Works (1)

Updated: July 5th, 2023 15:41

2014 journal article

Pathway-Guided Identification of Gene-Gene Interactions


By: X. Wang n, D. Zhang n & J. Tzeng n

author keywords: Pathway analysis; gene-gene interactions; bio-knowledge-guided
MeSH headings : Computer Simulation; Epistasis, Genetic; Genotype; Humans; Linear Models; Models, Genetic; Polymorphism, Single Nucleotide; Principal Component Analysis; Regression Analysis
TL;DR: A regression model with pathway‐guided regularization for detecting interactions among genes using the principal components to summarize the SNP‐SNP interactions between a gene pair, and an L1 penalty that incorporates adaptive weights based on biological guidance and trait supervision to identify important main and interaction effects is proposed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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