Wayne Tompkins Fogle, J. E., Tompkins, W. A., Campbell, B., Sumner, D., & Tompkins, M. B. (2011). Fozivudine Tidoxil as Single-Agent Therapy Decreases Plasma and Cell-Associated Viremia during Acute Feline Immunodeficiency Virus Infection. JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(3), 413–418. https://doi.org/10.1111/j.1939-1676.2011.0699.x Fogle, J. E., Mexas, A. M., Tompkins, W. A., & Tompkins, M. B. (2010). CD4(+)CD25(+) T Regulatory Cells Inhibit CD8(+) IFN-gamma Production During Acute and Chronic FIV Infection Utilizing a Membrane TGF-beta-Dependent Mechanism. AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(2), 201–216. https://doi.org/10.1089/aid.2009.0162 Fogle, J. E., Tompkins, W. A., & Tompkins, M. B. (2010). CD4(+)CD25(+) T regulatory cells from FIV+ cats induce a unique anergic profile in CD8(+) lymphocyte targets. RETROVIROLOGY, 7. https://doi.org/10.1186/1742-4690-7-97 Mexas, A. M., Fogle, J. E., Tompkins, W. A., & Tompkins, M. B. (2008). CD4(+)CD25(+) regulatory T cells are infected and activated during acute FIV infection. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 126(3-4), 263–272. https://doi.org/10.1016/j.vetimm.2008.08.003 Lankford, S., Petty, C., La Voy, A., Reckling, S., Tompkins, W., & Dean, G. A. (2008). Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 122(1-2), 159–166. https://doi.org/10.1016/j.vetimm.2007.11.007 Tompkins, M. B., & Tompkins, W. A. (2008, May 15). Lentivirus-induced immune dysregulation. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 123, pp. 45–55. https://doi.org/10.1016/j.vetimm.2008.01.011 Petty, C. S., Tompkins, M. B., & Tompkins, W. A. (2008). Transforming growth factor-beta/transforming growth factor-beta RII signaling may regulate CD4(+)CD25(+) T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 47(2), 148–160. https://doi.org/10.1097/QAI.0b013e318160df70 Joshi, A., Garg, H., Tompkins, M. B., & Tompkins, W. A. (2005). Different thresholds of T cell activation regulate FIV infection of CD4(+)CD25(+) and CD4(+)CD25(-) cells. VIROLOGY, 335(2), 212–221. https://doi.org/10.1016/j.virol.2005.02.016 Joshi, A., Garg, H., Tompkins, M. B., & Tompkins, W. A. (2005). Preferential feline immunodeficiency virus (FIV) infection of CD4(+) CD25(+) T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors. JOURNAL OF VIROLOGY, 79(8), 4965–4976. https://doi.org/10.1128/JVI.79.8.4965-4976.2005 Vahlenkamp, T. W., Tompkins, M. B., & Tompkins, W. A. F. (2005, October 18). The role of CD4(+)CD25(+) regulatory T cells in viral infections. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 108, pp. 219–225. https://doi.org/10.1016/j.vetimm.2005.07.011 Vahlenkamp, T. W., Bull, M. E., Dow, J. L., Collisson, E. W., Winslow, B. J., Phadke, A. P., … Tompkins, M. B. (2004). B7(+)CTLA4(+) T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(3-4), 203–214. https://doi.org/10.1016/j.vetimm.2003.12.006 Levy, J. K., Liang, Y. H., Ritchey, J. W., Davidson, M. G., Tompkins, W. A., & Tompkins, M. B. (2004). Failure of FIV-infected cats to control Toxoplasma gondii correlates with reduced IL2, IL6, and IL12 and elevated IL10 expression by lymph node T cells. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(1-2), 101–111. https://doi.org/10.1016/j.vetimm.2003.11.002 Garg, H., Joshi, A., & Tompkins, W. A. (2004). Feline immunodeficiency virus envelope glycoprotein mediates apoptosis in activated PBMC by a mechanism dependent on gp41 function. VIROLOGY, 330(2), 424–436. https://doi.org/10.1016/j.virol.2004.10.007 Vahlenkamp, T. W., Tompkins, M. B., & Tompkins, W. A. F. (2004). Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4(+)CD25(+) T regulatory cells. JOURNAL OF IMMUNOLOGY, 172(8), 4752–4761. https://doi.org/10.4049/jimmunol.172.8.4752 Garg, H., Fuller, F. J., & Tompkins, W. A. F. (2004). Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion. VIROLOGY, 321(2), 274–286. https://doi.org/10.1016/j.virol.2004.01.006 Joshi, A., Vahlenkamp, T. W., Garg, H., Tompkins, W. A. F., & Tompkins, M. B. (2004). Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation. VIROLOGY, 321(2), 307–322. https://doi.org/10.1016/j.virol.2004.01.014 Bull, M. E., Vahlenkamp, T. W., Dow, J. L., Collisson, E. W., Winslow, B. J., Phadke, A. P., … Tompkins, W. A. F. (2004). Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 99(1-2), 25–37. https://doi.org/10.1016/j.vetimm.2004.01.010 Bull, M. E., Kennedy-Stoskopf, S., Levine, J. F., Loomis, M., Gebhard, D. G., & Tompkins, W. A. F. (2003). Evaluation of T lymphocytes in captive African lions (Panthera leo) infected with feline immunodeficiency virus. AMERICAN JOURNAL OF VETERINARY RESEARCH, 64(10), 1293–1300. https://doi.org/10.2460/ajvr.2003.64.1293 Medinas, R. J., Lambert, D. M., & Tompkins, W. A. (2002). C-terminal gp40 peptide analogs inhibit feline immunodeficiency virus: Cell fusion and virus spread. JOURNAL OF VIROLOGY, 76(18), 9079–9086. https://doi.org/10.1128/JVI.76.18.9079-9086.2002 Burkhard, M. J., Valenski, L., Leavell, S., Dean, G. A., & Tompkins, W. A. F. (2002). Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats. VACCINE, 21(3-4), 258–268. https://doi.org/10.1016/S0264-410X(02)00455-3 Tompkins, M. B., Bull, M. E., Dow, J. L., Ball, J. M., Collisson, E. W., Winslow, B. J., … Tompkins, W. A. (2002, April 15). Feline immunodeficiency virus infection is characterized by B7(+)CTLA4(+) T cell apoptosis. JOURNAL OF INFECTIOUS DISEASES, Vol. 185, pp. 1077–1093. https://doi.org/10.1086/339847 Bragg, D. C., Childers, T. A., Tompkins, M. B., Tompkins, W. A., & Meeker, R. B. (2002). Infection of the choroid plexus by feline immunodeficiency virus. JOURNAL OF NEUROVIROLOGY, 8(3), 211–224. https://doi.org/10.1080/13550280290049688 Ma, J., Kennedy-Stoskopf, S., Jaynes, J. M., Thurmond, L. M., & Tompkins, W. A. (2002). Inhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro. JOURNAL OF VIROLOGY, 76(19), 9952–9961. https://doi.org/10.1128/JVI.76.19.9952-9961.2002 Bull, M. E., Gebhard, D. G., Tompkins, W. A. F., & Kennedy-Stoskopf, S. (2002). Polymorphic expression in the CD8 alpha chain surface receptor of African lions (Panthera leo). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 84(3-4), 181–189. https://doi.org/10.1016/S0165-2427(01)00401-9 Vahlenkamp, T. W., Bull, M. E., Dow, J., Anderson, J., Tompkins, M. B., & Tompkins, W. A. F. (2001). B7.1/B7.2 and CTLA4 expression on feline T cells in vitro correlates with apoptosis. Journal of Leukocyte Biology, (2001), 255. Ritchey, J. W., Levy, J. K., Bliss, S. K., Tompkins, W. A. F., & Tompkins, M. B. (2001). Constitutive expression of types 1 and 2 cytokines by alveolar macrophages from feline immunodeficiency virus-infected cats. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 79(1-2), 83–100. https://doi.org/10.1016/S0165-2427(01)00250-1 Tompkins, M. B., Bull, M. E., Dow, J. L., & Tompkins, W. A. F. (2001). Feline immunodeficiency virus (FIV) infection induces B7(+)CTLA4(+) T cell apoptosis: A model for T cell depletion and immunodeficiency. Journal of Leukocyte Biology, (2001), 254. Tompkins, W. A., Tompkins, M., & Yang, J.-S. (2001). Nucleic acids obtained from the envelope coding region of feline immunodeficiency virus molecular clone designated JSY3. Washington, DC: U.S. Patent and Trademark Office. Bull, M. E., Vahlenkamp, T. W., Tompkins, M. B., & Tompkins, W. A. F. (2001). T cell apoptosis in FIV-infected cats is blocked by the addition of antibodies to B7.1 and B7.2. Journal of Leukocyte Biology, (2001), 256. Harms, C. A., Kennedy-Stoskopf, S., Horne, W. A., Fuller, F. J., & Tompkins, W. A. F. (2000). Cloning and sequencing hybrid striped bass (Morone saxatilis x M. chrysops) transforming growth factor-β (TGF-β), and development of a reverse transcription quantitative competitive polymerase chain reaction (RT-qcPCR) assay to measure TGF-β mRNA of teleost fish. Fish & Shellfish Immunology, 10(1), 61–85. https://doi.org/10.1006/fsim.1999.0230 Liang, Y. H., Hudson, L. C., Levy, J. K., Ritchey, J. W., Tompkins, W. A. F., & Tompkins, M. B. (2000). T cells overexpressing interferon-gamma and interleukin-10 are found in both the thymus and secondary lymphoid tissues of feline immunodeficiency virus-infected cats. JOURNAL OF INFECTIOUS DISEASES, 181(2), 564–575. https://doi.org/10.1086/315226 Tompkins, W. A. (1999). [Review of Immunomodulation and therapeutic effects of the oral use of interferon-alpha: Mechanism of action]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 19(8), 817–828. https://doi.org/10.1089/107999099313325 Gebhard, D. H., Dow, J. L., Childers, T. A., Alvelo, J. I., Tompkins, M. B., & Tompkins, W. A. F. (1999). Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats. JOURNAL OF INFECTIOUS DISEASES, 180(5), 1503–1513. https://doi.org/10.1086/315089 Jordan, H. L., Liang, Y. H., Hudson, L. C., & Tompkins, W. A. (1999). Shedding of feline immunodeficiency virus in semen of domestic cats during acute infection. American Journal of Veterinary Research, 60(2), 211–215. Johnson, C. M., Papadi, G. P., Tompkins, W. A., Sellon, R. K., Orandle, M. S., Bellah, JR, & Bubenik, L. J. (1998). Biphasic thymus response by kittens inoculated with feline immunodeficiency virus during fetal development. VETERINARY PATHOLOGY, 35(3), 191–201. https://doi.org/10.1177/030098589803500304 Levy, J. K., Ritchey, J. W., Rottman, J. B., Davidson, M. G., Liang, Y. H., Jordan, H. L., … Tompkins, M. B. (1998, August). Elevated interleukin-10-to-interleukin-12 ratio in feline immunodeficiency virus-infected cats predicts loss of type 1 immunity to Toxoplasma gondii. JOURNAL OF INFECTIOUS DISEASES, Vol. 178, pp. 503–511. https://doi.org/10.1086/515632 Jordan, H. L., Howard, J., Barr, M. C., Kennedy-Stoskopf, S., Levy, J. K., & Tompkins, W. A. (1998). Feline immunodeficiency virus is shed in semen from experimentally and naturally infected cats. AIDS RESEARCH AND HUMAN RETROVIRUSES, 14(12), 1087–1092. https://doi.org/10.1089/aid.1998.14.1087 Jordan, H. L., Howard, J. G., Bucci, J. G., Butterworth, J. L., English, R., Kennedy-Stoskopf, S., … Tompkins, W. A. (1998). Horizontal transmission of feline immunodeficiency virus with semen from seropositive cats. Journal of Reproductive Immunology, 41(1-2), 341–357. https://doi.org/10.1016/s0165-0378(98)00070-9 Ritchey, J. W., & Tompkins, W. A. F. (1998). Immunology of the cat: Nonspecific immunity in the cat. In Handbook of vertebrate immunology. San Diego: Academic Press. Elder, J. H., Dean, G. A., Hoover, E. A., Hoxie, J. A., Malim, M. H., Mathes, L., … Miller, R. H. (1998). Lessons from the cat: Feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1. AIDS RESEARCH AND HUMAN RETROVIRUSES, 14(9), 797–801. https://doi.org/10.1089/aid.1998.14.797 Bucci, J. G., English, R. V., Jordan, H. L., Childers, T. A., Tompkins, M. B., & Tompkins, W. A. F. (1998, January). Mucosally transmitted feline immunodeficiency virus induces a CD8(+) antiviral response that correlates with reduction of cell-associated virus. JOURNAL OF INFECTIOUS DISEASES, Vol. 177, pp. 18–25. https://doi.org/10.1086/513822 Bucci, J. G., Gebhard, D. H., Childers, T. A., English, R. V., Tompkins, M. B., & Tompkins, W. A. F. (1998). The CD8(+) cell phenotype mediating antiviral activity in feline immunodeficiency virus-infected cats is characterized by reduced surface expression of the CD8 beta chain. JOURNAL OF INFECTIOUS DISEASES, 178(4), 968–977. https://doi.org/10.1086/515699 Tompkins, W. A. F., & Tompkins, M. B. (1997). Feline immunodeficiency virus isolate NCSU.sub.1. Washington, DC: U.S. Patent and Trademark Office. Tompkins, W. A. F., & Tompkins, M. B. (1995). Feline immunodeficiency virus isolate NCSU.sub.1Lb. Washington, DC: U.S. Patent and Trademark Office.