Works (1)
Updated: July 5th, 2023 15:41
2014 journal article
Pathway-Guided Identification of Gene-Gene Interactions
ANNALS OF HUMAN GENETICS, 78(6), 478–491.
author keywords: Pathway analysis; gene-gene interactions; bio-knowledge-guided
MeSH headings : Computer Simulation; Epistasis, Genetic; Genotype; Humans; Linear Models; Models, Genetic; Polymorphism, Single Nucleotide; Principal Component Analysis; Regression Analysis
TL;DR:
A regression model with pathway‐guided regularization for detecting interactions among genes using the principal components to summarize the SNP‐SNP interactions between a gene pair, and an L1 penalty that incorporates adaptive weights based on biological guidance and trait supervision to identify important main and interaction effects is proposed.
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Added: August 6, 2018
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