Xuan Mei

Works (15)

Updated: May 10th, 2025 05:03

2025 article

Minimally invasive snakebite inspired microneedle delivery system for internal organs

Mei, X., Zhu, D., Li, J., Huang, K., Hu, S., Xing, M., & Cheng, K. (2025, March 24). Bioactive Materials.

By: X. Mei n, D. Zhu* , J. Li n, K. Huang* , S. Hu* , M. Xing *, K. Cheng*

author keywords: Microneedle; Exosomes; Cardiac repair; Minimally invasive delivery
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Optical Coherence Tomography Applications; Connexins and lens biology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 24, 2025

2024 article

Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction

Li, J., Sun, S., Zhu, D., Mei, X., Lyu, Y., Huang, K., … Cheng, K. (2024, August 26). Circulation, Vol. 150, pp. 710–723.

By: J. Li n, S. Sun, D. Zhu* , X. Mei*, Y. Lyu n, K. Huang n , Y. Li n , S. Liu* ...

author keywords: CD36; extracellular vesicles; exosomes; inhalation; myocardial infarction
MeSH headings : Animals; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardial Infarction / physiopathology; Exosomes / metabolism; Mice; Mice, Inbred C57BL; Administration, Inhalation; Disease Models, Animal; Swine; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Male; Ventricular Function, Left; Humans; Myocardium / metabolism; Myocardium / pathology; Stem Cells / metabolism; CD36 Antigens / metabolism; CD36 Antigens / genetics
topics (OpenAlex): Extracellular vesicles in disease; Cardiovascular Effects of Exercise; Tissue Engineering and Regenerative Medicine
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 1, 2024

2024 article

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

Wang, Z., Hu, S., Popowski, K. D., Liu, S., Zhu, D., Mei, X., … Cheng, K. (2024, March 12). Nature Communications, Vol. 15.

By: Z. Wang n, S. Hu* , K. Popowski n , S. Liu*, D. Zhu* , X. Mei n, J. Li*, Y. Hu * ...

MeSH headings : Cricetinae; Female; Animals; Humans; Mice; SARS-CoV-2; COVID-19; Angiotensin-Converting Enzyme 2; Exosomes; Tissue Distribution; Spike Glycoprotein, Coronavirus; Antibodies, Neutralizing
topics (OpenAlex): Extracellular vesicles in disease; SARS-CoV-2 and COVID-19 Research; COVID-19 Clinical Research Studies
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu n , K. Huang n , S. Hu n , K. Popowski n , K. Cheng n

topics (OpenAlex): SARS-CoV-2 and COVID-19 Research; SARS-CoV-2 detection and testing; COVID-19 diagnosis using AI
TL;DR: A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 6, 2023

2023 journal article

Intrapericardial long non-coding RNA–Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair

European Heart Journal, 44(19), 1748–1760.

By: D. Zhu n , S. Liu n, K. Huang n , J. Li n, X. Mei n, Z. Li n, K. Cheng n

author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
topics (OpenAlex): Cardiac Valve Diseases and Treatments; Cardiac Fibrosis and Remodeling; Cancer-related molecular mechanisms research
TL;DR: Novel mechanisms underlying EV therapy for improving adverse remodelling are established and a lncRNA therapy for cardiac fibrosis is proposed, which could be a promising way to treat myocardial fibrosis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 4, 2023

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n , A. Moatti n , G. Scull n, D. Silkstone n, H. Lutz  n, B. López de Juan Abad  n, A. George n , E. Belcher  n ...

topics (OpenAlex): Extracellular vesicles in disease; RNA Interference and Gene Delivery; Inhalation and Respiratory Drug Delivery
TL;DR: The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 17, 2022

2022 article

Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

Zhang, C., Zhang, W., Zhu, D., Li, Z., Wang, Z., Li, J., … Zhong, B. (2022, January 15). Journal of Nanobiotechnology, Vol. 1.

By: C. Zhang  n, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong *

Contributors: C. Zhang  n, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong *

author keywords: Osteoporosis; CXCR4; Secretome; Mesenchymal stem cells; Bone targeting; Nanoparticles
MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Disease Models, Animal; Endothelial Cells / chemistry; Endothelial Cells / metabolism; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / metabolism; Nanoparticle Drug Delivery System; Nanoparticles; Osteoporosis / metabolism; Rats; Receptors, CXCR4 / metabolism; Secretome / metabolism
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics; Graphene and Nanomaterials Applications
TL;DR: In a rat model of osteoporosis, MSC-Sec/CXCR4 NP were found to accumulate in bone, and such treatment inhibited osteoclast differentiation while promoting osteogenic proliferation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022

2021 article

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

Mei, X., Zhu, D., Li, J., Huang, K., Hu, S., Li, Z., … Cheng, K. (2021, November 1). Med, Vol. 11, pp. 1253–1268.e4.

By: X. Mei n, D. Zhu n , J. Li n, K. Huang n , S. Hu n , Z. Li n, B. Juan Abad n, K. Cheng n

Contributors: X. Mei n, D. Zhu n , J. Li n, K. Huang n , S. Hu n , Z. Li n, B. Juan Abad  n, K. Cheng n

MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
topics (OpenAlex): Nerve injury and regeneration; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
TL;DR: A fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 3, 2021

2021 article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

Zhang, S., Zhu, D., Li, Z., Huang, K., Hu, S., Lutz, H., … Cheng, K. (2021, January 1). Theranostics, Vol. 11, pp. 8894–8908.

By: S. Zhang n, D. Zhu n , Z. Li n, K. Huang n , S. Hu n , H. Lutz  n, M. Xie n, X. Mei n ...

Contributors: S. Zhang n, D. Zhu n , Z. Li n, K. Huang n , S. Hu n , H. Lutz  n, M. Xie n, X. Mei n ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
topics (OpenAlex): Reproductive Biology and Fertility; Tissue Engineering and Regenerative Medicine; Ovarian function and disorders
TL;DR: In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2021

2021 article

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart

Li, J., Hu, S., Zhu, D., Huang, K., Mei, X., Juan Abad, B. L., & Cheng, K. (2021, April 20). Journal of the American Heart Association, Vol. 10.

By: J. Li n, S. Hu n , D. Zhu n , K. Huang n , X. Mei n, B. Juan Abad  n, K. Cheng n

Contributors: J. Li n, S. Hu n , D. Zhu n , K. Huang n , X. Mei n, B. Abad  n, K. Cheng n

author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Mesenchymal stem cell research
TL;DR: An in‐depth study of primary theories of cell loss, including low efficiency in cell injection, “washout” effects, and cell death, is undertaken and the literature from the past decade that focuses on cell transplantation to the heart using various cell delivery routes is organized. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021

2021 article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

Li, J., Lv, Y., Zhu, D., Mei, X., Huang, K., Wang, X., … Wang, J. (2021, August 10). Chemical Engineering Journal, Vol. 1, p. 131581.

By: J. Li n, Y. Lv *, D. Zhu n , X. Mei n, K. Huang n , X. Wang  n, Z. Li n, S. Zhang n ...

Contributors: J. Li n, Y. Lv *, D. Zhu n , X. Mei n, K. Huang n , X. Wang  n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Mesenchymal stem cell research
TL;DR: Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2021 article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

Hu, S., Wang, X., Li, Z., Zhu, D., Cores, J., Wang, Z., … Cheng, K. (2021, June 8). Nano Today, Vol. 8.

By: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
topics (OpenAlex): Extracellular vesicles in disease; Cardiovascular Effects of Exercise
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2020 article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

Xie, M., Li, J., Zhang, S., Zhu, D., Mei, X., Wang, Z., … Cheng, K. (2020, December 3). Bioactive Materials, Vol. 6, pp. 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
topics (OpenAlex): Ovarian function and disorders; Reproductive Biology and Fertility; Sperm and Testicular Function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 article

Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy

Zhang, S., Zhu, D., Mei, X., Li, Z., Li, J., Xie, M., … Cheng, K. (2020, December 25). Bioactive Materials, Vol. 6, pp. 1957–1972.

By: S. Zhang n, D. Zhu n , X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Lutz  n, S. Wang *, K. Cheng n

Contributors: S. Zhang n, D. Zhu n , X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang *, K. Cheng n

author keywords: Stem cells; Primary ovarian insufficiency; Cell therapy; Biomaterials
topics (OpenAlex): Reproductive Biology and Fertility; Tissue Engineering and Regenerative Medicine; Pluripotent Stem Cells Research
TL;DR: A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 article

Recent Development in Therapeutic Cardiac Patches

Mei, X., & Cheng, K. (2020, November 27). Frontiers in Cardiovascular Medicine.

By: X. Mei n & K. Cheng n

author keywords: biomaterials; cardiac patch; myocardial infarction; cell therapy; cardiac tissue regeneration
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Cardiac Structural Anomalies and Repair
TL;DR: This review will present the most state-of-the-art cardiac patches and analysis their compositional details, and the recent advances to obtain scaffold biomaterials will be highlighted, including synthetic and natural materials. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 4, 2021

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