; Immune Tolerance; Lymphocyte Activation; Mice; Picornaviridae Infections / immunology; Receptors, Interleukin-2 / metabolism; Retroviridae Infections / immunology; T-Lymphocyte Subsets / immunology; Virus Diseases / immunology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

B7(+)CTLA4(+) T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(3-4), 203โ€“214.

By: T. Vahlenkamp n, M. Bull n, J. Dow n, E. Collisson*, B. Winslow, A. Phadke*, W. Tompkins n, M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: FIV; apoptosis; 137 costimulatory molecules; CTLA4
MeSH headings : Animals; Antigens, CD / biosynthesis; Antigens, CD / immunology; Antigens, Differentiation / biosynthesis; Antigens, Differentiation / immunology; Apoptosis / immunology; B7-1 Antigen / biosynthesis; B7-1 Antigen / immunology; B7-2 Antigen; CTLA-4 Antigen; Cats; Cell Communication / immunology; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Ionomycin / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / immunology; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; T-Lymphocytes / virology; Tetradecanoylphorbol Acetate / immunology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Failure of FIV-infected cats to control Toxoplasma gondii correlates with reduced IL2, IL6, and IL12 and elevated IL10 expression by lymph node T cells

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(1-2), 101โ€“111.

By: J. Levyโ€‰*, Y. Liang n, J. Ritchey*, M. Davidson n, W. Tompkins n & M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: FIV; cytokine; Toxoplasma gondii
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Gene Expression; Immunodeficiency Virus, Feline; Interleukin-10 / genetics; Interleukin-12 / genetics; Interleukin-2 / genetics; Interleukin-6 / genetics; Interleukins / genetics; Lentivirus Infections / complications; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; T-Lymphocytes / immunology; Toxoplasmosis, Animal / complications; Toxoplasmosis, Animal / genetics; Toxoplasmosis, Animal / immunology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Feline immunodeficiency virus envelope glycoprotein mediates apoptosis in activated PBMC by a mechanism dependent on gp41 function

VIROLOGY, 330(2), 424โ€“436.

By: H. Garg n, A. Joshi n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: FIV; envelope; apoptosis; fusion; syncytia; CD134; CXCR4
MeSH headings : Animals; Anti-HIV Agents / pharmacology; Apoptosis; Benzylamines; Cats; Cell Fusion; Cell Survival; Cells, Cultured; Cyclams; Glycoproteins / genetics; Glycoproteins / physiology; Heterocyclic Compounds / pharmacology; Immunodeficiency Virus, Feline / pathogenicity; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / virology; Membrane Fusion; Mutation / genetics; Mutation / physiology; Receptors, CXCR4 / antagonists & inhibitors; Receptors, OX40; Receptors, Tumor Necrosis Factor; Viral Envelope Proteins / genetics; Viral Envelope Proteins / physiology; Viral Fusion Proteins / genetics; Viral Fusion Proteins / physiology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4(+)CD25(+) T regulatory cells

JOURNAL OF IMMUNOLOGY, 172(8), 4752โ€“4761.

By: T. Vahlenkamp n, M. Tompkins n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Antigens, CD / biosynthesis; Antigens, CD / metabolism; Antigens, Differentiation / biosynthesis; Antigens, Viral / biosynthesis; B7-1 Antigen / biosynthesis; B7-1 Antigen / metabolism; B7-2 Antigen; CTLA-4 Antigen; Cats; Cell Division / immunology; Cell Separation; Cells, Cultured; Chronic Disease; Coculture Techniques; Concanavalin A / pharmacology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Immunophenotyping; Interleukin-2 / biosynthesis; Interleukin-2 / deficiency; Ligands; Lipopolysaccharides / pharmacology; Lymph Nodes / cytology; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Lymphocyte Count; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / metabolism; Receptors, Interleukin-2 / biosynthesis; Receptors, Interleukin-2 / blood; Receptors, Interleukin-2 / metabolism; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism; T-Lymphocyte Subsets / virology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; T-Lymphocytes, Regulatory / virology; Up-Regulation / immunology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion

VIROLOGY, 321(2), 274โ€“286.

By: H. Garg n, F. Fuller nโ€‰ & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: feline immunodeficiency virus; glycoprotein-mediated fusion; lentiviruses
MeSH headings : Amino Acid Sequence; Animals; Benzylamines; CD4-Positive T-Lymphocytes / metabolism; CD4-Positive T-Lymphocytes / virology; Cats; Cell Line; Cyclams; Giant Cells; Heterocyclic Compounds / pharmacology; Immunodeficiency Virus, Feline / isolation & purification; Immunodeficiency Virus, Feline / physiology; Molecular Sequence Data; Peptides / chemical synthesis; Peptides / pharmacology; Protein Conformation; Protein Structure, Tertiary; Receptors, CXCR4 / antagonists & inhibitors; Receptors, CXCR4 / physiology; Sequence Alignment; Tryptophan; Viral Fusion Proteins / genetics; Viral Fusion Proteins / metabolism; Viral Fusion Proteins / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation

VIROLOGY, 321(2), 307โ€“322.

By: A. Joshi n, T. Vahlenkamp n, H. Garg n, W. Tompkins n & M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: FIV; HIV; AIDS; latency; stimulation; anergy; apoptosis; reservoir
MeSH headings : Animals; Apoptosis; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; Cats; Cell Division / immunology; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / physiology; Lymphocyte Activation; Receptors, Interleukin-2 / analysis; Virus Latency; Virus Replication
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 99(1-2), 25โ€“37.

By: M. Bull n, T. Vahlenkamp n, J. Dow n, E. Collisson*, B. Winslow, A. Phadke*, M. Tompkins n, W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: FIV; apoptosis; IL2; B7 co-stimulatory molecules; CTLA4
MeSH headings : Animals; Antibodies, Blocking / immunology; Antigens, CD / immunology; Apoptosis / drug effects; Apoptosis / immunology; B7-2 Antigen; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / virology; Cats; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Interleukin-2 / immunology; Interleukin-2 / pharmacology; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / antagonists & inhibitors; Membrane Glycoproteins / immunology; RNA, Viral / chemistry; RNA, Viral / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Evaluation of T lymphocytes in captive African lions (Panthera leo) infected with feline immunodeficiency virus

AMERICAN JOURNAL OF VETERINARY RESEARCH, 64(10), 1293โ€“1300.

By: M. Bull*, S. Kennedy-Stoskopf*, J. Levine*โ€‰, M. Loomis*, D. Gebhard & W. Tompkins

MeSH headings : Animals; Animals, Zoo; Antibodies, Viral / blood; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Female; Flow Cytometry; Immunodeficiency Virus, Feline; Lions / immunology; North Carolina; T-Lymphocytes / immunology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

C-terminal gp40 peptide analogs inhibit feline immunodeficiency virus: Cell fusion and virus spread

JOURNAL OF VIROLOGY, 76(18), 9079โ€“9086.

By: R. Medinas n, D. Lambert & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Animals; Antiviral Agents / chemical synthesis; Antiviral Agents / chemistry; Antiviral Agents / pharmacology; Cats; Cell Fusion; Dose-Response Relationship, Drug; HIV Envelope Protein gp41 / chemistry; HIV-1 / drug effects; HIV-1 / physiology; HeLa Cells; Humans; Immunodeficiency Virus, Feline / drug effects; Immunodeficiency Virus, Feline / physiology; Membrane Fusion / drug effects; Microbial Sensitivity Tests; Molecular Sequence Data; Peptide Fragments / chemical synthesis; Peptide Fragments / chemistry; Peptide Fragments / pharmacology; Protein Structure, Tertiary; Viral Plaque Assay
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats

VACCINE, 21(3-4), 258โ€“268.

By: M. Burkhard n, L. Valenski n, S. Leavell n, G. Dean n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Venezuelan equine encephalitis (VEE) virus; VEE-replicon particles; feline immunodeficiency virus (FIV)
MeSH headings : Animals; Antibodies, Viral / biosynthesis; Antibodies, Viral / blood; Cats; Encephalitis Virus, Venezuelan Equine / genetics; Evaluation Studies as Topic; Feline Acquired Immunodeficiency Syndrome / immunology; Female; Genetic Vectors / genetics; Glycoproteins; Immunodeficiency Virus, Feline / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Regulatory / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / immunology; Vagina / immunology; Vagina / virology; Viral Envelope Proteins; Viral Vaccines / administration & dosage; Viral Vaccines / immunology; Viremia / blood
Source: Web Of Science
Added: August 6, 2018

2002 article

Feline immunodeficiency virus infection is characterized by B7(+)CTLA4(+) T cell apoptosis

Tompkins, M. B., Bull, M. E., Dow, J. L., Ball, J. M., Collisson, E. W., Winslow, B. J., โ€ฆ Tompkins, W. A. (2002, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 185, pp. 1077โ€“1093.

By: M. Tompkins*, M. Bull*, J. Dow*, J. Ball, E. Collisson, B. Winslow, A. Phadke, T. Vahlenkamp*, W. Tompkins*

MeSH headings : Abatacept; Animals; Antigens, CD / analysis; Antigens, Differentiation / analysis; Apoptosis; B7-1 Antigen / analysis; B7-2 Antigen; CTLA-4 Antigen; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunoconjugates; In Situ Nick-End Labeling; Membrane Glycoproteins / analysis; T-Lymphocytes / physiology
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Infection of the choroid plexus by feline immunodeficiency virus

JOURNAL OF NEUROVIROLOGY, 8(3), 211โ€“224.

By: D. Bragg*, T. Childers n, M. Tompkins n, W. Tompkins n & R. Meekerโ€‰ n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: human immunodeficiency virus; macrophages; brain; AIDS; neural culture
MeSH headings : Animals; Cats; Cells, Cultured; Choroid Plexus / cytology; Choroid Plexus / virology; Coculture Techniques; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / isolation & purification; Immunodeficiency Virus, Feline / pathogenicity; Immunohistochemistry; Macrophages / cytology; Macrophages / virology; Neurons / cytology; Neurons / virology; Polymerase Chain Reaction; Proviruses / genetics; Proviruses / isolation & purification; Specific Pathogen-Free Organisms; T-Lymphocytes / cytology; T-Lymphocytes / virology; Virulence
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Inhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro

JOURNAL OF VIROLOGY, 76(19), 9952โ€“9961.

By: J. Maโ€‰ n, S. Kennedy-Stoskopf n, J. Jaynes, L. Thurmond* & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Animals; Antiviral Agents / pharmacology; Cats; Gene Products, gag / analysis; HIV Antigens / analysis; Immunodeficiency Virus, Feline / drug effects; Molecular Sequence Data; Peptides / pharmacology; Protein Structure, Secondary; RNA, Messenger / analysis; Reverse Transcriptase Inhibitors / pharmacology; Virus Assembly / drug effects; Virus Replication / drug effects; gag Gene Products, Human Immunodeficiency Virus
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Polymorphic expression in the CD8 alpha chain surface receptor of African lions (Panthera leo)

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 84(3-4), 181โ€“189.

By: M. Bull n, D. Gebhard*, W. Tompkins n & S. Kennedy-Stoskopf n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: African lion (Panthera leo); monoclonal antibody; cross-reactivity; CD8 alpha polymorphism
MeSH headings : Africa, Southern; Animals; Antibodies, Monoclonal; Antibody Specificity; Cats; Cross Reactions; Epitopes; Lions / genetics; Lions / immunology; Polymorphism, Genetic; Receptors, Antigen, T-Cell / chemistry; Receptors, Antigen, T-Cell / genetics; Species Specificity
Source: Web Of Science
Added: August 6, 2018

2001 conference paper

B7.1/B7.2 and CTLA4 expression on feline T cells in vitro correlates with apoptosis

Journal of Leukocyte Biology, (2001), 255.

By: T. Vahlenkamp, M. Bull, J. Dow, J. Anderson, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Constitutive expression of types 1 and 2 cytokines by alveolar macrophages from feline immunodeficiency virus-infected cats

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 79(1-2), 83โ€“100.

By: J. Ritchey n, J. Levy n, S. Bliss n, W. Tompkins n & M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: FIV; macrophages; interleukins
MeSH headings : Animals; Bronchoalveolar Lavage / veterinary; Cat Diseases / metabolism; Cats; Feline Acquired Immunodeficiency Syndrome / metabolism; Gene Products, gag / biosynthesis; Immunodeficiency Virus, Feline; Interleukin-10 / biosynthesis; Interleukin-12 / biosynthesis; Interleukin-6 / biosynthesis; Macrophages, Alveolar / metabolism; Male; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Tumor Necrosis Factor-alpha / biosynthesis; Viral Envelope Proteins / biosynthesis
Source: Web Of Science
Added: August 6, 2018

2001 conference paper

Feline immunodeficiency virus (FIV) infection induces B7(+)CTLA4(+) T cell apoptosis: A model for T cell depletion and immunodeficiency

Journal of Leukocyte Biology, (2001), 254.

By: M. Tompkins, M. Bull, J. Dow & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2001 patent

Nucleic acids obtained from the envelope coding region of feline immunodeficiency virus molecular clone designated JSY3

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins, M. Tompkins & J. Yang

Source: NC State University Libraries
Added: August 6, 2018

2001 conference paper

T cell apoptosis in FIV-infected cats is blocked by the addition of antibodies to B7.1 and B7.2

Journal of Leukocyte Biology, (2001), 256.

By: M. Bull, T. Vahlenkamp, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Cloning and sequencing hybrid striped bass (Morone saxatilis x M. chrysops) transforming growth factor-ฮฒ (TGF-ฮฒ), and development of a reverse transcription quantitative competitive polymerase chain reaction (RT-qcPCR) assay to measure TGF-ฮฒ mRNA of teleost fish

Fish & Shellfish Immunology, 10(1), 61โ€“85.

By: C. Harms nโ€‰, S. Kennedy-Stoskopf n, W. Horne n, F. Fuller nโ€‰ & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: transforming growth factor-beta; TGF-beta; sequence; hybrid striped bass; Morone saxatilis X M-chrysops; quantitative PCR
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Bass / metabolism; Blotting, Northern / veterinary; Blotting, Southern / veterinary; Chimera / genetics; Cloning, Molecular; Consensus Sequence; Humans; Kidney / chemistry; Molecular Sequence Data; Oncorhynchus mykiss; RNA, Messenger / analysis; Rats; Reverse Transcriptase Polymerase Chain Reaction / methods; Transforming Growth Factor beta / genetics; Xenopus
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2000 journal article

T cells overexpressing interferon-gamma and interleukin-10 are found in both the thymus and secondary lymphoid tissues of feline immunodeficiency virus-infected cats

JOURNAL OF INFECTIOUS DISEASES, 181(2), 564โ€“575.

By: Y. Liang n, L. Hudson n, J. Levy n, J. Ritchey n, W. Tompkins n & M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; B-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Gene Products, gag / metabolism; Immunodeficiency Virus, Feline / immunology; Immunohistochemistry; In Situ Hybridization; Interferon-gamma / biosynthesis; Interferon-gamma / genetics; Interleukin-10 / biosynthesis; Interleukin-10 / genetics; Lymph Nodes / immunology; Lymph Nodes / pathology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocyte Subsets / immunology; Thymus Gland / immunology; Thymus Gland / pathology
Source: Web Of Science
Added: August 6, 2018

1999 review

Immunomodulation and therapeutic effects of the oral use of interferon-alpha: Mechanism of action

[Review of ]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 19(8), 817โ€“828.

By: W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Adjuvants, Immunologic / therapeutic use; Administration, Oral; Antibody Formation; Dose-Response Relationship, Drug; Humans; Interferon-alpha / therapeutic use; Mucous Membrane / drug effects; Mucous Membrane / immunology
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats

JOURNAL OF INFECTIOUS DISEASES, 180(5), 1503โ€“1513.

By: D. Gebhard n, J. Dow n, T. Childers n, J. Alvelo n, M. Tompkins n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; CD8-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / immunology; Immunophenotyping; Integrins / metabolism; L-Selectin / analysis; Leukocytes, Mononuclear / immunology; Lymph Nodes / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / immunology
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Shedding of feline immunodeficiency virus in semen of domestic cats during acute infection

American Journal of Veterinary Research, 60(2), 211โ€“215.

By: H. Jordan, Y. Liang, L. Hudson & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Biphasic thymus response by kittens inoculated with feline immunodeficiency virus during fetal development

VETERINARY PATHOLOGY, 35(3), 191โ€“201.

By: C. Johnson*, G. Papadi*, W. Tompkins n, R. Sellon n, M. Orandle*, . Bellah*, L. Bubenik*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: animal models; lymphoid tissue; pediatrics; thymus
MeSH headings : Animals; Body Weight; CD4-CD8 Ratio / veterinary; Cats; Embryonic and Fetal Development; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Flow Cytometry / veterinary; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / isolation & purification; Immunodeficiency Virus, Feline / pathogenicity; In Situ Hybridization / veterinary; Lymphatic Diseases / immunology; Lymphatic Diseases / pathology; Lymphatic Diseases / veterinary; Lymphatic Diseases / virology; Lymphocyte Subsets; Organ Size; Pregnancy; Pregnancy Complications, Infectious / pathology; Pregnancy Complications, Infectious / veterinary; Pregnancy Complications, Infectious / virology; RNA, Viral / analysis; Thymus Gland / immunology; Thymus Gland / pathology; Thymus Gland / virology
Source: Web Of Science
Added: August 6, 2018

1998 article

Elevated interleukin-10-to-interleukin-12 ratio in feline immunodeficiency virus-infected cats predicts loss of type 1 immunity to Toxoplasma gondii

Levy, J. K., Ritchey, J. W., Rottman, J. B., Davidson, M. G., Liang, Y. H., Jordan, H. L., โ€ฆ Tompkins, M. B. (1998, August). JOURNAL OF INFECTIOUS DISEASES, Vol. 178, pp. 503โ€“511.

By: J. Levy n, J. Ritchey n, J. Rottmanโ€‰ n, M. Davidson n, Y. Liang n, H. Jordan n, W. Tompkins n, M. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Bronchi / immunology; Cats; Cytokines / biosynthesis; Cytokines / genetics; Disease Models, Animal; Immunity; Immunodeficiency Virus, Feline / immunology; Interleukin-10 / biosynthesis; Interleukin-10 / genetics; Interleukin-10 / immunology; Interleukin-12 / biosynthesis; Interleukin-12 / genetics; Interleukin-12 / immunology; Lentivirus Infections / complications; Lentivirus Infections / immunology; Lymph Nodes / immunology; Male; RNA, Messenger; Toxoplasmosis / complications; Toxoplasmosis / immunology
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Feline immunodeficiency virus is shed in semen from experimentally and naturally infected cats

AIDS RESEARCH AND HUMAN RETROVIRUSES, 14(12), 1087โ€“1092.

By: H. Jordan*, J. Howard*, M. Barr, S. Kennedy-Stoskopf*, J. Levy* & W. Tompkins*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Cats; Cell Line; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / isolation & purification; Male; Semen / virology; Virus Shedding
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Horizontal transmission of feline immunodeficiency virus with semen from seropositive cats

Journal of Reproductive Immunology, 41(1-2), 341โ€“357.

By: H. Jordan*, J. Howardโ€‰*, J. Bucci n, J. Butterworth n, R. English n, S. Kennedy-Stoskopf n, M. Tompkins n, W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Cats; Disease Transmission, Infectious; Female; Genitalia, Female / virology; Immunodeficiency Virus, Feline / physiology; Insemination, Artificial / adverse effects; Lentivirus Infections / transmission; Proviruses; Semen / virology; Vagina / virology; Virus Replication
Source: NC State University Libraries
Added: August 6, 2018

1998 chapter

Immunology of the cat: Nonspecific immunity in the cat

In Handbook of vertebrate immunology. San Diego: Academic Press.

By: J. Ritchey & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Lessons from the cat: Feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1

AIDS RESEARCH AND HUMAN RETROVIRUSES, 14(9), 797โ€“801.

By: J. Elder, G. Dean*, E. Hooverโ€‰*, J. Hoxieโ€‰*, M. Malim*, L. Mathes*, J. Neil*, T. North* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : AIDS Vaccines; Animals; Anti-HIV Agents / therapeutic use; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Feline Acquired Immunodeficiency Syndrome / therapy; Feline Acquired Immunodeficiency Syndrome / transmission; Feline Acquired Immunodeficiency Syndrome / virology; Genome, Viral; HIV Infections / prevention & control; HIV Infections / therapy; HIV Infections / transmission; HIV Infections / virology; HIV-1 / chemistry; Humans; Immunodeficiency Virus, Feline / chemistry; Immunodeficiency Virus, Feline / genetics
Source: Web Of Science
Added: August 6, 2018

1998 article

Mucosally transmitted feline immunodeficiency virus induces a CD8(+) antiviral response that correlates with reduction of cell-associated virus

Bucci, J. G., English, R. V., Jordan, H. L., Childers, T. A., Tompkins, M. B., & Tompkins, W. A. F. (1998, January). JOURNAL OF INFECTIOUS DISEASES, Vol. 177, pp. 18โ€“25.

By: J. Bucci n, R. English n, H. Jordan n, T. Childers n, M. Tompkins n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Antibodies, Viral / analysis; CD8-Positive T-Lymphocytes / immunology; Cats; Cells, Cultured; Coculture Techniques; Female; Immunodeficiency Virus, Feline; Lentivirus Infections / immunology; Lentivirus Infections / transmission; Lentivirus Infections / virology; Leukocytes, Mononuclear / virology; Longitudinal Studies; Specific Pathogen-Free Organisms; Vagina / virology; Viremia / immunology; Virus Replication / immunology
Source: Web Of Science
Added: August 6, 2018

1998 journal article

The CD8(+) cell phenotype mediating antiviral activity in feline immunodeficiency virus-infected cats is characterized by reduced surface expression of the CD8 beta chain

JOURNAL OF INFECTIOUS DISEASES, 178(4), 968โ€“977.

By: J. Bucci n, D. Gebhard n, T. Childers n, R. English n, M. Tompkins n & W. Tompkins n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Acute Disease; Animals; Antibody Specificity; CD8 Antigens / biosynthesis; CD8 Antigens / immunology; CD8-Positive T-Lymphocytes / immunology; Carrier State; Cats; Down-Regulation; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry; Immunity, Cellular; Immunodeficiency Virus, Feline / isolation & purification; Phenotype
Source: Web Of Science
Added: August 6, 2018

1997 patent

Feline immunodeficiency virus isolate NCSU.sub.1

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins & M. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1995 patent

Feline immunodeficiency virus isolate NCSU.sub.1Lb

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins & M. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

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